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1. 发明授权

US06351513B1 Fluoroscopy based 3-D neural navigation based on co-registration of other modalities with 3-D angiography reconstruction data 有权
标题翻译：基于3-D血管造影重建数据的其他方式的共同对照的基于荧光透视的3-D神经导航
公开(公告)号：US06351513B1
公开(公告)日：2002-02-26
申请号：US09607902
申请日：2000-06-30
申请人： Ali Bani-Hashemi , Arun Krishnan , James Williams
发明人： Ali Bani-Hashemi , Arun Krishnan , James Williams
IPC分类号： A61B603
CPC分类号： A61B6/481 , A61B5/055 , A61B6/12 , A61B6/504 , A61B6/5235 , A61B6/5247 , A61B2562/17 , Y10S378/901
摘要： A method and apparatus for providing a high-quality representation of a volume having a real-time 3-D reconstruction therein of movement of an object, wherein the real-time movement of the object is determined using a lower-quality representation of only a portion of the volume. The merger of 3-D angiography image representations acquired with other modalities, such as MR or CT, is disclosed. MR or CT modality images are registered with the 3-D Angiography data, such that those other images are brought into the same coordinate frame as the 3-D Angiography images. Movement of the object is detected in a 2-D X-ray fluoroscopy image and is reconstructed in a 3-D mode.
摘要翻译：一种用于提供其中具有物体的移动的实时3维重建的体积的高质量表示的方法和装置，其中使用较低质量的仅仅一个部分音量。公开了与其他方式（例如MR或CT）获得的3-D血管造影图像表示的合并。 MR或CT模态图像与3-D血管造影数据一起登记，使得其他图像被带入与3D血管造影图像相同的坐标系。在2维X射线荧光透视图像中检测物体的移动，并以3-D模式重建。

2. 发明授权

US06370421B1 Density modulated catheter for use in fluoroscopy based 3-D neural navigation 有权
标题翻译：用于基于荧光透视的3-D神经导航的密度调制导管
公开(公告)号：US06370421B1
公开(公告)日：2002-04-09
申请号：US09607901
申请日：2000-06-30
申请人： James Williams , Arun Krishnan , Ali Bani-Hashemi
发明人： James Williams , Arun Krishnan , Ali Bani-Hashemi
IPC分类号： A61M2500
CPC分类号： A61B6/481 , A61B6/12 , A61B6/504 , A61B6/5235 , A61B6/5247
摘要： A method and apparatus for providing a high-quality representation of a volume having a real-time 3-D reconstruction therein of movement of a catheter, wherein its real-time movement is determined using a lower-quality representation of only a portion of the volume. Movement of the catheter is detected in a 2-D X-ray fluoroscopy image and is reconstructed in a 3-D angiography (X-ray) reconstruction. Described is a catheter design for easier detection, and a technique for 3-D reconstruction of a catheter from real-time 2-D fluoroscopic images and stored 3-D angiography data, so as to present the 3-D reconstructed catheter in the common coordinate frame.
摘要翻译：一种用于提供其中具有导管运动的实时3维重建的体积的高质量表示的方法和装置，其中其实时运动使用仅仅一部分的一部分的较低质量的表示来确定卷。在2-D X射线荧光透视图像中检测导管的移动，并在3-D血管造影（X射线）重建中重建。描述的是用于更容易检测的导管设计，以及用于从实时二维透视图像和存储的三维血管造影数据中导管进行三维重建的技术，以将3-D重建的导管呈现在共同的坐标框。

3. 发明授权

US06389104B1 Fluoroscopy based 3-D neural navigation based on 3-D angiography reconstruction data 有权
标题翻译：基于3-D血管造影重建数据的基于荧光透视的3-D神经导航
公开(公告)号：US06389104B1
公开(公告)日：2002-05-14
申请号：US09607906
申请日：2000-06-30
申请人： Ali Bani-Hashemi , Arun Krishnan , James Williams
发明人： Ali Bani-Hashemi , Arun Krishnan , James Williams
IPC分类号： A61B603
CPC分类号： A61B6/504 , A61B6/12 , A61B6/4441 , A61B6/463 , A61B6/466 , A61B6/481 , A61B6/5235 , A61B6/5247 , A61B90/36 , G06T11/006 , G06T2211/404 , G06T2211/412 , G06T2211/428
摘要： A method and apparatus for providing a high-quality representation of a volume having a real-time 3-D reconstruction therein of movement of an object, wherein the real-time movement of the object is determined using a lower-quality representation of only a portion of the volume. Movement of the object is detected in a 2-D X-ray fluoroscopy image and is reconstructed in a 3-D angiography (X-ray) reconstruction. Using a common C-arm and X-ray geometry advantageously, the 2-D and 3-D data representative of vascular structures of a patient is acquired, thereby facilitating the merger of the real-time 2-D fluoroscopic images with the 3-D reconstructed vascular structures in a common 3-D-visualization framework. Also described is a technique for 3-D reconstruction of a catheter from real-time 2-D fluoroscopic images and stored 3-D angiography data, so as to present the 3-D reconstructed catheter in the common coordinate frame. The merger of 3-D angiography image representations acquired with other modalities, such as MR or CT, is also disclosed.
摘要翻译：一种用于提供其中具有物体的移动的实时3维重建的体积的高质量表示的方法和装置，其中使用较低质量的仅仅一个部分音量。在2-D X射线荧光透视图像中检测物体的移动，并在3-D血管造影（X射线）重建中重建。有利地使用常见的C形臂和X射线几何形状，代表患者的血管结构的2-D和3-D数据，从而有助于将实时2-D透视图像与3- D重建血管结构在一个共同的3-D可视化框架。还描述了一种用于从实时二维透视图像和存储的三维血管造影数据进行导管三维重建的技术，以将3-D重建的导管呈现在共同的坐标系中。还公开了与其他方式（例如MR或CT）获得的3-D血管造影图像表示的合并。

4. 发明申请

US20150159547A1 Cross Flow Turbine 审中-公开
标题翻译：横流涡轮机
公开(公告)号：US20150159547A1
公开(公告)日：2015-06-11
申请号：US14564700
申请日：2014-12-09
申请人： Pawel Bakula , Andrew Day , James Mawer , James Williams
发明人： Pawel Bakula , Andrew Day , James Mawer , James Williams
IPC分类号： F02B37/22 , F01D17/14 , F02B37/013 , F01D1/14
CPC分类号： F02B37/22 , F01D1/14 , F01D17/141 , F02B37/001 , F02B37/007 , F02B37/24 , F05D2220/40 , Y02T10/144
摘要： A turbocharger (10) with a cross flow turbine (30) where exhaust gas passes through a cross flow turbine wheel (18) on its outer diameter. A cross flow turbine (30) has radial exhaust gas inlet and outlet. Cross flow turbines (30) are suited for variable turbine geometry, including with a single guide vane (44) or multiple guide vanes in the turbine inlet (34) to control variable flow and thus performance of the turbine stage. Cross flow turbines (30) allow reduced size and excellent packaging options, such as a single or dual cross flow turbine wheel (18) between two compressor wheels (12).
摘要翻译：一种具有横流涡轮机（30）的涡轮增压器（10），其中废气在其外径上通过横流涡轮机叶轮（18）。横流式涡轮机（30）具有径向排气入口和出口。横流涡轮机（30）适用于可变涡轮机几何形状，包括在涡轮机入口（34）中具有单个导向叶片（44）或多个导向叶片，以控制涡轮机级的可变流量并由此执行。横流涡轮机（30）允许减小尺寸和优异的包装选项，例如在两个压缩机叶轮（12）之间的单或双横流涡轮机叶轮（18）。

5. 发明授权

US08466916B2 System and method for in-context volume visualization using virtual incision 有权
标题翻译：使用虚拟切口进行上下文卷可视化的系统和方法
公开(公告)号：US08466916B2
公开(公告)日：2013-06-18
申请号：US11675135
申请日：2007-02-15
申请人： Klaus Engel , James Williams
发明人： Klaus Engel , James Williams
IPC分类号： G06T17/00
CPC分类号： G06T15/08
摘要： A method for volume rendering a digitized medical image includes providing a digitized medical image volume comprising a plurality of intensities on a 3-dimensional grid of points, providing a projection plane comprising a 2-dimensional lattice of points onto which rendering rays are projected from a viewing point through the image volume, advancing a sampling point along a ray through the image volume, generating an incision region within the image volume, determining whether the sampling point is within the incision region, where a first transfer function is applied to a sample value interpolated from a first volume if the sampling point is within the incision region, and a second transfer function is applied to a sample value interpolated from a second volume if the sampling point is outside the incision region, and accumulating the output of the transfer function.
摘要翻译：用于体绘制数字化医学图像的方法包括在三维网格网格上提供包括多个强度的数字化医学图像体积，提供投影平面，该投影平面包括从其上投影渲染光线的点的二维点阵通过图像体积观察点，沿着光线推进采样点通过图像体积，在图像体积内产生切割区域，确定采样点是否在切口区域内，其中第一传递函数被应用于样本值如果采样点在切口区域内，则从第一卷内插，并且如果采样点在切口区域之外，则将第二传递函数应用于从第二卷内插的采样值，并累加传递函数的输出。

6. 发明申请

US20120100130A1 Novel Receptor Hetero-Dimers/-Oligomers 审中-公开
标题翻译：新型受体异构二聚体/ - 低聚物
公开(公告)号：US20120100130A1
公开(公告)日：2012-04-26
申请号：US13260530
申请日：2010-03-26
申请人： Kevin Donald George Pfleger , Matthew Blake Dalrymple , James Williams , Elizabeth McCall
发明人： Kevin Donald George Pfleger , Matthew Blake Dalrymple , James Williams , Elizabeth McCall
IPC分类号： A61K39/395 , G01N33/567 , C12N5/071 , C07K19/00 , C07K16/42
CPC分类号： G01N33/74 , C07K14/7158 , G01N33/6863 , G01N2333/7158 , G01N2500/04
摘要： A hetero-dimeric or hetero-oligomeric receptor, comprising at least one chemokine receptor subunit associated with at least one angiotensin receptor subunit.
摘要翻译：异二聚体或异低聚受体，其包含与至少一个血管紧张素受体亚基相关联的至少一个趋化因子受体亚单位。

7. 发明授权

US07568837B2 Method for activating an x-ray image recording system and an x-ray image recording system 有权
标题翻译：用于激活X射线图像记录系统和X射线图像记录系统的方法
公开(公告)号：US07568837B2
公开(公告)日：2009-08-04
申请号：US12077685
申请日：2008-03-20
申请人： Benno Heigl , Norbert Rahn , James Williams
发明人： Benno Heigl , Norbert Rahn , James Williams
IPC分类号： A61B6/02
CPC分类号： G03B42/026 , A61B6/02 , A61B6/08 , A61B6/12 , A61B6/4441 , A61B6/4458 , A61B6/469 , A61B6/488 , A61B6/545
摘要： To make optimum use of an x-ray image recording system with an x-ray C-arm, which has an x-ray radiation source and an x-ray detector and can be pivoted about any axis, 2D axis lines are plotted in two x-ray images of an object to be imaged more precisely and these 2D axis lines are used to define a 3D axis line and the x-ray image recording system is set so that it can be directly pivoted precisely about this 3D axis line. A sequence of x-ray images is then recorded in positions of the x-ray C-arm, between which the same can be pivoted about this defined axis. This displays the object optimally.
摘要翻译：为了最佳地利用具有x射线C臂的X射线图像记录系统，X射线C臂具有x射线辐射源和X射线检测器，并且可以围绕任何轴线枢转，将2D轴线绘制在两个要被成像的对象的X射线图像更精确，并且这些2D轴线被用于定义3D轴线，并且x射线图像记录系统被设置成使得其可以围绕该3D轴线精确地直接枢转。然后将X射线图像的序列记录在x射线C臂的位置，在该位置上，可以围绕该限定的轴线枢转X射线图像。这最好地显示对象。

8. 发明申请

US20080232554A1 Method for activating an x-ray image recording system and an x-ray image recording system 有权
标题翻译：用于激活X射线图像记录系统和X射线图像记录系统的方法
公开(公告)号：US20080232554A1
公开(公告)日：2008-09-25
申请号：US12077685
申请日：2008-03-20
申请人： Benno Heigl , Norbert Rahn , James Williams
发明人： Benno Heigl , Norbert Rahn , James Williams
IPC分类号： H05G1/26
CPC分类号： G03B42/026 , A61B6/02 , A61B6/08 , A61B6/12 , A61B6/4441 , A61B6/4458 , A61B6/469 , A61B6/488 , A61B6/545
摘要： To make optimum use of an x-ray image recording system with an x-ray C-arm, which has an x-ray radiation source and an x-ray detector and can be pivoted about any axis, 2D axis lines are plotted in two x-ray images of an object to be imaged more precisely and these 2D axis lines are used to define a 3D axis line and the x-ray image recording system is set so that it can be directly pivoted precisely about this 3D axis line. A sequence of x-ray images is then recorded in positions of the x-ray C-arm, between which the same can be pivoted about this defined axis. This displays the object optimally.
摘要翻译：为了最佳地利用具有x射线C臂的X射线图像记录系统，X射线C臂具有x射线辐射源和X射线检测器，并且可以围绕任何轴线枢转，将2D轴线绘制在两个要被成像的对象的X射线图像更精确，并且这些2D轴线被用于定义3D轴线，并且x射线图像记录系统被设置成使得其可以围绕该3D轴线精确地直接枢转。然后将X射线图像的序列记录在x射线C臂的位置，在该位置上，可以围绕该限定的轴线枢转X射线图像。这最好地显示对象。

9. 发明申请

US20080154565A1 AUTOMATIC ORGAN DETECTION USING MACHINE LEARNING AND CLASSIFICATION ALGORITHMS 有权
标题翻译：使用机器学习和分类算法的自动机器检测
公开(公告)号：US20080154565A1
公开(公告)日：2008-06-26
申请号：US11747961
申请日：2007-05-14
申请人： Charles Florin , James Williams
发明人： Charles Florin , James Williams
IPC分类号： G06G7/60
CPC分类号： G06K9/6256 , G06K2209/05 , G06T7/70 , G06T2207/10072 , G06T2207/30092
摘要： A method and apparatus of visually depicting an organ, having the steps of choosing a predefined set features for analysis, the predefined set of features having distinguishing weak learners for an algorithm, wherein the predefined set of features and the weak learners chosen distinguish features of the organ desired to be represented, developing a strong classifier for the algorithm for the organ desired to be represented based upon the weak learners for the organ, one of conducing a body scan to produce a body scan data set and obtaining a body scan data set of information for a patient, applying the strong classifier and the algorithm to the body scan data set to develop a result of a representation of the organ and outputting the result of the step of applying of the strong classifier and the algorithm to the body scan data set to represent the organ.
摘要翻译：一种视觉描绘器官的方法和装置，具有选择用于分析的预定义集合特征的步骤，所述预定义特征集合具有针对算法的区别弱学习者，其中所选择的特定组和弱学习者选择区分特征的特征期望被表示的器官，为基于用于器官的弱学习者所希望表示的器官的算法开发强分类器，其中一个是进行身体扫描以产生身体扫描数据集并且获得身体扫描数据集用于患者的信息，将强分类器和算法应用于身体扫描数据集以产生器官表示的结果，并将强分类器和算法的步骤的结果输出到身体扫描数据集代表器官。

10. 发明申请

US20070229500A1 SYSTEM AND METHOD FOR IN-CONTEXT MPR VISUALIZATION USING VIRTUAL INCISION VOLUME VISUALIZATION 有权
标题翻译：使用虚拟入侵体视觉化的内在MPR可视化的系统和方法
公开(公告)号：US20070229500A1
公开(公告)日：2007-10-04
申请号：US11684685
申请日：2007-03-12
申请人： Klaus Engel , James Williams
发明人： Klaus Engel , James Williams
IPC分类号： G06T17/00
CPC分类号： G06T19/00 , G06T15/08 , G06T2219/008 , Y10T428/24355 , Y10T428/25
摘要： A method for multi-planar reconstruction of digitized medical images includes providing an image volume, sampling the neighborhood about each point in a planar region and saving a color value and a depth, providing a projection plane onto which rendering rays are projected from a viewing point through said image volume, advancing sampling points along rays through the image volume, computing depths of each sampling point, determining for sampling points on rays that penetrates the planar region if a depth of said sampling point is less than the buffer depth of a corresponding point in the planar region and sampling neighborhoods of points about such sampling points, determining if sampling points are near said planar region, applying first transfer function to sample values interpolated from first volume for sampling points close to or inside the planar region, and otherwise applying second transfer function to sample values interpolated from second volume.
摘要翻译：一种用于数字化医学图像的多平面重构的方法包括提供图像体积，对平面区域中的每个点进行邻域采样，并且保存颜色值和深度，从而提供投影平面，在该投影平面上，从观察点通过所述图像体积，沿着光线通过图像体积推进采样点，计算每个采样点的深度，如果所述采样点的深度小于对应点的缓冲器深度，则确定穿透平面区域的射线上的采样点在平面区域中，并且对这些采样点的点的采样邻域，确定采样点是否靠近所述平面区域，将第一传递函数应用于从接近或在平面区域内的采样点从第一体积内插的采样值，传递函数到从第二卷插值的样本值。

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