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1. 发明申请

US20070122423A1 DERP1 AND PRODERP1 ALLERGEN DERIVATIVES 审中-公开
标题翻译： DERP1和PRODERP1过敏原
公开(公告)号：US20070122423A1
公开(公告)日：2007-05-31
申请号：US11623498
申请日：2007-01-16
申请人： Alex Bollen , Alain Jacquet , Mauro Magi
发明人： Alex Bollen , Alain Jacquet , Mauro Magi
IPC分类号： A61K39/00 , C07H21/04 , C12P21/06 , C07K14/435
CPC分类号： C07K14/43531 , A61K2039/53 , A61K2039/555 , A61K2039/57
摘要： The present invention provides a novel treatment for allergy comprising the provision of a recombinant DerP1/ProDerP1 allergen derivative with hypoallergenic activity. Pharmaceutical compositions comprising said mutant allergens which stimulate a Th1-type immune response in allergic or naive individuals thereby reducing the potential for an allergic response upon contact with the wild-type allergen, are also provided.
摘要翻译：本发明提供了一种新的过敏治疗方法，包括提供具有低变应原活性的重组DerP1 / ProDerP1变应原衍生物。还提供了包含所述突变过敏原的药物组合物，其在过敏或天真个体中刺激Th1型免疫应答，从而降低与野生型变应原接触时对过敏反应的可能性。

2. 发明申请

US20060099219A1 Mutated hpv-16e7 polypeptide, pharmaceutical composition comprising it and its preparation process 审中-公开
标题翻译：突变的hpv-16e7多肽，包含其的药物组合物及其制备方法
公开(公告)号：US20060099219A1
公开(公告)日：2006-05-11
申请号：US10512190
申请日：2003-04-24
申请人： Sophie Hallez , Arsene Burny , Alain Jacquet , Alex Bollen
发明人： Sophie Hallez , Arsene Burny , Alain Jacquet , Alex Bollen
IPC分类号： A61K39/12 , C12Q1/70 , C07H21/04 , C12N15/86 , C07K14/025
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C07K2319/00 , C12N2710/20022 , C12N2740/16322 , C12N2770/20022
摘要： The present invention is related to a mutated E7 polypeptide obtained from the human Papillomavirus HPV-16 as well as the pharmaceutical composition comprising it and its preparation process.
摘要翻译：本发明涉及从人乳头瘤病毒HPV-16获得的突变的E7多肽以及包含其的药物组合物及其制备方法。

3. 发明申请

US20070161083A1 Codon Optimized Recombinant Dermaphagoides Allergens 审中-公开
标题翻译：密码子优化重组皮肤过敏原
公开(公告)号：US20070161083A1
公开(公告)日：2007-07-12
申请号：US11609575
申请日：2006-12-12
申请人： Alex Bollen , Paul Jacobs , Alain Jacquet , Marc Massaer
发明人： Alex Bollen , Paul Jacobs , Alain Jacquet , Marc Massaer
IPC分类号： C07K14/435 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K14/43531 , A61K38/00
摘要： The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoides dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphagoides pteronyssinus, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions comprising the expression of the codon optimised polynucleotides, and vectors and transformed host cells comprising them.
摘要翻译：本发明涉及密码子优化的多核苷酸，其在哺乳动物细胞中有效表达，并编码来自Dermaphagoides尘螨的昆虫蛋白。特别地，优化的密码子多核苷酸编码来自Dermaphagoides pteronyssinus的蛋白质，例如DerP1或proDerP1。本发明还提供了制备包含密码子优化的多核苷酸表达的药物组合物的方法，以及包含它们的载体和转化的宿主细胞。

4. 发明授权

US07173117B2 Codon optimised recombinant Dermaphagoides allergens 失效
标题翻译：密码子优化重组Dermaphagoides过敏原
公开(公告)号：US07173117B2
公开(公告)日：2007-02-06
申请号：US10297563
申请日：2001-06-07
申请人： Alex Bollen , Paul Jacobs , Alain Jacquet , Marc Georges Francis Massaer
发明人： Alex Bollen , Paul Jacobs , Alain Jacquet , Marc Georges Francis Massaer
IPC分类号： C07H21/04 , C12N15/00 , C12N15/02 , C12P21/04 , G01N33/53
CPC分类号： C07K14/43531 , A61K38/00
摘要： The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoids dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphagoides pteronyssinus, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions comprising the expression of the codon optimised polynucleotides, and vectors and transformed host cells comprising them.
摘要翻译：本发明涉及密码子优化的多核苷酸，其在哺乳动物细胞中有效表达并编码来自皮肤螨类的昆虫蛋白质。特别地，优化的密码子多核苷酸编码来自Dermaphagoides pteronyssinus的蛋白质，例如DerP1或proDerP1。本发明还提供了制备包含密码子优化的多核苷酸表达的药物组合物的方法，以及包含它们的载体和转化的宿主细胞。

5. 发明申请

US20070275953A1 2-Pyridinone Derivatives, Having Hiv Inhibiting Properties 审中-公开
标题翻译：具有抑制性质的2-吡啶酮衍生物
公开(公告)号：US20070275953A1
公开(公告)日：2007-11-29
申请号：US10573143
申请日：2004-09-22
申请人： Kiet Le Van , Renoit Georges , Laszlo Heyesi , Christine Cauvin , Sandra Boland , Francois Durant , Dominique Demonte , Chris Van Lint , Arthu Burny , Alex Bollen , Alain Jacquet , Stephaine De Walque
发明人： Kiet Le Van , Renoit Georges , Laszlo Heyesi , Christine Cauvin , Sandra Boland , Francois Durant , Dominique Demonte , Chris Van Lint , Arthu Burny , Alex Bollen , Alain Jacquet , Stephaine De Walque
IPC分类号： A61K31/4747 , A61P31/18 , C07D211/86 , A61K31/443 , A61K31/4439 , A61K31/4436 , A61K31/4433 , C07D403/02 , C07D405/02 , C07D409/02
CPC分类号： C07D213/69 , C07D213/80
摘要： The present invention relates to 2-Pyridinone derivatives, more specifically 5-ethyl-6-methyl-2-pyridinone derivatives, according to general formula I that inhibit human immunodeficiency virus type 1 (HIV-1) replication and are therefore of interest in the treatment of Acquired Immune Deficiency Syndrome (AIDS). The present invention further relates to the synthesis of said compounds and their use, with or without other pharmaceutical agents, in the treatment of AIDS and viral infections by HIV-1.
摘要翻译：本发明涉及抑制人免疫缺陷病毒1型（HIV-1）复制物的通式I的2-吡啶酮衍生物，更具体地说是5-乙基-6-甲基-2-吡啶酮衍生物，因此在治疗获得性免疫缺陷综合征（AIDS）。本发明还涉及所述化合物的合成及其用于或不用其它药剂用于治疗HIV-1的AIDS和病毒感染的用途。

6. 发明申请

US20100273672A1 METHOD AND DEVICE FOR HIGH SENSITIVITY AND QUANTITATIVE DETECTION OF CHEMICAL/BIOLOGICAL MOLECULES 审中-公开
标题翻译：化学/生物分子的高灵敏度和定量检测方法和装置
公开(公告)号：US20100273672A1
公开(公告)日：2010-10-28
申请号：US12669191
申请日：2008-07-18
申请人： Sophie Demoustier-Champagne , Alain Jonas , Vincent Bayot , Bernard Nysten , Francoise Blondeau , Benoit Demeersman , Xiaohui Tang , Edmond Godfroid , Alain Jacquet , Pierre-Paul Prevot
发明人： Sophie Demoustier-Champagne , Alain Jonas , Vincent Bayot , Bernard Nysten , Francoise Blondeau , Benoit Demeersman , Xiaohui Tang , Edmond Godfroid , Alain Jacquet , Pierre-Paul Prevot
IPC分类号： C40B30/04 , C40B50/00 , C40B60/12
CPC分类号： G01N33/54373 , G01N27/4145 , G01N33/54353
摘要： A sensor for detecting the presence of predetermined chemical/biological molecules, the sensor having a MOSFET device (2, 3, 6, 7, 9, 10, 12, 13), the gate having an array of nanoscale fingers (6,7), and on fingers or in spaces between the fingers, chemical/biological receptor molecules (15) suitable for selectively binding with the predetermined chemical/biological molecules, the sensor also having circuitry (4, 5, 11, 12) for measuring a change in a change in drain current of the FET caused by the predetermined chemical/biological molecules becoming bound to the receptor molecules. Sensitivity and reliability can be increased compared to capacitive sensors.
摘要翻译：一种用于检测预定化学/生物分子的存在的传感器，所述传感器具有MOSFET器件（2,3,6,7,9,10,12,13），所述栅极具有纳米尺度指状物（6,7）阵列，，并且在手指或手指之间的空间中，适合于与预定化学/生物分子选择性结合的化学/生物受体分子（15），所述传感器还具有用于测量变化的电路（4,5,11,12）由预定化学/生物分子与受体分子结合引起的FET的漏极电流的变化。与电容传感器相比，灵敏度和可靠性可以提高。

7. 发明申请

US20120304893A1 PROCESS FOR PRODUCTION OF A HYDRAULIC COMPOSITION WITH ENTRAINED AIR 有权
标题翻译：生产含有空气的液压组合物的方法
公开(公告)号：US20120304893A1
公开(公告)日：2012-12-06
申请号：US13521519
申请日：2011-01-10
申请人： Sébastien Georges , Emmanuel Villard , Alain Jacquet , Laurent Barcelo , Anik Delagrave
发明人： Sébastien Georges , Emmanuel Villard , Alain Jacquet , Laurent Barcelo , Anik Delagrave
IPC分类号： C04B38/00
CPC分类号： C04B28/02 , C04B2111/1093 , Y02W30/92 , C04B18/08 , C04B24/2688 , C04B2103/006
摘要： A treatment process for the production of a hydraulic composition with entrained air including at least one admixture and a constituent including carbonaceous materials, the process including: obtaining a representative value of the adsorption of probe molecules by the carbonaceous materials; and producing the hydraulic composition or treating the constituent with a quantity of admixture which depends on the value.
摘要翻译：一种用于生产具有包含至少一种混合物的夹带空气的水硬性组合物和包含碳质材料的成分的处理方法，所述方法包括：通过碳质材料获得探针分子的吸附的代表性值; 并且生产水硬性组合物或用一定数量的取决于该值的混合物处理该组分。

8. 发明申请

US20110257475A1 SYSTEM FOR POSITIONING ON A PATIENT AN OBSERVATION AND/OR INTERVENTION DEVICE 有权
标题翻译：用于定位患者观察和/或干预装置的系统
公开(公告)号：US20110257475A1
公开(公告)日：2011-10-20
申请号：US13172700
申请日：2011-06-29
申请人： Peter Berkelman , Philippe Cinquin , Alain Jacquet , Jean Arnault
发明人： Peter Berkelman , Philippe Cinquin , Alain Jacquet , Jean Arnault
IPC分类号： A61B1/00
CPC分类号： B25J18/00 , A61B17/3403 , A61B34/20 , A61B34/70 , A61B90/11 , A61B90/361 , A61B90/50 , A61B2017/00398 , A61B2017/3407 , A61B2017/3409 , Y10S901/19 , Y10T74/20305
摘要： The present invention relates to a system for positioning with respect to a patient's body an observation and/or intervention device having a portion penetrating into the patient's body comprising a base laid on the patient's body; a means for supporting the device formed of a first portion movably assembled on the base according to a connection with one degree of freedom, and of a second portion movably assembled on the first portion according to a connection with one degree of freedom and connected to the device; and means for actuating the first portion with respect to the base, and the second portion with respect to the first portion, in which the base surrounds at a distance at least partially the device, said device being detachably connected to the second portion to enable removal of the positioning system while leaving in place the device.
摘要翻译：本发明涉及一种用于相对于患者身体定位的观察和/或干预装置，其具有穿透患者身体的部分，该部分包括放置在患者身上的基部; 根据具有一个自由度的连接可移动地组装在基座上的第一部分和根据一个自由度的连接可移动地组装在第一部分上的第二部分形成的装置的装置，设备; 以及用于相对于所述基座致动所述第一部分的装置，并且所述第二部分相对于所述第一部分，所述第一部分至少部分地围绕所述第一部分围绕所述装置，所述装置可拆卸地连接到所述第二部分，以使得能够移除的定位系统。

9. 发明申请

US20080060556A1 Impurity Inerting Composition 有权
标题翻译：杂质挥发成分
公开(公告)号：US20080060556A1
公开(公告)日：2008-03-13
申请号：US11575607
申请日：2005-09-21
申请人： Alain Jacquet , Emmanuel Villard , Olivier Watt
发明人： Alain Jacquet , Emmanuel Villard , Olivier Watt
IPC分类号： C04B24/30 , C04B24/26 , C08G12/16 , C08G73/02
CPC分类号： C04B20/1018 , C04B14/06 , C04B20/02 , C04B20/023 , C04B24/2652 , C04B24/30 , C04B2201/10 , C04B2201/20 , C08G12/16 , C08G73/0226
摘要： The invention concerns a composition useful for inerting clays in hydraulic compositions, comprising at least 50 wt. % of a cationic polymer having a cationic charge density more than 0.5 meq/g and an intrinsic viscosity less than 1 dl/g, as active substance.
摘要翻译：本发明涉及一种用于在水硬性组合物中惰化粘土的组合物，其包含至少50wt。％阳离子聚合物的阳离子电荷密度大于0.5meq / g，特性粘度小于1dl / g作为活性物质。

10. 发明申请

US20060058640A1 System for positioning an observation and/or intervention device on a patient 审中-公开
标题翻译：用于将观察和/或干预装置定位在患者身上的系统
公开(公告)号：US20060058640A1
公开(公告)日：2006-03-16
申请号：US11224722
申请日：2005-09-12
申请人： Philippe Cinquin , Alain Jacquet , Elise Taillant
发明人： Philippe Cinquin , Alain Jacquet , Elise Taillant
IPC分类号： A61B5/05
CPC分类号： A61B90/11 , A61B2017/00544 , A61B2090/374
摘要： A system for positioning with respect to a patient's body an observation and/or intervention device comprising at least a mechanical part and a system for actuating the mechanical part, the actuation system comprising a piston capable of sliding a rod and connected to means for supplying a fluid under pressure; a drive element connected to the mechanical part and comprising dissymmetrical teeth; and a bearing element assembled on the rod and capable, on displacement of the rod along a determined direction, of cooperating with a tooth of the drive element to displace the drive element by a determined distance and/or angle, the bearing element, on displacement of the rod along the direction opposite to the determined direction, exerting a substantially zero force on the drive element to avoid displacing the drive element.
摘要翻译：一种用于相对于患者身体定位的观察和/或干预装置的系统，所述观察和/或干预装置至少包括用于致动所述机械部件的机械部件和系统，所述致动系统包括能够滑动杆并连接到用于供应流体在压力下; 连接到所述机械部件并且包括不对称齿的驱动元件; 以及组装在所述杆上的支承元件，并且能够沿着确定的方向使所述杆移动，与所述驱动元件的齿配合，以使所述驱动元件移位一定距离和/或角度，所述轴承元件在位移所述杆沿着与所确定的方向相反的方向，在所述驱动元件上施加基本上为零的力以避免驱动元件移位。

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