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    • 5. 发明申请
    • Live bacterial preparation of bacillus coagulans for the treatment of ulcerative colitis, method for producing the same and use thereof
    • 用于治疗溃疡性结肠炎的凝结芽孢杆菌的活细菌制剂及其制备方法及其用途
    • US20060127381A1
    • 2006-06-15
    • US11191712
    • 2005-07-28
    • Yunlong Cui
    • Yunlong Cui
    • A61K35/74C12N1/20
    • C12N1/20A61K35/742
    • The present invention discloses a method for preparation of live Bacillus coagulans and the use of the bacteria in treatment of ulcerative colitis. The live bacteria are effective in the treatment of experimental ulcerative colitis in rats. They are also used in the clinical treatment of patients suffering from ulcerative colitis and the efficacy and safety are evaluated. The present invention also discloses the formulation and production method of the live bacterial preparation of Bacillus coagulans, the count of live bacterial in the preparation, and dosage form of the preparation. The present invention shows that the live bacterial preparation is effective and safe for treatment of ulcerative colitis, and the stability of said preparation is good and could be stored at room temperature. Patients can take the preparation for a long term without adverse effect. The present invention provides a new means for the treatment of ulcerative colitis and a new use of live bacterial preparation of Bacillus coagulans in treating ulcerative colitis.
    • 本发明公开了一种用于制备活凝固芽孢杆菌的方法和该细菌在治疗溃疡性结肠炎中的应用。 活细菌在大鼠实验性溃疡性结肠炎的治疗中是有效的。 它们也用于患有溃疡性结肠炎的患者的临床治疗,并评估其功效和安全性。 本发明还公开了凝结芽孢杆菌的活细菌制剂的制备和制备方法,制剂中活细菌的计数和制剂的剂型。 本发明表明活细菌制剂对治疗溃疡性结肠炎是有效和安全的,所述制剂的稳定性良好,可以在室温下储存。 患者可长期服药,无副作用。 本发明提供了一种治疗溃疡性结肠炎的新方法和用于治疗溃疡性结肠炎的凝结芽孢杆菌活细菌制剂的新用途。