专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050197359A1 Bicyclic modulators of androgen receptor function 有权
标题翻译：雄激素受体功能的双环调节剂
公开(公告)号：US20050197359A1
公开(公告)日：2005-09-08
申请号：US11070808
申请日：2005-03-02
申请人： Alexandra Nirschl , James Sutton , Lawrence Hamann , Tammy Wang , Yan Zou , Chongqing Sun
发明人： Alexandra Nirschl , James Sutton , Lawrence Hamann , Tammy Wang , Yan Zou , Chongqing Sun
IPC分类号： A61K31/424 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4745 , C07D263/60 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X, Y and n are defined herein.
摘要翻译：本发明涉及式I的双环化合物，含有这些化合物的药物组合物和使用这些化合物治疗雄激素受体相关病症例如年龄相关疾病，例如肌肉减少症的方法，其中R 1 R 2，R 5，X，Y和n在本文中定义。

2. 发明授权

US07625923B2 Bicyclic modulators of androgen receptor function 有权
标题翻译：雄激素受体功能的双环调节剂
公开(公告)号：US07625923B2
公开(公告)日：2009-12-01
申请号：US11070808
申请日：2005-03-02
申请人： Alexandra Nirschl , James C. Sutton , Lawrence Hamann , Tammy Wang , Yan Zou , Chongqing Sun
发明人： Alexandra Nirschl , James C. Sutton , Lawrence Hamann , Tammy Wang , Yan Zou , Chongqing Sun
IPC分类号： A61K31/4745 , C07D491/02
CPC分类号： C07D487/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R5, X, Y and n are defined herein.
摘要翻译：本发明涉及式I的双环化合物，含有这些化合物的药物组合物和使用这些化合物治疗雄激素受体相关病症如年龄相关疾病，例如肌肉减少症的方法，其中R1，R2，R5 ，X，Y和n如本文所定义。

3. 发明申请

US20050187267A1 Sulfonylpyrrolidine modulators of androgen receptor function and method 有权
公开(公告)号：US20050187267A1
公开(公告)日：2005-08-25
申请号：US11048439
申请日：2005-02-01
申请人： Lawrence Hamann , Yingzhi Bi , Mark Manfredi , Alexandra Nirschl , James Sutton
发明人： Lawrence Hamann , Yingzhi Bi , Mark Manfredi , Alexandra Nirschl , James Sutton
IPC分类号： A61K31/4015 , A61K31/433 , C07D207/48 , C07D285/06 , C07D285/14 , C07D498/04
CPC分类号： C07D285/14 , C07D207/48
摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1 is hydrogen (H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, arylalkyl or substituted arylalkyl, CO2R4a, CONR4aR4b, and CH2OR4a; R2 is hydrogen (H), OR3, SR3, halo, NHR3, NHCOR4c1, NHCO2R4c1, NHCONR4cR4d and NHSO2R4c; R3 in each functional group is hydrogen (H), alkyl or substituted alkyl, CHF2, CF3 and CON4e; R4, R4a, R4b, R4c, R4c1, R4d, R4e, R4f, R4g, or R4h in each functional group are the same or different and are hydrogen(H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, or heteroaryl or substituted heteroaryl; R5 and R5′ are the same or different and are hydrogen(H), alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, or heteroaryl or substituted heteroaryl, wherein at least one of R5 and R5′ is hydrogen, or R5 and R5′ taken together form a double bond with oxygen (O), sulfur (S), NR7 or CR7R7′; where R7 and R7′ are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; and n is an integer of 1 or 2, m is an integer of 1 or 2, Z is oxygen (—O—) or NR4h, a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.

4. 发明授权

US06670386B2 Bicyclic modulators of androgen receptor function 有权
标题翻译：雄激素受体功能的双环调节剂
公开(公告)号：US06670386B2
公开(公告)日：2003-12-30
申请号：US10209461
申请日：2002-07-31
申请人： Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang , Lawrence Hamann , David Augeri
发明人： Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang , Lawrence Hamann , David Augeri
IPC分类号： A01K4352
CPC分类号： C07D207/16 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The invention provides compounds of the formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.
摘要翻译：本发明提供式I化合物，其中取代基如本文所述。进一步提供的是使用这些化合物治疗核激素受体相关病症（例如年龄相关疾病，例如肌肉减少症）的方法，并且还提供药物组合物含有这些化合物。

5. 发明授权

US06992102B2 Bicyclic modulators of androgen receptor function 失效
公开(公告)号：US06992102B2
公开(公告)日：2006-01-31
申请号：US10685020
申请日：2003-10-14
申请人： Lawrence Hamann , David Augeri , Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang
发明人： Lawrence Hamann , David Augeri , Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D207/16 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The invention provides compounds of the formula I wherein the substitutents are as described herein.Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.

6. 发明申请

US20080108649A1 BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION 有权
标题翻译：雄激素受体功能的双相调制剂
公开(公告)号：US20080108649A1
公开(公告)日：2008-05-08
申请号：US11931282
申请日：2007-10-31
申请人： Chong-Qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James Sutton , James Li
发明人： Chong-Qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James Sutton , James Li
IPC分类号： A61K31/4545 , A61K31/4164 , A61K31/47 , A61P21/00 , C07D217/00 , C07D235/00 , C07D471/02
CPC分类号： C07D487/04 , C07D471/04
摘要： There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
摘要翻译：提供根据式I的化合物，其中取代基如本文所述。进一步提供的是使用这些化合物来治疗核激素受体相关病症的方法，例如年龄相关疾病，例如肌肉减少症。还提供了含有这些化合物的药物组合物和制备本发明的一些化合物的方法。还公开了其他实施例。

7. 发明申请

US20050182105A1 Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function 审中-公开
标题翻译：使用3-氰基-4-芳基吡啶衍生物作为雄激素受体功能的调节剂的方法
公开(公告)号：US20050182105A1
公开(公告)日：2005-08-18
申请号：US11048437
申请日：2005-02-01
申请人： Alexandra Nirschl , Lawrence Hamann
发明人： Alexandra Nirschl , Lawrence Hamann
IPC分类号： A61K31/44 , A61K31/4439 , A61K45/06
CPC分类号： A61K45/06 , A61K31/44 , A61K31/4439 , A61K2300/00
摘要： A method is provided for treating androgen receptor-associated conditions such as age-related diseases, for example sarcopenia, employing a compound of the structure wherein R1 is CN or H; X is O or S; R2 is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, or heteroaryl or substituted heteroaryl; R3 and R4 are the same or different and are independently selected from H, C(O)R2a, alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, or heteroaryl or substituted heteroaryl; R2a is alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, or heteroaryl or substituted heteroaryl; G is aryl or heteroaryl, or aryl or heteroaryl substituted with one, two, three, four or five, where possible, of the substituents selected from the group consisting of hydrogen (H), halo, NO2, CN, OR2b, OH, CF3, NR3aR4a; wherein R3a and R4a, and R2b are the same or different and are independently selected from alkyl or substituted alkyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, or heteroaryl and substituted heteroaryl; or a pharmaceutically acceptable salt thereof and a prodrug ester thereof.
摘要翻译：提供了一种用于治疗雄激素受体相关病症例如年龄相关疾病，例如肌钙蛋白减少症的方法，使用其中R 1为CN或H的结构的化合物; X是O或S; R 2是烷基或取代的烷基，环烷基或取代的环烷基，芳基烷基或取代的芳基烷基，芳基或取代的芳基或杂芳基或取代的杂芳基; R 3和R 4相同或不同，独立地选自H，C（O）R 2a，烷基或取代的烷基，环烷基或取代的环烷基，芳基烷基或取代的芳基烷基，芳基或取代的芳基，或杂芳基或取代的杂芳基; R 2a是烷基或取代的烷基，环烷基或取代的环烷基，芳烷基或取代的芳基烷基，芳基或取代的芳基或杂芳基或取代的杂芳基; G是芳基或杂芳基，或在可能的情况下用一个，两个，三个，四个或五个取代基取代的芳基或杂芳基，所述取代基选自氢（H），卤素，，CN，OR 2b，OH，CF 3，NR 3a，R 4a，其中R 3a和R 4a和R 2b相同或不同，并且独立地选自烷基或取代的烷基，环烷基或取代的环烷基，芳基烷基或取代的芳基烷基，芳基或取代的芳基，或杂芳基和取代的杂芳基; 或其药学上可接受的盐和其前药酯。

8. 发明授权

US07772267B2 Bicyclic modulators of androgen receptor function 有权
标题翻译：雄激素受体功能的双环调节剂
公开(公告)号：US07772267B2
公开(公告)日：2010-08-10
申请号：US11931282
申请日：2007-10-31
申请人： Chong-qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James C. Sutton , James J. Li
发明人： Chong-qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James C. Sutton , James J. Li
IPC分类号： A61K31/415 , C07D235/02
CPC分类号： C07D487/04 , C07D471/04
摘要： There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
摘要翻译：提供根据式I的化合物，其中取代基如本文所述。进一步提供的是使用这些化合物来治疗核激素受体相关病症的方法，例如年龄相关疾病，例如肌肉减少症。还提供了含有这些化合物的药物组合物和制备本发明的一些化合物的方法。还公开了其他实施例。

9. 发明授权

US07405234B2 Bicyclic modulators of androgen receptor function 有权
标题翻译：雄激素受体功能的双环调节剂
公开(公告)号：US07405234B2
公开(公告)日：2008-07-29
申请号：US10780415
申请日：2004-02-17
申请人： Chong-Qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James C. Sutton , James J. Li
发明人： Chong-Qing Sun , Lawrence Hamann , David Augeri , Yingzhi Bi , Jeffrey Robl , Yan-Ting Huang , Tammy Wang , Alexandra Holubec , Ligaya Simpkins , James C. Sutton , James J. Li
IPC分类号： A61K31/415 , C07D235/02
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.
摘要翻译：本发明提供式I化合物，其中取代基如本文所述。进一步提供的是使用这些化合物来治疗核激素受体相关病症的方法，例如年龄相关疾病，例如肌肉减少症。还提供了含有这些化合物的药物组合物和制备本发明的一些化合物的方法。

10. 发明申请

US20050239839A1 Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods 审中-公开
公开(公告)号：US20050239839A1
公开(公告)日：2005-10-27
申请号：US11149408
申请日：2005-06-09
申请人： Lawrence Hamann , Ashish Khanna , Mark Kirby , David Magnin , Ligaya Simpkins , James Sutton , Jeffrey Robl
发明人： Lawrence Hamann , Ashish Khanna , Mark Kirby , David Magnin , Ligaya Simpkins , James Sutton , Jeffrey Robl
IPC分类号： C07C255/46 , C07C255/47 , C07D207/16 , C07D209/52 , C07D277/04 , C07D295/185 , A61K31/445 , A61K31/275 , A61K31/401 , A61K31/403 , A61K31/426
CPC分类号： C07C255/46 , C07C255/47 , C07C2601/08 , C07C2602/18 , C07C2603/74 , C07D207/16 , C07D209/52 , C07D277/04 , C07D295/185
摘要： Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式