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1. 发明授权

US4762942A Antihypertensive phosphate derivatives 失效
标题翻译：抗高血压磷酸盐衍生物
公开(公告)号：US4762942A
公开(公告)日：1988-08-09
申请号：US679788
申请日：1984-12-10
申请人： Allan Wissner , Phaik E. Sum , Robert E. Schaub
发明人： Allan Wissner , Phaik E. Sum , Robert E. Schaub
IPC分类号： C07F9/10
CPC分类号： C07F9/10
摘要： Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein X is selected from one or more of: (a) C.sub.1 -C.sub.24 branched or straight chain alkyl; (b) C.sub.1 -C.sub.24 branched or straight chain alkoxy; (c) ##STR2## wherein n and m are integers from 0 to 25 and the sum of n and m is less than or equal to 25; phenyl; substituted phenyl wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, C.sub.1 -C.sub.20 branched or straight chain alkoxy, halogen, trifluoromethyl, phenyl, and substituted phenyl, phenoxy; and substituted phenoxy, wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, halogen, trifluoromethyl, phenyl and substituted phenyl; Q is selected from the group consisting of: ##STR3## wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 branched or straight chain alkyl, C.sub.1 -C.sub.4 branched or straight chain alkoxy and C.sub.1 -C.sub.4 branched or straight chain alkylamino and wherein R.sub.3 is C.sub.1 -C.sub.4 alkyl, with the proviso that when Q is ##STR4## then R.sub.1 is C.sub.1 -C.sub.4 branched or straight chain alkyl; T is a bivalent radical selected from the group consisting of --(CHR).sub.p -- and ##STR5## wherein p is an integer from 1 to 15, the moiety --(CHR).sub.p -- represents an alkylene chain substituted at any position with one or more C.sub.1 -C.sub.10 alkyl groups or phenyl groups, and the moiety ##STR6## is bound with the oxygen atom attached directly to the aromatic ring; and Z is ##STR7## wherein R.sub.2 is hydrogen or C.sub.1 -C.sub.4 branched or straight chain alkyl and q is an interger from 4 to 7; in either the racemic or optically active forms.
摘要翻译：描述了具有下式的抗高血压磷酸酯衍生物：其中X选自以下中的一种或多种：（a）C 1 -C 24支链或直链烷基; （b）C 1 -C 24支链或直链烷氧基; （c）其中n和m是0至25的整数，n和m的总和小于或等于25; 苯基; 取代基苯基，其中取代基选自C 1 -C 20支链或直链烷基，C 1 -C 20支链或直链烷氧基，卤素，三氟甲基，苯基和取代的苯基，苯氧基; 和取代的苯氧基，其中取代基选自C 1 -C 20支链或直链烷基，卤素，三氟甲基，苯基和取代的苯基; Q选自：其中R 1选自氢，C 1 -C 4支链或直链烷基，C 1 -C 4支链或直链烷氧基和C 1 -C 4支链或直链烷基氨基和其中R 3为C 1 -C 4烷基，条件是当Q为“IMA”时，R 1为C 1 -C 4支链或直链烷基; T是选自 - （CHR）p - 和的二价基团，其中p是1至15的整数， - （CHR）p - 部分代表在任何位置被一个或多个更多的C 1 -C 10烷基或苯基，并且部分“IMAGE”与直接与芳环连接的氧原子结合; 并且Z是，其中R 2是氢或C 1 -C 4支链或直链烷基，q是4至7的整数; 以外消旋或旋光形式。

2. 发明授权

US4640913A Phosphocholine derivatives having antihypertensive action 失效
标题翻译：具有抗高血压作用的磷酸胆碱衍生物
公开(公告)号：US4640913A
公开(公告)日：1987-02-03
申请号：US457097
申请日：1983-01-10
申请人： Allan Wissner , Robert E. Schaub , Phaik E. Sum
发明人： Allan Wissner , Robert E. Schaub , Phaik E. Sum
IPC分类号： C07F9/10 , A61K31/185
CPC分类号： C07F9/10
摘要： Phosphocholine derivatives and compositions are described which are useful as hypotensive agents and in the treatment of hypertension in warm-blooded animals.
摘要翻译：描述了磷酸胆碱衍生物和组合物，其可用作降血压剂和在温血动物中治疗高血压。

3. 发明授权

US4894367A Antihypertensive phosphate derivatives 失效
标题翻译：抗高血压磷酸盐衍生物
公开(公告)号：US4894367A
公开(公告)日：1990-01-16
申请号：US194748
申请日：1988-07-18
申请人： Allan Wissner , Phaik E. Sum , Robert E. Schaub
发明人： Allan Wissner , Phaik E. Sum , Robert E. Schaub
IPC分类号： C07F9/10
CPC分类号： C07F9/10
摘要： Antihypertensive phosphate derivatives having the following formula: ##STR1## wherein X is selected from one or more of C.sub.1 -C.sub.24 alkyl; C.sub.1 -C.sub.24 alkoxy; n and m are integers from 0 to 25 and the sum of which are less than or equal to 25; phenyl or substituted phenyl alkoxy, halogen, trifluoromethyl, phenyl, and substituted phenyl, phenoxy; and substituted phenoxy, wherein the substituents are C.sub.1 -C.sub.20 branched or straight chain alkyl, halogen, trifluoromethyl, phenyl and substituted phenyl; Q is selected from ##STR2## and --OR.sub.3 R.sub.1 is selected form hydrogen, C.sub.1 -C.sub.4 alkoxy and C.sub.1 -C.sub.4 alklyamino and R.sub.3 is C.sub.1 -C.sub.4 alkyl, with the provision that when Q is ##STR3## R.sub.1 is C.sub.1 -C.sub.4 branched or straight chain alkyl; T is a bivalent radical selected from alkylene or arylalkylene substituted at any position with one or more C.sub.1 -C.sub.10 alkyl with oxygen atom attached directly to the aromatic ring; Z is ##STR4## R.sub.2 is hydrogen or C.sub.1 -C.sub.4 branched straight chain alkyl; Q is an integer from 4-7.
摘要翻译：具有下式的抗高血压磷酸酯衍生物：其中X选自C 1 -C 24烷基中的一种或多种; C 1 -C 24烷氧基; n和m是0至25的整数，其总和小于或等于25; 苯基或取代的苯基烷氧基，卤素，三氟甲基，苯基和取代的苯基，苯氧基; 和取代的苯氧基，其中取代基是C 1 -C 20支链或直链烷基，卤素，三氟甲基，苯基和取代的苯基; Q选自，-OR3 R1选自氢，C1-C4烷氧基和C1-C4烷基氨基，R3是C1-C4烷基，条件是当Q是C1-C4支链或直链烷基; T是选自在具有一个或多个具有氧原子直接连接到芳环上的C 1 -C 10烷基的任何位置处取代的亚烷基或芳基亚烷基的二价基团; Z是R 2是氢或C 1 -C 4支链直链烷基; Q是4-7的整数。

4. 发明授权

US4883816A Antihypertensive derivatives 失效
标题翻译：抗高血压衍生物
公开(公告)号：US4883816A
公开(公告)日：1989-11-28
申请号：US157055
申请日：1988-02-16
申请人： Allan Wissner , Phaik E. Sum , Robert E. Schaub
发明人： Allan Wissner , Phaik E. Sum , Robert E. Schaub
IPC分类号： C07F9/10
CPC分类号： C07F9/10
摘要： Antihypertensive sulfonyl derivatives having the following formula are described: ##STR1## where R" is a C.sub.2 -C.sub.20 alkyl group,R".sub.1 is a C.sub.1 to C.sub.4 alkyl group,y is an integer from 2 to 10 andJ.sup.- is a pharmocologically acceptable anion.
摘要翻译：描述了具有下式的抗高血压磺酰基衍生物：其中R“为C 2 -C 20烷基，R”1为C 1至C 4烷基，y为2至10的整数，J为 - 药学上可接受的阴离子。

5. 发明授权

US4981989A Antihypertensive phosphate derivatives and intermediates thereof 失效
标题翻译：抗高血压磷酸酯衍生物及其中间体
公开(公告)号：US4981989A
公开(公告)日：1991-01-01
申请号：US434967
申请日：1989-11-08
申请人： Allan Wissner , Phaik E. Sum , Robert E. Schaub
发明人： Allan Wissner , Phaik E. Sum , Robert E. Schaub
IPC分类号： C07F9/10
CPC分类号： C07F9/10
摘要： Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein X is selected from one or more of: (a) C.sub.1 -C.sub.24 branched or straight chain alkyl; (b) C.sub.1 -C.sub.24 branched or straight chain alkoxy; (c) ##STR2## wherein n and m are integers from 0 to 25 and the sum of n and m is less than or equal to 25; phenyl; substituted phenyl wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, C.sub.1 -C.sub.20 branched or straight chain alkoxy, halogen, trifluoromethyl, phenyl, and substituted phenyl, phenoxy; and substituted phenoxy, wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, halogen, trifluoromethyl, phenyl and substituted phenyl; Q is selected from the group consisting of: ##STR3## wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 branched or straight chain alkyl, C.sub.1 -C.sub.4 branched or straight chain alkoxy and C.sub.1 -C.sub.4 branched or straight chain alkylamino and wherein R.sub.3 is C.sub.1 -C.sub.4 alkyl, with the proviso that when Q is ##STR4## then R.sub.1 is C.sub.1 -C.sub.4 branched or straight chain alkyl; T is a bivalent radical selected from the group consisting of --(CHR).sub.p -- and ##STR5## wherein p is an integer from 1 to 15, the moiety --(CHR).sub.p -- represents an alkylene chain substituted at any position with one or more C.sub.1 -C.sub.10 alkyl groups or phenyl groups, and the moiety ##STR6## is bound with the oxygen atom attached directly to the aromatic ring; and Z is ##STR7## wherein R.sub.2 is hydrogen or C.sub.1 -C.sub.4 branched or straight chain alkyl and q is an integer from 4 to 7; in either the racemic or optically active forms.
摘要翻译：描述了具有下式的抗高血压磷酸酯衍生物：其中X选自以下中的一种或多种：（a）C 1 -C 24支链或直链烷基; （b）C 1 -C 24支链或直链烷氧基; （c）其中n和m是0至25的整数，n和m的总和小于或等于25; 苯基; 取代基苯基，其中取代基选自C 1 -C 20支链或直链烷基，C 1 -C 20支链或直链烷氧基，卤素，三氟甲基，苯基和取代的苯基，苯氧基; 和取代的苯氧基，其中取代基选自C 1 -C 20支链或直链烷基，卤素，三氟甲基，苯基和取代的苯基; Q选自：其中R 1选自氢，C 1 -C 4支链或直链烷基，C 1 -C 4支链或直链烷氧基和C 1 -C 4支链或直链烷基氨基和其中R 3为C 1 -C 4烷基，条件是当Q为“IMA”时，R 1为C 1 -C 4支链或直链烷基; T是选自 - （CHR）p - 和的二价基团，其中p是1至15的整数， - （CHR）p - 部分代表在任何位置被一个或多个更多的C 1 -C 10烷基或苯基，并且部分“IMAGE”与直接与芳环连接的氧原子结合; 并且Z为，其中R 2为氢或C 1 -C 4支链或直链烷基，q为4至7的整数; 以外消旋或旋光形式。

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