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1. 发明授权

US08541543B2 Peptides specific for hepatocellular carcinoma cells and applications thereof 有权
公开(公告)号：US08541543B2
公开(公告)日：2013-09-24
申请号：US12292401
申请日：2008-11-18
申请人： Han-Chung Wu , Chin-Tarng Lin , Albert Lo
发明人： Han-Chung Wu , Chin-Tarng Lin , Albert Lo
IPC分类号： C07K5/00
CPC分类号： G01N33/57438 , A61K38/00 , C07K7/08
摘要： Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. Novel treatment strategies derived from increased knowledge of molecular oncology are constantly being developed to cure this disease. Here, we used phage display to identify novel peptides, including (SP94), which binds specifically to HCC cells. In vitro, the phage clone PC94 binds to HCC cell lines. In vivo, PC94 homed specifically to tumor tissues but not to normal visceral organs in SCID mice bearing human HCC xenografts. The homing ability could be competitively inhibited by synthetic peptide, SP94. PC94 localized to tumor tissues but could not be detected in SP94-competed tumor tissues or in normal organs. In addition, PC94 recognized the tumor tissue but not non-tumor tissue in surgical specimens from HCC patients, with a positive rate of 61.3% (19/31). With the conjugation of SP94 and liposomal doxorubicin, a targeted drug delivery system enhanced the therapeutic efficacy against HCC xenografts through enhanced tumor apoptosis and decreased tumor angiogenesis. Our results indicate that SP94 can improve the systemic treatment of patients with advanced HCC.

2. 发明申请

US20090136418A1 Peptides specific for hepatocellular carcinoma cells and applications thereof 有权
标题翻译：特异于肝细胞癌细胞的肽及其应用
公开(公告)号：US20090136418A1
公开(公告)日：2009-05-28
申请号：US12292401
申请日：2008-11-18
申请人： Han-Chung Wu , Chin-Tarng Lin , Albert Lo
发明人： Han-Chung Wu , Chin-Tarng Lin , Albert Lo
IPC分类号： A61K51/00 , C12N15/11 , C07K7/00 , C07K16/18 , G01N33/574 , A61K9/127 , A61K38/10
CPC分类号： G01N33/57438 , A61K38/00 , C07K7/08
摘要： Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. Novel treatment strategies derived from increased knowledge of molecular oncology are constantly being developed to cure this disease. Here, we used phage display to identify novel peptides, including (SP94), which binds specifically to HCC cells. In vitro, the phage clone PC94 binds to HCC cell lines. In vivo, PC94 homed specifically to tumor tissues but not to normal visceral organs in SCID mice bearing human HCC xenografts. The homing ability could be competitively inhibited by synthetic peptide, SP94. PC94 localized to tumor tissues but could not be detected in SP94-competed tumor tissues or in normal organs. In addition, PC94 recognized the tumor tissue but not non-tumor tissue in surgical specimens from HCC patients, with a positive rate of 61.3% (19/31). With the conjugation of SP94 and liposomal doxorubicin, a targeted drug delivery system enhanced the therapeutic efficacy against HCC xenografts through enhanced tumor apoptosis and decreased tumor angiogenesis. Our results indicate that SP94 can improve the systemic treatment of patients with advanced HCC.
摘要翻译：肝细胞癌（HCC）是全球第四大癌症死亡原因。不断开发从增加分子肿瘤学知识得出的新型治疗策略来治愈这种疾病。在这里，我们使用噬菌体展示来鉴定新型肽，包括特异性结合HCC细胞的（SP94）。在体外，噬菌体克隆PC94结合HCC细胞系。在体内，PC94特异性地归巢于肿瘤组织，而不是携带人类HCC异种移植物的SCID小鼠中的正常内脏器官。归巢能力可以被合成肽SP94竞争性抑制。 PC94定位于肿瘤组织，但在SP94竞争的肿瘤组织或正常器官中不能检测到。此外，PC94在HCC患者手术标本中识别肿瘤组织，但不识别非肿瘤组织，阳性率为61.3％（19/31）。通过SP94和脂质体多柔比星的缀合，靶向药物递送系统通过增强肿瘤细胞凋亡和减少肿瘤血管生成来增强对HCC异种移植物的治疗效果。我们的研究结果表明，SP94可以改善晚期HCC患者的全身治疗。

3. 发明申请

US20050214066A1 STRIDING SHANK FIXING DEVICE 失效
标题翻译： STRIDING SHANK固定装置
公开(公告)号：US20050214066A1
公开(公告)日：2005-09-29
申请号：US10806147
申请日：2004-03-23
申请人： Albert Lo
发明人： Albert Lo
IPC分类号： F16B2/06 , F16B7/04 , F16B7/10
CPC分类号： F16B2/065 , F16B7/04 , Y10T403/32451 , Y10T403/32459 , Y10T403/7041
摘要： A striding shank fixing device includes an insert tube, a guide tube, and an adjusting member. The guide tube has plural position holes, and the adjusting member has a hole for the guide tube to pass through and a position projection to fit in one of the position holes to secure the adjusting member with the guide tube at an adjusted location. A thumb screw screws through the adjusting member to press a driving strip to push forcefully against a vertical side of a wall to secure the shank fixing device striding on the wall so the shank of a parasol may be inserted in the insert tube and stabilized by a thumb screw screwing through the insert tube and pressing against a driving block in the insert tube and pressing against the shank to support the parasol stably.
摘要翻译：一种跨柄固定装置包括插入管，导管和调节构件。引导管具有多个位置孔，并且调节构件具有用于引导管穿过的孔和位置突起，以配合在一个位置孔中，以将调节构件与引导管固定在调整位置。翼形螺丝通过调节构件螺钉拧紧驱动条以强力地推靠在壁的垂直侧上，以将柄固定装置固定在壁上，使得阳伞的柄可以插入插入管中并由一个稳定的拇指螺钉通过插入管螺纹拧紧并压靠插入管中的驱动块并且压靠柄以稳定地支撑阳伞。

4. 发明申请

US20050045218A1 Connector for a rib and a spreader of a parasol 失效
标题翻译：肋骨连接器和阳伞的吊具
公开(公告)号：US20050045218A1
公开(公告)日：2005-03-03
申请号：US10647277
申请日：2003-08-26
申请人： Albert Lo
发明人： Albert Lo
IPC分类号： A45B19/10 , A45B25/00
CPC分类号： A45B19/10 , A45B25/00 , Y10T403/32591 , Y10T403/43
摘要： A connector for a rib and a spreader of a parasol includes a metal connector body and an inner block made of plastic. The connector body has an upper clamp portion for each rib to fit therein, and two studs extending down from the connector body and defining an inner opening for the inner block to fit therein. The inner block has two side walls defining an inner opening as a turning passageway for each spreader to fit and connected pivotally, and a stop respectively in two sides of the passageway for stopping each spreader in case of collapsing the parasol. Then the side walls can prevent the connector body from contacting the shank to scrape the paint coated on the shank and prevent said shank from rusting. Further the stops can maintain the contained angle between each rib and each spreader not excessively small to permit the parasol easily expanded.
摘要翻译：用于肋和伞的吊具的连接器包括金属连接器主体和由塑料制成的内部块。连接器主体具有用于每个肋的上部夹紧部分，以装配在其中，以及从连接器主体向下延伸并且限定用于内部块的内部开口以配合在其中的两个螺栓。内部块具有限定内部开口的两个侧壁，作为用于每个吊具的枢转通道，以便枢转地装配和连接，并且在通道的两侧分别设有用于在折叠遮阳伞的情况下停止每个吊具的止挡件。然后侧壁可以防止连接器主体接触柄部以刮擦涂覆在柄上的涂料并防止所述柄生锈。此外，止挡件可以保持每个肋和每个吊具之间的夹角不会过小，从而允许遮阳伞容易地膨胀。

5. 发明授权

US5996065A Apparatus for bypassing intermediate results from a pipelined floating point unit to multiple successive instructions 失效
标题翻译：用于将流水线浮点单元的中间结果旁路到多个连续指令的装置
公开(公告)号：US5996065A
公开(公告)日：1999-11-30
申请号：US831473
申请日：1997-03-31
申请人： Sivakumar Makineni , Brian L. Hughes , Sunhyuk Kimn , Michael Chow , Suri Babu Medapati , Albert Lo
发明人： Sivakumar Makineni , Brian L. Hughes , Sunhyuk Kimn , Michael Chow , Suri Babu Medapati , Albert Lo
IPC分类号： G06F7/57 , G06F9/38
CPC分类号： G06F9/3875 , G06F7/483 , G06F9/3826 , G06F2207/3884 , G06F7/49947
摘要： A microprocessor having a pipelined floating point unit operable to bypass pre-rounded results at clock cycle i and provide the pre-rounded results as an operand for a second instruction at clock cycle i+2. In one embodiment, the pipelined execution unit includes at least a first execution step at clock cycle i, and a second execution step at a clock cycle i+1 and clock cycle i+2. The unit includes a bypass leading from the first execution step at clock cycle i, however, there is no bypass leading from the second execution step at clock cycle i+1. The bypass carries the pre-rounded results from the end of the first execution step to the front end of the pipeline via a latched data path which delays the pre-rounded result one clock cycle.
摘要翻译：具有流水线浮点单元的微处理器，其可操作以在时钟周期i旁路预翻转结果，并将预翻转结果提供为在时钟周期i + 2处的第二指令的操作数。在一个实施例中，流水线执行单元至少包括在时钟周期i的第一执行步骤和在时钟周期i + 1和时钟周期i + 2的第二执行步骤。该单元包括在时钟周期i从第一执行步骤引出的旁路，然而，在时钟周期i + 1处没有从第二执行步骤引出的旁路。旁路通过锁存的数据路径将从第一执行步骤结束的前一轮结果传送到流水线的前端，该锁存数据路径延迟了一个时钟周期的预循环结果。

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