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1. 发明授权

US09023847B2 Azaheterocyclic compounds 有权
标题翻译：氮杂环化合物
公开(公告)号：US09023847B2
公开(公告)日：2015-05-05
申请号：US13388690
申请日：2010-07-22
申请人： Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
发明人： Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
IPC分类号： C07D471/04 , C07D333/02 , C07D487/04
CPC分类号： C07D471/04 , C07D333/02 , C07D487/04
摘要： The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译：本发明提供根据式（I）的新型取代的氮杂环化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

2. 发明申请

US20120277228A1 Novel Azaheterocyclic Compounds 有权
标题翻译：新型氮杂环化合物
公开(公告)号：US20120277228A1
公开(公告)日：2012-11-01
申请号：US13388690
申请日：2010-07-22
申请人： Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
发明人： Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/496 , C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P25/00 , A61P17/00 , A61P13/08 , A61P17/06 , A61P3/10 , A61P27/02 , A61K31/437
CPC分类号： C07D471/04 , C07D333/02 , C07D487/04
摘要： The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译：本发明提供根据式（I）的新型取代的氮杂环化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

3. 发明申请

US20140107156A1 Novel Amino Azaheterocyclic Carboxamides 审中-公开
标题翻译：新型氨基氮杂环烷酰胺
公开(公告)号：US20140107156A1
公开(公告)日：2014-04-17
申请号：US14105974
申请日：2013-12-13
申请人： Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号： C07D215/04 , A61K31/47
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译：本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

4. 发明授权

US08637532B2 Amino azaheterocyclic carboxamides 有权
标题翻译：氨基氮杂环甲酰胺
公开(公告)号：US08637532B2
公开(公告)日：2014-01-28
申请号：US13148903
申请日：2010-02-04
申请人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译：本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

5. 发明申请

US20120046269A1 Novel Amino Azaheterocyclic Carboxamides 有权
标题翻译：新型氨基氮杂环烷酰胺
公开(公告)号：US20120046269A1
公开(公告)日：2012-02-23
申请号：US13148903
申请日：2010-02-04
申请人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Steiber , Brian L. Hodous , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人： Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Steiber , Brian L. Hodous , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号： A61K31/517 , C07D401/12 , A61K31/4709 , C07D405/12 , C07D409/12 , C07D403/12 , C07D401/04 , C07D413/12 , A61K31/5377 , C07D413/04 , C07D401/14 , C07D417/12 , C07D413/14 , C07D409/10 , C07D471/04 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P17/00 , A61P9/00 , A61P17/06 , A61P3/10 , A61P27/02 , C07D239/94
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译：本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

6. 发明授权

US08710044B2 Bicyclic azaheterocyclic carboxamides 有权
标题翻译：双环氮杂环甲酰胺
公开(公告)号：US08710044B2
公开(公告)日：2014-04-29
申请号：US13703276
申请日：2011-07-01
申请人： Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人： Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号： A61K31/00 , A61K31/519 , C07D239/72
CPC分类号： C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要： The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译：本发明提供了根据式（I）的新型双环氮杂杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

7. 发明申请

US20130137677A1 Bicyclic Azaheterocyclic Carboxamides 有权
标题翻译：双环氮杂环酰胺
公开(公告)号：US20130137677A1
公开(公告)日：2013-05-30
申请号：US13703276
申请日：2011-07-01
申请人： Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人： Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号： C07D239/94 , A61K45/06 , A61K31/517 , C07D403/12
CPC分类号： C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要： The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译：本发明提供了根据式（I）的新型双环氮杂杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

8. 发明授权

US09938268B2 C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof 有权
公开(公告)号：US09938268B2
公开(公告)日：2018-04-10
申请号：US13140090
申请日：2009-12-02
申请人： Yufang Xiao , Bayard R. Huck , Amanda E. Sutton , Thomas E. Richardson , Srinivasa R. Karra
发明人： Yufang Xiao , Bayard R. Huck , Amanda E. Sutton , Thomas E. Richardson , Srinivasa R. Karra
IPC分类号： C07D471/04 , C07D471/14 , C07D491/147 , C07D495/14
CPC分类号： C07D471/04 , C07D471/14 , C07D491/147 , C07D495/14
摘要： Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.

9. 发明申请

US20110312951A1 C-Ring Modified Tricyclic Benzonaphthiridinone Protein Kinase Inhibitors and Use Thereof 审中-公开
标题翻译： C环改性三环苯并萘啶酮蛋白激酶抑制剂及其用途
公开(公告)号：US20110312951A1
公开(公告)日：2011-12-22
申请号：US13140090
申请日：2009-12-02
申请人： Yufang Xiao , Bayard R. Huck , Amanda E. Sutton , Thomas E. Richardson , Srinivasa R. Karra
发明人： Yufang Xiao , Bayard R. Huck , Amanda E. Sutton , Thomas E. Richardson , Srinivasa R. Karra
IPC分类号： A61K31/538 , C07D471/14 , C07D491/147 , C07D495/14 , C07D471/04 , A61P37/00 , A61P35/00 , A61P9/10 , A61P3/10 , A61P27/02 , A61P29/00 , A61P19/02 , A61P25/28 , A61P17/06 , A61P17/02 , A61P3/00 , A61K31/4375
CPC分类号： C07D471/04 , C07D471/14 , C07D491/147 , C07D495/14
摘要： Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
摘要翻译：公开了C环改性的三环苯并萘环酮化合物及其类似物，包含这些化合物的药物组合物及其制备方法。该化合物可用于治疗适于蛋白激酶信号转导抑制，调节和/或调节的疾病。

10. 发明申请

US20160253690A1 SYSTEM AND METHOD FOR PRICE ANALYSIS AND OPTIMIZATION 审中-公开
标题翻译：价格分析和优化的系统和方法
公开(公告)号：US20160253690A1
公开(公告)日：2016-09-01
申请号：US15055056
申请日：2016-02-26
申请人： Thomas E. Richardson
发明人： Thomas E. Richardson
IPC分类号： G06Q30/02 , G06Q40/00 , G06Q20/20
CPC分类号： G06Q30/0206 , G06Q20/201 , G06Q20/202 , G06Q20/203 , G06Q40/12
摘要： A system and method for providing insights into pricing strategy for a retail store, particularly for optimizing prices of fast moving, long life cycle items in the consumer package goods industries is disclosed. The system includes a computer having a display, a processor, and memory, an input device for allowing a user to interact with the computer processor and display to change one or more parameters of sales and gross margin percent (GM %) so as to determine a price for at least one item for sale and an output device for outputting new pricing information for the at least one item. The method includes steps of receiving sales and cost data for items, displaying one or more graphs of sales and GM % for a plurality of items, iteratively updating the graphs based on user selected optimization parameters and outputting new prices for the one or more items based on the optimization.
摘要翻译：公开了一种用于提供对零售商店的定价策略的洞察的系统和方法，特别是用于优化消费品包装产业中快速移动，长寿命周期项目的价格。该系统包括具有显示器，处理器和存储器的计算机，用于允许用户与计算机处理器交互并显示以改变销售额和毛利率百分比（GM％）的一个或多个参数的输入装置，以便确定至少一个待售物品的价格和用于输出至少一个物品的新定价信息的输出装置。该方法包括以下步骤：接收项目的销售和成本数据，显示多个项目的销售和GM％的一个或多个图表，并基于用户选择的优化参数迭代地更新图表，并输出用于一个或多个项目的新价格对优化。

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