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1. 发明授权

US07754225B2 Method of protecting against staphylococcal infection 失效
标题翻译：防止葡萄球菌感染的方法
公开(公告)号：US07754225B2
公开(公告)日：2010-07-13
申请号：US11490512
申请日：2006-07-20
申请人： Ali Fattom , Jawad Sarwar , Zuzana Kossaczka , Kimberly L. Taylor , Sofiane Ennifar
发明人： Ali Fattom , Jawad Sarwar , Zuzana Kossaczka , Kimberly L. Taylor , Sofiane Ennifar
IPC分类号： A61K39/385
CPC分类号： A61K39/085 , A61K2039/505 , A61K2039/6037 , C07K16/1271
摘要： A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate of PS1 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of Staphylococcus or various types of Staphylococcus epidermidis.
摘要翻译：公开了预防或治疗个体中葡萄球菌细菌感染的方法。基于PS1多糖抗原缀合物的疫苗可以用于在受到使其处于发展细菌感染的直接风险的条件下的个体中的主动保护，如在导管插入术或外科手术的情况下程序。或者，响应于抗原产生的抗体可用于治疗或提供个体的被动保护。该方法可用于患有各种葡萄球菌或各种类型的表皮葡萄球菌感染风险的患者群体。

2. 发明申请

US20080019983A1 Method of protecting against staphylococcal infection 失效
标题翻译：防止葡萄球菌感染的方法
公开(公告)号：US20080019983A1
公开(公告)日：2008-01-24
申请号：US11490512
申请日：2006-07-20
申请人： Ali Fattom , Jawad Sarwar , Zuzana Kossaczka , Kimberly L. Taylor , Sofiane Ennifar
发明人： Ali Fattom , Jawad Sarwar , Zuzana Kossaczka , Kimberly L. Taylor , Sofiane Ennifar
IPC分类号： A61K39/085 , A61K39/385 , A61K39/44 , C12N5/08
CPC分类号： A61K39/085 , A61K2039/505 , A61K2039/6037 , C07K16/1271
摘要： A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate of PS1 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of Staphylococcus or various types of Staphylococcus epidermidis.
摘要翻译：公开了预防或治疗个体中葡萄球菌细菌感染的方法。基于PS1多糖抗原缀合物的疫苗可以用于在受到使其处于发展细菌感染的直接风险的条件下的个体中的主动保护，如在导管插入术或外科手术的情况下程序。或者，响应于抗原产生的抗体可用于治疗或提供个体的被动保护。该方法可用于患有各种葡萄球菌或各种类型的表皮葡萄球菌感染风险的患者群体。

3. 发明申请

US20060228368A1 Method of protecting against staphylococcal infection 审中-公开
标题翻译：防止葡萄球菌感染的方法
公开(公告)号：US20060228368A1
公开(公告)日：2006-10-12
申请号：US11101386
申请日：2005-04-07
申请人： Ali Fattom , Jawad Sarwar , Zuzana Kossaczka , Kimberly Taylor , Sofiane Ennifar
发明人： Ali Fattom , Jawad Sarwar , Zuzana Kossaczka , Kimberly Taylor , Sofiane Ennifar
IPC分类号： A61K39/40 , A61K39/085
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , A61K2039/6068
摘要： A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate the 336 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of Staphylococcus or various types of Staphylococcus aureus.
摘要翻译：公开了预防或治疗个体中葡萄球菌细菌感染的方法。基于缀合物336多糖抗原的疫苗可以用于在受到使其处于发展细菌感染的立即风险的条件下的个体中的主动保护，如在导管插入术或外科手术的情况下程序。或者，响应于抗原产生的抗体可用于治疗或提供个体的被动保护。该方法可用于患有各种葡萄球菌或各种金黄色葡萄球菌感染风险的患者群体。

4. 发明申请

US20050136047A1 Hapten-carrier conjugates for treating and preventing nicotine addiction 失效
标题翻译：用于治疗和预防尼古丁成瘾的黑色素 - 载体缀合物
公开(公告)号：US20050136047A1
公开(公告)日：2005-06-23
申请号：US10909841
申请日：2004-08-03
申请人： Sofiane Ennifar , Ali Fattom , Robert Naso
发明人： Sofiane Ennifar , Ali Fattom , Robert Naso
IPC分类号： G01N33/53 , A61K31/787 , A61K39/00 , A61K39/385 , A61K39/395 , A61K45/00 , A61K47/48 , A61P25/34 , C07K14/16 , C07K14/21 , C07K16/44 , C12P21/08 , G01N33/577 , G08G1/16 , C07K14/47 , C07K16/18
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6803 , A61K2039/505 , A61K2039/6037 , A61K2039/6068 , C07K16/44 , Y10S435/975 , Y10S436/816 , Y10S530/807
摘要： Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality of nicotine in its native (S)-(−) state, and have good stability properties. The conjugates are useful in formulating vaccines for active immunization, that are used to prevent and treat nicotine addiction. The antibodies raised in response to the nicotine hapten-carrier conjugate are used for passive immunization. These antibodies are administered for prevention and treatment of nicotine addiction.
摘要翻译：新的半抗原 - 载体缀合物能够在体内诱导特异性结合尼古丁的抗体的产生。这些缀合物包含与免疫原性载体蛋白缀合的尼古丁半抗原。新型缀合物保留尼古丁在其天然（S） - （ - ）状态下的手性，并具有良好的稳定性。缀合物可用于配制用于主动免疫的疫苗，其用于预防和治疗尼古丁成瘾。针对尼古丁半抗原 - 载体缀合物产生的抗体被用于被动免疫。这些抗体用于预防和治疗尼古丁成瘾。

5. 发明申请

US20080026000A1 HAPTEN-CARRIER CONJUGATES FOR TREATING AND PREVENTING NICOTINE ADDICTION 失效
标题翻译：用于治疗和预防未成年人接触的携带者联合
公开(公告)号：US20080026000A1
公开(公告)日：2008-01-31
申请号：US11780742
申请日：2007-07-20
申请人： Sofiane Ennifar , Ali Fattom , Robert Naso
发明人： Sofiane Ennifar , Ali Fattom , Robert Naso
IPC分类号： A61K39/385 , A61P25/34
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6803 , A61K2039/505 , A61K2039/6037 , A61K2039/6068 , C07K16/44 , Y10S435/975 , Y10S436/816 , Y10S530/807
摘要： Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality of nicotine in its native (S)-(−) state, and have good stability properties. The conjugates are useful in formulating vaccines for active immunization, that are used to prevent and treat nicotine addiction. The antibodies raised in response to the nicotine hapten-carrier conjugate are used for passive immunization. These antibodies are administered for prevention and treatment of nicotine addiction.
摘要翻译：新的半抗原 - 载体缀合物能够在体内诱导特异性结合尼古丁的抗体的产生。这些缀合物包含与免疫原性载体蛋白缀合的尼古丁半抗原。新型缀合物保留尼古丁在其天然（S） - （ - ）状态下的手性，并具有良好的稳定性。缀合物可用于配制用于主动免疫的疫苗，其用于预防和治疗尼古丁成瘾。针对尼古丁半抗原 - 载体缀合物产生的抗体被用于被动免疫。这些抗体用于预防和治疗尼古丁成瘾。

6. 发明申请

US20100040638A1 SMOKING CESSATION KIT AND METHOD 失效
标题翻译：吸烟用具和方法
公开(公告)号：US20100040638A1
公开(公告)日：2010-02-18
申请号：US12481420
申请日：2009-06-09
申请人： Matthew KALNIK , Mathew Hohenboken , Paul Kessler , Ali Fattom , Raafat Fahim , Leslie Hudson
发明人： Matthew KALNIK , Mathew Hohenboken , Paul Kessler , Ali Fattom , Raafat Fahim , Leslie Hudson
IPC分类号： A61K39/00 , G01N33/53 , C12M1/34
CPC分类号： A61K31/465 , G01N33/6854 , G01N33/944
摘要： Described are smoking cessation devices and kits for determining an advantageous time for a subject to quit smoking, and/or for extending the duration of smoking abstinence, based on serum levels of anti-nicotine antibodies. Related methods are also described.
摘要翻译：描述了基于抗尼古丁抗体的血清水平，用于确定受试者戒烟的有利时间和/或延长戒烟持续时间的戒烟装置和试剂盒。还描述了相关方法。

7. 发明申请

US20060134141A1 Glycoconjugate vaccines containing peptidoglycan 审中-公开
标题翻译：糖聚糖疫苗含有肽聚糖
公开(公告)号：US20060134141A1
公开(公告)日：2006-06-22
申请号：US11010563
申请日：2004-12-14
申请人： Ali Fattom , Ed Hausknecht , Scott Winston , Steve Fuller
发明人： Ali Fattom , Ed Hausknecht , Scott Winston , Steve Fuller
IPC分类号： A61K39/085 , A61K31/739
CPC分类号： A61K39/39 , A61K39/085 , A61K2039/55511 , A61K2039/5555 , A61K2039/60
摘要： The present invention relates to vaccines for treating bacterial infections, which vaccines comprise a glycoconjugate immunogen comprising at least one capsular polysaccharide conjugated to a carrier protein, such that the capsular polysaccharide contains an amount of peptidoglycan effective to improve the vaccine's properties.
摘要翻译：本发明涉及用于治疗细菌感染的疫苗，该疫苗包含糖缀合物免疫原，其包含与载体蛋白缀合的至少一种荚膜多糖，使得荚膜多糖含有一定量的肽聚糖可有效改善疫苗的性质。

8. 发明授权

US4894161A Process for clarifying a liquid using a polymeric substance 失效
标题翻译：使用聚合物质澄清液体的方法
公开(公告)号：US4894161A
公开(公告)日：1990-01-16
申请号：US927947
申请日：1986-11-07
申请人： Moshe Shilo , Ali Fattom
发明人： Moshe Shilo , Ali Fattom
IPC分类号： C02F1/52 , C12N1/02 , C12P1/04 , C12P21/00
CPC分类号： C12P21/005 , C02F1/5263 , C12N1/02 , C12P1/04 , Y02W10/37 , Y10S435/946
摘要： J-1 which is a strain of cyanobacteria is used to form and excrete a material useful as a floculating agent and as an additive useful in soil conditioning. Method of separating and culturing the cyanobacteria under conditions necessary to achieve maximum formation and excretion of the material into solution. Method of purifying and separating excreted as well as intracellular material from cyanobacterial. Method of clarifying a particulate-laden liquid with a material excreted by cyanobacteria, and particularly species J-1. Extracellular polymeric material which is water-soluble, non-dialyzable, having a molecular weight greater than 100,000, based on Sephadex column elution G 150, containing sugar, peptide, and fatty acid moieties, giving a positive Anthrone test, having an absorption peak of 205 nm. using a Perkin-Elmer spectrophotometer Model 402.
摘要翻译：作为蓝藻菌株的J-1用于形成和排出可用作絮凝剂的材料和用作土壤调理剂中的添加剂。在达到最大限度地形成和排出溶液的条件下分离和培养蓝细菌的方法。从蓝细菌中纯化和分离排泄物以及细胞内物质的方法。用蓝细菌排泄的材料，特别是物种J-1来澄清含颗粒的液体的方法。基于含有糖，肽和脂肪酸部分的Sephadex柱洗脱G 150，分子量大于100,000的水溶性，不可透析的细胞外聚合物质，得到阳性蒽酮试验，其具有吸收峰 205nm。使用402型Perkin-Elmer分光光度计。

9. 发明申请

US20050118190A1 Staphylococcus antigen and vaccine 失效
公开(公告)号：US20050118190A1
公开(公告)日：2005-06-02
申请号：US11014997
申请日：2004-12-20
申请人： Viliam Pavliak , Ali Fattom
发明人： Viliam Pavliak , Ali Fattom
IPC分类号： G01N33/569 , A61K39/00 , A61K39/085 , A61K39/385 , A61K39/395 , A61K47/48 , A61L29/00 , A61P9/00 , A61P19/08 , A61P31/04 , C07K14/31 , C07K16/12 , C12P21/08 , G01N33/577 , G01N33/554 , A61K39/02
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/6037 , A61K2039/6068 , C07K14/31 , Y10S435/975 , Y10S530/866
摘要： A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of Staphylococcus, including S. epidermidis, S. haemolyticus, and S. hominis. Staphylococcus strains that carry the antigen include many clinically significant strains of Staphylococcus. The antigen and antibodies to the antigen are useful in kits and assays for diagnosing Staphylococcus infection. Vaccines of the antigen and of whole cells that carry the antigen also are disclosed.

10. 发明授权

US5250201A Polymeric substance and method of separating and culturing bacteria 失效
标题翻译：聚合物和分离培养细菌的方法
公开(公告)号：US5250201A
公开(公告)日：1993-10-05
申请号：US656866
申请日：1991-02-19
申请人： Moshe Shilo , Ali Fattom
发明人： Moshe Shilo , Ali Fattom
IPC分类号： C02F1/52 , C12N1/02 , C12P1/04 , C12P21/00 , E21B43/22
CPC分类号： C12P21/005 , C02F1/5263 , C12N1/02 , C12P1/04 , Y10S507/936
摘要： J-1 which is a strain of cyanobacteria is used to form and excrete a material useful as an emulsifying agent for forming emulsions of hydrocarbons and oils in liquids such as water.Method of separating and culturing the cyanobacteria under conditions necessary to achieve a maximum formation and excretion of the emulsifying agent into solution.Method of purifying and separating excreted as well as intracellular material from cyanobacteria.Method of removing stains with a material excreted by cyanobacteria, and particularly strain J-1.Method of effecting the secondary recovery of petroleum through the use of a material excreted by cyanobacteria, and particularly strain J-1.Extracellular polymeric material which is greater than 200,000 Daltons in molecular weight, and contains sugar, fatty acid, and protein moieties, and amide, carboxylic and amino groups.
摘要翻译：作为蓝细菌菌株的J-1用于形成和排出可用作形成乳液的材料，用于在液体如水中形成烃和油的乳液。在达到最大限度地形成和排出乳化剂至溶液中的条件下分离和培养蓝细菌的方法。从蓝细菌中纯化和分离排泄物以及细胞内物质的方法。用蓝细菌排泄物质去除污渍的方法，特别是菌株J-1。通过使用由蓝细菌排泄的材料，特别是菌株J-1来实现二次回收石油的方法。分子量大于200,000道尔顿，含有糖，脂肪酸和蛋白质部分以及酰胺，羧酸和氨基的细胞外聚合物材料。

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