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1. 发明授权

US09478022B2 Method and system for integrated radiological and pathological information for diagnosis, therapy selection, and monitoring 有权
标题翻译：用于诊断，治疗选择和监测的综合放射学和病理学信息的方法和系统
公开(公告)号：US09478022B2
公开(公告)日：2016-10-25
申请号：US14240534
申请日：2012-08-22
申请人： Ali Kamen , Leo Grady , Gianluca Paladini , Parmeshwar Khurd , Oliver Kutter , Dorin Comaniciu
发明人： Ali Kamen , Leo Grady , Gianluca Paladini , Parmeshwar Khurd , Oliver Kutter , Dorin Comaniciu
IPC分类号： G06K9/00 , G06T7/00 , A61B6/00 , A61B8/00 , G06F19/00 , A61B6/12 , A61B8/08 , A61B10/02
CPC分类号： G06T7/0012 , A61B6/12 , A61B6/463 , A61B6/467 , A61B8/0841 , A61B8/463 , A61B8/465 , A61B8/467 , A61B10/02 , G06F19/00 , G06F19/3481 , G06T2207/30004 , G16H50/20
摘要： A method and system for integrating radiological and pathological information for cancer diagnosis, therapy selection, and monitoring is disclosed. A radiological image of a patient, such as a magnetic resonance (MR), computed tomography (CT), positron emission tomography (PET), or ultrasound image, is received. A location corresponding to each of one or more biopsy samples is determined in the at least one radiological image. An integrated display is used to display a histological image corresponding to the each biopsy samples, the radiological image, and the location corresponding to each biopsy samples in the radiological image. Pathological information and radiological information are integrated by combining features extracted from the histological images and the features extracted from the corresponding locations in the radiological image for cancer grading, prognosis prediction, and therapy selection.
摘要翻译：公开了用于整合放射学和病理学信息用于癌症诊断，治疗选择和监测的方法和系统。接收患者的放射学图像，例如磁共振（MR），计算机断层摄影（CT），正电子发射断层摄影（PET）或超声图像。在至少一个放射图像中确定与一个或多个活检样本中的每一个对应的位置。使用集成显示器来显示对应于每个活检样本，放射图像和对应于放射图像中的每个活检样本的位置的组织学图像。通过组合图像提取的特征和从放射图像中相应位置提取的特征，进行癌症分级，预后预测和治疗选择，整合病理信息和放射学信息。

2. 发明授权

US09370332B2 Robotic navigated nuclear probe imaging 有权
标题翻译：机器人导航核探针成像
公开(公告)号：US09370332B2
公开(公告)日：2016-06-21
申请号：US13881209
申请日：2011-11-10
申请人： Gianluca Paladini , Ali Kamen , Oliver Kutter
发明人： Gianluca Paladini , Ali Kamen , Oliver Kutter
IPC分类号： A61B6/00 , A61B5/00 , A61B6/03
CPC分类号： A61B6/4458 , A61B5/0064 , A61B6/037 , A61B6/4057 , A61B6/4258 , A61B6/4417 , A61B6/4464 , A61B6/466 , A61B6/481 , A61B6/5223 , A61B6/5229 , A61B6/5247 , A61B34/30
摘要： Robotic navigation is provided for nuclear probe imaging. Using a three-dimensional scanner (19), the surface of a patient is determined (42). A calibrated robotic system positions (48) a nuclear probe about the patient based on the surface. The positioning (48) may be without contacting the patient and the surface may be used in reconstruction to account for spacing of the probe from the patient. By using the robotic system for positioning (48), the speed, resolution and/or quality of the reconstructed image may be predetermined, user settable, and/or improved compared to manual scanning. The reconstruction (52) may be more computationally efficient by providing for regular spacing of radiation detection locations within the volume.
摘要翻译：提供机器人导航用于核探针成像。使用三维扫描器（19），确定患者的表面（42）。校准的机器人系统基于表面定位（48）关于患者的核探针。定位（48）可以不与患者接触，并且可以在重建中使用表面以考虑探针与患者的间隔。通过使用用于定位的机器人系统（48），与手动扫描相比，重建图像的速度，分辨率和/或质量可以是预定的，用户可设置的和/或改进的。通过提供体积内的辐射检测位置的规则间隔，重建（52）可以更有计算效率。

3. 发明申请

US20130261446A1 Robotic Navigated Nuclear Probe Imaging 有权
标题翻译：机器人导航核探针成像
公开(公告)号：US20130261446A1
公开(公告)日：2013-10-03
申请号：US13881209
申请日：2011-11-10
申请人： Gianluca Paladini , Ali Kamen , Oliver Kutter
发明人： Gianluca Paladini , Ali Kamen , Oliver Kutter
IPC分类号： A61B6/00
CPC分类号： A61B6/4458 , A61B5/0064 , A61B6/037 , A61B6/4057 , A61B6/4258 , A61B6/4417 , A61B6/4464 , A61B6/466 , A61B6/481 , A61B6/5223 , A61B6/5229 , A61B6/5247 , A61B34/30
摘要： Robotic navigation is provided for nuclear probe imaging. Using a three-dimensional scanner (19), the surface of a patient is determined (42). A calibrated robotic system positions (48) a nuclear probe about the patient based on the surface. The positioning (48) may be without contacting the patient and the surface may be used in reconstruction to account for spacing of the probe from the patient. By using the robotic system for positioning (48), the speed, resolution and/or quality of the reconstructed image may be predetermined, user settable, and/or improved compared to manual scanning. The reconstruction (52) may be more computationally efficient by providing for regular spacing of radiation detection locations within the volume
摘要翻译：提供机器人导航用于核探针成像。使用三维扫描器（19），确定患者的表面（42）。校准的机器人系统基于表面定位（48）关于患者的核探针。定位（48）可以不与患者接触，并且可以在重建中使用表面以考虑探针与患者的间隔。通过使用用于定位的机器人系统（48），与手动扫描相比，重建图像的速度，分辨率和/或质量可以是预定的，用户可设置的和/或改进的。通过提供体积内的辐射检测位置的规则间隔，重建（52）可以更有计算效率

4. 发明授权

US07677078B2 Line-based calibration of ultrasound transducer integrated with a pose sensor 有权
标题翻译：与姿态传感器集成的超声波换能器的基于线路的校准
公开(公告)号：US07677078B2
公开(公告)日：2010-03-16
申请号：US11649391
申请日：2007-01-03
申请人： Frank Sauer , Ali Khamene , Oliver Kutter , Sebastian Kassner
发明人： Frank Sauer , Ali Khamene , Oliver Kutter , Sebastian Kassner
IPC分类号： G01M1/14
CPC分类号： A61B8/12 , A61B5/062 , A61B8/0833 , A61B8/4254 , A61B8/483 , A61B8/587 , B33Y80/00
摘要： Apparatus for calibrating an ultrasound transducer providing B-scans for two-dimensional (2D) images, includes: an ultrasound probe for providing B-scans; a position sensing device, the position sensing device being attached to the ultrasound probe and operating as part of a position sensing system in cooperation with a fixed sensing control unit, for labeling the B-scans with their respective relative positions and orientations (pose); a phantom marker for being imaged by the ultrasound probe for providing measurements which together with known physical properties of the phantom marker are used to derive calibration information for relating measurement data from the position sensing device to the poses of the B-scans to construct a 3D image; and the phantom marker comprising an encoded line object with distinctive calibration characteristics indicative of position along the line object, wherein the line object is disposed in a generally circumferential manner about a common axis with the probe.
摘要翻译：用于校准提供二维（2D）图像的B扫描的超声换能器的装置包括：用于提供B扫描的超声探头; 位置感测装置，所述位置感测装置附接到所述超声波探头，并且作为与固定感测控制单元协作的位置感测系统的一部分进行操作，用于以它们各自的相对位置和取向（姿势）标记B扫描; 用于由超声波探头成像的用于提供测量的幻影标记，其与模拟标记的已知物理特性一起用于导出校准信息，用于将来自位置感测装置的测量数据与B扫描的姿态相关联以构建3D 图片; 并且所述假想标记包括具有指示沿着所述线对象的位置的独特校准特性的编码线对象，其中所述线对象以围绕所述探针的公共轴线大致圆周方式设置。

5. 发明申请

US20080287787A1 Line-based calibration of ultrasound transducer integrated with a pose sensor 有权
标题翻译：与姿态传感器集成的超声波换能器的基于线路的校准
公开(公告)号：US20080287787A1
公开(公告)日：2008-11-20
申请号：US11649391
申请日：2007-01-03
申请人： Frank Sauer , Ali Khamene , Oliver Kutter , Sebastian Kassner
发明人： Frank Sauer , Ali Khamene , Oliver Kutter , Sebastian Kassner
IPC分类号： A61B8/13
CPC分类号： A61B8/12 , A61B5/062 , A61B8/0833 , A61B8/4254 , A61B8/483 , A61B8/587 , B33Y80/00
摘要： Apparatus for calibrating an ultrasound transducer providing B-scans for two-dimensional (2D) images, includes: an ultrasound probe for providing B-scans; a position sensing device, the position sensing device being attached to the ultrasound probe and operating as part of a position sensing system in cooperation with a fixed sensing control unit, for labeling the B-scans with their respective relative positions and orientations (pose); a phantom marker for being imaged by the ultrasound probe for providing measurements which together with known physical properties of the phantom marker are used to derive calibration information for relating measurement data from the position sensing device to the poses of the B-scans to construct a 3D image; and the phantom marker comprising an encoded line object with distinctive calibration characteristics indicative of position along the line object, wherein the line object is disposed in a generally circumferential manner about a common axis with the probe.
摘要翻译：用于校准提供二维（2D）图像的B扫描的超声换能器的装置包括：用于提供B扫描的超声探头; 位置感测装置，所述位置感测装置附接到所述超声波探头，并且作为与固定感测控制单元协作的位置感测系统的一部分进行操作，用于以它们各自的相对位置和取向（姿势）标记B扫描; 用于由超声波探头成像的用于提供测量的幻影标记，其与模拟标记的已知物理特性一起用于导出校准信息，用于将来自位置感测装置的测量数据与B扫描的姿态相关联以构建3D 图片; 并且所述假想标记包括具有指示沿着所述线对象的位置的独特校准特性的编码线对象，其中所述线对象以围绕所述探针的公共轴线大致圆周方式设置。

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