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1. 发明申请

US20100121231A1 MECHANICALLY ACTIVATED OBJECTS FOR TREATMENT OF DEGENERATIVE RETINAL DISEASE 有权
标题翻译：用于治疗退行性疾病的机械性激活物
公开(公告)号：US20100121231A1
公开(公告)日：2010-05-13
申请号：US12576891
申请日：2009-10-09
申请人： Alan Y. Chow , George Y. McLean , Vincent Y. Chow , Jay Cech , Christopher M. Bonner , Vladimir Gelfandbein
发明人： Alan Y. Chow , George Y. McLean , Vincent Y. Chow , Jay Cech , Christopher M. Bonner , Vladimir Gelfandbein
IPC分类号： A61F9/00
CPC分类号： A61N1/36046 , A61H5/00 , A61N1/0543 , A61N2/06 , A61N2/12
摘要： Mechanically activated objects or devices for use in treating degenerative retinal diseases are provided. Such devices apply mechanical forces to tissues of an eye to effectuate treatment and are configured for chronic implantation (thereby applying chronic stimulation/irritation) in or on the eye. The devices may be configured for contact with a retina of the eye, preferably positioned in a subretinal space. Various embodiments comprise a moving member configured for chronic contact with at least a portion of the eye, which moving member is activated by an actuator. In some embodiments, the actuator may be distally located relative to the moving member. Alternatively, the moving member may be supported by a body member that, optionally, also supports the actuator.
摘要翻译：提供用于治疗退行性视网膜疾病的机械活化物体或装置。这样的装置将机械力施加到眼睛的组织以实现治疗，并且被配置为在眼睛中或眼睛上进行慢性植入（从而施加慢性刺激/刺激）。所述装置可以被配置为与眼睛的视网膜接触，优选地定位在视网膜下空间中。各种实施例包括构造成用于与眼睛的至少一部分慢性接触的移动构件，该移动构件由致动器致动。在一些实施例中，致动器可以相对于移动构件向远侧定位。或者，移动构件可以由主体构件支撑，其可选地还支撑致动器。

2. 发明授权

US06574022B2 Integral differential optical signal receiver 失效
公开(公告)号：US06574022B2
公开(公告)日：2003-06-03
申请号：US09812214
申请日：2001-03-19
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： H04B1000
CPC分类号： H04B10/69 , G02B6/4202 , G02B6/4206 , H04B10/6911
摘要： An optical signal receiver for rapid and error free translation of optical signals into electrical signals is disclosed. The receiver is coupled to a light source. The light source is amplified and then split into two segments. One of the segments is delayed by a specific amount of time. Both segments are optically coupled to a photo detector. Each photo detector is coupled in parallel and are connected by two output terminals. When the voltage output by each photo detector is equal, the output terminals are balanced and will not have any voltage. The circuit will provide a voltage output on the terminal only on differential photocurrents sensed by the detector elements. The quiescent magnitude of the voltage output is a function of the value of the reverse bias voltage applied by the two voltage sources.

3. 发明授权

US6075251A Optical transmitter data compression system 失效
标题翻译：光发射机数据压缩系统
公开(公告)号：US6075251A
公开(公告)日：2000-06-13
申请号：US312145
申请日：1999-05-14
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： G01D21/00 , H01L25/16 , H01L27/14 , H01L27/146 , H01L31/08 , H01L31/10 , H03K17/00 , H03K17/78 , H04B10/00 , H04N7/24 , G02B27/00
CPC分类号： H04B10/032 , H04N3/1506 , H04N3/1512 , H04N3/155
摘要： The present invention relates to a transmission method and device for efficient compression of digital data. The invention uses an optoelectronic coupler to receive light signals from a light transmitter at two bandwidths. A modulated signal generator is coupled to the transmitter which coverts voltage phase data signals to light signals. The data signals are modulated with a plurality of master profiles and subprofiles with different cycle time variations. The optoelectronic coupler has a pair of photodiodes. Light filters disposed on both diodes allow either the first or second bandwidth of light to pass. Conductors electrically couple the anode of the each photodiode to the cathode of the other photodiode which produce the voltage phase signal. A signal receiver is connected to the coupler and decodes the voltage-phase signal.
摘要翻译：本发明涉及数字数据有效压缩的传输方法和装置。本发明使用光电耦合器以两个带宽从光发射器接收光信号。调制信号发生器耦合到发射器，其将电压相位数据信号覆盖到光信号。数据信号用具有不同周期时间变化的多个主配置文件和子配置进行调制。光电耦合器具有一对光电二极管。布置在两个二极管上的滤光片允许光的第一或第二带宽通过。导体将每个光电二极管的阳极电耦合到产生电压相位信号的另一个光电二极管的阴极。信号接收器连接到耦合器并解码电压相位信号。

4. 发明授权

US5949064A Opsistor image processor with a reference detector and a reference image 失效
标题翻译：具有参考检测器和参考图像的Opsistor图像处理器
公开(公告)号：US5949064A
公开(公告)日：1999-09-07
申请号：US977853
申请日：1997-11-25
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： G01D21/00 , H01L25/16 , H01L27/14 , H01L27/146 , H01L31/08 , H01L31/10 , H03K17/00 , H03K17/78 , H04B10/00 , H04N7/24 , H01J40/14
CPC分类号： H04B10/032 , H04N3/1506 , H04N3/1512 , H04N3/155
摘要： An image processing system for capturing and compressing images into a digital format is disclosed. The system has an array of imaging pixel elements which consist of two photodiode detectors (Opsistor). One photodiode detector is a capture detector while the other detector is a reference detector. The capture detector has an anode electrically coupled to the cathode of the reference detector. The cathode of the capture detector is electrically coupled to the anode of the reference detector. An image may be compared to a reference image detected by the reference detector. Different levels of light between the captured image and the reference image change the electrical output of the opsistor. Image compression is facilitated since only pixel elements which change from frame to frame need be stored. Additionally, a processing and compression circuit may use column and row scans to eliminate unchanged pixels and store only pixels with different light levels between images.
摘要翻译：公开了一种用于将图像捕获和压缩成数字格式的图像处理系统。该系统具有由两个光电二极管检测器（Opsistor）组成的成像像素元件阵列。一个光电二极管检测器是捕获检测器，而另一个检测器是参考检测器。捕获检测器具有电耦合到参考检测器的阴极的阳极。捕获检测器的阴极电耦合到参考检测器的阳极。可以将图像与由参考检测器检测到的参考图像进行比较。拍摄图像和参考图像之间的不同级别的光线会改变opsistor的电气输出。图像压缩是有利的，因为只需要存储从帧到帧改变的像素元素。此外，处理和压缩电路可以使用列扫描和行扫描来消除不变像素，并且仅存储图像之间具有不同光级的像素。

5. 发明授权

US06201234B1 Optical operational amplifier 失效
标题翻译：光学运算放大器
公开(公告)号：US06201234B1
公开(公告)日：2001-03-13
申请号：US09088579
申请日：1998-06-02
申请人： Alan Y Chow , Vincent Y. Chow
发明人： Alan Y Chow , Vincent Y. Chow
IPC分类号： H01J4014
CPC分类号： H01L31/08 , H04B10/032 , H04N3/155 , H04N5/374
摘要： An optical operational amplifier is disclosed. The operational amplifier has a first photodiode with an anode and a cathode. A second photodiode with an anode coupled to the cathode of the first photodiode, and an anode coupled to the cathode of the first photodiode to form an output terminal. A resistor is coupled in parallel with the first and second photodiodes. The inputs to the operational amplifier are light sources which generate different currents in the first and second photodiodes. The output voltage from the output terminal is a function of the difference in currents across the first and second photodiode. The output voltage is amplified in proportion to the value of the resistor. The basic optical operational amplifier configuration may be used in a variety of useful circuits. One example is the use of the amplifier in a position sensing device which determines position of a light beam by the output of photodiode sensing elements. A second example is the use of the operational amplifier in a retinal stimulator device. The output waveform of the operational amplifier may be shaped by the resistor and added capacitative elements to be more compatible with retina cells.
摘要翻译：公开了一种光学运算放大器。运算放大器具有带阳极和阴极的第一光电二极管。具有耦合到第一光电二极管的阴极的阳极的第二光电二极管，以及耦合到第一光电二极管的阴极以形成输出端的阳极。电阻器与第一和第二光电二极管并联耦合。运算放大器的输入是在第一和第二光电二极管中产生不同电流的光源。来自输出端子的输出电压是跨越第一和第二光电二极管的电流差的函数。输出电压与电阻值成比例放大。基本的光学运算放大器配置可以用在各种有用的电路中。一个示例是在位置感测装置中使用放大器，其通过光电二极管感测元件的输出来确定光束的位置。第二个例子是在视网膜刺激器装置中使用运算放大器。运算放大器的输出波形可以由电阻器形成，并且增加的电容元件与视网膜细胞更相容。

6. 发明申请

US20110238134A1 ARTIFICIAL RETINA DEVICE WITH STIMULATING AND GROUND RETURN ELECTRODES DISPOSED ON OPPOSITE SIDES OF THE NEURORETINA AND METHOD OF ATTACHMENT 有权
标题翻译：具有刺激和接地回路电极的人造背景装置处理在神经元的相对面上和附着方法
公开(公告)号：US20110238134A1
公开(公告)日：2011-09-29
申请号：US13153062
申请日：2011-06-03
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： A61F9/08
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： An artificial retina device to electrically stimulate a neuroretina of an eye to produce artificial vision, the artificial retina device comprising: an electrical source; at least one stimulating electrode connected with the electrical source; and at least one ground return electrode connected with the electrical source, wherein the stimulating electrode and ground return electrode are configured to be disposed within the eye on opposite sides of the neuroretina.
摘要翻译：一种人造视网膜装置，用于电刺激眼睛的神经视网膜以产生人造视觉，人造视网膜装置包括：电源; 至少一个与电源连接的刺激电极; 以及与电源连接的至少一个接地返回电极，其中所述刺激电极和接地返回电极被配置为设置在所述眼睛内的所述神经视网膜的相对侧上。

7. 发明授权

US07981062B2 Mechanically activated objects for treatment of degenerative retinal disease 有权
标题翻译：机械活化物体治疗退行性视网膜疾病
公开(公告)号：US07981062B2
公开(公告)日：2011-07-19
申请号：US12576891
申请日：2009-10-09
申请人： Alan Y. Chow , George Y. McLean , Vincent Y. Chow , Jay Cech , Christopher M. Bonner , Vladimir Gelfandbein
发明人： Alan Y. Chow , George Y. McLean , Vincent Y. Chow , Jay Cech , Christopher M. Bonner , Vladimir Gelfandbein
IPC分类号： A61H1/00
CPC分类号： A61N1/36046 , A61H5/00 , A61N1/0543 , A61N2/06 , A61N2/12
摘要： Mechanically activated objects or devices for use in treating degenerative retinal diseases are provided. Such devices apply mechanical forces to tissues of an eye to effectuate treatment and are configured for chronic implantation (thereby applying chronic stimulation/irritation) in or on the eye. The devices may be configured for contact with a retina of the eye, preferably positioned in a subretinal space. Various embodiments comprise a moving member configured for chronic contact with at least a portion of the eye, which moving member is activated by an actuator. In some embodiments, the actuator may be distally located relative to the moving member. Alternatively, the moving member may be supported by a body member that, optionally, also supports the actuator.
摘要翻译：提供用于治疗退行性视网膜疾病的机械活化物体或装置。这样的装置将机械力施加到眼睛的组织以实现治疗，并且被配置为在眼睛中或眼睛上进行慢性植入（从而施加慢性刺激/刺激）。所述装置可以被配置为与眼睛的视网膜接触，优选地定位在视网膜下空间中。各种实施例包括构造成用于与眼睛的至少一部分慢性接触的移动构件，该移动构件由致动器致动。在一些实施例中，致动器可以相对于移动构件向远侧定位。或者，移动构件可以由主体构件支撑，其可选地还支撑致动器。

8. 发明授权

US06427087B1 Artificial retina device with stimulating and ground return electrodes disposed on opposite sides of the neuroretina and method of attachment 有权
公开(公告)号：US06427087B1
公开(公告)日：2002-07-30
申请号：US09564841
申请日：2000-05-04
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： A61N108
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space, and a tail-like extension housing a distant electrical return ground electrode unit that may be placed in the vitreous cavity. The stimulating electrode unit includes an array of electrode subunits. Each electrode subunit includes one or more microphotodiodes electrically connected, for example, in series to provide increased voltage and current to its microelectrode. The stimulating electrode unit and the ground return electrode of the ground return electrode unit are preferably disposed on opposite sides of the neuroretina to allow for efficient and high resolution transretinal electrical stimulation of the neuroretinal cells. Additional photodiodes may be incorporated into the circuitry of the artificial retina device to provide additional bias voltage and current to the microelectrode subunits of the stimulating electrode unit. In another preferred embodiment, the ground return electrode in the tail-like extension is disposed in the capsular bag of the eye, after lens nucleus and cortex removal, where it is electrically connected to an additional bias photodiode or photodiodes.

9. 发明授权

US5837995A Wavelength-controllable voltage-phase photodiode optoelectronic switch ("opsistor") 失效
标题翻译：波长可控电压相位光电二极管光电开关（“opsistor”）
公开(公告)号：US5837995A
公开(公告)日：1998-11-17
申请号：US755729
申请日：1996-11-25
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： G01D21/00 , H01L25/16 , H01L27/14 , H01L27/146 , H01L31/08 , H01L31/10 , H03K17/00 , H03K17/78 , H04B10/00 , H04N7/24 , H01J40/14
CPC分类号： H04B10/032 , H04N3/1506 , H04N3/1512 , H04N3/155
摘要： A wavelength-portion controllable optoelectronic switch ("Opsistor") capable of rapid switch frequencies fabricated as a monolithic integrated circuit is disclosed. The Opsistor is comprised of two inverse parallel photodiodes in close proximity, preferably on a monolithic silicon substrate, such that the anode of one photodiode is electrically connected via a first conductor to the cathode of the second photodiode, and the cathode of the first photodiode is electrically connected via a second conductor to the anode of the second photodiode. The voltage-phase of the Opsistor is determined by the relative illumination to the Opsistor's two photodiodes and is rapidly switchable. As a receiving device for data signals, the Opsistor receives programming signals from a transmitter light source. By using different wavelength-portion bandwidth pass filters on each of the two Opsistor photodiodes, a OPS-F device is created, and by using a two-wavelength transmitter light source designated as TM2, a TM2/OPS-F system is created capable of high data transmission rates, and high resistance to signal noise. Applications suitable for the Opsistor and TM2/OPS-F system include high speed optocouplers, linear optical position sensors, edge and target detection sensors, image recognition sensors, the basic subunits of optically based state computers, and high resolution optical encoders.
摘要翻译：公开了一种能够制造为单片集成电路的快速开关频率的波长部分可控光电开关（“Opsistor”）。 Ops电阻由紧邻的两个反并联光电二极管组成，最好在单片硅衬底上，使得一个光电二极管的阳极经由第一导体与第二光电二极管的阴极电连接，第一光电二极管的阴极经由第二导体电连接到第二光电二极管的阳极。 Opsistor的电压相位由Opsistor的两个光电二极管的相对照度决定，可快速切换。作为数据信号的接收装置，Opsistor接收来自发射器光源的编程信号。通过在两个Opsistor光电二极管中的每一个上使用不同的波长部分带通滤波器，创建了OPS-F器件，并且通过使用被称为TM2的双波长发射器光源，创建TM2 / OPS-F系统，高数据传输速率，高抗信号噪声。适用于Opsistor和TM2 / OPS-F系统的应用包括高速光耦合器，线性光学位置传感器，边缘和目标检测传感器，图像识别传感器，基于光学的状态计算机的基本子单元和高分辨率光学编码器。

10. 发明授权

US08306626B2 Artificial retina device with stimulating and ground return electrodes disposed on opposite sides of the neuroretina and method of attachment 有权
标题翻译：具有设置在神经视网膜的相对侧上的刺激和接地返回电极的人造视网膜装置和附着方法
公开(公告)号：US08306626B2
公开(公告)日：2012-11-06
申请号：US13153062
申请日：2011-06-03
申请人： Alan Y. Chow , Vincent Y. Chow
发明人： Alan Y. Chow , Vincent Y. Chow
IPC分类号： A61F9/08
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： An artificial retina device to electrically stimulate a neuroretina of an eye to produce artificial vision, the artificial retina device comprising: an electrical source; at least one stimulating electrode connected with the electrical source; and at least one ground return electrode connected with the electrical source, wherein the stimulating electrode and ground return electrode are configured to be disposed within the eye on opposite sides of the neuroretina.
摘要翻译：一种人造视网膜装置，用于电刺激眼睛的神经视网膜以产生人造视觉，所述人造视网膜装置包括：电源; 至少一个与电源连接的刺激电极; 以及与电源连接的至少一个接地返回电极，其中所述刺激电极和接地返回电极被配置为设置在所述眼睛内的所述神经视网膜的相对侧上。

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