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1. 发明申请

US20080145469A1 EXTRUSION APPARATUS FOR MAKING MULTILAYER ARTICLES 有权
标题翻译：挤出装置制作多层文章
公开(公告)号：US20080145469A1
公开(公告)日：2008-06-19
申请号：US12032054
申请日：2008-02-15
申请人： Albert Chin , John Jianhua Chen , Thomas A. Svatek , Ronald A. Sahatjian
发明人： Albert Chin , John Jianhua Chen , Thomas A. Svatek , Ronald A. Sahatjian
IPC分类号： B29C47/00
CPC分类号： A61M25/1029 , A61M25/10 , A61M2025/1075 , B29C47/0023 , B29C47/065 , B29C47/263 , B29K2067/00 , B29K2067/006 , B29K2077/00 , B29L2022/022 , B29L2031/7542 , Y10T428/1334 , Y10T428/1352 , Y10T428/1359 , Y10T428/1393 , Y10T428/31736 , Y10T428/31786
摘要： In certain aspects of the invention, an extrusion apparatus for making a multilayer article includes multiple discs, each of which has at least one passageway configured to permit fluid flow therethrough in a flow direction. At least one of the discs includes a cone shaped portion extending substantially parallel to the flow direction.
摘要翻译：在本发明的某些方面，用于制造多层制品的挤出装置包括多个盘，每个盘具有至少一个通道，其构造成允许流体在流动方向上流过其中。至少一个盘包括基本上平行于流动方向延伸的锥形部分。

2. 发明授权

US06951675B2 Multilayer balloon catheter 有权
标题翻译：多层气囊导管
公开(公告)号：US06951675B2
公开(公告)日：2005-10-04
申请号：US10351695
申请日：2003-01-27
申请人： Albert Chin , John Jianhua Chen , Thomas A. Svatek , Ronald A. Sahatjian
发明人： Albert Chin , John Jianhua Chen , Thomas A. Svatek , Ronald A. Sahatjian
IPC分类号： A61F2/958 , A61M25/00 , B29C47/06 , A61M29/02
CPC分类号： A61M25/1029 , A61M25/10 , A61M2025/1075 , B29C47/0023 , B29C47/065 , B29C47/263 , B29K2067/00 , B29K2067/006 , B29K2077/00 , B29L2022/022 , B29L2031/7542 , Y10T428/1334 , Y10T428/1352 , Y10T428/1359 , Y10T428/1393 , Y10T428/31736 , Y10T428/31786
摘要： Multilayer medical devices, apparatuses for making such devices, and methods of making such devices are disclosed.
摘要翻译：公开了多层医疗装置，制造这种装置的装置以及制造这种装置的方法。

3. 发明授权

US07713047B2 Extrusion apparatus for making multilayer articles 有权
标题翻译：用于制造多层制品的挤出设备
公开(公告)号：US07713047B2
公开(公告)日：2010-05-11
申请号：US12032054
申请日：2008-02-15
申请人： Albert Chin , John Jianhua Chen , Ronald A. Sahatjian , Thomas A. Svatek
发明人： Albert Chin , John Jianhua Chen , Ronald A. Sahatjian , Thomas A. Svatek
IPC分类号： B29C47/06 , B29C47/20
CPC分类号： A61M25/1029 , A61M25/10 , A61M2025/1075 , B29C47/0023 , B29C47/065 , B29C47/263 , B29K2067/00 , B29K2067/006 , B29K2077/00 , B29L2022/022 , B29L2031/7542 , Y10T428/1334 , Y10T428/1352 , Y10T428/1359 , Y10T428/1393 , Y10T428/31736 , Y10T428/31786
摘要： In certain aspects of the invention, an extrusion apparatus for making a multilayer article includes multiple discs, each of which has at least one passageway configured to permit fluid flow therethrough in a flow direction. At least one of the discs includes a cone shaped portion extending substantially parallel to the flow direction.
摘要翻译：在本发明的某些方面，用于制造多层制品的挤出装置包括多个盘，每个盘具有至少一个通道，其构造成允许流体在流动方向上流过其中。至少一个盘包括基本上平行于流动方向延伸的锥形部分。

4. 发明授权

US07947059B2 Multilayer medical device 有权
标题翻译：多层医疗器械
公开(公告)号：US07947059B2
公开(公告)日：2011-05-24
申请号：US09798749
申请日：2001-03-02
申请人： Albert C. C. Chin , John Jianhua Chen , Yiqun Wang , David W. Lodin , Lixiao Wang , Ronald A. Sahatjian , Ismail Guler , Robert Burgmeier
发明人： Albert C. C. Chin , John Jianhua Chen , Yiqun Wang , David W. Lodin , Lixiao Wang , Ronald A. Sahatjian , Ismail Guler , Robert Burgmeier
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61M25/0009 , A61M25/0045 , A61M2025/1075 , B29C47/0023 , B29C47/0026 , B29C47/065 , B29C47/26 , B29C47/263 , B29C47/28 , B29K2055/02 , B29K2067/00 , B29K2067/006 , B29K2075/00 , B29K2077/00 , B29K2105/0079 , B29L2022/022 , B29L2031/7542
摘要： A medical device such as a tube or a balloon including wall structure with multiple layers. The wall structure can distribute stress, resulting in reduced defect propagation and failure.
摘要翻译：诸如管或气囊的医疗装置，包括具有多层的壁结构。壁结构可以分布应力，导致缺陷传播和故障的减少。

5. 发明授权

US07985234B2 Medical device 有权
标题翻译：医疗装置
公开(公告)号：US07985234B2
公开(公告)日：2011-07-26
申请号：US10083926
申请日：2002-02-27
申请人： Lixiao Wang , Steve Wu , Ronald A. Sahatjian , Albert Chin , Peter Dayton
发明人： Lixiao Wang , Steve Wu , Ronald A. Sahatjian , Albert Chin , Peter Dayton
IPC分类号： A61M25/10
CPC分类号： A61B17/320725 , A61M25/10 , A61M25/1027 , A61M2025/1088
摘要： A medical device includes an inflatable balloon formed having portions of different materials, and a cutting element carried by the balloon. The materials can have different distensibility and/or compliancy.
摘要翻译：医疗装置包括形成有不同材料部分的可膨胀气囊和由气囊承载的切割元件。这些材料可以具有不同的扩张性和/或符合性。

6. 发明授权

US09034346B2 Implantable or insertable medical device resistant to microbial growth and biofilm formation 有权
标题翻译：可植入或可插入的医疗器械抗微生物生长和生物膜形成
公开(公告)号：US09034346B2
公开(公告)日：2015-05-19
申请号：US13357033
申请日：2012-01-24
申请人： Kathleen M. Miller , Gregory T. Sydney , Kurt Geitz , Peter L. Dayton , Ronald A. Sahatjian
发明人： Kathleen M. Miller , Gregory T. Sydney , Kurt Geitz , Peter L. Dayton , Ronald A. Sahatjian
IPC分类号： A61L2/232 , A61L29/16 , A61L31/16
CPC分类号： A61L2/232 , A61L29/16 , A61L31/16 , A61L2300/202 , A61L2300/206 , A61L2300/21 , A61L2300/404 , A61L2300/45 , Y10T428/1334 , Y10T428/1352 , Y10T428/1372 , Y10T428/1379 , Y10T428/1386 , Y10T428/1393
摘要： Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.
摘要翻译：公开了可植入或可插入的医疗装置，其在装置的环境和环境中提供对微生物生长的抵抗力，并且抵抗微生物附着和在装置上的生物膜形成。特别地，本发明公开了可植入或可插入的医疗装置，其包括至少一个生物相容性基质聚合物区域，用于提供对微生物生长的抗性的抗微生物剂和用于抑制微生物附着的微生物粘附/生物膜合成抑制剂以及合成和积累生物膜在医疗器械的表面上。还公开了在基本上防止任何所述生物活性剂优先分配到生物相容性基质聚合物的表面并基本上防止所述生物活性剂的化学修饰的条件下制造这种装置的方法。

7. 发明申请

US20110172753A1 ENDOPROSTHESES 审中-公开
公开(公告)号：US20110172753A1
公开(公告)日：2011-07-14
申请号：US13053461
申请日：2011-03-22
申请人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
发明人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/022 , A61L31/04 , A61L31/16 , A61L2300/402 , Y10T428/24926 , C08L75/04 , C08L83/04
摘要： Endoprosthesis are disclosed.
摘要翻译：公开内置假体。

8. 发明授权

US5919145A Bodily sample collection balloon catheter 失效
标题翻译：身体样本采集球囊导管
公开(公告)号：US5919145A
公开(公告)日：1999-07-06
申请号：US787303
申请日：1997-01-24
申请人： Ronald A. Sahatjian
发明人： Ronald A. Sahatjian
IPC分类号： A61B10/00 , A61B10/04 , A61M29/02
CPC分类号： A61B10/04 , A61M2025/109 , A61M25/104
摘要： Treating a patient by collecting a bodily sample from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a polymer on its outer surface capable of receiving a substantial amount of bodily sample. The catheter is positioned within the body and the sample is taken by exposing the polymer by placing it in proximity within a desired location so that the bodily sample is received by the polymer. The catheter is removed from the patient and the sample is collected outside the body.
摘要翻译：通过从患者体内的深处收集身体样品并将样品收集在身体外部以便于治疗患者来治疗患者。以细长导管的形式提供采样探针，其具有保留在身体外侧的近端部分和可位于体内的远侧部分。远侧部分在其外表面上包括能够接收大量身体样品的聚合物。导管定位在体内，并且通过将聚合物放置在所需位置附近而使聚合物暴露而使样品被采集，使得身体样品被聚合物接收。从患者身上取出导管，将样品收集在体外。

9. 发明授权

US5797877A Medical device balloons containing thermoplastic elastomers 失效
公开(公告)号：US5797877A
公开(公告)日：1998-08-25
申请号：US653117
申请日：1996-05-24
申请人： Bruce Hamilton , Ronald A. Sahatjian
发明人： Bruce Hamilton , Ronald A. Sahatjian
IPC分类号： A61F2/958 , A61L29/00 , A61L29/04 , A61M25/00 , A61M29/00
CPC分类号： A61M25/1029 , A61L29/049 , A61M25/0045 , A61M25/1002 , A61M2025/1075 , A61M25/1038
摘要： A dilatation balloon and catheter for insertion into a bodily conduit. The catheter (10) includes shaft (12) and a dilatation balloon (24) at the distal end of the shaft. The balloon is inflated via a central lumen (14) in the shaft for delivery of a fluid inflation media. The balloon is fabricated from a combination of a thermoplastic elastomer (TPE), preferably an engineering thermoplastic elastomer (ETE), with a non-compliant structural polymeric material. The combination may be a blend of the non-compliant structural polymer and the TPE. Alternatively, the combination may be a layered balloon having, for example, a non-compliant structural polymer inner layer and a soft, abrasion resistant, elastomeric outer layer. Methods for fabricating the balloon from the combination of a TPE and a non-compliant structural polymer are also disclosed.

10. 发明授权

US5533516A Sample collection 失效
标题翻译：样品收集
公开(公告)号：US5533516A
公开(公告)日：1996-07-09
申请号：US392101
申请日：1995-02-22
申请人： Ronald A. Sahatjian
发明人： Ronald A. Sahatjian
IPC分类号： A61B10/00 , A61B10/02 , A61B10/04 , A61B17/00 , A61B17/22 , A61F2/958
CPC分类号： A61B10/0275 , A61B10/04 , A61B17/320725 , A61B2017/00292 , A61B2017/22001 , A61M2025/1072 , A61M2025/1086 , A61M2025/109 , A61M25/10
摘要： Taking a bodily sample, e.g., a cell sample, from deep within the body of a patient and collecting the sample outside the body to facilitate treatment of the patient. A sampling probe is provided in the form of an elongate catheter having a proximal portion that remains outside the body and a distal portion that can be located within the body. The distal portion includes a membrane with openings that communicate with space that communicates with a source of suction force. The catheter is positioned within the body. The sample is taken by exposing the membrane by placing it in proximity with a desired location so that the bodily sample is received by the membrane. The catheter is removed from the patient, the sample is collected outside the body, treated, disposed onto a device, such as a graft, stent, or catheter, and reintroduced into the body at a desired site.
摘要翻译：从患者体内的深处取出身体样品，例如细胞样品，并将样品收集在身体外部，以便于患者的治疗。以细长导管的形式提供采样探针，其具有保留在身体外侧的近端部分和可位于体内的远侧部分。远端部分包括具有开口的膜，所述开口与空气连通，其与吸力源连通。导管位于体内。通过将膜放置在所需位置附近，使膜暴露于样品，使得身体样品被膜接收。将导管从患者身上取出，将样品收集在身体外部，进行处理，置于诸如移植物，支架或导管的装置上，并在期望的位置重新引入体内。

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