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1. 发明申请

US20060078899A1 Methods and compositions for reducing label variation in array-based comparative genome hybridization assays 审中-公开
标题翻译：基于阵列的比较基因组杂交测定中减少标记变异的方法和组合物
公开(公告)号：US20060078899A1
公开(公告)日：2006-04-13
申请号：US10964505
申请日：2004-10-12
申请人： Alicia Scheffer , Paige Anderson , Diane Ilsley , Michael Barrett , Bo Curry
发明人： Alicia Scheffer , Paige Anderson , Diane Ilsley , Michael Barrett , Bo Curry
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6841 , C12Q2565/501 , C12Q2525/185
摘要： Methods and compositions for producing a labeled population of nucleic acids for use in an array-based comparative genome hybridization (CGH) assay are provided. In general, the methods involve cleaving a genomic source to produce a sample containing nucleic acid fragments, and end-labeling the nucleic acid fragments to provide a population of nucleic acids having a terminal label. Kits and systems for use in practicing the subject methods are also provided.
摘要翻译：提供了用于生产用于基于阵列的比较基因组杂交（CGH）测定中的标记的核酸群的方法和组合物。通常，所述方法包括切割基因组来源以产生含有核酸片段的样品，并且终止标记核酸片段以提供具有末端标记的核酸群体。还提供了用于实践主题方法的套件和系统。

2. 发明申请

US20050233339A1 Methods and compositions for determining the relationship between hybridization signal of aCGH probes and target genomic DNA copy number 审中-公开
标题翻译：用于确定aCGH探针的杂交信号与靶基因组DNA拷贝数之间关系的方法和组合物
公开(公告)号：US20050233339A1
公开(公告)日：2005-10-20
申请号：US10828907
申请日：2004-04-20
申请人： Michael Barrett , Alicia Scheffer
发明人： Michael Barrett , Alicia Scheffer
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6837
摘要： Methods for evaluating surface-bound polynucleotides are provided. Specifically, the methods involve contacting an array of surface-bound polynucleotides with a population of labeled nucleic acids made from a non-naturally occurring composition of chromosomes, and evaluating binding of the labeled nucleic acids to a surface-bound polynucleotide. The methods may be used, for example, to screen for surface bound polynucleotides that have desirable binding characteristics, e.g., suitability for use in array-based comparative genomic hybridization assays. Kits and computer programming for use in practicing the subject methods are also provided.
摘要翻译：提供了评价表面结合多核苷酸的方法。具体地说，所述方法包括使表面结合的多核苷酸阵列与由非天然存在的染色体组合物制成的标记核酸的群体接触，并评估标记的核酸与表面结合的多核苷酸的结合。所述方法可用于例如筛选具有所需结合特征的表面结合多核苷酸，例如用于基于阵列的比较基因组杂交测定中的适用性。还提供了用于实践主题方法的套件和计算机程序设计。

3. 发明申请

US20070134676A1 Methods and compositions for performing sample heterogeneity corrected comparative genomic hybridization (CGH) 审中-公开
标题翻译：用于进行样品异质性校正的比较基因组杂交（CGH）的方法和组合物
公开(公告)号：US20070134676A1
公开(公告)日：2007-06-14
申请号：US11298271
申请日：2005-12-08
申请人： Michael Barrett , Amir Ben-Dor , Alicia Scheffer , Anya Tsalenko , Zohar Yakhimi
发明人： Michael Barrett , Amir Ben-Dor , Alicia Scheffer , Anya Tsalenko , Zohar Yakhimi
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6837 , C12Q1/6886
摘要： Methods and compositions for performing sample heterogeneity corrected comparative genomic hybridization (CGH) are provided. In the subject methods, an initial CGH result is processed to account for potential sample heterogeneity to obtain a sample-heterogeneity corrected CGH result. Also provided are methods for evaluating candidate surface-bound nucleic acids, e.g., candidate aCGH probe nucleic acids, to identify probes useful in assaying heterogeneous samples.
摘要翻译：提供了用于进行样本异质性校正的比较基因组杂交（CGH）的方法和组合物。在主题方法中，处理初始CGH结果以考虑潜在的样本异质性，以获得样本异质性校正CGH结果。还提供了用于评估候选表面结合核酸（例如候选aCGH探针核酸）以鉴定可用于测定异质样品的探针的方法。

4. 发明申请

US20050233340A1 Methods and compositions for assessing CpG methylation 审中-公开
标题翻译：用于评估CpG甲基化的方法和组合物
公开(公告)号：US20050233340A1
公开(公告)日：2005-10-20
申请号：US10828986
申请日：2004-04-20
申请人： Michael Barrett , Alicia Scheffer
发明人： Michael Barrett , Alicia Scheffer
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34
CPC分类号： C12Q1/6888 , C12Q1/683 , C12Q1/6837 , C12Q2600/154 , C12Q2565/501 , C12Q2521/331
摘要： Methods and compositions for assessing CpG island methylation are provided. Specifically, the invention provides an unstructured nucleic acid (UNA) oligonucleotide that base pairs with, i.e., hybridizes to, CpG islands. The subject oligonucleotide may be present in an array, and find use in methods for evaluating methylation of CpG islands in cells. Kits and computer programming for use in practicing the subject methods are also provided.
摘要翻译：提供了用于评估CpG岛甲基化的方法和组合物。具体地，本发明提供了与CpG岛碱基配对，即杂交的非结构化核酸（UNA）寡核苷酸。受试寡核苷酸可以以阵列存在，并且可用于评估细胞中CpG岛的甲基化的方法。还提供了用于实践主题方法的套件和计算机程序设计。

5. 发明申请

US20050233338A1 Methods and compositions for assessing chromosome copy number 审中-公开
标题翻译：用于评估染色体拷贝数的方法和组合物
公开(公告)号：US20050233338A1
公开(公告)日：2005-10-20
申请号：US10828892
申请日：2004-04-20
申请人： Michael Barrett , Alicia Scheffer
发明人： Michael Barrett , Alicia Scheffer
IPC分类号： C12M1/34 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q1/6881 , C12Q2600/156
摘要： Methods and compositions for assessing chromosome copy number are provided. Specifically, the invention provides an array containing a plurality of features including at least one feature that contains oligonucleotides that are complementary to a structural region of a chromosome. The subject methods and compositions may be used to detect chromosome copy number in a cell, and, as such, may be employed in a variety of diagnostic and research applications. Kits and computer programming for use in practicing the subject methods are also provided.
摘要翻译：提供了评估染色体拷贝数的方法和组合物。具体而言，本发明提供一种包含多个特征的阵列，其包括至少一个特征，其包含与染色体的结构区域互补的寡核苷酸。本发明的方法和组合物可用于检测细胞中的染色体拷贝数，因此可用于多种诊断和研究应用。还提供了用于实践主题方法的套件和计算机程序设计。

6. 发明授权

US08277830B2 Posterior segment drug delivery 有权
公开(公告)号：US08277830B2
公开(公告)日：2012-10-02
申请号：US13252998
申请日：2011-10-04
申请人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
发明人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , Hanson S. Gifford, III , K. Angela MacFarlane , Cary J. Reich , Michael Barrett , Randolph E. Campbell , Douglas Sutton
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： G01N33/558 , A61F9/0017 , A61K9/0048 , A61K9/0051 , A61K31/57 , A61K31/573 , A61K31/58 , A61K38/385 , A61K47/32 , A61K47/34 , A61K47/38 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/55 , Y10T29/49826
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

7. 发明申请

US20110010910A1 BRONCHIAL FLOW CONTROL DEVICES AND METHODS OF USE 有权
公开(公告)号：US20110010910A1
公开(公告)日：2011-01-20
申请号：US12820393
申请日：2010-06-22
申请人： Michael J. Hendricksen , Michael Barrett
发明人： Michael J. Hendricksen , Michael Barrett
IPC分类号： B23P11/00
CPC分类号： A61F2/04 , A61B17/12104 , A61B17/12172 , A61B17/12177 , A61F2002/043 , Y10T29/49826
摘要： Disclosed is an assembly for loading a bronchial flow control device into a container, such as into a delivery catheter. The assembly includes a funnel housing and a puller housing that mate with one another. The funnel housing defines a funnel-shaped loading cavity that receives a flow control device and that gradually reduces in size moving in a first direction. The puller housing is removably attached to the funnel housing and is also removably attachable to a bronchial flow control device that can be positioned in the loading cavity. The puller housing pulls the bronchial flow control device in the first direction through the funnel housing to gradually contract the bronchial flow control device into a compressed state of reduced size relative to the expanded size.
摘要翻译：公开了一种用于将支气管流量控制装置装载到诸如输送导管之类的容器中的组件。该组件包括一个漏斗壳体和一个相互配合的拔出器壳体。漏斗壳体限定漏斗形加载腔，其接纳流量控制装置，并逐渐减小尺寸沿第一方向移动。牵引器壳体可移除地附接到漏斗壳体，并且还可移除地附接到能够定位在加载腔中的支气管流量控制装置。牵引器壳体通过漏斗壳体沿着第一方向拉动支气管流量控制装置，以逐渐将支气管流量控制装置收缩成相对于膨胀尺寸减小尺寸的压缩状态。

8. 发明授权

US07837696B2 Articulating suturing device and method 有权
标题翻译：铰接缝合装置及方法
公开(公告)号：US07837696B2
公开(公告)日：2010-11-23
申请号：US10729541
申请日：2003-12-05
申请人： D. Bruce Modesitt , Michael Zung , Michael Barrett , Bernard H. Andreas , Lewis Isbell
发明人： D. Bruce Modesitt , Michael Zung , Michael Barrett , Bernard H. Andreas , Lewis Isbell
IPC分类号： A61B17/04
CPC分类号： A61B17/0625 , A61B17/0057 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00672 , A61B2017/047 , A61B2017/0472 , A61B2017/0477 , A61B2017/0496 , A61B2017/06057 , A61B2017/2927
摘要： Devices, systems, and methods for suturing of body lumens allow the suturing of vascular puncture sites located at the distal end of a percutaneous tissue tract. An elongated articulated foot near a distal end of a shaft is inserted through the penetration and actuated so that the foot extends along the lumenal axis. The foot carries suturing attachment cuffs, and needles are advanced from the shaft through the vessel wall outside of the penetration and into engagement with the needle cuffs after the foot has been drawn proximally up against the endothelial surface of the blood vessel. The cross-section of the shaft within the tissue tract can be minimized by laterally deflecting the needles as they leave the shaft, while tapered depressions within the foot can guide the advancing needles into engagement with the cuffs. The cuffs lockingly engage the needles and can be withdrawn proximally along the needle paths and through the tissue tract so as to form a loop of suture across the puncture. The articulating foot may be realigned with the shaft and withdrawn proximally through the tissue tract without dilating the tissue tract.
摘要翻译：用于缝合体腔的装置，系统和方法允许缝合位于经皮组织道远端的血管穿刺部位。在轴的远端附近的细长的铰接脚插入穿过并被致动，使得脚沿着内腔轴线延伸。脚承载缝合附着袖口，并且针从轴穿过穿透外部的血管壁前进，并且在足部被近端拉到血管的内皮表面之后与针箍接合。当针在离开轴时横向偏转针，组织道内的轴的横截面可以被最小化，而脚内的锥形凹陷可以引导前进的针与袖口接合。袖口锁定地接合针，并且可以沿着针路径并通过组织管向近端撤回，以便在穿刺部分上形成缝合线。关节脚可以与轴重新对准并且在组织管道的近侧退回，而不会扩张组织管道。

9. 发明授权

US07445626B2 Device and method for suturing tissue 失效
标题翻译：用于缝合组织的装置和方法
公开(公告)号：US07445626B2
公开(公告)日：2008-11-04
申请号：US10737668
申请日：2003-12-16
申请人： Ronald W. Songer , James W. Vetter , Enrique J. Klein , Bernard A. Andreas , Michael Barrett , Mark J. Foley , Brian Gore , Lewis Isbell , T. Daniel Gross , Tomoaki Hinohara
发明人： Ronald W. Songer , James W. Vetter , Enrique J. Klein , Bernard A. Andreas , Michael Barrett , Mark J. Foley , Brian Gore , Lewis Isbell , T. Daniel Gross , Tomoaki Hinohara
IPC分类号： A61B17/06
CPC分类号： A61B17/11 , A61B17/0057 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/06066 , A61B17/3417 , A61B17/3421 , A61B2017/00004 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0496 , A61B2017/06057 , A61F2002/30093 , A61F2210/0019
摘要： Systems for suturing a tissue layer having two sides with a suture be releasably retaining at least a portion of the suture in a stationary position on one side of the tissue layer. The portion of the suture is retrieved through the tissue layer from the opposite side whereby the suture is drawn from one side to the opposite side. Systems for suturing the wall of a tubular graft having two sides is also provided using a suture by releasably retaining at least a portion of the suture on one side of the wall. the portion of the length of suture is retrieved through the wall of the graft to the opposite side of the wall.
摘要翻译：通过可靠地将至少一部分缝合线保持在组织层的一侧上的静止位置来提供用于用缝合线缝合具有两侧的组织层的系统。缝线的部分从相对侧通过组织层回收，由此将缝合线从一侧拉到相对侧。也可以使用缝合线通过可释放地将缝合线的至少一部分保持在壁的一侧上来缝合具有两侧的管状移植物的壁的系统。缝合长度的一部分通过移植物的壁回收到壁的相对侧。

10. 发明授权

US07431207B1 System and method for two-step payment transaction authorizations 有权
标题翻译：用于两步付款交易授权的系统和方法
公开(公告)号：US07431207B1
公开(公告)日：2008-10-07
申请号：US11031111
申请日：2005-01-05
申请人： Trey Neemann , Fred Bishop , Michael Barrett , David Armes
发明人： Trey Neemann , Fred Bishop , Michael Barrett , David Armes
IPC分类号： G06K5/00
CPC分类号： G06Q20/40 , G06Q20/10 , G06Q20/385 , G06Q30/0603
摘要： To process a commercial transaction, a merchant receives a card payment request from a customer. The merchant redirects the customer to the card issuer. The authorization computer of the card issuer communicates with the customer and authenticates the identity of the customer as the true cardholder of the card presented for payment. In a first embodiment, the merchant submits an authorization request in response to a card payment request to the authorization computer. The merchant receives an authorization confirmation from the authorization computer upon authentication of the identity of the cardholder. In a second embodiment, the customer receives an authorization confirmation from the authorization computer upon the authentication of the identity of the cardholder. The customer then submits the authorization confirmation to the merchant. The merchant, in turn, confirms the authorization confirmation with the authorization computer.
摘要翻译：为了处理商业交易，商家从客户接收卡付款请求。商家将客户重定向到发卡机构。发卡机构的授权计算机与客户进行通信，并将客户的身份认证为提供付款卡的真实持卡人。在第一实施例中，商家向授权计算机提交响应于卡支付请求的授权请求。验证持卡人的身份后，商家将从授权计算机收到授权确认。在第二实施例中，客户在认证持卡人的身份时从授权计算机接收授权确认。客户然后向商家提交授权确认。反过来，商家确认授权计算机的授权确认。

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