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1. 发明申请

US20070237771A1 Multicomponent conjugates which bind to target molecules and stimulate T cell lysis 审中-公开
标题翻译：结合靶分子并刺激T细胞裂解的多组分缀合物
公开(公告)号：US20070237771A1
公开(公告)日：2007-10-11
申请号：US11804945
申请日：2007-05-21
申请人： Alena Donda , Jean-Pierre Mach , Valerie Cesson , Bruno Robert , Pedro Romero , Immanuel Leuscher , Philippe Guillaume
发明人： Alena Donda , Jean-Pierre Mach , Valerie Cesson , Bruno Robert , Pedro Romero , Immanuel Leuscher , Philippe Guillaume
IPC分类号： A61K39/395 , A61K38/16 , A61P35/00 , C07K14/00 , C07K16/00
CPC分类号： C07K16/3007 , A61K38/00 , A61K47/6811 , A61K47/6843 , A61K47/6849 , A61K47/6853 , A61K47/6855 , A61K47/6875 , A61K2039/505 , C07K16/2896 , C07K16/32 , C07K16/46 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2319/33
摘要： The invention relates to immunoconjugates of formula: A-B—(C)n where B may be present or absent, A is a specific binding protein such as an antibody or an antibody binding fragment, or a ligand binding to a receptor present on target cells B comprises at least one molecule to which “A” and “C” bind, such as an avidin/streptavidin complex, “C” is an MHC molecule, and “n” is a whole number ranging from 1 to 10. The conjugates provide the exquisite binding specificity of antibodies, combined with an ability to stimulate cytotoxic T cells to identify and to destroy cells on which the conjugate is bound and oligomerized. The conjugates are useful both therapeutically and diagnostically.
摘要翻译：本发明涉及下式的免疫缀合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> AB-（C）

2. 发明申请

US20060269540A1 Targeted cd1d molecules 有权
标题翻译：靶向cd1d分子
公开(公告)号：US20060269540A1
公开(公告)日：2006-11-30
申请号：US10529221
申请日：2003-09-26
申请人： Bruno Robert , Alena Donda , Valerie Cesson , Jean-Pierre Mach , Maurice Zauderer
发明人： Bruno Robert , Alena Donda , Valerie Cesson , Jean-Pierre Mach , Maurice Zauderer
IPC分类号： A61K39/40 , A61K39/42 , C07K16/46
CPC分类号： C07K16/30 , C07K14/70539 , C07K2317/54 , C07K2317/55 , C07K2319/00
摘要： The invention is directed to a compound comprising one or more CD1d complexes in association with an antibody specific for a cell surface marker. The CD1d complexes comprise a CD1d, a β2-microglobulin molecule, and may further comprise an antigen bound to the CD1d binding groove. The invention is further directed to methods of inhibiting or stimulating an immune response with the CD1d-antibody compounds, in particular anti-tumor and autoimmunity responses.
摘要翻译：本发明涉及包含一种或多种与特异于细胞表面标志物的抗体结合的CD1d复合物的化合物。 CD1d复合物包含CD1d，β2-微球蛋白分子，并且还可以包含与CD1d结合槽结合的抗原。本发明进一步涉及用CD1d抗体化合物抑制或刺激免疫应答的方法，特别是抗肿瘤和自身免疫应答。

3. 发明授权

US09809654B2 Targeted CD1d molecules 有权
公开(公告)号：US09809654B2
公开(公告)日：2017-11-07
申请号：US10529221
申请日：2003-09-26
申请人： Bruno Robert , Alena Donda , Valerie Cesson , Jean-Pierre Mach , Maurice Zauderer
发明人： Bruno Robert , Alena Donda , Valerie Cesson , Jean-Pierre Mach , Maurice Zauderer
IPC分类号： C07K19/00 , C07K16/30 , C07K14/74 , A61K35/17
CPC分类号： C07K16/30 , C07K14/70539 , C07K2317/54 , C07K2317/55 , C07K2319/00
摘要： The invention is directed to a compound comprising one or more CD1d complexes in association with an antibody specific for a cell surface marker. The CD1d complexes comprise a CD1d, a β2-microglobulin molecule, and may further comprise an antigen bound to the CD1d binding groove. The invention is further directed to methods of inhibiting or stimulating an immune response with the CD1d-antibody compounds, in particular anti-tumor and autoimmunity responses.

4. 发明授权

US09409988B2 Anti-Axl antibodies and uses thereof 有权
标题翻译：抗Axl抗体及其用途
公开(公告)号：US09409988B2
公开(公告)日：2016-08-09
申请号：US14127416
申请日：2012-06-22
申请人： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
发明人： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC分类号： C07K16/40 , C07K16/28 , C07K16/32 , G01N33/574 , G01N33/68 , A61K39/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872
摘要： The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9 and SEQ ID NO: 10.
摘要翻译：本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。所述单克隆抗体通过SEQ ID NO：9和SEQ ID NO：10与Ax1的细胞外结构域结合。

5. 发明授权

US09249228B2 Anti-Axl antibodies and uses thereof 有权
标题翻译：抗Axl抗体及其用途
公开(公告)号：US09249228B2
公开(公告)日：2016-02-02
申请号：US14127415
申请日：2012-06-22
申请人： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
发明人： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , C07K16/40 , G01N33/574 , A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492
摘要： The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.
摘要翻译：本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。所述单克隆抗体通过SEQ ID NO：9，SEQ ID NO：10和SEQ ID NO：11结合Ax1的细胞外结构域。

6. 发明申请

US20140302041A1 ANTI-AXL ANTIBODIES AND USES THEREOF 有权
标题翻译：抗轴抗体及其用途
公开(公告)号：US20140302041A1
公开(公告)日：2014-10-09
申请号：US14127415
申请日：2012-06-22
申请人： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
发明人： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC分类号： C07K16/30 , G01N33/574 , C07K16/40
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492
摘要： The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.
摘要翻译：本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。所述单克隆抗体通过SEQ ID NO：9，SEQ ID NO：10和SEQ ID NO：11结合Ax1的细胞外结构域。

7. 发明申请

US20140227283A1 ANTI-AXL ANTIBODIES AND USES THEREOF 有权
标题翻译：抗轴抗体及其用途
公开(公告)号：US20140227283A1
公开(公告)日：2014-08-14
申请号：US14127416
申请日：2012-06-22
申请人： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
发明人： Bruno Robert , Benedicte Fauvel , Gwenael Cheve , Aziz Yasri , Christel Larbouret , Wilhem Leconet , Thierry Chardes , Christian Larroque , Andre Pelegrin
IPC分类号： C07K16/28 , G01N33/68 , G01N33/574
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872
摘要： The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9 and SEQ ID NO: 10.
摘要翻译：本发明涉及抗Ax1抗体及其在诊断和治疗方法中的用途。更具体地说，本发明涉及对Ax1具有特异性的单克隆抗体，其包含H-CDR1区中包含SEQ ID NO：2的重链可变区，H-CDR2区中的SEQ ID NO：3和SEQ ID NO： 4在H-CDR3区域; 以及包含L-CDR1区中的SEQ ID NO：6，L-CDR2区的SEQ ID NO：7和L-CDR3区的SEQ ID NO：8的轻链可变区。所述单克隆抗体通过SEQ ID NO：9和SEQ ID NO：10与Ax1的细胞外结构域结合。

8. 发明授权

US06169497A Mobile tracking and positioning system 失效
标题翻译：移动跟踪定位系统
公开(公告)号：US06169497A
公开(公告)日：2001-01-02
申请号：US08358792
申请日：1994-12-16
申请人： Bruno Robert
发明人： Bruno Robert
IPC分类号： G08G1123
CPC分类号： G08G1/20 , G08G1/127
摘要： A mobile tracking and positioning system includes a plurality of mobile transmit and receive stations that track a mobile target which emits a radio signal in response to the occurrence of a tracking effort initiation event. The tracking stations have a GPS receiver or like means for determining their position, a radio direction finder responsive to the radio signal that determines the vector to the mobile target, a two-way communications system and a computer. The mobile transmit and receive stations exchange their position and direction to target information via the two-way communications systems, enabling the stations to triangulate the location of the target with their computers.
摘要翻译：移动跟踪和定位系统包括多个移动发射和接收站，所述移动发射和接收站跟踪响应于跟踪作用启动事件的发生发射无线电信号的移动目标。跟踪站具有用于确定其位置的GPS接收器或类似装置，响应于确定向移动目标的向量的无线电信号的无线电测向器，双向通信系统和计算机。移动发射和接收站通过双向通信系统交换其位置和方向以定位信息，使得站能够利用其计算机对目标的位置进行三角测量。

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