专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06212047B1 Hard disk drive with magnetoresistive head and perpendicular media 失效
标题翻译：具有磁阻头和垂直介质的硬盘驱动器
公开(公告)号：US06212047B1
公开(公告)日：2001-04-03
申请号：US08771468
申请日：1996-12-20
申请人： Alexander P. Payne , William C. Cain , Michael E. Devillier , Harold J. Hamilton , Robert D. Hempstead , Darren T. Imai , Dimitre A. Latev , Mark A. Lauer , David D. Roberts
发明人： Alexander P. Payne , William C. Cain , Michael E. Devillier , Harold J. Hamilton , Robert D. Hempstead , Darren T. Imai , Dimitre A. Latev , Mark A. Lauer , David D. Roberts
IPC分类号： G11B539
CPC分类号： G11B5/6005 , G11B5/1278 , G11B5/3106 , G11B5/3176 , G11B5/3183 , G11B5/3967 , G11B5/6076
摘要： An information storage system having a ring head in such close proximity to a rigid magnetic storage disk that the magnetic field felt by the media layer or layers of the disk has a larger perpendicular than longitudinal component so that data is stored in a perpendicular mode. Reading of data is accomplished with a magnetoresistive sensor which may be coupled to the magnetically permeable core of the ring head far from the poletips, which may contact the disk. The media preferably has a high perpendicular anisotropy, and may be formed in a plurality of films with crystalline structures traversing the films.
摘要翻译：一种信息存储系统，其具有如此靠近刚性磁存储盘的环形头，所述刚性磁存储盘使得所述介质层感觉到的磁场或所述盘的层具有比纵向分量更大的垂直于垂直模式的数据。数据读取是通过一个磁阻传感器实现的，该磁阻传感器可耦合到远离可以接触磁盘的引脚的环形头部的导磁芯。介质优选具有高垂直各向异性，并且可以形成为具有穿过膜的结晶结构的多个膜。

2. 发明授权

US06320725B1 Hard disk drive having ring head with predominantly perpendicular media fields 失效
标题翻译：具有环形头的硬盘驱动器，主要具有垂直的介质场
公开(公告)号：US06320725B1
公开(公告)日：2001-11-20
申请号：US08577493
申请日：1995-12-22
申请人： Alexander P. Payne , William C. Cain , Michael E. DeVillier , Harold J. Hamilton , Robert D. Hempstead , Darren T. Imai , Mark A. Lauer , Dimitre A. Latev , David D. Roberts
发明人： Alexander P. Payne , William C. Cain , Michael E. DeVillier , Harold J. Hamilton , Robert D. Hempstead , Darren T. Imai , Mark A. Lauer , Dimitre A. Latev , David D. Roberts
IPC分类号： G11B5127
CPC分类号： G11B5/6005 , G11B5/1278 , G11B5/3106 , G11B5/3176 , G11B5/3183 , G11B5/3967 , G11B5/6076
摘要： An information storage system having a ring head sliding on a rigid magnetic storage disk in such close proximity that the magnetic field felt by the media layer or layers of the disk has a larger perpendicular than longitudinal component so that data is stored in a perpendicular mode. The head to media separation during writing of data to the media is a small fraction of the amagnetic gap separating the poletips of the head. Reading of data may be inductive or may be via a magnetoresistive sensor which is coupled to the magnetically permeable core of the ring head far from the poletips. The media preferably has a high perpendicular anisotropy.
摘要翻译：一种信息存储系统，其具有在刚性磁存储盘上滑动的环形头，所述环形头在所述介质层或所述盘的层中感觉到的磁场具有比纵向分量更大的垂直于垂直模式的数据。在向媒体写入数据期间的媒体分离的头部是分离头部poletips的磁性间隙的一小部分。数据的读取可以是感性的，或者可以是经由磁阻传感器，该磁阻传感器耦合到远离耳环的环形头的导磁芯。介质优选具有高垂直各向异性。

3. 发明授权

US06493191B1 Planar magnetic ring head for contact recording with a rigid disk 失效
标题翻译：平面磁环头，用于与刚性盘接触记录
公开(公告)号：US06493191B1
公开(公告)日：2002-12-10
申请号：US08528890
申请日：1995-09-15
申请人： William C. Cain , Richard D. Anderson , Michael A. Baldwinson , Keith R. Berding , Michael E. Devillier , Garrett A. Garrettson , Randolph S. Gluck , Harold J. Hamilton , Robert D. Hempstead , Darren T. Imai , Kwang K. Kim , Dimitre A. Latev , Alexander P. Payne , David D. Roberts
发明人： William C. Cain , Richard D. Anderson , Michael A. Baldwinson , Keith R. Berding , Michael E. Devillier , Garrett A. Garrettson , Randolph S. Gluck , Harold J. Hamilton , Robert D. Hempstead , Darren T. Imai , Kwang K. Kim , Dimitre A. Latev , Alexander P. Payne , David D. Roberts
IPC分类号： G11B5187
CPC分类号： G11B5/3163 , G11B5/3106 , G11B5/3183
摘要： A transducer for a hard disk drive system has a planar magnetic core and a pair of poletips that project transversely from the core for sliding contact with the disk during reading and writing. The transducer is formed entirely of thin films in the shape of a low profile table having three legs that slide on the disk, the poletips being exposed at a bottom of one of the legs for high resolution communication with the disk, the throat height of the poletips affording sufficient tolerance to allow for wear. The legs elevate the transducer from the disk sufficiently to minimize lifting by a thin air layer that moves with the spinning disk which, in combination with the small size of the thin film head allows a low load and a flexible beam and gimbal to hold the transducer to the disk. The transducer includes a loop shaped core of magnetic material that ends at the poletips, the core extending further parallel than perpendicular to the disk surface and preferably being formed of a plurality of slightly spaced ribbons of magnetic material in order to increase high frequency permeance. A high magnetic saturation layer may be formed adjoining the gap in at least the trailing poletip, in order to avoid saturation at the poletips during writing. The dimensions of the yoke adjacent to the poletips are also designed to avoid saturation at the poletips by saturating at a lower flux in the yoke than the poletips. The close relationship between the transducer and the media of the disk affords high density magnetic data storage and retrieval.
摘要翻译：用于硬盘驱动系统的换能器具有平面磁芯和一对从芯体横向突出的小纸片，用于在读写期间与盘滑动接触。传感器完全由薄板形成，其具有在盘上滑动的三条腿的小型表，其中一条腿露出在一条腿的底部，用于与盘的高分辨率通信，喉部的高度小腿提供足够的耐受性以允许磨损。这些腿将传感器从盘上提升到足以最小化由旋转盘移动的薄空气层的提升，其与小尺寸的薄膜头允许低负载并且柔性梁和万向节保持换能器到磁盘。换能器包括磁性材料的环形磁芯，其在端部终止，芯体比垂直于磁盘表面进一步平行延伸，并且优选地由多个稍微间隔的磁性材料带形成，以便增加高频磁导率。至少可以在至少尾部poletip中形成邻接间隙的高磁饱和层，以避免写入期间在poletips处的饱和。靠近小翼片的轭的尺寸也被设计成通过在轭中的低通量饱和而不是poletips饱和。传感器与磁盘介质之间的紧密关系提供了高密度的磁数据存储和检索。

4. 发明授权

US07095585B2 Hard disk drive for perpendicular recording with transducer having submicron gap between pole tips 有权
公开(公告)号：US07095585B2
公开(公告)日：2006-08-22
申请号：US10970782
申请日：2004-10-20
申请人： Alexander P. Payne , William C. Cain , Michael E. Devillier , Harold J. Hamilton , Robert D. Hempstead , Darren T. Imai , Dimitre A. Latev , David D. Roberts
发明人： Alexander P. Payne , William C. Cain , Michael E. Devillier , Harold J. Hamilton , Robert D. Hempstead , Darren T. Imai , Dimitre A. Latev , David D. Roberts
IPC分类号： G11B5/147 , G11B5/235
CPC分类号： G11B5/6005 , G11B5/1278 , G11B5/3106 , G11B5/3176 , G11B5/3183 , G11B5/3967 , G11B5/6076
摘要： An information storage system includes a transducer having a loop of ferromagnetic material with pole tips separated by an nonferromagnetic gap located adjacent to a medium such as a rigid disk. During writing the separation between the pole tips and the media layer of the disk is a small fraction of the gap separation. Due to the small separation between the pole tips and the media layer, the magnetic field generated by the transducer and felt by the media has a larger perpendicular than longitudinal component, favoring perpendicular recording over longitudinal recording. The media may have an easy axis of magnetization oriented substantially along the perpendicular direction, so that perpendicular data storage is energetically favored. The transducer may also include a magnetoresistive sensor for reading magnetic information from the disk.

5. 发明授权

US6008969A Planar recording head having formed yokes 失效
标题翻译：具有形成磁轭的平面记录头
公开(公告)号：US6008969A
公开(公告)日：1999-12-28
申请号：US993719
申请日：1997-12-18
申请人： Darren T. Imai , David D. Roberts , Dimitre A. Latev , William C. Cain
发明人： Darren T. Imai , David D. Roberts , Dimitre A. Latev , William C. Cain
IPC分类号： G11B5/31 , G11B5/60
CPC分类号： G11B5/3183 , G11B5/3163
摘要： A planar thin film magnetic head comprises an insulating substrate, a pair of insulating pedestals formed on the substrate, a top magnetic yoke having a central portion disposed over the substrate and having opposite ends supported on each of the pedestals. A conductor is provided over the top yoke central portion, and an insulating layer is disposed between the conductor and the top magnetic yoke. A bottom magnetic yoke is disposed over the conductor and has a gap in a central portion and opposite ends in contact with the top yoke ends.
摘要翻译：平面薄膜磁头包括绝缘基板，形成在基板上的一对绝缘基座，顶部磁轭，其中心部分设置在基板上并具有支撑在每个基座上的相对端部。导体设置在顶部磁轭中心部分之上，绝缘层设置在导体和顶部磁轭之间。底部磁轭设置在导体上方，并且在中心部分具有间隙，并且相对端部与顶部磁轭端部接触。

6. 发明授权

US08951527B2 Radioprotectants targeting thrombospondin-1 and CD47 有权
标题翻译：靶向血小板反应蛋白-1和CD47的放射防护剂
公开(公告)号：US08951527B2
公开(公告)日：2015-02-10
申请号：US13057447
申请日：2009-08-05
申请人： Jeffrey S. Isenberg , David D. Roberts , Justin Maxhimer
发明人： Jeffrey S. Isenberg , David D. Roberts , Justin Maxhimer
IPC分类号： A61K38/08 , A61K38/10 , A61K38/36 , C12N15/11 , A61K38/39 , C07K14/705 , C07K14/78 , C07K16/18 , C12N15/113 , C07K16/28 , A61K39/00 , A61N5/10
CPC分类号： A61K38/39 , A61K2039/505 , A61N2005/1094 , C07K14/70596 , C07K14/78 , C07K16/18 , C07K16/2803 , C07K2317/70 , C12N15/1138 , C12N2310/11 , C12N2310/3233
摘要： Described herein is the discovery that cell and tissue survival can be dramatically increased following radiation exposure through inhibition of the interaction between TSP-1 and CD47. This effect is shown using antisense molecules, peptides, and antibodies, which can now be used as radioprotectant agents. These agents find application in minimizing, reducing and/or preventing tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage and by increasing tumor ablation following radiation treatment.
摘要翻译：本文描述的是通过抑制TSP-1和CD47之间的相互作用在辐射暴露后细胞和组织存活可以显着增加的发现。这种效应使用反义分子，肽和抗体显示，其现在可以用作放射防护剂。这些试剂在减少，减少和/或预防有意和意外的辐射暴露后的组织损伤中的应用，以及通过保护非目标组织免受附带的辐射损伤并通过在放射治疗之后增加肿瘤消融来增加放射疗法的治疗功效。

7. 发明申请

US20080249026A1 PEPTIDES AND THEIR UTILITY IN MODULATION OF BEHAVIOR OF CELLS EXPRESSING alpha3beta1 INTEGRINS 有权
标题翻译：肽及其在表达α3β1整合的细胞行为调节中的应用
公开(公告)号：US20080249026A1
公开(公告)日：2008-10-09
申请号：US11466718
申请日：2006-08-23
申请人： David D. Roberts , Henry C. Krutzsch
发明人： David D. Roberts , Henry C. Krutzsch
IPC分类号： A61K38/10 , C07K5/00 , C07K7/06 , C07K7/08 , A61P35/00 , C12N5/00 , A61P9/00 , A61K38/07 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00
摘要： The present invention relates to a peptide comprising the sequence R1-X1-X2-X3-X4-R2, wherein X1 is selected from the group consisting of N, Q, D and S; X2 is selected from the group consisting of V, I and L; X1 is selected from the group consisting of R and K; and X4 is selected from the group consisting of V, I, L and F; R1 is a hydrogen or a peptide of 1 to 6 amino acids, and acyl or an aryl group; and R2 is a peptide of 1 to 3 amino acids, a hydroxide or an amide. The invention also relates to partial or full retro-inverso peptides comprising the above sequences. The invention also relates to peptide-substrate combination comprising a substrate suitable for cell growth and the peptide of the invention, and to a vascular graft and an artificial blood vessel comprising the peptide-substrate combination. The invention also relates to a pharmaceutical composition and a peptide conjugate comprising the peptide of the invention. The invention also relates to a method of inhibiting adhesion of a cell expressing α3β1 integrin to an extracellular matrix, inhibiting α3β1-integrin-mediated cell motility, inhibiting α3β1-integrin mediated cell proliferation, promoting α3β1-integrin mediated cell proliferation and inhibiting angiogenesis utilizing the peptides of the invention.
摘要翻译：本发明涉及包含序列R 1 -X 1 -X 2 -X 3 -X 3的肽， X 4 -R 2，其中X 1选自N，Q，D和S; X 2选自V，I和L; X 1选自R和K; 并且X 4选自V，I，L和F; R 1是氢或1至6个氨基酸的肽，酰基或芳基; R 2是1至3个氨基酸的肽，氢氧化物或酰胺。本发明还涉及包含上述序列的部分或全部逆转肽。本发明还涉及包含适合于细胞生长的底物和本发明的肽的肽 - 底物组合以及包含肽 - 底物组合的血管移植物和人造血管。本发明还涉及包含本发明的肽的药物组合物和肽缀合物。本发明还涉及一种抑制细胞外基质表达α3β1整联蛋白的细胞粘附的方法，抑制α3β1，整合素介导的细胞运动，抑制α3-β1整联蛋白介导的细胞增殖，促进α3β - 整合素介导的细胞增殖并利用本发明的肽抑制血管生成。

8. 发明授权

US5491130A Peptide inhibitors of fibronectin and related collagen-binding proteins 失效
标题翻译：纤连蛋白和相关胶原结合蛋白的肽抑制剂
公开(公告)号：US5491130A
公开(公告)日：1996-02-13
申请号：US973235
申请日：1992-11-10
申请人： David D. Roberts , Henry C. Krutzsch , John M. Sipes , Neng-hua Guo , Eric Negre
发明人： David D. Roberts , Henry C. Krutzsch , John M. Sipes , Neng-hua Guo , Eric Negre
IPC分类号： A61K38/00 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/78 , C07K7/00
CPC分类号： C07K14/78 , A61K38/00
摘要： Peptides derived from the second type 1 repeat of human endothelial cell thrombospondin which bind to the gelatin-binding domain of fibronectin have been isolated and synthetically produced. The peptides can be used to bind to fibronectin or other related collagen-binding proteins to inhibit fibronectin-dependent cell adhesion to collagen matrices and to inhibit interactions with collagen of other proteins that share homologies with the gelatin-binding domain of fibronectin.
摘要翻译：衍生自结合纤连蛋白的明胶结合结构域的人内皮细胞血小板反应蛋白的第二类型1重复的肽已被分离并合成产生。肽可以用于结合纤连蛋白或其他相关的胶原结合蛋白，以抑制纤连蛋白依赖性细胞对胶原基质的粘附，并抑制与纤连蛋白的明胶结合结构域共享的其它蛋白质的胶原的相互作用。

9. 发明授权

US5225330A Diagnostic kit and diagnostic method utilizing carbohydrate receptors 失效
标题翻译：使用碳水化合物受体的诊断试剂盒和诊断方法
公开(公告)号：US5225330A
公开(公告)日：1993-07-06
申请号：US417691
申请日：1989-10-05
申请人： Victor Ginsburg , Howard C. Krivan , David D. Roberts
发明人： Victor Ginsburg , Howard C. Krivan , David D. Roberts
IPC分类号： C12Q1/04 , A61K31/70 , C07H15/00 , C12N11/00 , C12Q1/24 , C12R1/01 , C12R1/19 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/569
CPC分类号： G01N33/56933 , A61K31/70 , A61K31/7004 , C12Q1/24 , G01N33/54313 , G01N33/54366 , G01N33/566 , G01N33/569 , G01N33/56911 , G01N2333/30 , G01N2400/00 , Y10S435/87 , Y10S435/975
摘要： A diagnostic kit for detecting the presence of microorganisms, comprising an insoluble substrate; and a carbohydrate receptor immobilized on the insoluble substrate, the carbohydrate receptor being capable of adsorbing microorganisms; and a labelled reagent useful for detecting the presence of microorganisms bound to the carbohydrate receptors and a method for detecting the presence of specified microorganisms in a sample, which comprises contacting a sample to be tested with carbohydrate receptors immobilized on an insoluble substrate; and determining the extent of binding of microorganisms in the sample to the carbohydrate receptors by use of a labelled reagent.
摘要翻译：一种用于检测微生物存在的诊断试剂盒，其包含不溶性底物; 和固定在不溶性底物上的碳水化合物受体，能够吸附微生物的碳水化合物受体; 和用于检测与碳水化合物受体结合的微生物的存在的标记试剂和检测样品中特定微生物的存在的方法，其包括将被检样品与固定在不溶性底物上的碳水化合物受体接触; 并通过使用标记的试剂测定样品中的微生物与碳水化合物受体的结合程度。

10. 发明申请

US20110135641A1 RADIOPROTECTANTS TARGETING THROMBOSPONDIN-1 AND CD47 有权
标题翻译：靶向THROMBOSPONDIN-1和CD47的放射治疗
公开(公告)号：US20110135641A1
公开(公告)日：2011-06-09
申请号：US13057447
申请日：2009-08-05
申请人： Jeffrey S. Isenberg , David D. Roberts , Justin Maxhimer
发明人： Jeffrey S. Isenberg , David D. Roberts , Justin Maxhimer
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/17 , A61K38/08 , A61K38/10 , A61P35/00 , A61P39/00
CPC分类号： A61K38/39 , A61K2039/505 , A61N2005/1094 , C07K14/70596 , C07K14/78 , C07K16/18 , C07K16/2803 , C07K2317/70 , C12N15/1138 , C12N2310/11 , C12N2310/3233
摘要： Described herein is the discovery that cell and tissue survival can be dramatically increased following radiation exposure through inhibition of the interaction between TSP-1 and CD47. This effect is shown using antisense molecules, peptides, and antibodies, which can now be used as radioprotectant agents. These agents find application in minimizing, reducing and/or preventing tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage and by increasing tumor ablation following radiation treatment.
摘要翻译：本文描述的是通过抑制TSP-1和CD47之间的相互作用在辐射暴露后细胞和组织存活可以显着增加的发现。这种效应使用反义分子，肽和抗体显示，其现在可以用作放射防护剂。这些试剂在减少，减少和/或预防有意和意外的辐射暴露后的组织损伤中的应用，以及通过保护非目标组织免受附带的辐射损伤并通过在放射治疗之后增加肿瘤消融来增加放射疗法的治疗功效。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式