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1. 发明授权

US5527964A Acetaldehyde derivatives, their preparation process and their use 失效
标题翻译：乙醛衍生物，其制备方法及其用途
公开(公告)号：US5527964A
公开(公告)日：1996-06-18
申请号：US431033
申请日：1995-04-28
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： C07C249/02 , C07C213/02 , C07C217/40 , C07C251/88 , C07C249/16
CPC分类号： C07C213/02 , C07C217/40 , C07C251/88
摘要： Azines of formula (I): ##STR1## in which R and R' either are identical and represent an alkyl radical containing 1 to 4 carbon atoms or an alkenyl radical containing 3 to 5 carbon atoms, or together form a radical of formula (II):--CHR.sub.1 --(CR.sub.2 R.sub.3).sub.n --CHR.sub.4 -- (II)in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4, identical or different, represent a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms and n represents 0 or 1, in their different stereoisomer forms, their preparation process and their use.
摘要翻译：式（I）的吖嗪：其中R和R'相同并且表示含有1至4个碳原子的烷基或含有3至5个碳原子的烯基，或一起形成基团式（II）：-CHR1-（CR2R3）n-CHR4-（Ⅱ），其中R1，R2，R3和R4相同或不同，表示氢原子或含有1至4个碳原子的烷基，n表示0 或1，以其不同的立体异构体形式，其制备方法及其用途。

2. 发明授权

US4504678A Pure crystalline racemic sodium parahydroxymandelate, process for its preparation and uses thereof 失效
标题翻译：纯结晶外消旋钠对羟基扁桃酸钠，其制备及其用途
公开(公告)号：US4504678A
公开(公告)日：1985-03-12
申请号：US455143
申请日：1983-01-03
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： C07C59/52 , C07C59/50
CPC分类号： C07C59/52
摘要： Pure crystalline racemic sodium parahydroxymandelate free from any ions of chloride, acetate, formate and sulfate group, is manufactured by condensing in water, in the presence of sodium hydroxide at a temperature between 30.degree. and 100.degree. C., glyoxylic acid or sodium glyoxylate with an excess of phenol, concentrating it hot, until the start of crystallization of the solution thus obtained after neutralization and removal of the unconverted phenol either by steam distillation, or by extraction with a water-immiscible organic solvent. The resulting suspension obtained is cooled, drained after some hours of standing at a temperature close to 5.degree. C., and the resulting precipitate recovered by washing it with iced water followed by drying to constant weight. The product is useful for the manufacture of crystalline sodium paraformylphenolate.
摘要翻译：不含氯离子，乙酸盐，甲酸盐和硫酸盐基团的任何离子的纯结晶外消旋钠对羟基扁桃酸盐，在氢氧化钠存在下，在30〜100℃的温度下，在水中冷凝，乙醛酸或乙醛酸钠与过量的苯酚，将其浓缩，直到通过蒸汽蒸馏中和除去未转化的酚后，或通过与水不混溶的有机溶剂萃取，所得溶液开始结晶。将得到的悬浮液冷却，在接近5℃的温度下静置几小时后排干，通过用冰水洗涤所得沉淀物，然后干燥至恒重。该产品可用于制造结晶多聚甲酚钠。

3. 发明授权

US5550250A Preparation process for 2 formyl imidazole acetals 失效
标题翻译： 2甲酰咪唑缩醛的制备方法
公开(公告)号：US5550250A
公开(公告)日：1996-08-27
申请号：US511251
申请日：1995-08-04
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： C07D233/54 , C07D233/64 , C07D405/04
CPC分类号： C07D233/64
摘要： Preparation process for a product of formula (I): ##STR1## in which R.sub.1 and R.sub.2, either are identical and represent a C.sub.1 -C.sub.4 alkyl radical, or form together a group of formula (II):--CHR.sub.3 .paren open-st.CR.sub.4 R.sub.5 .paren close-st..sub.n CHR.sub.6 -- (II)in which R.sub.3, R.sub.4, R.sub.5 and R.sub.6, identical or different, represent a hydrogen atom or a C.sub.1 -C.sub.4 alkyl radical, and n represents 0 or 1, in which an aqueous mixture of glyoxal and an ethanal of formula (III): ##STR2## in which R.sub.1 and R.sub.2 have the meaning given above, is reacted with ammonia.
摘要翻译：式（I）的产物的制备方法：其中R 1和R 2相同并且表示C1-C4烷基，或者一起形成式（II）的基团： - CHR 3 + 545 CR4R5 + 546 nCHR6-（Ⅱ），其中R3，R4，R5和R6相同或不同，表示氢原子或C1-C4烷基，n表示0或1，其中乙二醛和式（III）的乙醛：其中R 1和R 2具有上述含义的化合物与其反应。

4. 发明授权

US5354897A Process for obtaining orthohydroxymandelic acid and its salts 失效
标题翻译：获得邻羟基扁桃酸及其盐的方法
公开(公告)号：US5354897A
公开(公告)日：1994-10-11
申请号：US15429
申请日：1993-02-12
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： B01J27/24 , C07B61/00 , C07C51/367 , C07C59/11 , C07C59/48
CPC分类号： C07C51/367
摘要： Preparation process for orthohydroxymandelic acid, as well as its salts, in which glyoxylic acid is reacted with phenol in the presence of a tertiary amine and catalytic quantities of trivalent metal cations, in order to obtain the expected product which is isolated and, if desired, salified.
摘要翻译：在叔胺和催化量的三价金属阳离子存在下，其中乙醛酸与苯酚反应的邻羟基扁桃酸及其盐的制备方法，以获得分离的预期产物，如果需要，成盐

5. 发明授权

US4384137A Process for preparation of hydroxyarylglyoxylic acids and their alkaline salts, and application thereof to preparation of sodium parahydroxyphenylglyoxylate 失效
标题翻译：羟基芳基乙醛酸及其碱式盐的制备方法及其在制备对羟基苯基乙醛酸钠
公开(公告)号：US4384137A
公开(公告)日：1983-05-17
申请号：US375124
申请日：1982-04-20
申请人： Alain Schouteeten , Yani Christidis , Jean-Claude Vallejos
发明人： Alain Schouteeten , Yani Christidis , Jean-Claude Vallejos
IPC分类号： C07C59/90 , B01J27/00 , B01J31/04 , C07C45/39 , C07C47/575 , C07C51/00 , C07C51/235 , C07C51/373 , C07C51/41 , C07C51/487 , C07C67/00 , C07C65/40
CPC分类号： C07C51/412 , C07C45/39 , C07C47/575 , C07C51/373 , C07C51/487
摘要： The invention relates to a process for preparation of hydroxyarylglyoxylic acids starting from hydroxyarylglycolic acids, by catalytic oxidation in an aqueous alkaline medium to pH higher than, or equal to, 11.5, through oxygen or oxygen-containing gas, characterized in that it is carried out in homogeneous phase at a temperature lower than, or equal to, 30.degree. C., and in the presence of cupric ions, and in that at the end of the reaction, the desired acid is isolated from the reactional medium through acidification to pH of about 0.5.The sodium parahydroxyphenylglyoxylate is obtained when acidification is stopped at pH=5, at the end of the reaction.
摘要翻译： PCT No.PCT / FR81 / 00108 Sec。 1982年4月20日 102（e）1982年4月20日PCT PCT日期：1981年8月27日PCT公布。公开号WO82 / 00821 1982年3月18日。本发明涉及由羟基芳基乙醇酸制备羟基芳基乙醛酸的方法，通过在含水碱性介质中通过氧或含氧气体在含水碱性介质中的催化氧化至pH高于或等于11.5，其特征在于其在低于或等于30℃的温度下并且在铜离子存在下在均相中进行，并且在反应结束时，将所需的酸从反应介质通过酸化至约0.5的pH。在反应结束时酸化停止pH = 5时得到对羟基苯基乙醛酸钠。

6. 发明授权

US5091566A Process for the manufacture of aqueous solutions of glyoxylic acid 失效
标题翻译：制备葡萄糖酸水溶液的方法
公开(公告)号：US5091566A
公开(公告)日：1992-02-25
申请号：US374818
申请日：1989-07-03
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： B01J27/24 , C07B61/00 , C07C51/235 , C07C51/27 , C07C59/153
CPC分类号： C07C51/235 , C07C51/27
摘要： The invention relates to the preparation of glyoxylic acid by oxidizing an aqueous solution of glyoxal having a pH less than 1 with molecular oxygen in the presence of nitrogen monoxide as a catalyst.This process allows the practically total conversion of the starting glyoxal with a good yield of glyoxylic acid.
摘要翻译：本发明涉及通过在一氧化氮作催化剂存在下用分子氧氧化pH小于1的乙二醛水溶液来制备乙醛酸。该方法允许起始乙二醛的实际总转化率与乙醛酸的良好收率。

7. 发明授权

US4408070A Pure crystalline racemic sodium parahydroxymandelate, process for its preparation and uses thereof 失效
公开(公告)号：US4408070A
公开(公告)日：1983-10-04
申请号：US284835
申请日：1981-07-20
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： C07C45/39 , C07C45/81 , C07C59/52 , C07C65/135
CPC分类号： C07C59/52 , C07C45/39 , C07C45/81
摘要： Pure crystalline racemic sodium parahydroxymandelate free from any ions of chloride, acetate, formate and sulfate group, is manufactured by condensing in water, in the presence of sodium hydroxide at a temperature between 30.degree. and 100.degree. C., glyoxylic acid or sodium glyoxylate with an excess of phenol, concentrating it hot, until the start of crystallization of the solution thus obtained after neutralization and removal of the unconverted phenol either by steam distillation, or by extraction with a water-immiscible organic solvent. The resulting suspension obtained is cooled, drained after some hours of standing at a temperature close to 5.degree. C., and the resulting precipitate recovered by washing it with iced water followed by drying to constant weight. The product is useful for the manufacture of crystalline sodium paraformylphenolate.

8. 发明授权

US5600001A Acetaldehyde derivatives, their preparation process and their use 失效
标题翻译：乙醛衍生物，其制备方法及其用途
公开(公告)号：US5600001A
公开(公告)日：1997-02-04
申请号：US605792
申请日：1996-02-22
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： C07C249/02 , C07C213/02 , C07C217/40 , C07C251/88 , C07C209/42 , C07C209/00
CPC分类号： C07C213/02 , C07C217/40 , C07C251/88
摘要： Azines of formula (I): ##STR1## in which R and R' either are identical and represent an alkyl radical containing 1 to 4 carbon atoms or an alkenyl radical containing 3 to 5 carbon atoms, or together form a radical of formula (II):--CHR.sub.1 --(CR.sub.2 R.sub.3).sub.n --CHR.sub.4 -- (II)in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4, identical or different, represent a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms and n represents 0 or 1, in their different stereoisomer forms, their preparation process and their use.
摘要翻译：式（I）的吖嗪：其中R和R'相同并且表示含有1至4个碳原子的烷基或含有3至5个碳原子的烯基，或一起形成基团式（II）：-CHR1-（CR 2 R 3）n -CHR 4 - （II）其中R 1，R 2，R 3和R 4相同或不同表示氢原子或含有1至4个碳原子的烷基，n表示0 或1，以其不同的立体异构体形式，其制备方法及其用途。

9. 发明授权

US4385006A Process for preparing aromatic nitriles 失效
标题翻译：制备芳香腈的方法
公开(公告)号：US4385006A
公开(公告)日：1983-05-24
申请号：US367125
申请日：1982-04-09
申请人： Alain Schouteeten , Yani Christidis
发明人： Alain Schouteeten , Yani Christidis
IPC分类号： C07C255/49 , C07C255/53 , C07C120/08
CPC分类号： C07C253/22
摘要： The invention relates to obtaining aromatic nitriles of general formula: (R).sub.n --C.sub.6 H.sub.4 --CN, where n=1, 2 or 3, and the rest R, identical or different represent an atom of hydrogen, chlorine or bromine or an alkyl, aryl, alkoxy, alkylamino, hydroxy or amino group, by a process comprising decarboxylating ammoxidation reaction, in an alkaline aqueous medium, at a pH higher than, or equal to, 13, in the presence of a catalyst based on one or several transition metals and an alkaline hydroxide, applied to an arylglyoxylic acid free or salified, of the formula: (R).sub.n --C.sub.6 H.sub.4 --CO--COOH (where n and R have the above-mentioned meanings), or to one of its functional derivatives of the lactone, lactame or C.sub.1 -C.sub.3 -alkyl ester type.
摘要翻译：本发明涉及获得通式为（R）n-C6H4-CN的芳族腈，其中n = 1,2或3，其余的R，相同或不同，表示氢原子，氯原子或溴原子或烷基，芳基，烷氧基，烷基氨基，羟基或氨基，在碱性水性介质中，在基于一种或多种过渡金属的催化剂的存在下，在高于或等于13的pH下进行脱羧氨基化反应和（R）n-C 6 H 4 -CO-COOH（其中n和R具有上述含义），或其功能衍生物之一的式（R）n-C6H4-CO-COOH（其中n和R具有上述含义），不溶或盐化的芳基乙醛酸的碱性氢氧化物内酯，内酯或C1-C3-烷基酯类。

10. 发明授权

US4105690A Process for manufacturing N-acyl derivatives of hydroxy-arylglycines 失效
标题翻译：制备羟基 - 芳基甘氨酸的N-酰基衍生物的方法
公开(公告)号：US4105690A
公开(公告)日：1978-08-08
申请号：US722284
申请日：1976-09-10
申请人： Yani Christidis , Alain Schouteeten
发明人： Yani Christidis , Alain Schouteeten
IPC分类号： C07C231/00 , C07C67/00 , C07C231/08 , C07C231/12 , C07C233/45 , C07C233/47 , C07C233/49 , C07C237/00 , C07D307/77 , C07C102/00 , C07C103/30 , C07C103/46 , C07C103/66
CPC分类号： C07D307/77 , C07C233/45 , C07C237/00
摘要： Condensation of the addition product of glyoxylic acid and amides with hydroxyaryl compounds is effected by a first step, wherein the reaction is carried out hot, at a temperature below 60.degree. C, of an aliphatic amide having at the most 4 carbon atoms selected from the group of acetamide, chloracetamide, propionamide, acrylamide and butyramide, on an aqueous solution of glyoxylic acid. Then in a second step, after the addition of acetic acid and gaseous hydrochloric acid, condensation is effected at a temperature below 35.degree. C of the carboxamidoglycolic acid with an excess reaching 500% of hydroxyaryl compound selected from the group comprising phenol and its alkyl derivatives, their halogen derivatives, polyphenols and their ethers and betanaphthol. After the condensation of said second step, the volatile products are removed by vacuum distillation. When the hydroxyaryl compound is phenol, the crude product resulting from this distillation is taken up in nitromethane or water, which are a non-solvent of the N-acyl derivative of parahydroxyphenylglycine but a solvent of the corresponding ortho derivative; the proportion of the para derivative in the resulting compound is then of the order of 100%.
摘要翻译：乙醛酸和酰胺与羟基芳基化合物的加成产物的缩合是通过第一步进行的，其中反应在低于60℃的温度下进行，所述脂族酰胺选自最多4个碳原子，乙酰胺，氯乙酰胺，丙酰胺，丙烯酰胺和丁酰胺的组合在乙醛酸水溶液中。然后在第二步中，在加入乙酸和气态盐酸后，在羧酰胺聚糖酸的低于35℃的温度下进行冷凝，过量的达到500％的选自苯酚及其烷基衍生物的羟基芳基化合物，它们的卤素衍生物，多酚及其醚和β-萘酚。在所述第二步骤冷凝后，通过真空蒸馏除去挥发性产物。当羟基芳基化合物是苯酚时，由该蒸馏产生的粗产物溶于硝基甲烷或水中，硝基甲烷或水是对羟基苯基甘氨酸的N-酰基衍生物的非溶剂，但是相应的邻位衍生物的溶剂; 所得化合物中对位衍生物的比例为约100％。

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