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1. 发明申请

US20110257137A1 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：组胺类受体的治疗疾病的杂环抑制剂
公开(公告)号：US20110257137A1
公开(公告)日：2011-10-20
申请号：US13044906
申请日：2011-03-10
申请人： Allen Borchardt , Robert Davis , Clay Beauregard , Daniel Becker , Daniel Gamache , Stewart A. Noble , Mark Hellberg , Peter Klimko , Zhihai Qiu , Joseph Payne , John Yanni
发明人： Allen Borchardt , Robert Davis , Clay Beauregard , Daniel Becker , Daniel Gamache , Stewart A. Noble , Mark Hellberg , Peter Klimko , Zhihai Qiu , Joseph Payne , John Yanni
IPC分类号： A61K31/56 , C07D498/04 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K31/5377 , A61K31/496 , A61P29/00 , A61P37/08 , A61P11/06 , A61P27/02 , A61P11/00 , A61P17/00 , A61P17/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。

2. 发明申请

US20110237599A1 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开
公开(公告)号：US20110237599A1
公开(公告)日：2011-09-29
申请号：US13044035
申请日：2011-03-09
申请人： Allen Borchardt , Robert Davis , Clay Beauregard , Daniel Gamache , Mark Hellberg , Peter Klimko , John Yanni
发明人： Allen Borchardt , Robert Davis , Clay Beauregard , Daniel Gamache , Mark Hellberg , Peter Klimko , John Yanni
IPC分类号： A61K31/496 , C07D487/04 , A61P35/00 , A61P27/02 , A61P27/12 , A61P11/06 , A61P11/00 , A61P37/08 , A61P17/04
CPC分类号： A61K31/381 , A61K31/519 , C07D495/14
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

3. 发明授权

US08569300B2 Substituted tetrazolo[1,5-A]pyrazine inhibitors of histamine receptors for the treatment of disease 有权
标题翻译：用于治疗疾病的组胺受体的取代四唑[1,5-A]吡嗪抑制剂
公开(公告)号：US08569300B2
公开(公告)日：2013-10-29
申请号：US13044661
申请日：2011-03-10
申请人： Allen Borchardt , Robert Davis , Stewart A. Noble
发明人： Allen Borchardt , Robert Davis , Stewart A. Noble
IPC分类号： A61K31/495
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04
摘要： The present invention relates to substituted tetrazolo[1,5-a]pyrazine compounds for Formula IX: as well as pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及用于式IX的取代的四唑[1,5-a]吡嗪化合物及其药物组合物，其可用作H4R的抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病。

4. 发明申请

US20110237565A1 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 有权
标题翻译：组胺类受体的治疗疾病的杂环抑制剂
公开(公告)号：US20110237565A1
公开(公告)日：2011-09-29
申请号：US13044661
申请日：2011-03-10
申请人： Allen Borchardt , Robert Davis , Stewart A. Noble
发明人： Allen Borchardt , Robert Davis , Stewart A. Noble
IPC分类号： A61K31/397 , C07D487/04 , A61K31/496 , C07D413/14 , C07D471/04 , A61K31/4985 , A61P37/08 , A61P27/02 , A61P17/04 , A61P11/00
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及可用作H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。

5. 发明申请

US20080021217A1 HETEROCYCLIC INHIBITORS OF RHO KINASE 审中-公开
标题翻译： RHO激酶的杂环抑制剂
公开(公告)号：US20080021217A1
公开(公告)日：2008-01-24
申请号：US11780735
申请日：2007-07-20
申请人： Allen Borchardt , Mehmet Kahraman , Travis Cook , Robert Davis , Elizabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins , Michael Sertic , Dana Siegel
发明人： Allen Borchardt , Mehmet Kahraman , Travis Cook , Robert Davis , Elizabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins , Michael Sertic , Dana Siegel
IPC分类号： A61K31/44 , A61K31/495 , A61K31/519 , C07D237/26 , C07D401/14 , C07D413/00 , C07D413/14 , C07D417/04 , C07D487/00
CPC分类号： A61K31/395 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
摘要翻译：本发明涉及可用作Rho激酶抑制剂用于治疗或预防疾病的化合物和方法。

6. 发明申请

US20080021026A1 BENZOTHIOPHENE INHIBITORS OF RHO KINASE 审中-公开
标题翻译： RHO激酶的苯并噻吩抑制剂
公开(公告)号：US20080021026A1
公开(公告)日：2008-01-24
申请号：US11780834
申请日：2007-07-20
申请人： Mehmet Kahraman , Allen Borchardt , Travis Cook , Robert Davis , Elisabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins
发明人： Mehmet Kahraman , Allen Borchardt , Travis Cook , Robert Davis , Elisabeth Gardiner , James Malecha , Stewart Noble , Thomas Prins
IPC分类号： A61K31/44 , A61K31/415 , A61K31/497 , A61K31/535
CPC分类号： A61K31/395 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
摘要翻译：本发明涉及可用作Rho激酶抑制剂用于治疗或预防疾病的化合物和方法。

7. 发明授权

US10223891B2 Real-time multi-component web based travel safety system and method 有权
公开(公告)号：US10223891B2
公开(公告)日：2019-03-05
申请号：US11804542
申请日：2007-05-17
申请人： Peter Chlubek , Robert Davis , John Chlubek , Michael Chlubek
发明人： Peter Chlubek , Robert Davis , John Chlubek , Michael Chlubek
IPC分类号： G06Q50/26 , G08B21/10 , G08B27/00 , G08B31/00
摘要： A real-time system and method that monitors and maintains greatly enhanced safety and security for travelers and corporations by creating a multi layered and integrated system of multi faceted intelligence collection and dissemination, global electronic monitoring, locating and tracking technology, telecommunications, multi channel electronic distribution of relevance-parameterized advice and information to travelers with full acknowledgements and audit trail of critical alert messages both pushed to the traveler or traveler-requested, individual and corporate global security services, emergency response, search and rescue operations initiated either/both by monitor processes or by the traveler and a wide range of travel safety and security related ancillary services, all coordinated under the management of a central international command and control center with regional sub control centers throughout the world. All these component parts are brought together by the method and process to work synergistically in a way not previously described or existing.

8. 发明授权

US08640901B2 Portable dam assemblies and methods for assembling same 有权
标题翻译：便携式水坝组件及其组装方法
公开(公告)号：US08640901B2
公开(公告)日：2014-02-04
申请号：US13480469
申请日：2012-05-24
申请人： Robert Davis , Mark Ritchey
发明人： Robert Davis , Mark Ritchey
IPC分类号： B65D88/12 , B65D90/04 , B65D25/14 , B65D25/16
CPC分类号： E02B3/10 , B65D25/16 , B65D88/12 , B65D88/1656 , B65D88/528 , B65D90/023 , B65D90/047 , B65D90/205 , E02B3/106 , E02D19/04 , Y02A10/13
摘要： A water containment apparatus includes a straight strut arrangement comprising a plurality of straight strut assemblies forming an alternating v-shape and inverted v-shape pattern; and a curved strut arrangement comprising a plurality of corner strut assemblies forming a desired curvature and connecting two straight strut arrangements to form a closed loop water containment system.
摘要翻译：一种防水装置包括：直支柱装置，其包括形成交替的V形和倒V形图案的多个直支柱组件; 以及弯曲的支柱装置，其包括形成期望曲率的多个角支撑组件，并且连接两个直的支柱装置以形成闭环水容纳系统。

9. 发明申请

US20130075341A1 METHOD FOR CLARIFYING INDUSTRIAL WASTEWATER 审中-公开
标题翻译：澄清工业废水的方法
公开(公告)号：US20130075341A1
公开(公告)日：2013-03-28
申请号：US13491008
申请日：2012-06-07
申请人： Robert Davis , Stuart Davis
发明人： Robert Davis , Stuart Davis
IPC分类号： C02F1/54
CPC分类号： B01D17/048
摘要： Methods are described for removing contaminates from aqueous industrial wastewater process streams, specifically industrial laundries to yield a less contaminated aqueous effluent for discharge to a sewer and reduce the sludge generated therefrom. A premixed medium/high molecular weight and medium/high charged cationic coagulant solution polymer and an inorganic aluminum species is added to the wastewater, and after at least a two second delay, a high molecular weight highly charged anionic flocculent is injected into the wastewater which reduces sludge generation, while maintaining or exceeding effluent quality. Also, no coagulant, flocculent or sludge aids are needed to attain the results and the sludge can be dewatered in a plate and frame press.
摘要翻译：描述了用于从水性工业废水工艺流，特别是工业洗涤物中除去污染物的方法，以产生较少污染的含水废水排放到下水道并减少由其产生的污泥。向废水中加入预混合的中等/高分子量和中等/高电荷的阳离子凝结剂溶液聚合物和无机铝物质，至少延迟两秒钟后，将高分子量高电荷的阴离子絮凝剂注入废水中减少污泥产生，同时保持或超过污水质量。此外，不需要凝结剂，絮凝剂或污泥辅助剂来获得结果，并且污泥可以在板框压机中脱水。

10. 发明申请

US20110087197A1 ANTEGRADE COLONIC INSTILLATION APPARATUS 审中-公开
公开(公告)号：US20110087197A1
公开(公告)日：2011-04-14
申请号：US12988672
申请日：2008-04-21
申请人： Bruno Mombrinie , Jeff Brian Eidsen , Cindy Carol Eidsen , Joe Peterson , Robert Davis
发明人： Bruno Mombrinie , Jeff Brian Eidsen , Cindy Carol Eidsen , Joe Peterson , Robert Davis
IPC分类号： A61M1/00
CPC分类号： A61M3/0258 , A61M3/0208 , A61M3/022 , A61M2205/3306 , A61M2205/3386 , A61M2205/50 , A61M2210/1064
摘要： The present invention provides an apparatus for instilling fluid into a patient having an intestinal stoma so as to administer an antegrade colonic enema. The portable instillation apparatus comprising in combination: a fluid reservoir, a pump assembly, a control module, a fluid delivery tube and an intestinal stoma catheter wherein the control module is operable to automatically deliver a predetermined volume of instillation fluid at a specific flow rate and pressure range suitable for a particular patient. The portable instillation apparatus utilities a gear pump manifold and a robust empty reservoir detection mechanism, facilitating the portability, durability and reliability of the apparatus over-coming the disadvantages of traditional peristaltic pump mechanisms. The portable instillation apparatus maximizes the ease of transport and use of the device while also enabling a method for a patient to self-administer an antegrade colonic enema within a short time period and without intervention.
摘要翻译：本发明提供了一种用于将流体滴入患有肠口的患者以便施用顺行性结肠灌肠剂的装置。便携式滴注装置组合包括：流体储存器，泵组件，控制模块，流体输送管和肠造口导管，其中控制模块可操作以自动地以特定流速输送预定体积的滴注液，适用于特定患者的压力范围。便携式滴管装置使用齿轮泵歧管和坚固的空容器检测机构，便于设备的便携性，耐用性和可靠性，从而克服了传统蠕动泵机构的缺点。便携式滴注装置最大化装置的运输和使用的便利性，同时还使得患者能够在短时间内自主施用顺行性结肠灌肠并且无需干预的方法。

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