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1. 发明申请

US20060142231A1 DNA damage repair inhibitors for treatment of cancer 有权
标题翻译： DNA损伤修复抑制剂治疗癌症
公开(公告)号：US20060142231A1
公开(公告)日：2006-06-29
申请号：US11245735
申请日：2005-10-06
申请人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
发明人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
IPC分类号： A61K48/00 , A61K31/522 , A61K31/502 , A61K31/473 , A61K31/517 , A61K31/4704 , A61K31/4035 , A61K31/366
CPC分类号： A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要： DNA Damage Repair Inhibitors for Treatment of Cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译：用于治疗癌症的DNA损伤修复抑制剂本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。本文提供了使用靶向基础切除修复组分（如PARP）的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。

2. 发明授权

US08143241B2 DNA damage repair inhibitors for treatment of cancer 有权
标题翻译： DNA损伤修复抑制剂治疗癌症
公开(公告)号：US08143241B2
公开(公告)日：2012-03-27
申请号：US11245735
申请日：2005-10-06
申请人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
发明人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
IPC分类号： A61K31/50 , A61K31/44 , A61K31/415 , A01N43/00
CPC分类号： A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要： The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译：本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。本文提供了使用靶向基础切除修复组分（如PARP）的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。

3. 发明申请

US20120135983A1 DNA Damage Repair Inhibitors for the Treatment of Cancer 审中-公开
标题翻译： DNA损伤修复抑制剂治疗癌症
公开(公告)号：US20120135983A1
公开(公告)日：2012-05-31
申请号：US13286475
申请日：2011-11-01
申请人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
发明人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
IPC分类号： A61K31/551 , A61P35/00 , G01N33/566 , C12Q1/06 , A61K31/502 , C12Q1/68
CPC分类号： A61K31/366 , A61K31/00 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要： The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译：本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。本文提供了使用靶向基础切除修复组分（如PARP）的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。

4. 发明授权

US08071579B2 DNA damage repair inhibitors for the treatment of cancer 有权
标题翻译： DNA损伤修复抑制剂治疗癌症
公开(公告)号：US08071579B2
公开(公告)日：2011-12-06
申请号：US11001474
申请日：2004-11-30
申请人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
发明人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
IPC分类号： A61K31/50 , A61K31/44 , A61K31/415 , A61K31/40 , A01N43/00
CPC分类号： A61K31/366 , A61K31/00 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要： The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译：本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。本文提供了使用靶向基础切除修复组分（如PARP）的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。

5. 发明申请

US20060149059A1 Phthalazinone derivatives 有权
标题翻译：酞嗪衍生物
公开(公告)号：US20060149059A1
公开(公告)日：2006-07-06
申请号：US11318155
申请日：2005-12-23
申请人： Niall Martin , Graeme Smith , Stephen Jackson , Vincent Loh , Xiao-Ling Cockcroft , Ian Matthews , Keith Menear , Frank Kerrigan , Alan Ashworth
发明人： Niall Martin , Graeme Smith , Stephen Jackson , Vincent Loh , Xiao-Ling Cockcroft , Ian Matthews , Keith Menear , Frank Kerrigan , Alan Ashworth
IPC分类号： C07D403/02 , A61K31/502
CPC分类号： A61K31/00 , C07D237/32 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , C07D495/04
摘要： Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X=NRX then n is 1 or 2 and if X=CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.
摘要翻译：式（I）的化合物：其中A和B一起表示任选取代的稠合芳环; X可以是NR X或X X R O Y; 如果X = NR X，则n为1或2，并且如果X = CR X R Y Y，则n为1; R X选自H，任选取代的C 1-20烷基，C 5-20-20芳基，C 1〜酰胺基，磺酰基，磺酰基，酰基和磺酰基; R Y选自H，羟基，氨基; 或R X和R Y可以一起形成螺C 3-7环烷基或杂环基; R C1和R C2都是氢，或者当X是CR X R Y，R O， C 1，R 2，R 2，X和R Y以及它们所连接的碳原子可以形成任选取代的稠合芳环; R 1和R 2选自H和卤素。

6. 发明申请

US20050227919A1 DNA damage repair inhibitors for the treatment of cancer 有权
标题翻译： DNA损伤修复抑制剂治疗癌症
公开(公告)号：US20050227919A1
公开(公告)日：2005-10-13
申请号：US11001474
申请日：2004-11-30
申请人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
发明人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
IPC分类号： A61K31/00 , A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , A61K38/54 , A61K48/00
CPC分类号： A61K31/366 , A61K31/00 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要： The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译：本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。本文提供了使用靶向基础切除修复组分（如PARP）的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。

7. 发明申请

US20050059663A1 Phthalazinone derivatives 有权
标题翻译：酞嗪衍生物
公开(公告)号：US20050059663A1
公开(公告)日：2005-03-17
申请号：US10876080
申请日：2004-06-24
申请人： Niall Morrison Martin , Graeme Smith , Stephen Jackson , Vincent M Loh , Xiao-Ling Cockcroft , Ian Timothy Matthews , Keith Menear , Frank Kerrigan , Alan Ashworth
发明人： Niall Morrison Martin , Graeme Smith , Stephen Jackson , Vincent M Loh , Xiao-Ling Cockcroft , Ian Timothy Matthews , Keith Menear , Frank Kerrigan , Alan Ashworth
IPC分类号： A61K31/00 , C07D237/32 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/20 , C07D491/04 , C07D495/04 , C07D237/26 , A61K31/502 , C07D43/02
CPC分类号： A61K31/00 , C07D237/32 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , C07D495/04
摘要： Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X═NRX then n is 1 or 2 and if X═CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.
摘要翻译：式（I）的化合物：其中A和B一起表示任选取代的稠合芳环; X可以是NR X或CR X R Y; 如果X = NR X，那么n是1或2，如果X = CR X R Y，那么n是1; R X选自H，任选取代的C 1-20烷基，C 5-20芳基，C 3-20杂环基，酰氨基，硫代酰氨基，酯，酰基和磺酰基; R Y选自H，羟基，氨基; 或R X和R Y可以一起形成螺C 3-7环烷基或杂环基; R C1和R C2都是氢，或者当X是CR X R Y，R C1，R C2，R X和R Y时，与碳它们所连接的原子可以形成任选取代的稠合芳环; 且R 1选自H和卤素。

8. 发明授权

US08034587B2 Prokaryotic DNA repair ligases 失效
标题翻译：原核DNA修复连接酶
公开(公告)号：US08034587B2
公开(公告)日：2011-10-11
申请号：US10568055
申请日：2004-08-02
申请人： Aidan Doherty , Marina Della , Geoffrey Weller , Stephen Jackson
发明人： Aidan Doherty , Marina Della , Geoffrey Weller , Stephen Jackson
IPC分类号： C12P19/34 , C12N9/12
CPC分类号： C12Q1/6816 , C12N9/93 , C12Q2521/501 , C12Q2521/514
摘要： The present invention relates to the cloning and characterization of a prokaryotic DNA repair ligase, which is shown to possess a range of activities that allow the ligation and repair of non-compatible DNA ends and double strand breaks (DSBs). The enzyme has a range of applications in the manipulation and cloning of nucleic acids.
摘要翻译：本发明涉及原核DNA修复连接酶的克隆和表征，其显示具有允许不兼容DNA末端和双链断裂（DSB）的连接和修复的一系列活性。该酶在核酸的操作和克隆中具有一系列应用。

9. 发明申请

US20070133116A1 Detection of data cartridges in an automated data storage library 失效
标题翻译：在自动数据存储库中检测数据盒式磁带
公开(公告)号：US20070133116A1
公开(公告)日：2007-06-14
申请号：US11298327
申请日：2005-12-09
申请人： Brian Goodman , Stephen Jackson , Lenore Mackey
发明人： Brian Goodman , Stephen Jackson , Lenore Mackey
IPC分类号： G11B19/02 , G11B15/68
CPC分类号： G11B15/6885
摘要： In an automated library, data cartridges, such as magnetic tape cartridges, are stored in storage cells or shelves and accessed by data storage drives. An accessor with a gripper transports cartridges between storage cells and storage drives. Cartridges on the library floor may damage the accessor. A cartridge sensor is provided and positioned to detect cartridges on the floor of the library. The sensor may be mounted to the base of the accessor, may be mounted to the gripper, or one or more sensors may be mounted proximate to the floor of the library. If the library includes more than one library frame, a sensor may be mounted proximate to the floor of each of one or more of the frames, thereby allowing for the location of a dropped cartridge to be identified.
摘要翻译：在自动化库中，数据盒式磁带（如磁带盒）存储在存储单元或架子中，并由数据存储驱动器访问。具有夹持器的存取器在存储单元和存储驱动器之间传送墨盒。图书馆楼层的墨盒可能会损坏访问者。提供盒式传感器并定位以检测图书馆地板上的墨盒。传感器可以安装到存取器的基座上，可以安装到夹具上，或者一个或多个传感器可以靠近图书馆的地板安装。如果图书馆包括多于一个书架框架，传感器可以安装在靠近一个或多个框架中的每一个的底板附近，从而允许识别掉落筒的位置。

10. 发明申请

US20060055537A1 Methods, identification tags and computer program products for automated location and monitoring of mobile devices 有权
公开(公告)号：US20060055537A1
公开(公告)日：2006-03-16
申请号：US11108324
申请日：2005-04-18
申请人： Stephen Jackson
发明人： Stephen Jackson
IPC分类号： G08B13/14
CPC分类号： G08B21/0275 , G08B13/1427 , G08B21/023 , G08B21/028 , G08B21/0286
摘要： Methods are provided for providing location information associated with a mobile device. A request for presence information is received at an identification circuit associated with the mobile device. The request is received from a location circuit within a predetermined proximity of the identification circuit. The requested presence information is transmitted to the location circuit responsive to the request for presence information. Related identification tags and computer program products are also provided.

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