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1. 发明申请

US20100120741A1 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：组胺类受体的治疗疾病的杂环抑制剂
公开(公告)号：US20100120741A1
公开(公告)日：2010-05-13
申请号：US12556866
申请日：2009-09-10
申请人： Allen J. Borchardt , Clay Beauregard , Travis Cook , Robert L. Davis , Daniel A. Gamache , John M. Yanni
发明人： Allen J. Borchardt , Clay Beauregard , Travis Cook , Robert L. Davis , Daniel A. Gamache , John M. Yanni
IPC分类号： A61K31/397 , A61P11/06 , A61K31/55 , A61K31/551 , A61K31/4985 , C07D487/04 , A61P19/02
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04 , C07D519/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。

2. 发明申请

US20120065187A1 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：组胺类受体的治疗疾病的杂环抑制剂
公开(公告)号：US20120065187A1
公开(公告)日：2012-03-15
申请号：US13301131
申请日：2011-11-21
申请人： Allen J. Borchardt , Clay Beauregard , Travis Cook , Robert L. Davis , Daniel A. Gamache , John M. Yanni
发明人： Allen J. Borchardt , Clay Beauregard , Travis Cook , Robert L. Davis , Daniel A. Gamache , John M. Yanni
IPC分类号： A61K31/4985 , A61K31/55 , A61K31/551 , A61K31/5415 , A61P11/06 , A61P37/00 , A61P37/08 , A61P27/02 , A61P17/04 , A61P17/00 , C07D487/04 , A61P29/00
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04 , C07D519/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。

3. 发明申请

US20100063047A1 AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：用于治疗疾病的组胺受体的氨基嘧啶抑制剂
公开(公告)号：US20100063047A1
公开(公告)日：2010-03-11
申请号：US12556842
申请日：2009-09-10
申请人： Allen J. Borchardt , Clay Beauregard , Robert L. Davis , Daniel A. Gamache , John M. Yanni
发明人： Allen J. Borchardt , Clay Beauregard , Robert L. Davis , Daniel A. Gamache , John M. Yanni
IPC分类号： A61K31/5377 , C07D495/04 , A61K31/497 , A61K31/519 , A61K31/4365
CPC分类号： C07D495/04 , A61K9/0043 , A61K9/0048 , A61K9/0073 , A61K31/4365 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。

4. 发明授权

US08080566B1 Carbazole inhibitors of histamine receptors for the treatment of disease 失效
标题翻译：咔唑抑制剂组胺受体用于治疗疾病
公开(公告)号：US08080566B1
公开(公告)日：2011-12-20
申请号：US12482989
申请日：2009-06-11
申请人： Mehmet Kahraman , Allen J. Borchardt , Robert L. Davis , Stewart A. Noble , James W. Malecha
发明人： Mehmet Kahraman , Allen J. Borchardt , Robert L. Davis , Stewart A. Noble , James W. Malecha
IPC分类号： C07D401/14 , A61K31/454
CPC分类号： A61K31/454
摘要： The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及咔唑化合物，包含它们的药物组合物，以及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的方法。

5. 发明授权

US08739739B2 Apparatus for supporting an animal with a seatbelt 有权
标题翻译：用于支撑具有安全带的动物的装置
公开(公告)号：US08739739B2
公开(公告)日：2014-06-03
申请号：US13359013
申请日：2012-01-26
申请人： Robert L. Davis
发明人： Robert L. Davis
IPC分类号： A01K1/02
CPC分类号： B60R22/10 , A01K1/0272 , B60R2022/006
摘要： This invention generally relates to an animal or pet restraint apparatus for supporting an animal in a vehicle. The animal restraint apparatus adapted to engage with a vehicle seatbelt assembly having a waist strap portion and a shoulder strap portion. The apparatus is comprised of a flat tubular body having a tubular passage configured for releasably receiving the seatbelt assembly and a means for releasably engaging the back panel portion of the flat tubular body to the lower chest portion of a pet, avoiding the neck area. The present invention and its embodiments provide a means for safely and comfortably transporting a pet in a vehicle.
摘要翻译：本发明总体上涉及用于在车辆中支撑动物的动物或宠物约束装置。适于与具有腰带部分和肩带部分的车辆安全带组件接合的动物约束装置。该装置包括扁平管状体，该管状通道构造成用于可释放地接收安全带组件，以及用于将扁平管状体的后片部分可释放地接合到宠物的下胸部的装置，以避免颈部区域。本发明及其实施例提供了一种用于在车辆中安全和舒适地运输宠物的装置。

6. 发明授权

US07147412B2 Doweling jig for woodworking 失效
标题翻译：木工加工夹具
公开(公告)号：US07147412B2
公开(公告)日：2006-12-12
申请号：US10458214
申请日：2003-06-10
申请人： Robert L. Davis
发明人： Robert L. Davis
IPC分类号： B23B47/28
CPC分类号： B23B47/288 , B23B2222/04 , B23B2222/84 , B23B2260/004 , B23B2260/092 , B23B2270/16 , Y10T408/563 , Y10T408/567
摘要： The invention relates generally to clamping devices and mechanisms which provide versatile and/or accurate coupling between the communicating members. Some embodiments relate to the field of woodworking and a doweling jig therefor having a hinged jaw mechanism to provide improved clamping between the doweling jig and a workpiece. Some embodiments relate to a connection or attachment device having a hinged jaw mechanism for detachably attaching a body portion to a structure or support element. Advantageously, the hinged jaw mechanism compensates for angular variations and irregularity in shape of the workpiece, structure or support. The hinged jaw mechanism desirably provides load bearing substantially over its entire length span.
摘要翻译：本发明一般涉及在通信构件之间提供通用和/或精确耦合的夹紧装置和机构。一些实施例涉及木工领域，其具有铰链夹爪机构以提供在定位夹具和工件之间的改进夹紧的定位夹具。一些实施例涉及具有用于将主体部分可拆卸地附接到结构或支撑元件的铰接爪机构的连接或附接装置。有利的是，铰接爪机构补偿工件，结构或支撑件的角度变化和形状的不规则性。铰链钳爪机构理想地在其整个长度跨度上提供负载承载。

7. 发明授权

US5900512A Oxidation process 失效
标题翻译：氧化工艺
公开(公告)号：US5900512A
公开(公告)日：1999-05-04
申请号：US927657
申请日：1997-09-11
申请人： Hassan Y. Elnagar , Robert L. Davis
发明人： Hassan Y. Elnagar , Robert L. Davis
IPC分类号： C07C315/02 , C07C317/14 , C07F9/53
CPC分类号： C07C315/02 , C07F9/53
摘要： An oxidation process for organic compounds employs stabilized bromine chloride solutions as the oxidizing agent. Organic compounds which contain an oxidizable moiety, such as thioanisole and triphenylphosphine, are rapidly converted to sulfoxides and phosphine oxides, respectively, without over-oxidation.
摘要翻译：有机化合物的氧化方法使用稳定的溴化氯溶液作为氧化剂。含有可氧化部分的有机化合物如硫代苯甲醚和三苯基膦分别快速转化为亚砜和氧化膦，而不会过度氧化。

8. 发明授权

US5696133A Steroid receptor modulator compounds and methods 失效
标题翻译：类固醇受体调节剂化合物及方法
公开(公告)号：US5696133A
公开(公告)日：1997-12-09
申请号：US465556
申请日：1995-06-05
申请人： Todd K. Jones , Mark E. Goldman , Charlotte L.F. Pooley , David T. Winn , James P. Edwards , Sarah J. West , Christopher M. Tegley , Lin Zhi , Lawrence G. Hamann , Luc J. Farmer , Robert L. Davis
发明人： Todd K. Jones , Mark E. Goldman , Charlotte L.F. Pooley , David T. Winn , James P. Edwards , Sarah J. West , Christopher M. Tegley , Lin Zhi , Lawrence G. Hamann , Luc J. Farmer , Robert L. Davis
IPC分类号： C07D215/06 , C07D221/18 , C07D311/80 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D491/052 , A61K31/47
CPC分类号： C07D401/04 , C07D215/06 , C07D221/18 , C07D311/80 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiting steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.
摘要翻译：公开了用于类固醇受体的高亲和力，高选择性调节剂的非甾体化合物。还公开了掺入这种化合物的药物组合物，使用所公开的化合物的方法和用于治疗需要类固醇受体激动剂或拮抗剂治疗的患者的组合物，可用于制备化合物的中间体和用于制备类固醇受体调节剂化合物的方法。

9. 发明授权

US4670598A Process for preparing (hydrocarbylthio)aromatic amines 失效
标题翻译：制备（烃硫基）芳族胺的方法
公开(公告)号：US4670598A
公开(公告)日：1987-06-02
申请号：US796201
申请日：1985-11-08
申请人： Robert L. Davis
发明人： Robert L. Davis
IPC分类号： C07C149/42
摘要： (Hydrocarbylthio)aromatic polyamines are prepared by reacting an aromatic polyamine, such as a diaminobenzene, with a hydrocarbyl disulfide, such as an alkyl disulfide, in the presence of an iodide or bromide of a metal other than an alkali metal as a catalyst.
摘要翻译：（烃基硫代）芳族多胺通过芳族多胺如二氨基苯与烃基二硫化物如烷基二硫化物在除了碱金属以外的金属的碘化物或溴化物作为催化剂的存在下反应来制备。

10. 发明授权

US3983539A Polymorphic programmable units employing plural levels of sub-instruction sets 失效
公开(公告)号：US3983539A
公开(公告)日：1976-09-28
申请号：US594668
申请日：1975-07-10
申请人： Ulbe Faber , Robert L. Davis , David A. Fisher , Joseph D. McGonagle
发明人： Ulbe Faber , Robert L. Davis , David A. Fisher , Joseph D. McGonagle
IPC分类号： G06F9/22 , G06F9/24 , G06F9/40 , G06F9/06
CPC分类号： G06F9/4425 , G06F9/223 , G06F9/24
摘要： This disclosure relates to a programmable unit employing plural levels of sub-instruction sets in addition to conventional instruction sets. The conventional level of instruction sets is employed to specify computational routines and other processing algorithms to be carried out by the unit. Each instruction in a conventional set is implemented in the unit by a sequence of first level sub-instructions which specify the various operations to be carried out within the unit which operations are comprised within the specific routine. In turn, the various first level sub-instructions are implemented by second level sub-instructions which specify the various control signals required to set the various gates as required for the particular unit operation to be carried out. With this hierarchy of sub-instruction sets, first level sub-instruction sets may be interchanged dynamically during the operation of the unit to dynamically change the processing capability of the unit. This eliminates the requirement for any special logic circuitry to accommodate particular computational routines and allows the arithmetic logic unit to be designed as multiples of the basic logic unit in accordance with particular desired data path widths. A manner is disclosed by which the interchanging of first level sub-instruction sets provides for placing the unit in different control modes such as input-output control or processing control. A manner is also disclosed by which interchanging of different first level sub-instruction sets accommodates the execution of programs written in different program language forms.

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