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1. 发明授权

US07183294B2 Indole derivatives useful for the treatment of diseases 失效
标题翻译：用于治疗疾病的吲哚衍生物
公开(公告)号：US07183294B2
公开(公告)日：2007-02-27
申请号：US10800253
申请日：2004-03-12
申请人： Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon John Mantell
发明人： Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon John Mantell
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/4045 , C07D401/12 , C07D209/14
CPC分类号： C07D209/42 , C07D401/12 , C07D417/12
摘要： The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及吲哚衍生物和制备用于制备含有这些衍生物的组合物和用途的中间体的方法。根据本发明的吲哚衍生物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

2. 发明授权

US07067541B2 2-amino-pyridine derivatives useful for the treatment of diseases 失效
标题翻译：用于治疗疾病的2-氨基 - 吡啶衍生物
公开(公告)号：US07067541B2
公开(公告)日：2006-06-27
申请号：US10860771
申请日：2004-06-03
申请人： Alan Daniel Brown , Justin Stephen Bryans , Charlotte Alice Louise Lane , Simon John Mantell
发明人： Alan Daniel Brown , Justin Stephen Bryans , Charlotte Alice Louise Lane , Simon John Mantell
IPC分类号： A61K31/47 , C07D211/72
CPC分类号： C07D213/73
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

3. 发明申请

US20110251164A1 Carboxamide Derivatives As Muscarinic Receptor Antagonists 有权
标题翻译：甲酰胺衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US20110251164A1
公开(公告)日：2011-10-13
申请号：US12828732
申请日：2010-07-01
申请人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
发明人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
IPC分类号： A61K31/58 , A61K31/423 , A61P11/00 , A61K31/397 , A61K31/56 , A61P11/06 , A61K31/40 , A61K31/445
CPC分类号： C07D207/12 , C07D205/02 , C07D205/04 , C07D207/04 , C07D211/26 , C07D211/46 , C07D413/12
摘要： The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.
摘要翻译：本发明涉及式的化合物及其制备中间体，它们用作毒蕈碱性拮抗剂和含有它们的药物组合物。

4. 发明授权

US07772223B2 Carboxamide derivatives as muscarinic receptor antagonists 有权
标题翻译：甲酰胺衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US07772223B2
公开(公告)日：2010-08-10
申请号：US11522840
申请日：2006-09-18
申请人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
发明人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
IPC分类号： A61K31/397 , C07D205/04
CPC分类号： C07D207/12 , C07D205/02 , C07D205/04 , C07D207/04 , C07D211/26 , C07D211/46 , C07D413/12
摘要： The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.
摘要翻译：本发明涉及式的化合物及其制备中间体，它们用作毒蕈碱性拮抗剂和含有它们的药物组合物。

5. 发明授权

US08486992B2 Carboxamide derivatives as muscarinic receptor antagonists 有权
标题翻译：甲酰胺衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US08486992B2
公开(公告)日：2013-07-16
申请号：US12828732
申请日：2010-07-01
申请人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
发明人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
IPC分类号： A61K31/40 , A61K31/423 , A61K31/445
CPC分类号： C07D207/12 , C07D205/02 , C07D205/04 , C07D207/04 , C07D211/26 , C07D211/46 , C07D413/12
摘要： The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.
摘要翻译：本发明涉及式的化合物及其制备中间体，它们用作毒蕈碱性拮抗剂和含有它们的药物组合物。

6. 发明授权

US08268881B2 Carboxamide derivatives as muscarinic receptor antagonists 有权
标题翻译：甲酰胺衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US08268881B2
公开(公告)日：2012-09-18
申请号：US12556285
申请日：2009-09-09
申请人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
发明人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
IPC分类号： A61K31/40 , C07D295/22
CPC分类号： C07D207/12 , C07D205/02 , C07D205/04 , C07D207/04 , C07D211/26 , C07D211/46 , C07D413/12
摘要： The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.
摘要翻译：本发明涉及式的化合物及其制备中间体，它们用作毒蕈碱性拮抗剂和含有它们的药物组合物。

7. 发明申请

US20110306597A1 Nicotinamide Derivatives 审中-公开
标题翻译：烟酰胺衍生物
公开(公告)号：US20110306597A1
公开(公告)日：2011-12-15
申请号：US12997987
申请日：2009-06-12
申请人： James Michael Crawforth , Paul Alan Glossop , Bruce Cameron Hamper , Wei Huang , Bradley Elwood Neal , Simon John Mantell , Kirk Olson , Atli Thorarensen , Steve Ronald Turner
发明人： James Michael Crawforth , Paul Alan Glossop , Bruce Cameron Hamper , Wei Huang , Bradley Elwood Neal , Simon John Mantell , Kirk Olson , Atli Thorarensen , Steve Ronald Turner
IPC分类号： A61K31/55 , A61K31/437 , C07D417/12 , A61K31/4439 , C07D401/12 , A61K31/444 , C07D487/04 , A61K31/519 , C07D413/14 , A61K31/5377 , C07D213/82 , A61K31/44 , C07D413/12 , A61K31/5355 , C07D451/02 , A61K31/46 , A61P11/00 , A61P37/08 , A61P11/06 , C07D471/04
CPC分类号： C07D471/04 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D471/08 , C07D487/04
摘要： The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are defined herein, to compositions containing such compounds and to the uses of such compounds for the treatment of allergic and respiratory conditions.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基在本文中定义为含有这些化合物的组合物以及这些化合物用于治疗过敏和呼吸病症的用途。

8. 发明申请

US20100029720A1 Carboxamide Derivatives As Muscarinic Receptor Antagonists 有权
标题翻译：甲酰胺衍生物作为毒蕈碱受体拮抗剂
公开(公告)号：US20100029720A1
公开(公告)日：2010-02-04
申请号：US12556285
申请日：2009-09-09
申请人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
发明人： Paul Alan Glossop , Simon John Mantell , Anthony Wood , Christine Anne Louise Watson
IPC分类号： A61K31/423 , C07D207/12 , C07D413/12 , C07D211/44 , A61K31/4015 , A61K31/45 , A61P11/00 , A61P29/00
CPC分类号： C07D207/12 , C07D205/02 , C07D205/04 , C07D207/04 , C07D211/26 , C07D211/46 , C07D413/12
摘要： The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.
摘要翻译：本发明涉及式的化合物及其制备中间体，它们用作毒蕈碱性拮抗剂和含有它们的药物组合物。

9. 发明授权

US06525032B2 Purine derivatives 失效
标题翻译：嘌呤衍生物
公开(公告)号：US06525032B2
公开(公告)日：2003-02-25
申请号：US09789236
申请日：2001-02-20
申请人： Simon John Mantell , Sandra Marina Monaghan , Peter Thomas Stephenson
发明人： Simon John Mantell , Sandra Marina Monaghan , Peter Thomas Stephenson
IPC分类号： A61K3170
CPC分类号： C07D473/00 , C07H13/08 , C07H15/04 , C07H19/16
摘要： The present invention relates to compounds of the class of purin-2-ylcarboxamides, useful as anti-inflammatory agents, having the formula: and pharmaceutically acceptable salts and solvates thereof; wherein R1 is H, C1-C 6 alkyl or C3-C7 cycloalkyl, each optionally substituted by 1 or 2 of hydroxyl, fluorenyl, or optionally substituted phenyl or naphthyl ; A is a bond or C1-C6 alkylene; R2 is (i) H, C1-C6 alkyl, or optionally substituted C3-C7 cycloalkyl, phenyl, or naphthyl; or (ii) when A is C2-C6 alkylene, —NR3R3, —OR3, —COOR3, —OCOR4, —SO2R4, —CN, —SO2NR3R4, —NR3SO2R4, —NR3COR4 or —CONR3R3; or (iii) a C-linked, 4 to 11 membered, mono or bicyclic heterocycle having either from 1 to 4 ring nitrogen atom(s) or 1 or 2 nitrogen and 1 oxygen or 1 sulphur ring atoms, said heterocycle being optionally C-substituted or N-substituted; or (iv) when A is C2-C6 alkylene, optionally substituted N-linked azetidinyl, pyrrolidinyl, morpholinyl, tetrahydroisoquinolinyl, piperidinyl or piperazinyl; R7 is H, C1-C6 alkyl, C3-C7 cycloalkyl, phenyl, naphthyl, azetidin-3-yl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl, or het; and R8 is H or C1-C6 alkyl; and to intermediates used in processes for the preparation of, compositions containing, and uses as adenosine A2a receptor agonists of, compounds of formula (I).
摘要翻译：本发明涉及可用作抗炎剂的具有下式的嘌呤-2-基甲酰胺类化合物及其药学上可接受的盐和溶剂合物：其中R 1是H，C 1 -C 6烷基或C 3 -C 7环烷基，各自任选被1或2个羟基，芴基或任选取代的苯基或萘基取代; A是键或C1-C6亚烷基; R 2是（i）H，C 1 -C 6烷基或任选取代的C 3 -C 7环烷基，苯基或萘基; 或（ii）当A是C 2 -C 6亚烷基，-NR 3 R 3，-OR 3，-COOR 3，-OCOR 4，-SO 2 R 4，-CN，-SO 2 NR 3 R 4，-NR 3 SO 2 R 4，-NR 3 COR 4或-CONR 3 R 3时; 或（iii）具有1至4个环氮原子或1或2个氮和1个氧或1个硫环原子的C连接的4至11元单环或双环杂环，所述杂环任选为C- 取代或N-取代的; 或（iv）当A为C 2 -C 6亚烷基时，任选取代的N-连接的氮杂环丁烷基，吡咯烷基，吗啉基，四氢异喹啉基，哌啶基或哌嗪基; R 7是H，C 1 -C 6烷基，C 3 -C 7环烷基，苯基，萘基，氮杂环丁烷-3-基，吡咯烷-3-基，哌啶-3-基，哌啶-4-基或咔唑; 且R 8为H或C 1 -C 6烷基; 以及用于制备含有和用作式（I）化合物的腺苷A2a受体激动剂的组合物的方法中使用的中间体。

10. 发明授权

US06417194B1 Quinolines and quinazolines useful in therapy 失效
标题翻译：喹啉和喹唑啉可用于治疗
公开(公告)号：US06417194B1
公开(公告)日：2002-07-09
申请号：US09499623
申请日：2000-02-07
申请人： David Nathan Abraham Fox , Alan John Collis , Simon John Mantell
发明人： David Nathan Abraham Fox , Alan John Collis , Simon John Mantell
IPC分类号： A61K3147
CPC分类号： C07D401/04 , C07D403/04 , C07D405/14
摘要： Compounds of formula I, wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 and R3 independently represent H or C1-6 alkoxy (which is optionally substituted); R4 represents a 4-, 5-, 6- or 7-membered heterocyclic ring, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic, the ring system as a whole being optionally substituted; X represents CH or N; and L is absent, or represents a cyclic group of formula Ia, or represents a chain of formula Ib, and pharmaceutically acceptable salts thereof; are useful in therapy, in particular in the treatment of benign prostatic hyperplasia.
摘要翻译：式I化合物，其中R 1表示任选被一个或多个氟原子取代的C 1-4烷氧基; R 2和R 3独立地表示H或C 1-6烷氧基（其任选被取代）; R 4表示4-，5-，6-或所述环任选地与苯环或5-或6-元杂环稠合，所述环系统作为整体任选被取代; X表示CH或N; 并且L不存在，或表示式Ia的环状基团，或表示式Ib的链及其药学上可接受的盐; 可用于治疗，特别是治疗良性前列腺增生。

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