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1. 发明申请

WO2004089953A1 PURIN-6-ONE-DERIVATIVES 审中-公开
标题翻译：嘌呤-6-酮衍生物
公开(公告)号：WO2004089953A1
公开(公告)日：2004-10-21
申请号：PCT/EP2004/050234
申请日：2004-03-02
申请人： ALTANA PHARMA AG , TENOR, Hermann , BAER, Thomas , HATZELMANN, Armin
发明人： TENOR, Hermann , BAER, Thomas , HATZELMANN, Armin , QUINTINI, Gianluca
IPC分类号： C07D473/30
CPC分类号： C07D473/30
摘要： The compounds of a certain formula (I) in which e.g. R2, R3, R4 and R5 have the meanings as given below are novel effective PDE2 inhibitors. R2 is hydrogen, 1-4C-alkyl, 1-hydroxy-2-4C-alkyl, 1-4C-alkylcarbonyl or 1-(acetyloxy)-2-4C-alkyl and R3 is Arylbutyl, Heteroarylbutyl, Arylpropyl, Heteroarylpropyl, Arylethyl or Heteroarylethyl; wherein Aryl is phenyl, naphthalenyl or indanyl, each of which optionally substituted up to three times identically or differently by halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy or 1-4C-alkoxycarbonyl, Heteroaryl is pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, quinazolinyl, quinoxalinyl, cinnolinyl, quinolyl, isoquinolyl, naphthyridinyl, phthalazinyl, indolyl, isoindolyl, indazolyl, purinyl, pteridinyl, benzofuranyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrrolyl, pyrazolyl, furanyl or thiophenyl, each of which optionally substituted up to three times identically or differently by halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy or 1-4C-alkoxycarbonyl, R4 is 1-4C-alkoxy which is completely or predominantly substituted by fluorine and R5 is halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1 -4C-alkoxy which is completely or predominantly substituted by fluorine, 1-4C-alkoxycarbonyl, amino, mono- or di-1-4C-alkylamino, aminocarbonyl, mono- or di-1-4C-alkylaminocarbonyl, 1-4C-alkylcarbonylamino, 1-4C-alkylcarbonyloxy, 1-4C-alkylsulfonylamino, phenylcarbonylamino, phenylcarbonylamino substituted in the phenyl moiety by R6 and/or R7, benzylcarbonylamino, benzylcarbonylamino substituted in the phenyl moiety by R8 and/or R9, phenylsulfonylamino, phenylsulfonylamino substituted in the phenyl moiety by R10 and/or R11, benzylsulfonylamino or benzylsulfonylamino substituted in the phenyl moiety by R12 and/or R13.
摘要翻译：某些式（I）的化合物，其中例如 R2，R3，R4和R5具有以下给出的含义是新型有效的PDE2抑制剂。 R2是氢，1-4C-烷基，1-羟基-24C-烷基，1-4C-烷基羰基或1-（乙酰氧基）-2-4C-烷基，R3是芳基丁基，异芳基丁基，芳基丙基，异芳基丙基，芳基乙基或 Heteroarylethyl; 其中芳基是苯基，萘基或茚满基，其中的每一个任选被卤素，羟基，硝基，三氟甲基，羧基，1-4C-烷基，1-4C-烷氧基或1-4C-烷氧基羰基相同或不同地取代三次，杂芳基是吡啶基，吡嗪基，哒嗪基，嘧啶基，喹唑啉基，喹喔啉基，噌啉基，喹啉基，异喹啉基，萘啶基，喹喔啉基，吲哚基，异吲哚基，吲唑基，嘌呤基，蝶啶基，苯并呋喃基，苯并恶唑基，苯并噻唑基，苯并咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，咪唑基，吡咯基，吡唑基，呋喃基或噻吩基，其各自任选被卤素，羟基，硝基，三氟甲基，羧基，1-4C-烷基，1-4C-烷氧基或1-4C-烷氧基羰基 R4是完全或主要被氟取代的1-4C-烷氧基，R5是卤素，羟基，硝基，三氟甲基，羧基，1-4C-烷基，1-4C-烷氧基，1-4C-烷氧基，其完全或 predo 1-4位烷基羰基，1-4C-烷氧羰基，氨基，单 - 或二 - 1-4C-烷基氨基，氨基羰基，单 - 或二 - 1-4C-烷基氨基羰基，1-4C-烷基羰基氨基，1-4C-烷基羰氧基，1 由R 6和/或R 7在苯基部分取代的苯基羰基氨基，苯基羰基氨基，苯基羰基氨基，苄基羰基氨基，在苯基部分被R8和/或R9取代的苄基羰基氨基，苯基磺酰基氨基，在R10和/或R11在苯基部分取代的苯基磺酰基氨基，由R12和/或R13在苯基部分取代的苄基磺酰基氨基或苄基磺酰基氨基。

2. 发明申请

WO2006072615A2 TRIAZOLOPHTHALAZINES 审中-公开
公开(公告)号：WO2006072615A2
公开(公告)日：2006-07-13
申请号：PCT/EP2006/050041
申请日：2006-01-04
申请人： ALTANA Pharma AG , SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KÜLZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
发明人： SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KÜLZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
CPC分类号： C07D487/04
摘要： The compounds of formula (I) in which R1 and R2 have the meanings as given in the description are novel effective PDE2 inhibitors.
摘要翻译：其中R1和R2具有如说明书中给出的含义的式（I）化合物是新的有效的PDE2抑制剂。

3. 发明申请

WO2006111495A1 ROFLUMILAST FOR THE TREATMENT OF PULMONARY HYPERTENSION 审中-公开
标题翻译：肺结核治疗肺动脉高压
公开(公告)号：WO2006111495A1
公开(公告)日：2006-10-26
申请号：PCT/EP2006/061557
申请日：2006-04-12
申请人： ALTANA Pharma AG , BEUME, Rolf , HATZELMANN, Armin , MARX, Degenhard , SCHUDT, Christian , TENOR, Hermann , EDDAHIBI, Saadia , ADNOT, Serge
发明人： BEUME, Rolf , HATZELMANN, Armin , MARX, Degenhard , SCHUDT, Christian , TENOR, Hermann , EDDAHIBI, Saadia , ADNOT, Serge
IPC分类号： A61K31/44 , A61K31/4412 , A61K31/519 , A61K31/4985 , A61K31/53 , A61K31/506 , A61K31/5025 , A61P9/12
CPC分类号： A61K31/4412 , A61K31/44 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/53
摘要： The invention relates to the use of Roflumilast, Roflumilast-N-Oxide or a pharmaceutically acceptable salt of either for the treatment of pulmonary hypertension. The invention additionally relates to the use of Roflumilast, Roflumilast-N-oxide or a pharmaceutically acceptable salt of either in combination with a PDE5 inhibitor or a pharmaceutically acceptable salt thereof for the treatment of pulmonary hypertension.
摘要翻译：本发明涉及罗氟司特，罗氟司特-N-氧化物或其药学上可接受的盐用于治疗肺动脉高压的用途。本发明还涉及Roflumilast，Roflumilast-N-氧化物或其药学上可接受的盐与PDE5抑制剂或其药学上可接受的盐的组合用于治疗肺动脉高压的用途。

4. 发明申请

WO2006072612A2 TRIAZOLOPHTHALAZINES 审中-公开
公开(公告)号：WO2006072612A2
公开(公告)日：2006-07-13
申请号：PCT/EP2006/050032
申请日：2006-01-04
申请人： ALTANA PHARMA AG , SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KÜLZER, Raimund , TENOR, Hermann , KLEY, Hans-peter
发明人： SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KÜLZER, Raimund , TENOR, Hermann , KLEY, Hans-peter
CPC分类号： C07D487/04
摘要： The compounds of formula I in which R1, R2 and R3 have the meanings as given in the description are novel effective PDE2 inhibitors.
摘要翻译：其中R1，R2和R3具有本说明书中给出的含义的式I化合物是新型有效的PDE2抑制剂。

5. 发明申请

WO2006024640A2 TRIAZOLOPHTHALAZINES 审中-公开
公开(公告)号：WO2006024640A2
公开(公告)日：2006-03-09
申请号：PCT/EP2005/054266
申请日：2005-08-31
申请人： ALTANA PHARMA AG , SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KUELZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
发明人： SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KUELZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
CPC分类号： C07D487/04
摘要： The compounds of formula (I) in which R1 and R2 have the meanings as given in the description are novel effective PDE2 inhibitors.
摘要翻译：其中R 1和R 2具有如在说明书中给出的含义的式（I）化合物是新的有效PDE 2抑制剂。

6. 发明申请

WO2004062671A2 PDE4 INHIBITORS FOR THE TREATMENT OF NEOPLASMS OF LYMPHOID CELLS 审中-公开
标题翻译： PDE4抑制剂治疗淋巴细胞的神经细胞
公开(公告)号：WO2004062671A2
公开(公告)日：2004-07-29
申请号：PCT/EP2004/000196
申请日：2004-01-14
申请人： ALTANA PHARMA AG , BRAUNGER, Jürgen , SCHUDT, Christian
发明人： BRAUNGER, Jürgen , SCHUDT, Christian , HATZELMANN, Armin , TENOR, Hermann , GEKELER, Volker , SANDERS, Karl , GARATTINI, Enrico
IPC分类号： A61K31/502
CPC分类号： A61K45/06 , A61K31/00 , A61K31/502 , A61K2300/00
摘要： The invention relates to the use of certain PDE4 inhibitors alone or in combination with one or more differentiation inducing agents and/or an agent effective in raising intracellular concentrations of cAMP or a stable analogue of cAMP in the preparation of pharmaceutical compositions for the treatment of neoplasms of lymphoid cells.
摘要翻译：本发明涉及在制备用于治疗肿瘤的药物组合物中单独或与一种或多种分化诱导剂和/或有效提高cAMP或cAMP稳定类似物的细胞内浓度的某些PDE4抑制剂的用途的淋巴细胞。

7. 发明公开

EP1587512A2 PDE4 INHIBITORS FOR THE TREATMENT OF NEOPLASMS OF LYMPHOID CELLS 审中-公开
标题翻译： PDE4抑制剂用于淋巴样细胞的肿瘤治疗中
公开(公告)号：EP1587512A2
公开(公告)日：2005-10-26
申请号：EP04701902.1
申请日：2004-01-14
申请人： ALTANA Pharma AG
发明人： BRAUNGER, Jürgen , SCHUDT, Christian , HATZELMANN, Armin , TENOR, Hermann , GEKELER, Volker , SANDERS, Karl , GARATTINI, Enrico
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P35/02 , A61K31/502
CPC分类号： A61K45/06 , A61K31/00 , A61K31/502 , A61K2300/00
摘要： The invention relates to the use of certain PDE4 inhibitors alone or in combination with one or more differentiation inducing agents and/or an agent effective in raising intracellular concentrations of cAMP or a stable analogue of cAMP in the preparation of pharmaceutical compositions for the treatment of neoplasms of lymphoid cells.

8. 发明公开

EP1791543A2 TRIAZOLOPHTHALAZINES 有权
公开(公告)号：EP1791543A2
公开(公告)日：2007-06-06
申请号：EP05784647.9
申请日：2005-08-31
申请人： Altana Pharma AG
发明人： SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KUELZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
IPC分类号： A61K31/5025 , C07D487/04
CPC分类号： C07D487/04
摘要： The compounds of formula (I) in which R1 and R2 have the meanings as given in the description are novel effective PDE2 inhibitors.
摘要翻译：其中R 1和R 2具有如在说明书中给出的含义的式（I）化合物是新的有效PDE 2抑制剂。

9. 发明公开

EP1601675A1 PURIN-6-ONE-DERIVATIVES 审中-公开
标题翻译： PURIN-6-ON DERIVATE
公开(公告)号：EP1601675A1
公开(公告)日：2005-12-07
申请号：EP04716252.4
申请日：2004-03-02
申请人： ALTANA Pharma AG
发明人： TENOR, Hermann , BAER, Thomas , HATZELMANN, Armin , QUINTINI, Gianluca
IPC分类号： C07D473/30 , A61K31/522 , A61P9/00
CPC分类号： C07D473/30
摘要： The compounds of a certain formula (I) in which e.g. R2, R3, R4 and R5 have the meanings as given below are novel effective PDE2 inhibitors. R2 is hydrogen, 1-4C-alkyl, 1-hydroxy-2-4C-alkyl, 1-4C-alkylcarbonyl or 1-(acetyloxy)-2-4C-alkyl and R3 is Arylbutyl, Heteroarylbutyl, Arylpropyl, Heteroarylpropyl, Arylethyl or Heteroarylethyl; wherein Aryl is phenyl, naphthalenyl or indanyl, each of which optionally substituted up to three times identically or differently by halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy or 1-4C-alkoxycarbonyl, Heteroaryl is pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, quinazolinyl, quinoxalinyl, cinnolinyl, quinolyl, isoquinolyl, naphthyridinyl, phthalazinyl, indolyl, isoindolyl, indazolyl, purinyl, pteridinyl, benzofuranyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrrolyl, pyrazolyl, furanyl or thiophenyl, each of which optionally substituted up to three times identically or differently by halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy or 1-4C-alkoxycarbonyl, R4 is 1-4C-alkoxy which is completely or predominantly substituted by fluorine and R5 is halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1 -4C-alkoxy which is completely or predominantly substituted by fluorine, 1-4C-alkoxycarbonyl, amino, mono- or di-1-4C-alkylamino, aminocarbonyl, mono- or di-1-4C-alkylaminocarbonyl, 1-4C-alkylcarbonylamino, 1-4C-alkylcarbonyloxy, 1-4C-alkylsulfonylamino, phenylcarbonylamino, phenylcarbonylamino substituted in the phenyl moiety by R6 and/or R7, benzylcarbonylamino, benzylcarbonylamino substituted in the phenyl moiety by R8 and/or R9, phenylsulfonylamino, phenylsulfonylamino substituted in the phenyl moiety by R10 and/or R11, benzylsulfonylamino or benzylsulfonylamino substituted in the phenyl moiety by R12 and/or R13.

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