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1. 发明申请

US20060229298A1 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效
公开(公告)号：US20060229298A1
公开(公告)日：2006-10-12
申请号：US11436099
申请日：2006-05-17
申请人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Dollar , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl Steenstra , Helen Yin , Robert DeSimone , Xiao-shu He
发明人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Dollar , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl Steenstra , Helen Yin , Robert DeSimone , Xiao-shu He
IPC分类号： A61K31/496 , A61K31/551 , A61K31/495 , C07D403/02
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

2. 发明申请

US20050065162A1 MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES 失效
标题翻译：梅拉宁浓缩激素受体配体：取代的1-苄氧基-4-芳基哌嗪类似物
公开(公告)号：US20050065162A1
公开(公告)日：2005-03-24
申请号：US10152189
申请日：2002-05-21
申请人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Doller , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Yiping Shen , Cheryl Steenstra , Helen Yin , Xiao-shu He
发明人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Doller , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Yiping Shen , Cheryl Steenstra , Helen Yin , Xiao-shu He
IPC分类号： G01N33/53 , A61K31/352 , A61K31/451 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/551 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P43/00 , C07D209/86 , C07D211/44 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D223/04 , C07D239/47 , C07D243/08 , C07D295/08 , C07D295/096 , C07D295/108 , C07D295/18 , C07D311/18 , C07D311/58 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D513/04 , G01N33/566 , C07D43/14
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译：提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

3. 发明授权

US07241765B2 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效
标题翻译：黑色素浓缩激素受体配体：取代的1-苄基-4-芳基哌嗪类似物
公开(公告)号：US07241765B2
公开(公告)日：2007-07-10
申请号：US11436099
申请日：2006-05-17
申请人： Alan J. Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl K. Steenstra , Helen Yin , Robert W. DeSimone , Xiao-shu He
发明人： Alan J. Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl K. Steenstra , Helen Yin , Robert W. DeSimone , Xiao-shu He
IPC分类号： A61K31/495 , C07D295/096 , A61K31/451
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译：提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

4. 发明授权

US06953801B2 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效
标题翻译：黑色素浓缩激素受体配体：取代的1-苄基-4-芳基哌嗪类似物
公开(公告)号：US06953801B2
公开(公告)日：2005-10-11
申请号：US10152189
申请日：2002-05-21
申请人： Alan Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Yiping Shen , Cheryl Steenstra
发明人： Alan Hutchison , Linda M. Gustavson , John M. Peterson , Dario Doller , Timothy M. Caldwell , Taeyoung Yoon , Wallace C. Pringle , Yiping Shen , Cheryl Steenstra
IPC分类号： G01N33/53 , A61K31/352 , A61K31/451 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/551 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P43/00 , C07D209/86 , C07D211/44 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D223/04 , C07D239/47 , C07D243/08 , C07D295/08 , C07D295/096 , C07D295/108 , C07D295/18 , C07D311/18 , C07D311/58 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D513/04 , G01N33/566
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译：提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物）。这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

5. 发明授权

US07160879B2 Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues 失效
标题翻译：黑色素浓缩激素受体配体：取代的2-（4-苄基 - 哌嗪-1-基甲基） - 和2-（4-苄基 - 二氮杂环庚烷-1-基甲基）-1H-苯并咪唑类似物
公开(公告)号：US07160879B2
公开(公告)日：2007-01-09
申请号：US10339499
申请日：2003-01-09
申请人： Robert W. DeSimone , John M. Peterson , Cheryl Steenstra , Yiping Shen , Linda M. Gustavson , Christopher Mach , Alan Hutchison
发明人： Robert W. DeSimone , John M. Peterson , Cheryl Steenstra , Yiping Shen , Linda M. Gustavson , Christopher Mach , Alan Hutchison
IPC分类号： A61P15/00 , A61K31/55 , A61K31/495 , C07D243/08 , C07D401/00
CPC分类号： C07D401/06 , C07D235/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要： Melanin concentrating hormone receptor ligands (especially substituted 2-(4-benzyl-piperazin-1-ylmethyl)-1H-benzoimidazole analogues), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
摘要翻译：提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是取代的2-（4-苄基 - 哌嗪-1-基甲基）-1H-苯并咪唑类似物）。这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

6. 发明授权

US08003326B2 Method for diagnosing autism spectrum disorder 有权
标题翻译：诊断自闭症谱系障碍的方法
公开(公告)号：US08003326B2
公开(公告)日：2011-08-23
申请号：US12347411
申请日：2008-12-31
申请人： Bai-Lin Wu , Yiping Shen , David T. Miller , Orah S. Platt
发明人： Bai-Lin Wu , Yiping Shen , David T. Miller , Orah S. Platt
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides methods of diagnosing and/or predicting autism spectrum disorder comprising determining the presence of microdeletions and microduplications on chromosomes 15 and 16.
摘要翻译：本发明提供诊断和/或预测自闭症谱系障碍的方法，包括确定染色体15和16上微缺失和微复制的存在。

7. 发明授权

US08776240B1 Pre-scan by historical URL access 有权
标题翻译：按历史URL访问进行预扫描
公开(公告)号：US08776240B1
公开(公告)日：2014-07-08
申请号：US13105379
申请日：2011-05-11
申请人： Weimin Wu , Kai Yu , Yiping Shen , Xuewen Zhu , Xingqi Ding
发明人： Weimin Wu , Kai Yu , Yiping Shen , Xuewen Zhu , Xingqi Ding
IPC分类号： G06F11/00
CPC分类号： G06F21/567 , G06F21/568 , G06F2221/2115 , G06F2221/2119
摘要： A Web browser or operating system of a computer maintains a historical URL list of Web sites and Web pages that have been accessed in the past. When a prescan module of antivirus software performs an initial prescan of a computer before the antivirus software is installed, it queries this historical URL list to obtain the URLs that have been accessed in the past. These URLs are sent to a URL online query service located remotely over the Internet in order to determine the status of any of these URLs. Each URL is attempted to be matched with a database of known malicious URLs including associated malicious files and associated cleanup patterns. The query service then informs the requesting computer of the status of a particular URL sent, sending back any related malicious files and any appropriate cleanup pattern. A time period associated with each URL in the database indicates when it is known that the URL was malicious.
摘要翻译：计算机的Web浏览器或操作系统维护过去访问过的网站和网页的历史URL列表。当防病毒软件的预扫描模块在安装防病毒软件之前执行计算机的初始预扫描时，它会查询此历史URL列表以获取过去访问过的URL。这些URL被发送到通过Internet远程位置的URL在线查询服务，以便确定这些URL中的任何一个的状态。尝试将每个URL与已知恶意URL的数据库进行匹配，包括相关联的恶意文件和关联的清理模式。查询服务然后通知请求计算机发送的特定URL的状态，发回任何相关的恶意文件和任何适当的清理模式。与数据库中的每个URL相关联的时间段指示何时知道URL是恶意的。

8. 发明授权

US07365068B2 Substituted aryl acylthioureas and related compounds; inhibitors of viral replication 失效
标题翻译：取代的芳基酰基硫脲和相关化合物; 病毒复制抑制剂
公开(公告)号：US07365068B2
公开(公告)日：2008-04-29
申请号：US11131013
申请日：2005-05-17
申请人： Avinash Phadke , Dawei Chen , Milind Deshpande , Andrew Thurkauf , Xiangzhu Wang , Yiping Shen , Cuixian Liu , Jesse Quinn , Junko Ohkanda , Shouming Li
发明人： Avinash Phadke , Dawei Chen , Milind Deshpande , Andrew Thurkauf , Xiangzhu Wang , Yiping Shen , Cuixian Liu , Jesse Quinn , Junko Ohkanda , Shouming Li
IPC分类号： A61K31/496 , A61K31/444 , A61K31/5377 , C07D211/78 , C07D401/02 , C07D401/06 , C07D413/02 , C07D413/06
CPC分类号： C07D295/15 , C07C335/26 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/64 , C07D211/78 , C07D213/56 , C07D213/82 , C07D215/54 , C07D231/14 , C07D233/54 , C07D233/64 , C07D233/90 , C07D237/24 , C07D239/28 , C07D241/24 , C07D241/44 , C07D249/06 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D265/30 , C07D271/12 , C07D277/56 , C07D277/68 , C07D285/06 , C07D307/68 , C07D307/84 , C07D307/85 , C07D309/38 , C07D311/58 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
摘要翻译：本发明提供式I的化合物和药学上可接受的盐，其中变量A 1，A 2，R 1，R 2， / SUB>，V，W，X，Y和Z在本文中定义。某些本文所述的具有强抗病毒活性的式I化合物。本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。这些传染病包括病毒感染，特别是HCV感染。本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

9. 发明授权

US07767706B2 Substituted aryl acylthioureas and related compounds; inhibitors of viral replication 失效
标题翻译：取代的芳基酰基硫脲和相关化合物; 病毒复制抑制剂
公开(公告)号：US07767706B2
公开(公告)日：2010-08-03
申请号：US12036728
申请日：2008-02-25
申请人： Avinash Phadke , Dawei Chen , Milind Deshpande , Andrew Thurkauf , Xiangzhu Wang , Yiping Shen , Cuixian Liu , Jesse Quinn , Junko Ohkanda , Shouming Li
发明人： Avinash Phadke , Dawei Chen , Milind Deshpande , Andrew Thurkauf , Xiangzhu Wang , Yiping Shen , Cuixian Liu , Jesse Quinn , Junko Ohkanda , Shouming Li
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D295/15 , C07C335/26 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/64 , C07D211/78 , C07D213/56 , C07D213/82 , C07D215/54 , C07D231/14 , C07D233/54 , C07D233/64 , C07D233/90 , C07D237/24 , C07D239/28 , C07D241/24 , C07D241/44 , C07D249/06 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D265/30 , C07D271/12 , C07D277/56 , C07D277/68 , C07D285/06 , C07D307/68 , C07D307/84 , C07D307/85 , C07D309/38 , C07D311/58 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
摘要翻译：本发明提供式I的化合物和药学上可接受的盐，其中变量A1，A2，R1，R2，V，W，X，Y和Z在本文中定义。某些本文所述的具有强抗病毒活性的式I化合物。本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。这些传染病包括病毒感染，特别是HCV感染。本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

10. 发明申请

US20060014836A1 Substituted aryl thioureas and related compounds; inhibitors of viral replication 失效
公开(公告)号：US20060014836A1
公开(公告)日：2006-01-19
申请号：US11015300
申请日：2004-12-17
申请人： Dawei Chen , Milind Deshpande , Andrew Thurkauf , Avinash Phadke , Xiangzhu Wang , Yiping Shen , Cuixian Liu , Jesse Quinn , Junko Ohkanda , Shouming Li
发明人： Dawei Chen , Milind Deshpande , Andrew Thurkauf , Avinash Phadke , Xiangzhu Wang , Yiping Shen , Cuixian Liu , Jesse Quinn , Junko Ohkanda , Shouming Li
IPC分类号： A61K31/17 , C07C335/26
CPC分类号： C07D209/48 , C07C335/26 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/16 , C07D207/34 , C07D207/416 , C07D209/42 , C07D211/14 , C07D211/62 , C07D211/70 , C07D211/86 , C07D213/64 , C07D213/65 , C07D213/81 , C07D215/06 , C07D215/48 , C07D217/04 , C07D231/14 , C07D233/42 , C07D233/90 , C07D239/26 , C07D241/24 , C07D241/44 , C07D249/06 , C07D257/04 , C07D261/18 , C07D263/34 , C07D263/57 , C07D271/08 , C07D271/12 , C07D277/56 , C07D277/66 , C07D277/68 , C07D285/06 , C07D295/135 , C07D295/15 , C07D307/52 , C07D307/68 , C07D307/85 , C07D311/24 , C07D311/66 , C07D317/66 , C07D319/20 , C07D333/20 , C07D333/34 , C07D333/38 , C07D333/70 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04
摘要： The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

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