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1. 发明申请

US20090125076A1 SYSTEM FOR NEURAL THERAPY 有权
标题翻译：神经系统治疗
公开(公告)号：US20090125076A1
公开(公告)日：2009-05-14
申请号：US12269558
申请日：2008-11-12
申请人： Allan C. Shuros , Craig Stolen , Timothy Meyer , Stephen Ruble
发明人： Allan C. Shuros , Craig Stolen , Timothy Meyer , Stephen Ruble
IPC分类号： A61N1/365
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36114
摘要： This document discusses, among other things, a system and method for calculating a neural stimulation energy at an external patient management (EPM) system using received information about a chemical characteristic indicative of a physiological state of a subject.
摘要翻译：本文件尤其涉及使用接收到的关于指示受试者的生理状态的化学特征的信息来计算外部患者管理（EPM）系统的神经刺激能量的系统和方法。

2. 发明授权

US08855772B2 System for neural therapy 有权
标题翻译：神经治疗系统
公开(公告)号：US08855772B2
公开(公告)日：2014-10-07
申请号：US12269558
申请日：2008-11-12
申请人： Allan C. Shuros , Craig Stolen , Timothy Meyer , Stephen Ruble
发明人： Allan C. Shuros , Craig Stolen , Timothy Meyer , Stephen Ruble
IPC分类号： A61N1/18 , A61N1/32 , A61N1/08 , A61N1/36
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36114
摘要： This document discusses, among other things, a system and method for calculating a neural stimulation energy at an external patient management (EPM) system using received information about a chemical characteristic indicative of a physiological state of a subject.
摘要翻译：本文件尤其涉及使用接收到的关于指示受试者的生理状态的化学特性的信息来计算外部患者管理（EPM）系统的神经刺激能量的系统和方法。

3. 发明授权

US08483821B2 Blood volume redistribution therapy for heart failure 有权
标题翻译：血容量再分配治疗心力衰竭
公开(公告)号：US08483821B2
公开(公告)日：2013-07-09
申请号：US12843444
申请日：2010-07-26
申请人： Viktoria A. Averina , Jason J. Hamann , Stephen Ruble , Allan C. Shuros
发明人： Viktoria A. Averina , Jason J. Hamann , Stephen Ruble , Allan C. Shuros
IPC分类号： A61N1/00 , A61B5/02 , A61B5/05
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.
摘要翻译：可以使用与肺水肿相关的肺液体状态和非肺液体状态的第二流体状态指示器的第一流体状态指示器来提供警报或控制肺水肿的治疗。此外，间歇性心脏血容量再分配治疗可用于在心力衰竭患者中提供心脏调节。

4. 发明授权

US09259568B2 Systems and methods for delivering electric current for spinal cord stimulation 有权
标题翻译：用于输送脊髓刺激电流的系统和方法
公开(公告)号：US09259568B2
公开(公告)日：2016-02-16
申请号：US12431607
申请日：2009-04-28
申请人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
发明人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36071 , A61N1/36114
摘要： Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.
摘要翻译：各种系统实施例包括具有远端和近端的引线。远端包括多个电极。引线被配置为被馈送到人的背部硬膜外区域到脊柱的期望区域，并且被横向地供给至少部分地包围所需区域中的脊髓，以将至少一个刺激电极置于适当位置刺激背神经根和至少另一个刺激电极，以刺激腹侧神经根。所需区域可包括颈椎，胸椎或腰椎。一些实施方案刺激T1-T5区域中的脊髓。

5. 发明申请

US20090270960A1 SYSTEMS AND METHODS FOR DELIVERING ELECTRIC CURRENT FOR SPINAL CORD STIMULATION 有权
标题翻译：用于输送脊髓刺激电流的系统和方法
公开(公告)号：US20090270960A1
公开(公告)日：2009-10-29
申请号：US12431607
申请日：2009-04-28
申请人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
发明人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36071 , A61N1/36114
摘要： Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.
摘要翻译：各种系统实施例包括具有远端和近端的引线。远端包括多个电极。引线被配置为被馈送到人的背部硬膜外空间到脊柱的期望区域，并且被横向馈送以至少部分地环绕所需区域中的脊髓，以将至少一个刺激电极置于适当位置刺激背神经根和至少另一个刺激电极，以刺激腹侧神经根。所需区域可包括颈椎，胸椎或腰椎。一些实施方案刺激T1-T5区域中的脊髓。

6. 发明申请

US20110087301A1 IMPLANTABLE DEVICE WITH HEMODYNAMIC SUPPORT OR RESUSCITATION THERAPY 审中-公开
标题翻译：具有HEMODYNAMIC支持或恢复治疗的可植入装置
公开(公告)号：US20110087301A1
公开(公告)日：2011-04-14
申请号：US12892298
申请日：2010-09-28
申请人： Dan Li , Allan C. Shuros , Arjun Sharma , Stephen Ruble
发明人： Dan Li , Allan C. Shuros , Arjun Sharma , Stephen Ruble
IPC分类号： A61N1/365 , A61N1/36 , A61N1/39
CPC分类号： A61N1/3601 , A61N1/3621 , A61N1/36507 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/3956
摘要： An apparatus comprises an implantable sensor, a stimulation circuit, and a controller. The implantable sensor is configured to provide a sensor signal representative of hemodynamic function of a subject. The stimulation circuit is configured to provide electrical simulation energy to an implantable electrode. The controller is communicatively coupled to the stimulation circuit and the implantable sensor and includes a hemodynamic monitor module. The hemodynamic monitor module is configured to detect an episode of reduced hemodynamic capacity in a subject using the sensor signal. In response to the detected episode, the controller is configured to initiate delivery of the electrical stimulation energy to artificially induce at least one of deep ventilation or rapid ventilation in the subject. The hemodynamic monitor module is configured to obtain a measure of hemodynamic performance after delivery of the electrical stimulation energy.
摘要翻译：一种装置包括可植入传感器，刺激电路和控制器。可植入传感器被配置为提供代表受试者的血液动力学功能的传感器信号。刺激电路被配置为向可植入电极提供电气模拟能量。控制器通信地耦合到刺激电路和可植入传感器并且包括血液动力学监测器模块。血液动力学监测器模块被配置为使用传感器信号来检测受试者中降低的血流动力学容量的发作。响应于检测到的情节，控制器被配置为启动电刺激能量的传递以人为地诱导受试者中深层通气或快速通气中的至少一种。血液动力学监测器模块被配置为在递送电刺激能量之后获得血流动力学性能的量度。

7. 发明申请

US20110022127A1 BLOOD VOLUME REDISTRIBUTION THERAPY FOR HEART FAILURE 有权
标题翻译：血液重新分配治疗心脏失败的血液
公开(公告)号：US20110022127A1
公开(公告)日：2011-01-27
申请号：US12843444
申请日：2010-07-26
申请人： Viktoria A. Averina , Jason J. Hamann , Stephen Ruble , Allan C. Shuros
发明人： Viktoria A. Averina , Jason J. Hamann , Stephen Ruble , Allan C. Shuros
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.
摘要翻译：可以使用与肺水肿相关的肺液体状态和非肺液体状态的第二流体状态指示器的第一流体状态指示器来提供警报或控制肺水肿的治疗。此外，间歇性心脏血容量再分配治疗可用于在心力衰竭患者中提供心脏调节。

8. 发明申请

US20090270935A1 SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING NERVE ROOTS 有权
标题翻译：用于选择性刺激神经病变的系统和方法
公开(公告)号：US20090270935A1
公开(公告)日：2009-10-29
申请号：US12431621
申请日：2009-04-28
申请人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
发明人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36139 , A61N1/3627 , A61N1/365 , A61N1/37241
摘要： Various system embodiments comprise an implantable lead, an implantable housing, a neural stimulation circuit in the housing, and a controller in the housing and connected to the neural stimulation circuit. The lead has a proximal end and a distal end. The distal end is adapted to deliver neural stimulation pulses to the ventral nerve root and the dorsal nerve root. The proximal end of the lead is adapted to connect to the housing. The neural stimulation circuit is adapted to generate neural stimulation pulses to stimulate the ventral nerve root or the dorsal nerve root using the implantable lead. The controller is adapted to control the neural stimulation circuit to deliver a neural stimulation treatment.
摘要翻译：各种系统实施例包括可植入引线，可植入壳体，壳体中的神经刺激电路以及壳体中的控制器并连接到神经刺激电路。引线具有近端和远端。远端适于将神经刺激脉冲输送到腹侧神经根和背神经根。引线的近端适于连接到外壳。神经刺激电路适于产生神经刺激脉冲，以使用可植入引线刺激腹侧神经根或背神经根。控制器适于控制神经刺激电路以递送神经刺激治疗。

9. 发明授权

US08386045B2 Systems and methods for selectively stimulating nerve roots 有权
标题翻译：选择性刺激神经根的系统和方法
公开(公告)号：US08386045B2
公开(公告)日：2013-02-26
申请号：US12431621
申请日：2009-04-28
申请人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
发明人： Weiying Zhao , Stephen Ruble , Allan C. Shuros , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36139 , A61N1/3627 , A61N1/365 , A61N1/37241
摘要： Various system embodiments comprise an implantable lead, an implantable housing, a neural stimulation circuit in the housing, and a controller in the housing and connected to the neural stimulation circuit. The lead has a proximal end and a distal end. The distal end is adapted to deliver neural stimulation pulses to the ventral nerve root and the dorsal nerve root. The proximal end of the lead is adapted to connect to the housing. The neural stimulation circuit is adapted to generate neural stimulation pulses to stimulate the ventral nerve root or the dorsal nerve root using the implantable lead. The controller is adapted to control the neural stimulation circuit to deliver a neural stimulation treatment.
摘要翻译：各种系统实施例包括可植入引线，可植入壳体，壳体中的神经刺激电路以及壳体中的控制器并连接到神经刺激电路。引线具有近端和远端。远端适于将神经刺激脉冲输送到腹侧神经根和背神经根。引线的近端适于连接到外壳。神经刺激电路适于产生神经刺激脉冲，以使用可植入引线刺激腹侧神经根或背神经根。控制器适于控制神经刺激电路以递送神经刺激治疗。

10. 发明申请

US20100228310A1 SYSTEMS AND METHODS FOR AUTONOMIC NERVE MODULATION 审中-公开
标题翻译：用于自动神经调制的系统和方法
公开(公告)号：US20100228310A1
公开(公告)日：2010-09-09
申请号：US12715862
申请日：2010-03-02
申请人： Allan C. Shuros , Weiying Zhao , Jason J. Hamann , Stephen Ruble
发明人： Allan C. Shuros , Weiying Zhao , Jason J. Hamann , Stephen Ruble
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36117 , A61N1/36185 , A61N1/36585
摘要： According to various embodiments of a method for modulating autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct, at least one programmed therapy is implemented using an implanted medical device to modulate autonomic neural activity. Implementing the therapy includes increasing or decreasing sympathetic activity in sympathetic nerves branching from a first region of the spinal cord using a first electrode in the thoracic duct, and further includes increasing or decreasing parasympathetic activity in parasympathetic nerves adjacent to the desired thoracic lymphatic vessel or sympathetic activity in sympathetic nerves branching from a second region of the spinal cord using a second electrode in the desired thoracic lymphatic vessel.
摘要翻译：根据用于调节具有脊髓，锁骨下静脉和包括胸导管和右淋巴管的胸部淋巴管的身体中的自主神经活动的方法的各种实施例，至少一个程序化治疗使用植入的医疗装置调节自主神经活动。实施治疗包括使用胸导管中的第一电极从脊髓的第一区域分支的交感神经中增加或减少交感神经活动，并且还包括增加或减少邻近所需胸部淋巴管或交感神经的副交感神经中的副交感神经活动在所需胸廓淋巴管中使用第二电极从脊髓的第二区域分支的交感神经中的活动。

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