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1. 发明授权

US4540697A Aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones, pharmaceutical compositions and use 失效
标题翻译： 2-羟基-β-苯基 - 苯丙酮的氨基丙醇衍生物，药物组合物和用途
公开(公告)号：US4540697A
公开(公告)日：1985-09-10
申请号：US613389
申请日：1984-05-23
申请人： Albrecht Franke , Josef Muller , Helmut Lietz , Walter-Wielant Wiersdorff , Hans-Gunther Hege , Claus D. Muller , Josef Gries , Dieter Lenke , Gerda von Philipsborn , Manfred Raschack
发明人： Albrecht Franke , Josef Muller , Helmut Lietz , Walter-Wielant Wiersdorff , Hans-Gunther Hege , Claus D. Muller , Josef Gries , Dieter Lenke , Gerda von Philipsborn , Manfred Raschack
IPC分类号： C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D295/092 , C07D303/22 , C07D303/24 , A61K31/135 , A61K31/495 , C07C97/10 , C07D295/12
CPC分类号： C07D295/088 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D303/22 , C07D303/24
摘要： Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
摘要翻译： 2-羟基-β-苯基 - 苯丙酮的新型氨基丙醇衍生物及其生理上可接受的酸加成化合物，其制备方法和含有这些衍生物的治疗剂，可用作抗心律失常药物。

2. 发明授权

US4571409A Aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones, their preparation and therapeutic agents containing these compounds 失效
标题翻译： 2-羟基-β-苯基 - 苯丙酮的氨基丙醇衍生物，它们的制备和含有这些化合物的治疗剂
公开(公告)号：US4571409A
公开(公告)日：1986-02-18
申请号：US733631
申请日：1985-05-13
申请人： Albrecht Franke , Josef Mueller , Helmut Lietz , Walter-Wielant Wiersdorff , Hans-Guenther Hege , Claus D. Mueller , Josef Gries , Dieter Lenke , Gerda von Philipsborn , Manfred Raschack
发明人： Albrecht Franke , Josef Mueller , Helmut Lietz , Walter-Wielant Wiersdorff , Hans-Guenther Hege , Claus D. Mueller , Josef Gries , Dieter Lenke , Gerda von Philipsborn , Manfred Raschack
IPC分类号： C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/092 , C07D303/22 , C07D303/24 , A61K31/135 , C07C97/10
CPC分类号： C07D295/088 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D303/22 , C07D303/24
摘要： Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
摘要翻译： 2-羟基-β-苯基 - 苯丙酮的新型氨基丙醇衍生物及其生理上可接受的酸加成化合物，其制备方法和含有这些衍生物的治疗剂，可用作抗心律失常药物。

3. 发明授权

US5118685A Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds 失效
标题翻译：取代的2-羟基丙酸的氨基酚衍生物和含有这些化合物的治疗剂
公开(公告)号：US5118685A
公开(公告)日：1992-06-02
申请号：US677307
申请日：1984-12-03
申请人： Albrecht Franke , Wolfgang Spiegler , Hardo Siegel , Claus D. Mueller , Gerda von Philipsborn , Dieter Lenke , Josef Gries
发明人： Albrecht Franke , Wolfgang Spiegler , Hardo Siegel , Claus D. Mueller , Gerda von Philipsborn , Dieter Lenke , Josef Gries
IPC分类号： A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/495 , A61P9/06 , C07D207/32 , C07D207/333 , C07D213/50 , C07D231/12 , C07D307/46 , C07D333/22 , C07D409/12
CPC分类号： C07D207/333 , C07D213/50 , C07D231/12 , C07D307/46 , C07D333/22 , C07D409/12
摘要： Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.Het is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4-yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, and antiarrhythmic agents containing these compounds.
摘要翻译：具有下式的氨基丙醇衍生物：其中R 1和R 2相同或不同，并且各自为氢，烷基，环烷基，烯基，炔基或羟烷基，各自不超过6个碳原子，烷氧基烷基，烷硫基烷基或二烷基氨基烷基，各自为不超过9个碳原子，或苯基烷基或苯氧基烷基，其中烷基不超过6个碳原子，苯基是未取代的或被不多于3个碳原子的烷基或烷氧基取代，或者R1和 R2与连接它们的氮原子一起形成可被一个或两个苯基和/或羟基取代的5元至7元饱和杂环，并且可以含有氧或氮原子作为另外的杂原子并且这样的另外的氮原子可以被1至3个碳原子的烷基或苯基取代，并且 - ＆C 1 H e是噻吩-2-基，噻吩-3-基，吡啶-2-基，吡啶-2-基，吡啶-4-基，呋喃-2-基，1-烷基吡咯-2-基，1-烷基 1-吡咯-3-基或1-烷基吡唑-4-基，具有1至3个碳原子的烷基，以及它们与酸的生理上可耐受的加成盐，和含有这些化合物的抗心律不齐剂。

4. 发明授权

US5118682A p-Hydroxy phenone derivatives and the use thereof 失效
标题翻译： P-羟基苯酮衍生物及其用途
公开(公告)号：US5118682A
公开(公告)日：1992-06-02
申请号：US378966
申请日：1989-07-12
申请人： Wilfried Lubisch , Manfred Raschack , Gerda von Philipsborn
发明人： Wilfried Lubisch , Manfred Raschack , Gerda von Philipsborn
IPC分类号： A61K31/135 , A61K31/40 , A61K31/445 , A61P9/06 , C07C217/22 , C07D295/08 , C07D295/092
CPC分类号： C07D295/088 , C07C217/22
摘要： p-Hydroxy phenone derivatives of the general formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and are methyl, chlorine, bromine and hydrogen, but R.sup.1, R.sup.2 and R.sup.3 are not all H,R.sup.4 and R.sup.5 are identical or different and are H, C.sub.1 -C.sub.4 -alkyl, or OR.sup.6, but R.sup.4 and R.sup.5 are not both H,X is a --CH.dbd.CH--, --CH.sub.2 CH.sub.2 or --CH.sub.2 -- bridge,Y is a straight-chain or branched, saturated or unsaturated C.sub.1 -C.sub.4 bridge, andZ is NR.sup.6 R.sup.7, where R.sup.6 and R.sup.7 are, independently of one another, hydrogen or C.sub.1-4 -alkyl, or Z is a 5- or 6-membered ring with a nitrogen atom in the 1 position and, where appropriate, additionally a second N atom or an O or S atom, the second N atom being substituted by R.sup.7, as well as the physiologically tolerated salts thereof,are used to prepare drugs antiarrhythmic of Vaughan-Williams class III.
摘要翻译：通式I的对羟基苯酮衍生物其中R 1，R 2和R 3相同或不同，为甲基，氯，溴和氢，但R 1，R 2和R 3不全为H，R 4和R 5相同或不同的是H，C 1 -C 4烷基或OR 6，但R 4和R 5不同时为H，X为-CH = CH-，-CH 2 CH 2或-CH 2 - 桥，Y为直链或支链，饱和或不饱和的C 1 -C 4桥，Z为NR 6 R 7，其中R 6和R 7彼此独立地为氢或C 1-4 - 烷基，或Z为在1位上具有氮原子的5-或6-元环位置，并且在适当的情况下另外还有第二个N原子或O或S原子，被R7取代的第二个N原子及其生理上耐受的盐用于制备Vaughan-Williams III类抗心律不齐药物。

5. 发明授权

US4459301A Method of treating cardiac disorders using bispidine derivatives 失效
标题翻译：使用双脒衍生物治疗心脏病的方法
公开(公告)号：US4459301A
公开(公告)日：1984-07-10
申请号：US354515
申请日：1982-03-03
申请人： Fritz Binnig , Claus D. Mueller , Manfred Raschack , Gerda von Philipsborn
发明人： Fritz Binnig , Claus D. Mueller , Manfred Raschack , Gerda von Philipsborn
IPC分类号： A61K31/435 , A61P9/00 , A61P9/06 , C07D471/08 , A61K31/445
CPC分类号： C07D471/08
摘要： Bispidine derivatives of the formula I ##STR1## where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds possess antiarrhythmic properties.
摘要翻译：其中R是氢或氨基的式I的二甲苯衍生物及其与生理上耐受的酸的盐。该化合物具有抗心律失常性质。

6. 发明授权

US4329352A Piperidine derivatives of 3-hydroxy-thiophene-2-carboxylic acid esters and pharmaceutical formulations containing these compounds 失效
标题翻译： 3-羟基 - 噻吩-2-羧酸酯的哌啶衍生物和含有这些化合物的药物制剂
公开(公告)号：US4329352A
公开(公告)日：1982-05-11
申请号：US212631
申请日：1980-12-03
申请人： Fritz-Frieder Frickel , Gerda von Philipsborn , Claus D. Mueller , Dieter Lenke
发明人： Fritz-Frieder Frickel , Gerda von Philipsborn , Claus D. Mueller , Dieter Lenke
IPC分类号： A61K31/4433 , A61K31/445 , A61P9/06 , C07D333/38 , C07D409/12 , A61K31/38 , C07D417/12
CPC分类号： C07D333/38 , Y10S514/821
摘要： Substituted piperidino-alkyl ethers of 3-hydroxy-thiophene-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and which may be used in the treatment of cardiac arrhythmias.
摘要翻译： 3-羟基 - 噻吩-2-羧酸酯的取代的哌啶子基 - 烷基醚及其与酸的生理学耐受加成盐，其制备方法和含有这些化合物的药物制剂，其可用于治疗心律失常。

7. 发明授权

US4556662A Bispidine derivatives and antiarrhythmic compositions 失效
标题翻译：双嘧啶衍生物和抗心律不齐组合物
公开(公告)号：US4556662A
公开(公告)日：1985-12-03
申请号：US537838
申请日：1983-09-30
申请人： Fritz Binnig , Claus D. Mueller , Manfred Raschack , Gerda von Philipsborn
发明人： Fritz Binnig , Claus D. Mueller , Manfred Raschack , Gerda von Philipsborn
IPC分类号： A61K31/435 , A61P9/00 , A61P9/06 , C07D471/08
CPC分类号： C07D471/08
摘要： Bispidine derivatives of the formula I ##STR1## where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.
摘要翻译：其中R是氢或氨基的式I的二甲苯衍生物及其与生理上耐受的酸的盐。该化合物具有抗心律失常性质。

8. 发明授权

US4242332A 4,5-Methano-bufadienolide-rhamnosides, their preparation, and drugs containing these compounds 失效
标题翻译： 4,5-Methano-bufadienolide-rhamnosides，它们的制备和含有这些化合物的药物
公开(公告)号：US4242332A
公开(公告)日：1980-12-30
申请号：US73107
申请日：1979-09-06
申请人： Hans P. Albrecht , Gerda von Philipsborn , Hans U. Siebeneick , Manfred Raschack
发明人： Hans P. Albrecht , Gerda von Philipsborn , Hans U. Siebeneick , Manfred Raschack
IPC分类号： A61K31/704 , A61P9/04 , C07J53/00 , A61K31/705 , C07J19/00
CPC分类号： C07J53/004
摘要： 4,5-methano-bufadienolide-rhamnosides of the formula I ##STR1## where R.sup.1 is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, R.sup.2 and R.sup.3 are identical or different and each is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, or both together are ##STR2## where R.sup.4 and R.sup.5 are identical or different and each is hydrogen or alkyl or alkoxy of 1 or 2 carbon atoms.The novel compounds may be used for counteracting cardiac insufficiency.
摘要翻译：其中R 1是氢或1-4个碳原子的烷基或酰基，其中R 1和R 3相同或不同，并且各自是氢或烷基或酰基，其中R 1，R 2，R 3， 4个碳原子或两者一起是，其中R 4和R 5是相同或不同的，并且各自是氢或1或2个碳原子的烷基或烷氧基。新型化合物可用于抵抗心功能不全。

9. 发明授权

US4206217A 3-[4-(1,3-Diazacycloalken-2-yl)-phenyl]-1,2-benzisothiazoles, their manufacture, and drugs containing these compounds 失效
标题翻译： 3- [4-（1,3-二氮杂环烯-2-基） - 苯基] -1,2-苯并异噻唑，它们的制造和含有这些化合物的药物
公开(公告)号：US4206217A
公开(公告)日：1980-06-03
申请号：US928815
申请日：1978-07-28
申请人： Helmut Hagen , Dieter Lenke , Gerda von Philipsborn
发明人： Helmut Hagen , Dieter Lenke , Gerda von Philipsborn
IPC分类号： C07D275/04 , C07D277/62
CPC分类号： C07D275/04
摘要： 3-[4-(1,3-Diazacyclo-2-yl)]-1,2-benzisothiazoles, their addition salts with acids, their manufacture, and pharmaceutical formulations which contain these compounds as active ingredients and which may be used for the pharmacotherapy of cardiac arrhythmias.
摘要翻译： 3- [4-（1,3-二氮杂环-2-基）] - 1,2-苯并异噻唑，它们与酸的加成盐，它们的制备和药物制剂，其含有这些化合物作为活性成分并且可用于心律失常药物治疗。

10. 发明授权

US5214047A Tetracyclic quinazoline derivatives, effective as antiarrythmic agents 失效
标题翻译：作为抗菌药物有效的四环喹诺酮衍生物
公开(公告)号：US5214047A
公开(公告)日：1993-05-25
申请号：US243469
申请日：1988-09-12
申请人： Bernd Ostersehlt , Rainer Schlecker , Beatrice Rendenbach , Gerda von Philipsborn , Albrecht Franke, deceased
发明人： Bernd Ostersehlt , Rainer Schlecker , Beatrice Rendenbach , Gerda von Philipsborn , Albrecht Franke, deceased
IPC分类号： A61K31/505 , A61P9/06 , C07D471/14 , C07D487/14
CPC分类号： C07D471/14 , C07D487/14
摘要： A tetracyclic quinazoline derivative of the formula I: ##STR1## wherein A is C.sub.2-3 -alkylene or C.sub.2-3 -alkylene which is substituted by one or two C.sub.1-4 -alkyl radicals or A is cyclohexylene; X is phenyl, naphthyl or phenyl or naphthyl which is substituted by halogen, nitro, amino, C.sub.1-4 -alkylamino, sulfonylamino, C.sub.1-4 -acylamino, hydroxyl, C.sub.1-4 -alkoxy, --O--(CH.sub.2).sub.2-4 --NR.sup.1 R.sup.2, C.sub.1-4 -alkyl or C.sub.1-4 -alkylsulfonyl, wherein R.sup.1 and R.sup.2 are each hydrogen or C.sub.1-4 -alkyl; or X is thienyl or thienyl which is substituted by chlorine, fluorine, methyl, ethyl, methoxy, ethoxy, nitro or hydroxyl; and R is hydrogen, halogen, nitro, amino, C.sub.1-4 -alkylamino, sulfonylamino, C.sub.1-4 -acylamino, hydroxyl, C.sub.1-4 -alkoxy, --O--(CH.sub.2).sub.2-4 --NR.sup.3 R.sup.4, C.sub.1-4 -alkyl or C.sub.1-4 -alkylsulfonyl, wherein R.sup.3 and R.sup.4 are each hydrogen or C.sub.1-4 -alkyl, and the pharmaceutically acceptable salts thereof. The compounds and compositions of the present invention are effective as antiarrhythmic agents.
摘要翻译：式I的四环喹唑啉衍生物：其中A是被一个或两个C 1-4 - 烷基取代的C 2-3亚烷基或C 2-3亚烷基，或者A是亚环己基; X是被卤素，硝基，氨基，C 1-4 - 烷基氨基，磺酰基氨基，C 1-4 - 酰氨基，羟基，C 1-4 - 烷氧基，-O-（CH 2）2-4取代的苯基，萘基或苯基或萘基 -NR 1 R 2，C 1-4 - 烷基或C 1-4 - 烷基磺酰基，其中R 1和R 2各自为氢或C 1-4 - 烷基; 或X是被氯，氟，甲基，乙基，甲氧基，乙氧基，硝基或羟基取代的噻吩基或噻吩基; 并且R是氢，卤素，硝基，氨基，C 1-4 - 烷基氨基，磺酰基氨基，C 1-4 - 酰氨基，羟基，C 1-4 - 烷氧基，-O-（CH 2）2-4 -NR 3 R 4，C 1-4 - 烷基或C 1-4 - 烷基磺酰基，其中R 3和R 4各自为氢或C 1-4 - 烷基，及其药学上可接受的盐。本发明的化合物和组合物作为抗心律失常药有效。

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