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    • 10. 发明授权
    • Use of substituted vinyl-tetrahydronaphthalenes and vinyl-benzotetrahydropyrans as light protection agents
    • 使用取代的乙烯基 - 四氢萘和乙烯基 - 苯并四氢吡喃作为防光剂
    • US06680390B2
    • 2004-01-20
    • US10173277
    • 2002-06-18
    • Frank PrechtlThorsten HabeckHorst WestenfelderThomas Wilnsch
    • Frank PrechtlThorsten HabeckHorst WestenfelderThomas Wilnsch
    • C07D31174
    • A61K8/40A61K8/368A61K8/37A61K8/498A61K2800/52A61Q17/04
    • The invention relates to the use of compounds of the formula I in which X is the divalent radical of oxygen, a carbonyl radical, optionally aliphatically substituted imino or the radical ═CR9R10, Y is a carbonyl group or the radical ═CR9R10, R1 and R2 are identical or different electron-withdrawing radicals, chosen from the group consisting of cyano, alkyl- or arylcarbonyl, alkyloxy- or aryloxycarbonyl, optionally substituted aminocarbonyl, alkyl- or arylsulfinyl, alkyl- or arylsulfonyl and optionally substituted aminosulfonyl, R3 is a hydrogen atom, a cyano, hydroxyl, carboxyl or aminocarbonyl group or a C5-C20-aryl radical or C1-C20-alkylradical optionally bonded via an oxygen bridge, an aminocarbonyl bridge or oxycarbonyl bridge, R4 is a hydrogen atom, a hydroxyl group, an amino group, or a C5-C20-aryl radical or C1-C20-alkyl radical optionally bonded via an oxygen bridge, and R5 to R10 independently of one another are hydrogen or C1-C20-alkyl radicals and where in addition R7 and R8 together with the chain carbon atom are a carbonyl group, as photostable UV filters in cosmetic and pharmaceutical preparations for protecting human skin and human hair from solar rays, alone or together with compounds which absorb in the UV region and are known per se for cosmetic and pharmaceutical preparations.
    • 本发明涉及式Iin的化合物,其中X是氧的二价基团,羰基,任选地是脂族取代的亚氨基或基团= CR 9 R 10,Y是羰基或基团= CR 9 R 10,R 1和R 2是相同或不同的吸电子基团,选自氰基,烷基 - 或芳基羰基,烷氧基 - 或芳氧基羰基,任选取代的氨基羰基,烷基 - 或芳基亚磺酰基,烷基 - 或芳基磺酰基和任选取代的氨基磺酰基,R 3是氢原子,氰基,羟基,羧基或氨基羰基或C 5 -C 20 - 芳基或任选经氧连接的C 1 -C 20 - 烷基 桥,氨基羰基桥或氧羰基桥,R 4是氢原子,羟基,氨基或任选通过氧桥键合的C 5 -C 20 - 芳基或C 1 -C 20 - 烷基, R 5至R 10彼此独立地是氢或C 1 -C 20烷基,并且其中 R 7和R 8与链碳原子一起是羰基,作为用于保护人类皮肤和人类头发免受太阳光线影响的化妆品和药物制剂中的光稳定性UV过滤剂,单独或与在 UV区域,并且本身已知化妆品和药物制剂。