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    • 5. 发明申请
    • Spectrophotometer
    • 分光光度计
    • US20060290926A1
    • 2006-12-28
    • US10546886
    • 2004-02-27
    • Martin MastersMartin Masters
    • Martin MastersMartin Masters
    • G01J3/30G01J3/28G01N21/64
    • G01J3/10G01J3/02G01J3/0208G01J3/0224G01J3/42G01J3/44G01N21/253
    • A spectrophotometer having an optical system for directing a beam of substantially monochromatic excitation light to a liquid sample contained in a well (3) of a well plate for interaction with the sample for absorption or emission measurements to analyse the sample. The optical system includes two apertures (46, 28) for establishing a Kohler illumination region outside the well, that is an excitation beam region between conjugate images (18, 21) of the two apertures. This excitation beam region is then demagnified and imaged (10, 9) into the well (3). The invention provides for the shape of the Kohler illumination region to correspond to the shape of the well space so that all of the liquid sample is uniformly illuminated without the well obstructing any portion of the illuminating excitation beam of light. Advantages of the invention are that the Kohler illumination region of the excitation beam is convenient for insertion of filters (20), apertures and polarisers (19) into the excitation optical system and permits use of small and thus cheaper filters and polarisers. Also the invention provides for accurate absorption or emission measurements from a liquid sample in a well notwithstanding that the sample may only partially fill the well.
    • 一种分光光度计,其具有用于将基本上单色的激发光束射入包含在孔板的孔(3)中的液体样品的光学系统,用于与样品相互作用以进行吸收或发射测量以分析样品。 光学系统包括用于在井外建立科勒照明区域的两个孔(46,28),即两个孔的共轭图像(18,21)之间的激发束区域。 然后将该激发束区域缩小并成像(10,9)到井(3)中。 本发明提供了科勒照明区域的形状以对应于井的空间形状,使得所有的液体样品均匀地被照射,而不会妨碍照射激发光束的任何部分。 本发明的优点是激发光束的科勒照明区域便于将滤光器(20),孔径和偏光镜(19)插入激发光学系统中,并且允许使用小且因此更便宜的滤光器和偏振器。 此外,本发明提供了从井中的液体样品进行精确的吸收或发射测量,尽管样品可能仅部分填充孔。
    • 7. 发明授权
    • Implantable devices having ultrasonic echographic signature
    • 具有超声波回波记录特征的可植入装置
    • US5201715A
    • 1993-04-13
    • US797115
    • 1991-11-19
    • Martin Masters
    • Martin Masters
    • A61B8/08A61B19/00A61M5/42
    • A61B8/0841A61B8/0833A61M5/427A61B2090/3925
    • A target having a characteristic ultrasonic signature for implantation beneath the skin is described. The target, when placed within an implanted injection port enables ultrasonic echographic discrimination of the target from surrounding tissue. In particular, the target enables one to locate its position beneath the skin non-invasively by means of ultrasonic echograpy. In practice, the signature comprises reflections of ultrasonic waves from a target comprising varying thicknesses of a material having sound transmission characteristics different from human tissue. Ultrasonic sound waves reflected from different surfaces of the target arrive at a detector with a characteristic time delay thereby providing a signature. Biocompatible plastics, such as methacrylate, polysulfone, polytetrafluoroethylene or polyethylene, or elastomers such as silicone may be used for the target.
    • 描述了具有用于植入皮肤下方的特征超声波签名的靶。 当放置在植入的注射端口内时,目标使得能够对来自周围组织的靶进行超声波回波分析。 特别地,目标使得人们可以通过超声波回波治疗非侵入性地将其位于皮肤下方的位置。 在实践中,签名包括来自目标的超声波的反射,包括具有不同于人体组织的声音传播特性的材料的变化厚度。 从目标的不同表面反射的超声声波到达具有特征时间延迟的检测器,从而提供签名。 可以使用生物相容性塑料,例如甲基丙烯酸酯,聚砜,聚四氟乙烯或聚乙烯,或弹性体如硅酮。