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    • 4. 发明申请
      WO1993016719A2 USE OF PLATELET DERIVED GROWTH FACTOR IN OPHTHALMIC WOUND HEALING 审中-公开
    • USE OF PLATELET DERIVED GROWTH FACTOR IN OPHTHALMIC WOUND HEALING
    • 使用平板电脑衍生生长因子进行OPHTHALMIC WOUND HEALING
    • WO1993016719A2
    • 1993-09-02
    • PCT/US1993001731
    • 1993-02-24
    • ALLERGAN, INC.
    • ALLERGAN, INC. , STERN, Michael, E. , WHEELER, Larry, A. , NICOLSON, Margery, A.
    • A61K37/02
    • C07K14/49 , A61K38/1858
    • A method of accelerating corneal wound healing and/or improving the quality of wound healing in a mammal comprises: (1) providing an ophthalmically compatible solution of platelet-derived growth factor; and (2) applying the solution to the cornea of a mammal at the time of or subsequent to occurrence of a corneal wound in a quantity sufficient to accelerate clinically detectable healing, the healing being accelerated through proliferation of epithelial cells and/or keratocytes of the cornea stimulated by application of the platelet-derived growth factor to the cornea. The method also improves the quality of wound healing. The platelet-derived growth factor can be selected from the group consisting of the AA isoform, the AB isoform, the BB isoform, and mixtures thereof. A preferable form of platelet-derived growth factor is a recombinantly-derived refolded B-chain homodimer of 119 amino acids, having the amino acid sequence of S-L-G-S-L-T-I-A-E-P-A-M-I-A-E-C-K-T-R-T-E-V-F-E-I-S-R-R-L-I-D-R-T-N-A- N-F-L-V-W-P-P-C-V-E-V-Q-R-C-S-G-C-C-N-N-R-N-V-Q-C-R-P-T-Q-V-Q-L-R-P-V- Q-V-R-K-I-E-I-V-R-K-K-P-I-F-K-K-A-T-V-T-L-E-D-H-L-A-C-K-C-E-T-V-A-A-A- R-P-V-T-R-S-P-G-G-S-Q-E-Q-R. The concentration of platelet-derived growth factor in the solution can be from about 10 mu g/ml to about 1000 mu g/ml, preferably from about 50 mu g/ml to about 500 mu g/ml, and most preferably about 100 mu g/ml. The invention also comprises pharmaceutical compositions for application to the cornea of a mammal for accelerating corneal wound healing and/or improving the quality of wound healing and tablets for preparation of the pharmaceutical compositions.
    • 加速角膜伤口愈合和/或改善哺乳动物伤口愈合质量的方法包括：（1）提供血小板衍生生长因子的眼科相容溶液; 和（2）在足以加速临床上可检测到的愈合的量的角膜伤口发生时或之后发生的哺乳动物的角膜施用该溶液，通过上皮细胞和/或角膜细胞的增殖加速愈合 通过将血小板衍生生长因子应用于角膜来刺激角膜。 该方法也提高了伤口愈合的质量。 血小板衍生生长因子可以选自AA同种型，AB同种型，BB同种型及其混合物。 的血小板衍生的生长因子的优选形式是119个氨基酸的重组衍生的重折叠B链同源二聚体，具有S-L-G-S-L-T-I-A-E-P-A-M-I-A-E-C-K-T-R-T-E-V-F-E-I-S-R-R-L-I-D-R-T-N-A- N-F-L-V-W-P-P-C-V-E-V-Q-R-C-S-G-C-C-N-N-R-N-V-Q-C-R-P-T-Q-V-Q-L-R-P-V-Q-V-R-K-I-E-I-V-R-K-K-P-I-F-K-K-A-T-V-T-L-E-D-H-L-A-C-K-C-E-T-V-A-A-A- R-P-V-T-R-S-P-G-G-S-Q-E-Q-R的氨基酸序列。 溶液中血小板衍生生长因子的浓度可以为约10μg/ ml至约1000μg/ ml，优选约50μg/ ml至约500μg/ ml，最优选为约100μg 克/毫升。 本发明还包括用于哺乳动物角膜的药物组合物，用于加速角膜伤口愈合和/或改善伤口愈合质量和用于制备药物组合物的片剂。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 5. 发明公开
      EP0639980A1 USE OF PLATELET DERIVED GROWTH FACTOR IN OPHTHALMIC WOUND HEALING 失效
    • USE OF PLATELET DERIVED GROWTH FACTOR IN OPHTHALMIC WOUND HEALING
    • 生长因子的使用，血小板来自于眼科创伤愈合的。
    • EP0639980A1
    • 1995-03-01
    • EP93907054.0
    • 1993-02-24
    • ALLERGAN, INC. , AMGEN INC.
    • STERN, Michael, E. , WHEELER, Larry, A. , NICOLSON, Margery, A.
    • A61K38 , A61P27 , A61P43 , C07K14
    • C07K14/49 , A61K38/1858
    • A method of accelerating corneal wound healing and/or improving the quality of wound healing in a mammal comprises: (1) providing an ophthalmically compatible solution of platelet-derived growth factor; and (2) applying the solution to the cornea of a mammal at the time of or subsequent to occurrence of a corneal wound in a quantity sufficient to accelerate clinically detectable healing, the healing being accelerated through proliferation of epithelial cells and/or keratocytes of the cornea stimulated by application of the platelet-derived growth factor to the cornea. The method also improves the quality of wound healing. The platelet-derived growth factor can be selected from the group consisting of the AA isoform, the AB isoform, the BB isoform, and mixtures thereof. A preferable form of platelet-derived growth factor is a recombinantly-derived refolded B-chain homodimer of 119 amino acids, having the amino acid sequence of S-L-G-S-L-T-I-A-E-P-A-M-I-A-E-C-K-T-R-T-E-V-F-E-I-S-R-R-L-I-D-R-T-N-A-N-F-L-V-W-P-P-C-V-E-V-Q-R-C-S-G-C-C-N-N-R-N-V-Q-C-R-P-T-Q-V-Q-L-R-P-V-Q-V-R-K-I-E-I-V-R-K-K-P-I-F-K-K-A-T-V-T-L-E-D-H-L-A-C-K-C-E-T-V-A-A-A-R-P-V-T-R-S-P-G-G-S-Q-E-Q-R. The concentration of platelet-derived growth factor in the solution can be from about 10 νg/ml to about 1000 νg/ml, preferably from about 50 νg/ml to about 500 νg/ml, and most preferably about 100 νg/ml. The invention also comprises pharmaceutical compositions for application to the cornea of a mammal for accelerating corneal wound healing and/or improving the quality of wound healing and tablets for preparation of the pharmaceutical compositions.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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