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    • 1. 发明授权
    • Process of surface activation of biocompatible and bioabsorbable
aliphatic polyesters and polyesters thus activated
    • 生物相容性和生物可吸收的脂肪族聚酯和聚酯的表面活化过程由此活化
    • US6107453A
    • 2000-08-22
    • US11320
    • 1998-01-27
    • Alessandro ZuccatoGian Domenico CellaGabriele Perego
    • Alessandro ZuccatoGian Domenico CellaGabriele Perego
    • A61L27/00A61L27/28C08J7/12C08F6/00
    • C08J7/12C08J7/123C08J2367/00
    • A process of surface activation of a material based on one or more of the copolymers of lactic acid and .epsilon.-caprolactone is carried out on bioabsorbable and biocompatible aliphatic polyesters chosen from the group formed by homo- and copolymers derived from L-lactide, D-lactide, racemic D,L-lactide, meso D,L Lactide, .epsilon.-caprolactone, glycolide, .delta.-valerolactone, p-dioxanone, preferably copolymers of L-lactide, D-lactide, racemic D,L lactide, meso D,L-lactide with .epsilon.-caprolactone; the process consists of performing at least one of the following treatments: acid or base hydrolysis, treatment by means of cold plasma, by chemical reactions or electromagnetic radiations.The process brings about a substantial increase in surface hydrophilicity and, consequently, a significant lowering of the wetting angle measured with water at 23 degrees Celsius in air.This can in many cases favor cellular adherence to bioabsorbable medical prostheses realized using these materials, and thus surface-activated, such as for example endothelialisation processes in vascular grafts.
    • PCT No.PCT / IT96 / 00149 Sec。 371日期:1998年1月27日 102(e)日期1998年1月27日PCT提交1996年7月24日PCT公布。 公开号WO97 / 05193 日期1997年2月13日,基于一种或多种乳酸和ε-己内酯的共聚物的材料的表面活化方法是在生物可吸收和生物相容的脂族聚酯上进行的,所述脂族聚酯选自由L衍生的均聚物和共聚物形成的基团 丙交酯,D-丙交酯,外消旋D,L-丙交酯,内消旋D,L丙交酯,ε-己内酯,乙交酯,δ-戊内酯,对二恶烷酮,优选L-丙交酯,D-丙交酯,外消旋D,L丙交酯的共聚物 ,内消旋D,L-丙交酯与ε-己内酯; 该方法包括进行以下处理中的至少一种:酸或碱水解,通过冷等离子体处理,通过化学反应或电磁辐射。 该方法导致表面亲水性的显着增加,并因此导致在空气中在23摄氏度下用水测量的润湿角度的显着降低。 在许多情况下,这可以有利于细胞粘附到使用这些材料实现的生物可吸收的医用假体,并因此有利于表面活化,例如血管移植物中的内皮化过程。
    • 2. 发明授权
    • Bioresorbable material and method for producing the same
    • 生物可再吸收材料及其制造方法
    • US06361789B1
    • 2002-03-26
    • US09051990
    • 1998-08-03
    • Alessandro ZuccatoGabriele Perego
    • Alessandro ZuccatoGabriele Perego
    • A61F202
    • C08G63/08A61L31/06C08L67/04
    • A synthetic material is disclosed, which is constituted by a copolymer of D, L-lactide and &egr;-caprolactone (which itself is characterized by lower degradation times than those obtainable with copolymers of L-lactic acid and &egr;-caprolactone), obtained by using as reaction control agent a sugar dianhyide with non-toxic characteristics. The use of suar dianhydrde in the reaction has a considerable control effect on the molecular weight of the copolymer and, thanks to its low molecular weight, this copolymer is characterized by extreraely short resorption times, in the order for the example of one or two months. The copolymer is used as covering clement to be placed around tendon sutures and/or nerve tracts with the aim of preventing formation of scarry adherences between the suture lines and the soft surrounding tissues.
    • 公开了一种合成材料,其由D,L-丙交酯和ε-己内酯的共聚物(其本身的特征在于比由L-乳酸和ε-己内酯的共聚物获得的那些更低的降解时间),其通过使用 作为反应控制剂,具有无毒特性的糖二乙酸盐。 在反应中使用唾液酸二酐对共聚物的分子量具有相当大的控制效果,并且由于其低分子量,该共聚物的特征在于极短的吸收时间,其顺序为一个或两个月的例子 。 该共聚物用作覆盖物被放置在肌腱缝线和/或神经束周围,目的是防止在缝线和软周围组织之间形成疤痕粘附。
    • 4. 发明申请
    • Integrated Automatic System For Managing the Access of Vehicles to Controlled Parking Areas
    • 用于管理车辆到受控停车场的综合自动化系统
    • US20080235082A1
    • 2008-09-25
    • US11795169
    • 2004-12-21
    • Gianfranco ZanottiAlessandro Zuccato
    • Gianfranco ZanottiAlessandro Zuccato
    • G07C13/00
    • G07B15/02
    • An integrated automatic system for monitoring and managing the access, transit and parking of vehicles in predetermined controlled traffic areas, in particular in parking areas equipped with a plurality of individual parking spaces comprises: an electronic vehicle identification device; an electronic vehicle detection device; at least one local data processing unit; at least one central data processing unit. The data transmitted by the electronic vehicle identification device are associated with the data relative to the electronic vehicle detection device and the result of this association is transmitted to one of the local data processing units. Furthermore, the data processed by the local units are transmitted to the central processing unit which generates a signal relative to the payment of a predetermined fee for the access and/or transit and/or parking of a vehicle inside the controlled area.
    • 一种用于监视和管理预定受控交通区域中的车辆的接入,中转和停放的综合自动系统,特别是在配备有多个单独停车位的停车区域中,包括:电子车辆识别装置; 电子车辆检测装置; 至少一个本地数据处理单元; 至少一个中央数据处理单元。 由电子车辆识别装置发送的数据与相对于电子车辆检测装置的数据相关联,并且将该关联的结果发送到本地数据处理单元之一。 此外,由本地单元处理的数据被发送到中央处理单元,该中央处理单元产生相对于对受控区域内的车辆的访问和/或运输和/或停车的预定费用的支付的信号。