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1. 发明申请

US20060275787A1 Compositions and methods for array-based genomic nucleic acid analysis of biological molecules 审中-公开
标题翻译：用于基于阵列的生物分子基因组核酸分析的组合物和方法
公开(公告)号：US20060275787A1
公开(公告)日：2006-12-07
申请号：US11319752
申请日：2005-12-27
申请人： Allan Bradley , Wei-Wen Cai , Upendra Marathi
发明人： Allan Bradley , Wei-Wen Cai , Upendra Marathi
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34 , C07H21/04
CPC分类号： C07H21/00 , B01J2219/00369 , B01J2219/00497 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00722 , C07B2200/11 , C07H21/04 , C12Q1/6806 , C12Q1/6837 , C12Q2525/197 , C40B40/00
摘要： The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2 , wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or “biochips,” comprising these modified biological molecules. Also provided are methods for making and using these compositions.
摘要翻译：本发明提供通过与具有下式的化合物反应而修饰的生物分子：R 1 -XR 2 N，其中R 1是环醚基或氨基，R 2是烷氧基硅烷基，X是化学上适合于将环醚基或氨基连接到烷氧基硅烷基的部分。本发明还提供包含这些修饰的生物分子的阵列或“生物芯片”。还提供了制备和使用这些组合物的方法。

2. 发明授权

US06979728B2 Articles of manufacture and methods for array based analysis of biological molecules 失效
标题翻译：制造和生物分子阵列分析方法
公开(公告)号：US06979728B2
公开(公告)日：2005-12-27
申请号：US09853343
申请日：2001-05-10
申请人： Allan Bradley , Wei-Wen Cai , Upendra Marathi
发明人： Allan Bradley , Wei-Wen Cai , Upendra Marathi
IPC分类号： C07B61/00 , C07H21/00 , C12Q1/68 , C07H21/02 , C07K1/00 , C01N33/544
CPC分类号： C07H21/00 , B01J2219/00369 , B01J2219/00497 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00722 , C07B2200/11 , C07H21/04 , C12Q1/6806 , C12Q1/6837 , C12Q2525/197 , C40B40/00
摘要： The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2, wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or “biochips,” comprising these modified biological molecules. Also provided are methods for making and using these compositions.
摘要翻译：本发明提供通过与具有下式的化合物反应而修饰的生物分子：R 1 -XR 2 N，其中R 1是环醚基或氨基，R 2是烷氧基硅烷基，X是化学上适合于将环醚基或氨基连接到烷氧基硅烷基的部分。本发明还提供包含这些修饰的生物分子的阵列或“生物芯片”。还提供了制备和使用这些组合物的方法。

3. 发明授权

US06975943B2 Clone-array pooled shotgun strategy for nucleic acid sequencing 失效
标题翻译：用于核酸测序的克隆阵列合并霰弹枪策略
公开(公告)号：US06975943B2
公开(公告)日：2005-12-13
申请号：US09969111
申请日：2001-09-24
申请人： Richard Gibbs , Allan Bradley , Wei-Wen Cai
发明人： Richard Gibbs , Allan Bradley , Wei-Wen Cai
IPC分类号： C12N15/10 , C12Q1/68 , G06F19/00 , G01N33/48
CPC分类号： C12N15/1034 , C12Q1/6874
摘要： A simplified strategy for sequencing large genomes has been developed. Clone-Array Pooled Shotgun Sequencing (CAPSS) is based upon pooling rows and columns of arrayed genomic clones, for shotgun library construction. Random sequences are accumulated and the data are assembled by sequential comparison of rows and columns, to resolve the sequence of clones at points of intersection. Compared to either a clone-by-clone approach or whole genome shotgun sequencing, CAPSS requires relatively few library constructions and only minimal computational power for a complete genome assembly. The strategy is suitable for sequencing large genomes for which there are no sequence-ready maps, but for which relatively high resolution STS maps and highly redundant BAC libraries are available. It is immediately applicable to the sequencing of mouse, rat, zebra fish and other important genomes, and can be managed in a cooperative fashion to take advantage of the distributed international DNA sequencing capacity.
摘要翻译：已经开发了用于测序大基因组的简化策略。克隆阵列池式霰弹枪测序（CAPSS）基于汇集排列的基因组克隆的行和列，用于霰弹枪库构建。随机序列被累积，并且数据通过行和列的顺序比较来组装，以解决交叉点处的克隆序列。与克隆克隆方法或全基因组鸟枪法测序相比，CAPSS需要相对较少的文库构建，并且对于完整的基因组装配仅需要最小的计算能力。该策略适用于对没有序列准备图的大型基因组进行排序，但对于相对较高分辨率的STS图和高度冗余的BAC库可用。它可以立即适用于小鼠，大鼠，斑马鱼等重要基因组的测序，可以以合作的方式管理，以利用分布式国际DNA测序能力。

4. 发明申请

US20050064494A1 Chemically modified biological molecules and methods for coupling biological molecules to solid support 审中-公开
标题翻译：化学修饰的生物分子和将生物分子与固体支持物偶联的方法
公开(公告)号：US20050064494A1
公开(公告)日：2005-03-24
申请号：US10948858
申请日：2004-09-24
申请人： Allan Bradley , Wei-Wen Cai
发明人： Allan Bradley , Wei-Wen Cai
IPC分类号： G01N33/53 , C07B61/00 , C07H21/00 , C07H23/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C12Q1/6806 , C12Q1/6837 , G01N37/00 , C12M1/34
CPC分类号： C12Q1/6806 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C12Q2525/197 , C40B40/00
摘要： The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified molecules as well as methods for preparing these microarrays are also useful.
摘要翻译：本发明涉及对固体支持物（例如玻璃）具有增强的不稳定性的新的化学修饰的生物分子。这些改性分子可以容易地固定到固体支持物，例如玻璃表面，而不首先使玻璃表面衍生化。基于这些修饰分子的高密度微阵列以及制备这些微阵列的方法也是有用的。

5. 发明申请

US20090069195A1 COMPOSITIONS AND METHODS FOR ARRAY-BASED NUCLEIC ACID HYBRIDIZATION 审中-公开
标题翻译：用于基于阵列核酸混合的组合物和方法
公开(公告)号：US20090069195A1
公开(公告)日：2009-03-12
申请号：US12210335
申请日：2008-09-15
申请人： Allan Bradley , Wei-Wen Cai
发明人： Allan Bradley , Wei-Wen Cai
IPC分类号： C40B30/04 , C40B70/00
CPC分类号： C12Q1/6837 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00722 , B01L3/508 , C12Q1/6816 , C12Q1/6832 , C40B40/06 , C12Q2563/107 , C12Q2527/125 , C12Q2565/501 , C12Q2547/101 , C12Q2525/204
摘要： The invention provides compositions and methods for generating a molecular profile of genomic DNA by hybridization of labeled nucleic acid representing the genomic DNA to immobilized nucleic acid probes, e.g., arrays or biochips.
摘要翻译：本发明提供了通过将表示基因组DNA的标记的核酸与固定的核酸探针例如阵列或生物芯片杂交来产生基因组DNA的分子谱的组合物和方法。

6. 发明授权

US06858713B1 Chemically modified biological molecules and methods for coupling biological molecules to solid support 失效
公开(公告)号：US06858713B1
公开(公告)日：2005-02-22
申请号：US09546085
申请日：2000-04-10
申请人： Allan Bradley , Wei-Wen Cai
发明人： Allan Bradley , Wei-Wen Cai
IPC分类号： G01N33/53 , C07B61/00 , C07H21/00 , C07H23/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N37/00 , C07H21/02 , C07K1/00 , G01N33/544
CPC分类号： C12Q1/6806 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C12Q2525/197 , C40B40/00
摘要： The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified molecules as well as methods for preparing these microarrays are also useful.

7. 发明申请

US20130005591A1 METHOD FOR PARALLEL AMPLIFICATION OF NUCLEIC ACIDS 审中-公开
标题翻译：核酸平行放大的方法
公开(公告)号：US20130005591A1
公开(公告)日：2013-01-03
申请号：US13349780
申请日：2012-01-13
申请人： Wei-Wen Cai
发明人： Wei-Wen Cai
IPC分类号： C40B50/06 , C40B30/04 , C12P19/34
CPC分类号： C12Q1/686 , C12Q2537/143 , C12Q2563/155 , C12Q2563/159
摘要： A new method that enables parallel amplification of nucleic sequences from a complex source is disclosed. The amplification is compartmentized into microdroplets by porous-walled hollow glass microspheres and subjected to PCR thermal cycling or isothermal amplification. The rigid wall of the glass microspheres allows very simple and conventional manipulation of the amplification products for downstream application such as sequencing or detection of copy number of specific sequences in a complex sample.
摘要翻译：公开了一种能够从复杂源平行扩增核酸序列的新方法。通过多孔壁中空玻璃微球将扩增室分成微滴，进行PCR热循环或等温扩增。玻璃微球的刚性壁允许用于下游应用的扩增产物的非常简单和常规的操作，例如在复杂样品中测序或检测特异性序列的拷贝数。

8. 发明申请

US20130130917A1 METHOD FOR SPECIFIC ENRICHMENT OF NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：用于特异性增强核酸序列的方法
公开(公告)号：US20130130917A1
公开(公告)日：2013-05-23
申请号：US13349718
申请日：2012-01-13
申请人： Wei-Wen Cai
发明人： Wei-Wen Cai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00288 , B01J2219/00423 , B01J2219/00509 , C12N15/1003
摘要： The invention discloses a method for immobilizing nucleic acid probes to solid substrates. Also disclosed is a micro column format for specific sequence capture which enables efficient and convenient enrichment of target sequences from a complex source. The capture probes are immobilized onto microspheres or fibrous filter as the active component inside the column. The column format allows hybridization, post-hybridization wash and recovery of captured sequences all to take place in a simple device without sophisticated equipment.
摘要翻译：本发明公开了一种将核酸探针固定在固体基质上的方法。还公开了用于特定序列捕获的微柱形式，其能够从复杂源有效且方便地富集靶序列。将捕获探针固定在微球或纤维过滤器上作为柱内活性成分。列格式允许杂交，杂交后洗涤和捕获序列的恢复全部发生在没有精密设备的简单设备中。

9. 发明授权

US07335470B2 Compilations of nucleic acids and arrays and methods of using them 失效
标题翻译：核酸和阵列的汇编以及使用它们的方法
公开(公告)号：US07335470B2
公开(公告)日：2008-02-26
申请号：US10273399
申请日：2002-10-15
申请人： Mansoor Mohammed , Jason Kang , Shishir Shah , Wei-Wen Cai
发明人： Mansoor Mohammed , Jason Kang , Shishir Shah , Wei-Wen Cai
IPC分类号： C12Q1/68 , C12N15/00 , C12N15/11
CPC分类号： C40B40/08 , C07H21/00 , C40B20/04 , C40B30/04 , C40B60/10
摘要： In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided.
摘要翻译：在一个方面，本发明提供了核酸，制品，例如阵列和用于检测染色体异常（例如染色体非整倍体，缺失，扩增等）的方法的汇编，以及相关的综合征的诊断或预后具有连续的基因异常。还提供套件。

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