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1. 发明授权

US3976546A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US3976546A
公开(公告)日：1976-08-24
申请号：US628057
申请日：1975-11-03
申请人： Alan Smith , Ronald W. Larner
发明人： Alan Smith , Ronald W. Larner
IPC分类号： C07D501/04 , C12P35/00 , C12D9/00
CPC分类号： C12P35/00 , Y10S435/911
摘要： 3-Acyloxymethylceph-3-em-4-carboxylic acids, for example cephalosporin C, are enzymically deacylated to their 3-hydroxymethyl analogues by means of esterases produced by culturing microorganisms or mutants thereof of the class Basidiomycetes, particularly of the genus Rhodosporidium, for example a microorganism of the species Rhodosporidium toruloides.
摘要翻译： 3-环氧基甲基头孢-3-烯-4-羧酸，例如头孢菌素C，通过将类似担子菌纲，特别是红假单胞菌属的微生物或其突变体培养而产生的酯酶，酶解为其3-羟甲基类似物，例如红景天菌属的微生物。

2. 发明授权

US09078814B2 Intranasal spray device containing pharmaceutical composition 有权
标题翻译：含有药物组合物的鼻内喷雾装置
公开(公告)号：US09078814B2
公开(公告)日：2015-07-14
申请号：US13541325
申请日：2012-07-03
申请人： Peter James Watts , Jonathan David Castile , William Columbus Ian Lafferty , Alan Smith
发明人： Peter James Watts , Jonathan David Castile , William Columbus Ian Lafferty , Alan Smith
IPC分类号： A61F13/00 , A61K31/445 , A01N43/40 , A01N43/16 , A61K31/35 , A61K9/00 , A61K31/4468
CPC分类号： A61K31/4468 , A61K9/0043 , A61K47/26 , A61K47/36 , A61M11/00 , A61M15/08
摘要： An intrasnal spray device contains a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
摘要翻译：包含用于将芬太尼或其药学上可接受的盐鼻内递送给动物的组合物包括芬太尼或其药学上可接受的盐的水溶液和选自以下的药学上可接受的添加剂：（i）果胶和（ii）泊洛沙姆和壳聚糖或其盐或衍生物; 条件是当组合物包含果胶时，其基本上不含二价金属离子; 并且与以相同剂量鼻内施用的芬太尼的简单水溶液相比，提供了芬太尼（C max）的峰值血浆浓度，其为使用芬太尼简单的水溶液，其在鼻内给药时的10至80％芬太尼剂量相同。还公开了通过鼻内施用组合物治疗或治疗疼痛的方法。

3. 发明授权

US08710028B2 Pharmaceutical powder compositions 失效
标题翻译：药粉组合物
公开(公告)号：US08710028B2
公开(公告)日：2014-04-29
申请号：US12675306
申请日：2008-08-29
申请人： Peter James Watts , Yu-Hui Cheng , Alan Smith , Jonathan Castile
发明人： Peter James Watts , Yu-Hui Cheng , Alan Smith , Jonathan Castile
IPC分类号： A61K31/55 , A61K31/70
CPC分类号： A61K9/0043 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K9/19 , A61K31/5513 , A61K31/5517
摘要： A powder composition for intranasal delivery includes a benzodiazepine drug and chitosan, a salt of chitosan, a derivative of chitosan or a salt of a derivative of chitosan.
摘要翻译：用于鼻内递送的粉末组合物包括苯并二氮杂药物和壳聚糖，壳聚糖的盐，壳聚糖的衍生物或壳聚糖的衍生物的盐。

4. 发明授权

US08709996B2 Pharmaceutical treatment process using chitosan or derivative thereof 失效
标题翻译：使用壳聚糖或其衍生物的药物处理方法
公开(公告)号：US08709996B2
公开(公告)日：2014-04-29
申请号：US12766487
申请日：2010-04-23
申请人： Michael Leane , Alan Smith , Lisbeth Illum
发明人： Michael Leane , Alan Smith , Lisbeth Illum
IPC分类号： A61K31/722 , A61K38/28 , A61K38/16 , A61K33/42 , A61K38/12 , A61K38/21 , A61K38/20 , A61K9/48
CPC分类号： A61K9/4808 , A61K9/1617 , A61K9/1652 , A61K9/205 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/722 , A61K38/00
摘要： The present invention provides a solid composition for oral administration comprising: (i) a drug compound; (ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of chitosan; and (iii) an organic acid. Preferably the drug compound is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide. The compositions of the invention provide enhance absorption of the drug compound.
摘要翻译：本发明提供一种用于口服给药的固体组合物，其包含：（i）药物化合物; （ii）壳聚糖或其衍生物或壳聚糖的盐或壳聚糖衍生物的盐; 和（iii）有机酸。优选地，药物化合物是分子量为1KDa或更小的极性分子，肽，蛋白质或多糖。本发明的组合物提供药物化合物的增强吸收。

5. 发明授权

US07947257B2 Method of intranasal administration of granisetron 有权
标题翻译：格拉司琼鼻内给药方法
公开(公告)号：US07947257B2
公开(公告)日：2011-05-24
申请号：US11004556
申请日：2004-12-03
申请人： Peter James Watts , Alan Smith , Jonathan Castile
发明人： Peter James Watts , Alan Smith , Jonathan Castile
IPC分类号： A61K9/08 , A61K9/12
CPC分类号： A61K9/0043 , A61K31/435
摘要： Compositions are provided for the intranasal administration of granisetron or a pharmaceutically acceptable salt thereof. Preferred compositions are in the form of an aqueous solution. Optionally, the compositions comprise chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention of nausea and/or vomiting.
摘要翻译：提供了用于格拉司琼或其药学上可接受的盐的鼻内给药的组合物。优选的组合物是水溶液的形式。任选地，组合物包含壳聚糖，其盐或衍生物或壳聚糖衍生物的盐。该组合物可用于治疗或预防恶心和/或呕吐。

6. 发明授权

US07384396B2 System and method for continuous analyte monitoring 有权
标题翻译：用于连续分析物监测的系统和方法
公开(公告)号：US07384396B2
公开(公告)日：2008-06-10
申请号：US10435221
申请日：2003-05-08
申请人： Mark A. Samuels , Jonathan A. Eppstein , Michael R. Hatch , Alan Smith , Mark Faupel
发明人： Mark A. Samuels , Jonathan A. Eppstein , Michael R. Hatch , Alan Smith , Mark Faupel
IPC分类号： A61B5/00
CPC分类号： A61B5/14514 , A61B5/00 , A61B5/0002 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/150862 , A61B5/150969 , A61B5/150984 , A61B5/15134 , A61B5/155 , A61B5/157 , A61B10/0045 , A61B2010/008
摘要： A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.
摘要翻译：一种用于从生物体提取生物流体并连续监测其特征的系统和方法。该系统包括适于定位在生物体的生物膜的表面上或周围的组织界面装置以及耦合到组织界面装置的监测和控制单元。组织接口装置包括定位在流体的流动路径中的传感器，用于在生物流体从形成在生物膜中的一个或多个人造开口流出时持续感测生物流体的特性。传感器产生代表其的传感器信号。监视器和控制单元以电或光学方式读取传感器，以连续的方式获得生物流体特性的浓度，例如特定分析物的浓度。

7. 发明申请

US20060214592A1 Gas discharge lamp power supply 失效
标题翻译：气体放电灯电源
公开(公告)号：US20060214592A1
公开(公告)日：2006-09-28
申请号：US11091350
申请日：2005-03-28
申请人： William Hopkins , Anthony Banks , Alan Smith , Louis Pickvet , Robert Towe , Charles Schlemm
发明人： William Hopkins , Anthony Banks , Alan Smith , Louis Pickvet , Robert Towe , Charles Schlemm
IPC分类号： H01J13/46
CPC分类号： H05B41/00
摘要： A gas discharge lamp power supply having a base, a pair of opposed side walls extending from the base, and opposed first and second end walls extending from the base between the opposed side walls. The first end wall has a sloped wall extending angularly between the side walls, and two input terminals are mounted on the sloped wall. In another embodiment, the power supply has a control with a nonvolatile memory for storing an error code in response to a detected fault condition, thereby permitting the error code to be displayed upon power being removed from and then, subsequently reapplied.
摘要翻译：一种气体放电灯电源，具有基座，从基座延伸的一对相对的侧壁，以及在相对的侧壁之间从基部延伸的相对的第一和第二端壁。第一端壁具有在侧壁之间成角度延伸的倾斜壁，并且两个输入端子安装在倾斜壁上。在另一个实施例中，电源具有用于响应于检测到的故障状况而存储错误代码的非易失性存储器的控制，从而允许在从被重新施加电力并随后被重新应用的电力时显示错误代码。

8. 发明申请

US20060189857A1 System and method for monitoring or treating a health condition 审中-公开
标题翻译：用于监测或治疗健康状况的系统和方法
公开(公告)号：US20060189857A1
公开(公告)日：2006-08-24
申请号：US11412491
申请日：2006-04-27
申请人： Mark Faupel , Raulee Marcus , Alan Smith , Difei Yang
发明人： Mark Faupel , Raulee Marcus , Alan Smith , Difei Yang
IPC分类号： A61B5/00
CPC分类号： A61B5/145 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/441 , A61B5/4839
摘要： The present invention relates to a system and method for monitoring or treating a health condition. The method can include accessing a biological fluid, evaluating an analyte in the fluid, presenting a measurement parameter based on the evaluation, and/or administering a treatment based on the evaluation. The measurement parameter can prompt administering a treatment. The system can include a fluid handling device, a display and/or alert device, and/or an administration device. This abstract is provided for searching purposes only and is not meant for construing the claims.
摘要翻译：本发明涉及一种用于监测或治疗健康状况的系统和方法。该方法可以包括进入生物流体，评估流体中的分析物，基于评估呈现测量参数，和/或基于评估进行治疗。测量参数可以促进治疗。该系统可以包括流体处理装置，显示器和/或警报装置，和/或管理装置。本摘要仅用于搜索目的，而不是用于解释权利要求。

9. 发明申请

US20060129871A1 Apparatus, system, and method for analyzing trace data 有权
标题翻译：用于分析跟踪数据的装置，系统和方法
公开(公告)号：US20060129871A1
公开(公告)日：2006-06-15
申请号：US10999452
申请日：2004-11-30
申请人： Alan Smith
发明人： Alan Smith
IPC分类号： G06F11/00
CPC分类号： G06F11/3476 , G06F17/30569 , Y10S707/99945 , Y10S707/99948
摘要： An apparatus, system, and method are disclosed for analyzing trace data that facilitates the analysis by minimizing extraneous results presented to a user. The apparatus includes a user interface to define a query expression based on a condition and one or more parameters and to display a report of trace entries satisfying the query expression. A record handler retrieves an unstructured trace record from a storage device or database. A structuring module divides the unstructured trace record logically into two or more trace entries based on structural information. A comparison module applies the query expression to each entry. This application of the query expression may include further sub-dividing the entry logically to search on a sub-entry level. The comparison module assembles entries satisfying the query expression into an abridged trace record. A report engine combines the abridged trace records into a report of trace entries satisfying the query expression.
摘要翻译：公开了一种用于分析跟踪数据的装置，系统和方法，用于通过使提供给用户的外部结果最小化来便于分析。该装置包括用户界面，用于基于条件和一个或多个参数定义查询表达式，并显示满足查询表达式的跟踪条目的报告。记录处理程序从存储设备或数据库中检索非结构化跟踪记录。结构化模块基于结构信息将非结构化跟踪记录逻辑地分成两个或多个跟踪条目。比较模块将查询表达式应用于每个条目。查询表达式的该应用可以包括在逻辑上进一步细分条目以在子条目级上搜索。比较模块将满足查询表达式的条目汇编成一条精简的跟踪记录。报告引擎将简化的跟踪记录合并到满足查询表达式的跟踪条目的报告中。

10. 发明授权

US07041057B1 Tissue interface device 失效
标题翻译：组织界面装置
公开(公告)号：US07041057B1
公开(公告)日：2006-05-09
申请号：US10130686
申请日：2000-11-17
申请人： Mark L. Faupel , Krishna Kumar , J. David Farquhar , Mark Vreeke , Alan Smith , Michael Hatch , Teresa Woods
发明人： Mark L. Faupel , Krishna Kumar , J. David Farquhar , Mark Vreeke , Alan Smith , Michael Hatch , Teresa Woods
IPC分类号： A61B5/00 , A61B5/05 , A61B5/04
CPC分类号： A61B5/1486
摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.
摘要翻译：适于定位在生物体的生物膜中的一个或多个人造开口上或周围的组织界面装置（10），并用于耦合到监测和控制单元和真空源。组织接口装置（10）包括壳体（100），传感器通道（130）和传感器（150）。壳体（100）限定孔口（120），孔口（120）在壳体（100）的底端（102）上具有开放的入口端口（122）和远端（124），该远端端部与传感器通道（130）连接。孔口（120）与从生物膜中形成的人造开口流动的流体流体连通。传感器通道（130）用于耦合到真空源并与之流体连通。传感器（150）在流体的流动路径中位于传感器通道（130）中，用于感测流体从人造开口流出时的特性。传感器产生代表其的传感器信号。

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