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1. 发明申请

WO2005097142A1 BIOLOGICALLY ACTIVE COMPOUNDS WITH ANTI-ANGIOGENIC PROPERTIES 审中-公开
标题翻译：具有抗生物性质的生物活性化合物
公开(公告)号：WO2005097142A1
公开(公告)日：2005-10-20
申请号：PCT/AU2005/000506
申请日：2005-04-07
申请人： ALCHEMIA LIMITED , HALLIDAY, Judy , MEUTERMANS, Wim , TOMETZKI, Gerald , RAMSDALE, Tracie, Elizabeth , ZUEGG, Johannes , BECKER, Bernd , MULDOON, Craig , MCKEVENEY, Declan , PREMRAJ, Rajaratnam , CONDIE, Glenn
发明人： HALLIDAY, Judy , MEUTERMANS, Wim , TOMETZKI, Gerald , RAMSDALE, Tracie, Elizabeth , ZUEGG, Johannes , BECKER, Bernd , MULDOON, Craig , MCKEVENEY, Declan , PREMRAJ, Rajaratnam , CONDIE, Glenn
IPC分类号： A61K31/7008
CPC分类号： A61K31/7008 , A61K31/70
摘要： A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X' are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X' may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function.
摘要翻译：一种用于抑制受试者血管发生的方法，其包括向所述受试者施用至少一种通式（I）的化合物，其中所述环或任何手性中心可以是任何构型; Z是硫，氧，CH 2，C（O），C（O）HN，NH，NRA或氢时，在Z是氢的情况下，R1不存在，RA选自为R1至R5定义的集合， X和X'独立地是氧或氮，条件是至少一个通式（I）的X是氮，X或X'也可以独立地与R 1至R 5中的一个组合形成叠氮化物，R 1至R 5独立地选自包括但不限于H或任选取代的1-20个原子的烷基，酰基，烯基，炔基，杂烷基，芳基，杂芳基，芳烷基或杂芳基烷基取代基，并且可以是支链或直链的以下定义，和 R6和R7是氢，或者可以结合形成羰基官能团。

2. 发明申请

WO2006081616A1 CLASSES OF COMPOUNDS THAT INTERACT WITH INTEGRINS 审中-公开
标题翻译：与INTEGRINS互动的化合物类
公开(公告)号：WO2006081616A1
公开(公告)日：2006-08-10
申请号：PCT/AU2006/000129
申请日：2006-02-02
申请人： ALCHEMIA LIMITED , MEUTERMANS, Wim , WEST, Michael Leo , THANH LE, Giang , HALLIDAY, Judy , CLARK, Christopher
发明人： MEUTERMANS, Wim , WEST, Michael Leo , THANH LE, Giang , HALLIDAY, Judy , CLARK, Christopher
IPC分类号： A61K31/351 , A61P3/10 , A61P11/06 , A61P17/02 , A61P25/28 , A61P35/00 , A61P37/08
CPC分类号： A61K31/351 , A61K31/70
摘要： A method of inhibiting or effecting the activity of an integral receptor which comprises contacting an integrin with a compound of formula I, or a pharmaceutically acceptable salt thereof; General Formula I Wherein the ring may be of any configuration; Z is sulphur, oxygen, CH 2 , NH, NR A or hydrogen, in the case where Z is hydrogen then R 1 is not present, R A is selected from the set defined for R 1 to R 5 , X is oxygen or NR A providing that at least one X of General Formula I is NR A , X may also combine independently with one of R 1 to R 5 to form an azide, R1 to R5 are independently selected from the group comprising H, -(CO)R 6 or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, wherein R 6 is selected from the group comprising an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear wherein substituents may optionally be further substituted, with the proviso that XR 2 or XR 3 or XR 4 or XR 5 is not NH 2 , with the further proviso that not more than one of R2 to R5 is hydrogen, where the group X is NR A and R A is not hydrogen, the groups R A and the corresponding group R 2 to R 5 may combine to form a cycle.
摘要翻译：一种抑制或影响整体受体活性的方法，其包括使整联蛋白与式I化合物或其药学上可接受的盐接触; 通式I其中环可以是任何配置; Z是硫，氧，CH 2，NH，NR A或氢，在Z是氢的情况下，R 1不存在 R A选自从R 1至R 5定义的集合，X是氧或NR A，条件是通式I的至少一个X为NR A，X还可以独立地与R 1至R 5中的一个结合形成叠氮化物，R 1至R 5独立地选自H， - （CO）R 6 N或烷基，酰基，烯基，炔基，杂烷基，芳基，杂芳基，芳烷基或杂芳基烷基取代基至20个原子，其任选被取代，并且可以是支链或直链的，其中取代基可任选被进一步取代，其中R 6选自烷基，酰基，烯基，炔基，杂烷基， 1至20个原子的芳基，杂芳基，芳基烷基或杂芳基烷基取代基，其任选被取代，并且可以是支链或直链的在取代基中可以任选地被进一步取代，条件是XR 2或XR 3或XR 4或XR 5 不是NH 2，另外条件是R 2至R 5中不超过一个是氢，其中基团X是NR A和R A， / SUP>不是氢，基团R A和相应的R 2至R 5可以组合形成一个周期。

3. 发明公开

EP1549325A1 CLASSES OF COMPOUNDS THAT INTERACT WITH GPCRS 审中-公开
标题翻译：与GPCR的INTERACT相关的类
公开(公告)号：EP1549325A1
公开(公告)日：2005-07-06
申请号：EP03747740.3
申请日：2003-10-10
申请人： Alchemia Limited
发明人： MEUTERMANS, Wim , LE THANH, Giang , ABBENANTE, Giovani , TOMETZKI, Gerald , HALLIDAY, Judy , ZEUGG, Johannes
IPC分类号： A61K31/7008 , A61K31/70
CPC分类号： A61K31/7008 , A61K31/7034 , A61K31/7036 , A61K31/7052
摘要： A method of inhibiting or effecting the activity of a GPCR which comprises contacting a GPCR with a compound of general formula (I), or a pharmaceutically acceptable salt thereof General Formula (I).

4. 发明公开

EP1732573A1 BIOLOGICALLY ACTIVE COMPOUNDS WITH ANTI-ANGIOGENIC PROPERTIES 审中-公开
标题翻译：生物活性化合物的抗血管生成特性
公开(公告)号：EP1732573A1
公开(公告)日：2006-12-20
申请号：EP05729499.3
申请日：2005-04-07
申请人： Alchemia Limited
发明人： HALLIDAY, Judy , MEUTERMANS, Wim , TOMETZKI, Gerald , RAMSDALE, Tracie, Elizabeth , ZUEGG, Johannes , BECKER, Bernd , MULDOON, Craig , MCKEVENEY, Declan , PREMRAJ, Rajaratnam , CONDIE, Glenn
IPC分类号： A61K31/7008 , A61K31/70 , A61P35/00
CPC分类号： A61K31/7008 , A61K31/70
摘要： A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X' are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X' may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function.

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