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1. 发明授权

US08862244B2 Intracerebral electrode 有权
标题翻译：脑内电极
公开(公告)号：US08862244B2
公开(公告)日：2014-10-14
申请号：US13522569
申请日：2011-01-24
申请人： Alexandre Carpentier , Christophe Boillon
发明人： Alexandre Carpentier , Christophe Boillon
IPC分类号： A61N1/05 , A61B5/0478 , A61B18/00
CPC分类号： A61B5/0478 , A61B2018/00023 , A61N1/0534
摘要： An intracerebral electrode (11) which includes a narrow elongated body (1) for being implanted in a patient's brain. The body has contact pads (2) that are electrically connected to a measuring apparatus, and a mounting member (4) for attachment to the body to the patient's head. The electrode body has a closed distal end (5) and is hollow for receiving a treatment instrument (6). The intracerebral electrode (11) comprises a closed inner fluid flow circuit (20) formed inside the body (1) of the electrode to an area adjacent the closed distal end (5), and a connection mechanism (7) located outside the body which connects the closed inner fluid flow circuit to an outer fluid flow circuit so that fluid, flowing through the outer fluid flow circuit, flows into the electrode through the inner fluid flow circuit and controls the temperature of the electrode (11).
摘要翻译：一种脑内电极（11），其包括用于植入患者脑内的细长体（1）。身体具有电连接到测量装置的接触垫（2）和用于附接到身体到患者头部的安装构件（4）。电极体具有封闭的远端（5），并且是中空的，用于接收治疗仪器（6）。大脑内电极（11）包括形成在电极本体（1）内部的闭合的内部流体流动回路（20）到与封闭的远端（5）相邻的区域，以及位于主体外部的连接机构（7）将封闭的内部流体流路连接到外部流体流动回路，使得流过外部流体流动回路的流体通过内部流体流动回路流入电极并控制电极（11）的温度。

2. 发明申请

US20120296404A1 INTRACEREBRAL ELECTRODE 有权
标题翻译：内耳电极
公开(公告)号：US20120296404A1
公开(公告)日：2012-11-22
申请号：US13522569
申请日：2011-01-24
申请人： Alexandre Carpentier , Christophe Boillon
发明人： Alexandre Carpentier , Christophe Boillon
IPC分类号： A61N1/05
CPC分类号： A61B5/0478 , A61B2018/00023 , A61N1/0534
摘要： An intracerebral electrode (11) which includes a narrow elongated body (1) for being implanted in a patient's brain. The body has contact pads (2) that are electrically connected to a measuring apparatus, and a mounting member (4) for attachment to the body to the patient's head. The electrode body has a closed distal end (5) and is hollow for receiving a treatment instrument (6). The intracerebral electrode (11) comprises a closed inner fluid flow circuit (20) formed inside the body (1) of the electrode to an area adjacent the closed distal end (5), and a connection mechanism (7) located outside the body which connects the closed inner fluid flow circuit to an outer fluid flow circuit so that fluid, flowing through the outer fluid flow circuit, flows into the electrode through the inner fluid flow circuit and controls the temperature of the electrode (11).
摘要翻译：一种脑内电极（11），其包括用于植入患者脑内的细长体（1）。身体具有电连接到测量装置的接触垫（2）和用于附接到身体到患者头部的安装构件（4）。电极体具有封闭的远端（5），并且是中空的，用于接收治疗仪器（6）。大脑内电极（11）包括形成在电极本体（1）内部的闭合的内部流体流动回路（20）到与封闭的远端（5）相邻的区域，以及位于主体外部的连接机构（7）将封闭的内部流体流路连接到外部流体流动回路，使得流过外部流体流动回路的流体通过内部流体流动回路流入电极并控制电极（11）的温度。

3. 发明授权

US08942781B2 Medical system comprising a percutaneous probe 有权
标题翻译：包括经皮探针的医疗系统
公开(公告)号：US08942781B2
公开(公告)日：2015-01-27
申请号：US12937166
申请日：2009-04-09
申请人： Alexandre Carpentier , Julian Itzcovitz
发明人： Alexandre Carpentier , Julian Itzcovitz
IPC分类号： A61B5/05 , A61B8/08 , A61B5/00 , A61B8/12 , A61N7/02 , A61B5/01 , A61B5/0402 , A61B5/0476 , A61B5/055 , A61B17/00 , A61B19/00 , A61N7/00
CPC分类号： A61B8/0833 , A61B5/0068 , A61B5/0084 , A61B5/01 , A61B5/0402 , A61B5/0476 , A61B5/055 , A61B5/6848 , A61B8/12 , A61B2017/00084 , A61B2017/00911 , A61B2090/374 , A61B2090/3784 , A61N7/02 , A61N2007/0073 , A61N2007/025
摘要： The percutaneous probe, made in MRI-compatible materials, comprises: a body percutaneously inserted into the tissue of a patient's body organ (8) having a region (10) to be analyzed, treated and monitored during a single medical procedure; at least one information collection sensing device (30,33,34); treatment application transducers (30) 360° disposed to emit focused or defocused therapeutic ultra-sound waves. The computerized system comprises a parametrizable command device (50) adapted to simulate then command a generation of the therapeutic ultra-sound waves, and to monitor the treatment by thermal MRI images.
摘要翻译：在与MRI相容的材料中制成的经皮探针包括：经皮插入患者身体器官（8）的组织中的身体，其具有在单个医疗过程期间被分析，治疗和监测的区域（10）; 至少一个信息收集感测装置（30,33,34）; 治疗应用传感器（30）360°设置以发射聚焦或散焦的治疗性超声波。计算机化系统包括可参数化命令装置（50），其适于模拟然后命令产生治疗性超声波，并且通过热MRI图像来监视治疗。

4. 发明授权

US06391054B1 Expandable annuloplasty ring 有权
公开(公告)号：US06391054B1
公开(公告)日：2002-05-21
申请号：US09785976
申请日：2001-02-16
申请人： Alexandre Carpentier , Alain Carpentier
发明人： Alexandre Carpentier , Alain Carpentier
IPC分类号： A61F206
摘要： An expandable annuloplasty ring which may either expand spontaneously, in situ, as the patient grows or be expanded by surgical intervention by balloon dilatation. The distensible annuloplasty ring of the invention may be usable in pediatric patients whose growth, subsequent to surgical implantation of the ring, will necessitate subsequent enlargement of the ring to accommodate growth of the annulus. The ring may include a solid core of non-elastic material which plastically retains its shape upon natural expansion of the annulus, or after surgical expansion. A discontinuity may be positioned along the anterior side of the ring or around the posterior side.

5. 发明授权

US06217610B1 Expandable annuloplasty ring 失效
标题翻译：可扩张瓣环成形术环
公开(公告)号：US06217610B1
公开(公告)日：2001-04-17
申请号：US09124657
申请日：1998-07-29
申请人： Alexandre Carpentier , Alain Carpentier , Hung Lam , Than Nguyen , Van Le Huynh , Crystal Cunanan
发明人： Alexandre Carpentier , Alain Carpentier , Hung Lam , Than Nguyen , Van Le Huynh , Crystal Cunanan
IPC分类号： A61F224
CPC分类号： A61F2/2448 , A61F2250/0004 , A61F2250/0082
摘要： An expandable annuloplasty ring which may either expand spontaneously, in situ, as the patient grows or be expanded by surgical intervention by balloon dilatation. The distensible annuloplasty ring of the invention may be usable in pediatric patients whose growth, subsequent to surgical implantation of the ring, will necessitate subsequent enlargement of the ring to accommodate growth of the annulus. The ring may include relatively expandable segments to enable the enlargement thereof. The ring segments may include engaging teeth which cooperate with notches or slots formed in the tubes to provide some resistance to ring distention, while preventing collapse of the ring in the opposite direction. The teeth may be of different sizes or shapes to regulate the amount of force needed to expand the ring at different stages of the patient's growth. Alternatively, the adjustable ring includes a solid core of non-elastic material which plastically retains its shape upon natural expansion of the annulus, or after surgical expansion. In one embodiment, segments are coupled together with a discontinuity around the ring periphery. Pivot regions are provided between adjacent segments that, along with the discontinuity, enable the ring to expand upon annulus growth. The discontinuity may be positioned along the anterior side of the ring or around the posterior side. A further version makes use of telescoped segments with no discontinuity. The segments are coupled together with tubular sheaths, and expand without decoupling. A fabric covering may be omitted.
摘要翻译：可膨胀的瓣环成形术环，当患者通过球囊扩张的外科手术生长或扩大时，可以自发扩张。本发明的可扩张瓣环成形术环可用于儿科患者，其生长在环的手术植入之后将需要随后的扩大环以适应环的生长。环可以包括相对可扩展的部分，以使其能够扩大。环段可以包括与形成在管中的凹口或槽配合的接合齿，以提供一定阻力的环膨胀，同时防止环在相反方向上的塌陷。牙齿可以具有不同的尺寸或形状以调节在患者生长的不同阶段扩张环所需的力的量。或者，可调环包括非弹性材料的实心芯，其在环的自然膨胀时塑性地保持其形状，或者在手术扩张之后。在一个实施例中，段围绕环外围以不连续的方式耦合在一起。在相邻段之间提供枢轴区域，随着不连续性，环可以在环形增长时扩张。不连续性可以沿着环的前侧或者在后侧周围定位。另一个版本使用无间断的伸缩部分。这些节段与管状护套耦合在一起，并且在没有解耦的情况下膨胀。可以省略织物覆盖物。

6. 发明授权

US09669239B2 Device for treating the sensory capacity of a person and method of treatment with the help of such a device 有权
公开(公告)号：US09669239B2
公开(公告)日：2017-06-06
申请号：US14234672
申请日：2012-07-24
申请人： Alexandre Carpentier
发明人： Alexandre Carpentier
IPC分类号： A61H1/00 , A61N7/00 , A61N1/375 , A61N1/05 , A61N1/36 , A61B8/08 , A61B8/00 , H04R25/00
CPC分类号： A61N7/00 , A61B8/0816 , A61B8/582 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/3756 , A61N2007/0026 , H04R25/353 , H04R2225/67
摘要： A system for treating at least one sensory capacity of a person with the help of a stimulation device comprises an electronic converter of a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal. The stimulation device for direct ultrasound stimulation of the sensory cortex of a brain comprises at least one support that is implantable in a skull and that includes at least one internal wall and at least one ultrasound transducer carried by the support. Means for emitting focused ultrasound waves through the internal wall of the support towards a determined zone of the sensory cortex of the patient's brain in order to generate modulation of the brain activity in the cortex are provided. The ultrasound transducer is driven by the electronic converter to emit focused ultrasound signals that are images of the sensory signal.

7. 发明申请

US20110040172A1 MEDICAL SYSTEM COMPRISING A PERCUTANEOUS PROBE 有权
标题翻译：包含PERCUTANEOUS PROBE的医疗系统
公开(公告)号：US20110040172A1
公开(公告)日：2011-02-17
申请号：US12937166
申请日：2009-04-09
申请人： Alexandre Carpentier , Julian Itzcovitz
发明人： Alexandre Carpentier , Julian Itzcovitz
IPC分类号： A61B8/00 , A61N7/00 , A61B5/055
CPC分类号： A61B8/0833 , A61B5/0068 , A61B5/0084 , A61B5/01 , A61B5/0402 , A61B5/0476 , A61B5/055 , A61B5/6848 , A61B8/12 , A61B2017/00084 , A61B2017/00911 , A61B2090/374 , A61B2090/3784 , A61N7/02 , A61N2007/0073 , A61N2007/025
摘要： The percutaneous probe, made in MRI-compatible materials, comprises: a body percutaneously inserted into the tissue of a patient's body organ (8) having a region (10) to be analyzed, treated and monitored during a single medical procedure; at least one information collection sensing device (30,33,34); treatment application transducers (30) 360° disposed to emit focused or defocused therapeutic ultra-sound waves. The computerized system comprises a parametrizable command device (50) adapted to simulate then command a generation of the therapeutic ultra-sound waves, and to monitor the treatment by thermal MRI images.
摘要翻译：在与MRI相容的材料中制成的经皮探针包括：经皮插入患者身体器官（8）的组织中的身体，其具有在单个医疗过程期间被分析，治疗和监测的区域（10）; 至少一个信息收集感测装置（30,33,34）; 治疗应用传感器（30）360°设置以发射聚焦或散焦的治疗性超声波。计算机化系统包括可参数化命令装置（50），其适于模拟然后命令产生治疗性超声波，并且通过热MRI图像来监视治疗。

8. 发明授权

US08977361B2 Apparatus for the treatment of brain affections and method implementing thereof 有权
标题翻译：用于治疗脑部感觉的装置及其实施方法
公开(公告)号：US08977361B2
公开(公告)日：2015-03-10
申请号：US13577938
申请日：2011-02-22
申请人： Alexandre Carpentier , Cyril Lafon , Jean-Yves Chapelon , Michael Sean Canney , Kévin Beccaria
发明人： Alexandre Carpentier , Cyril Lafon , Jean-Yves Chapelon , Michael Sean Canney , Kévin Beccaria
IPC分类号： A61N1/00 , A61N1/36 , A61N5/06 , A61N7/02 , A61B8/08 , A61N7/00
CPC分类号： A61N1/3606 , A61B8/0816 , A61B8/56 , A61N5/0601 , A61N7/02 , A61N2005/0651 , A61N2007/0021 , A61N2007/0052 , A61N2007/0078 , A61N2007/025
摘要： The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.
摘要翻译：本发明涉及一种用于治疗脑部感受的装置，其包括由非铁磁材料制成的至少一个植入式发生器（4），该植入式发生器由非壳型材料制成，其包括壳体（7），超声波产生处理装置（11）以通过发射超声波来诱导大脑感受治疗，以及用于将可植入的外壳固定到颅骨中的装置。该装置还包括电力控制器（PwC），用于向可植入发电机的处理装置供电并设置和控制其工作参数，以及连接装置（6）以连接可植入发电机的功率控制器和处理装置。还公开了用这种装置治疗脑感染的方法。

9. 发明申请

US20140249454A1 DEVICE FOR TREATING THE SENSORY CAPACITY OF A PERSON AND METHOD OF TREATMENT WITH THE HELP OF SUCH A DEVICE 有权
标题翻译：用于治疗人的感觉能力的装置和这种装置的帮助的治疗方法
公开(公告)号：US20140249454A1
公开(公告)日：2014-09-04
申请号：US14234672
申请日：2012-07-24
申请人： Alexandre Carpentier
发明人： Alexandre Carpentier
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/0816 , A61B8/582 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/3756 , A61N2007/0026 , H04R25/353 , H04R2225/67
摘要： A system (1) for treating at least one sensory capacity of a person with the help of a stimulation device comprising: an electronic converter (7) of a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal; the stimulation device is a device (3) for direct ultrasound stimulation of the sensory cortex of the patient's brain (B), comprising: at least one support (2) that is implantable in the patient's skull (C) and that includes at least one internal wall (22); and at least one ultrasound transducer (4) carried by the support (2) and including means for emitting focused ultrasound waves (U) through the internal wall (22) of the support towards a determined zone of the sensory cortex of the patient's brain (B) in order to generate modulation of the brain activity in the cortex, the ultrasound transducer (4) being driven by the electronic converter to emit focused ultrasound signals (U) that are images of the sensory signal.
摘要翻译：一种用于在刺激装置的帮助下治疗人的至少一种感觉能力的系统（1），包括：将感觉信号转换成电子信号的电子转换器（7），用于控制至少一个用于发射作为图像的信号的换能器的感觉信号; 所述刺激装置是用于直接超声刺激患者脑部（B）的感觉皮层的装置（3），包括：可植入患者颅骨（C）中的至少一个支架（2），并且包括至少一个内壁（22）; 以及由所述支撑件（2）承载的至少一个超声换能器（4），并且包括用于经由所述支撑体的内壁（22）朝向所述患者脑的感觉皮质的确定区域发射聚焦超声波（U）的装置（ B）为了产生大脑在脑皮质中的活动调节，超声换能器（4）由电子转换器驱动，发射作为感觉信号图像的聚焦超声信号（U）。

10. 发明授权

US08597338B2 Intracerebral probe and device for the treatment of neurological or psychiatric dysfunctions 有权
标题翻译：脑内探针和用于治疗神经系统或精神功能障碍的装置
公开(公告)号：US08597338B2
公开(公告)日：2013-12-03
申请号：US12063837
申请日：2006-08-18
申请人： Alexandre Carpentier
发明人： Alexandre Carpentier
IPC分类号： A61H21/00 , A61B5/04 , A61B18/18
CPC分类号： A61B18/22 , A61B5/04001 , A61B5/055 , A61B5/6864 , A61B18/02 , A61B90/40 , A61B2017/00039 , A61B2018/00434 , A61N1/0529
摘要： An intracerebral probe (11) comprising a first part (20) with laser or cryogenic treatment means and further comprising a hollow second part (22) surrounding the first, the first part sliding inside the second part along its longitudinal axis (A); and a plurality of detectors (16) distributed along a portion of the second part (22) in such a manner as to be capable of identifying a brain dysfunction zone along the longitudinal axis (A) of the second part. Advantageously, the probe presents a lateral treatment window enabling the action of the treatment means to be directed. The invention also provides a kit and a treatment system including such a probe, and the use thereof of treating cell dysfunctions that give rise to neurological or psychiatric symptoms.
摘要翻译：包括具有激光或低温处理装置的第一部分（20）的脑内探针（11），并且还包括围绕所述第一部分的空心第二部分（22），所述第一部分沿着其纵向轴线（A）在第二部分内滑动; 以及沿着第二部分（22）的一部分分布的多个检测器（16），以便能够识别沿着第二部分的纵向轴线（A）的脑功能障碍区域。有利地，探针具有能够引导治疗装置的作用的侧向治疗窗口。本发明还提供了包括这种探针的试剂盒和治疗系统及其治疗引起神经或精神症状的细胞功能障碍的用途。

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