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1. 发明授权

US07304058B2 Carbamic acid esters of benzothiazoles 失效
标题翻译：苯并噻唑的氨基甲酸酯
公开(公告)号：US07304058B2
公开(公告)日：2007-12-04
申请号：US10848436
申请日：2004-05-18
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K31/428 , A61K31/5377 , C07D277/62 , C07D413/04 , C07D417/04
CPC分类号： C07D277/82 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to a compound of formula I wherein R, X and n are defined hereinabove, and to a pharmaceutically acceptable salt thereof. The compound may be used for the treatment of diseases related to the A2A receptor.
摘要翻译：本发明涉及式I化合物

2. 发明授权

US06727247B2 Substituted benzothiazole amide derivatives 失效
标题翻译：取代的苯并噻唑酰胺衍生物
公开(公告)号：US06727247B2
公开(公告)日：2004-04-27
申请号：US10308338
申请日：2002-12-03
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K315377
CPC分类号： A61K31/428 , A61K31/5377 , C07D277/82 , C07D417/12 , C07D451/06 , C07D453/06 , C07D471/10 , C07D487/10 , C07D491/08
摘要： A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A2 receptor system comprising administering a compound of formula to a person in need of such treatment.
摘要翻译：式I化合物和与腺苷A2受体系统的调节相关的疾病的治疗方法，包括给予需要这种治疗的人的配制化合物。

3. 发明授权

US07371748B2 Benzothiazole derivatives 有权
标题翻译：苯并噻唑衍生物
公开(公告)号：US07371748B2
公开(公告)日：2008-05-13
申请号：US10847558
申请日：2004-05-17
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： C07D413/14 , C07D417/02 , A61K31/4436 , A61K31/5377
CPC分类号： C07D417/04 , C07D417/14 , C07D491/10
摘要： This invention relates to compounds of formula I wherein R1 and R2 are defined herein, or a pharmaceutically acceptable salt thereof. It has been found that the compounds of formula I are adenosine receptor ligands with good affinity to the A2A-receptor and a high selectivity to the A1- and A3 receptors. These compounds are useful, inter alia, in treatment of Alzheimer's disease, depression, Parkinson's disease and ADHD.
摘要翻译：本发明涉及其中R 1和R 2 2定义的式I化合物或其药学上可接受的盐。已经发现，式I化合物是对A 2A受体具有良好亲和力的腺苷受体配体，对A 1 - 和 - A _{3个受体。这些化合物尤其可用于治疗阿尔茨海默氏病，抑郁症，帕金森病和ADHD。}

4. 发明授权

US07019001B2 Substituted benzothiazole amide derivatives 失效
标题翻译：取代的苯并噻唑酰胺衍生物
公开(公告)号：US07019001B2
公开(公告)日：2006-03-28
申请号：US10691770
申请日：2003-10-23
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： A61K31/428 , A61K31/5377 , C07D277/82 , C07D417/12 , C07D451/06 , C07D453/06 , C07D471/10 , C07D487/10 , C07D491/08
摘要： A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A2 receptor system comprising administering a compound of formula to a person in need of such treatment.
摘要翻译：式I的化合物和与腺苷A 2受体系统的调节相关的疾病的治疗方法，包括向需要这种治疗的人施用配方的化合物。

5. 发明授权

US06620811B2 Isonicotin- and nicotinamide derivatives of benzothiazoles 有权
标题翻译：苯并噻唑的异烟酰胺和烟酰胺衍生物
公开(公告)号：US06620811B2
公开(公告)日：2003-09-16
申请号：US10288100
申请日：2002-11-05
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K315377
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of the formula wherein R1, A and R are as described within. The compounds of the present invention have been found to be adenosine receptor ligands. Specifically, the compounds of the present invention have an affinity to the A2A-receptor and are therefore useful in the treatment of diseases related to this receptor.
摘要翻译：本发明涉及式R 1，A和R的化合物如上所述。已经发现本发明的化合物是腺苷受体配体。具体地说，本发明的化合物对A2A受体具有亲和性，因此可用于治疗与该受体有关的疾病。

6. 发明授权

US07285548B2 Urea substituted benzothiazoles 有权
标题翻译：脲取代苯并噻唑
公开(公告)号：US07285548B2
公开(公告)日：2007-10-23
申请号：US10854059
申请日：2004-05-26
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K31/5377 , C07D413/04 , C07D417/04
CPC分类号： C07D277/82
摘要： The present invention relates to compounds of formula I wherein R1 and R2 are described herein, and their pharmaceutically acceptable salts thereof for the treatment of diseases, related to the A2A receptor.
摘要翻译：本发明涉及本文所述的其中R 1和R 2 2的式I化合物及其药学上可接受的盐，用于治疗与A < SUB> 2A 受体。

7. 发明授权

US06734179B2 Benzothiazoles 失效
标题翻译：苯并噻唑
公开(公告)号：US06734179B2
公开(公告)日：2004-05-11
申请号：US10307698
申请日：2002-12-02
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K314436
CPC分类号： C07D417/04 , C07D277/84 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of the formula wherein R1 and R2 are as described within. The compounds of formula I have been found to be adenosine receptor ligands. Specifically, the compounds of the present invention have a good affinity to the A2A-receptor and they may be used in the treatment of diseases, related to this receptor.
摘要翻译：本发明涉及式（Ⅳ）化合物，其中R 1和R 2如上所述。已发现式I化合物是腺苷受体配体。具体而言，本发明的化合物对A2A受体具有良好的亲和力，可用于治疗与该受体有关的疾病。

8. 发明授权

US06624163B2 Benzothiazole derivatives 失效
标题翻译：苯并噻唑衍生物
公开(公告)号：US06624163B2
公开(公告)日：2003-09-23
申请号：US10295500
申请日：2002-11-15
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K315377
CPC分类号： C07D277/82
摘要： The present invention relates to compounds of the formula wherein R1 and R2 are as defined herewithin. The compounds of formula I have been found to be adenosine receptor ligands. Specifically, the compounds of the present invention have a good affinity to the A2A-receptor and they are therefore useful in the treatment of diseases, related to this receptor.
摘要翻译：本发明涉及式R 1和R 2的化合物如下文所定义。已发现式I化合物是腺苷受体配体。具体地说，本发明化合物对A2A受体具有良好的亲和性，因此可用于治疗与该受体有关的疾病。

9. 发明授权

US06599901B1 Pyridone substituted benzothiazole derivatives 失效
标题翻译：吡啶酮取代的苯并噻唑衍生物
公开(公告)号：US06599901B1
公开(公告)日：2003-07-29
申请号：US10288531
申请日：2002-11-05
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K315377
CPC分类号： C07D417/14 , C07D417/12
摘要： The present invention relates to compounds of the formula wherein R is as defined herewithin. The compounds of formula I have a good affinity to the A2A receptor and therefore they may be used in the control or prevention of illnesses based on the modulation of the adenosine system, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, drug addiction, such as amphetamine, cocaine, opioids, ethanol, nicotine, cannabinoids, or against asthma, allergic responses, hypoxia, ischaemia, seizure and substance abuse. Furthermore, compounds of the present invention may be useful as sedatives, muscle relaxants, antipsychotics, antiepileptics, aniticonvulsants and cardiaprotective agents for disorders such as coronary artery disease and heart failure.
摘要翻译：本发明涉及式（Ⅳ）化合物，其定义如下。式I的化合物对A2A受体具有良好的亲和力，因此它们可以用于控制或预防基于腺苷系统的调节，例如阿尔茨海默病，帕金森氏病，亨廷顿病，神经保护，精神分裂症，焦虑，疼痛，呼吸困难，抑郁症，药物成瘾，如安非他明，可卡因，阿片样物质，乙醇，尼古丁，大麻素，或抗哮喘，过敏反应，缺氧，局部缺血，癫痫发作和药物滥用。此外，本发明的化合物可用作镇静剂，肌肉松弛剂，抗精神病药，抗癫痫剂，抗惊厥药和用于诸如冠状动脉疾病和心力衰竭的病症的心脏保护剂。

10. 发明授权

US07122545B2 Imidazo-benzothiazoles 失效
标题翻译：咪唑 - 苯并噻唑
公开(公告)号：US07122545B2
公开(公告)日：2006-10-17
申请号：US10843241
申请日：2004-05-11
申请人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
发明人： Alexander Flohr , Roland Jakob-Roetne , Roger David Norcross , Claus Riemer
IPC分类号： A61K31/5377 , A61K31/55 , A61K31/428 , C07D413/02 , C07D487/04 , C07D417/04
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The invention relates to 2-imidazo-benzothiazoles of general formula wherein R1, R2, R3, R4, R5, R6, R7, R′, R″, X, R′″ and n are defined herein, or a pharmaceutically acceptable salt thereof. It has been found that the compound of formula I are adenosine receptor ligands with good affinity to the A1 and A3 receptors. These compounds have useful pharmaceutical activities.
摘要翻译：本发明涉及以下通式的2-咪唑并苯并噻唑：其中R 1，R 2，R 3，R 4， R 5，R“，R”，X“，R”'和n被定义，R“，R”，R“，R” 或其药学上可接受的盐。已经发现，式I化合物是对Aβ1和3 N 3受体具有良好亲和力的腺苷受体配体。这些化合物具有有用的药物活性。

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