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1. 发明授权

US06815437B1 Streptogramines, their preparation and compositions containing them 失效
标题翻译： Streptogramines，它们的制备和含有它们的组合物
公开(公告)号：US06815437B1
公开(公告)日：2004-11-09
申请号：US09492392
申请日：2000-01-27
申请人： Alain Commerçon , Hervé Bouchard , Yves Ribeill , Eric Bacque , Baptiste Ronan , Jean-Claude Barriere , Gérard Puchault , Corinne Terrier
发明人： Alain Commerçon , Hervé Bouchard , Yves Ribeill , Eric Bacque , Baptiste Ronan , Jean-Claude Barriere , Gérard Puchault , Corinne Terrier
IPC分类号： A61K3133
CPC分类号： C07K5/06182 , A61K38/00
摘要： Group A streptogramin derivatives of formula (I): the salts thereof, and mixtures of stereoisomers thereof, as well as processes for preparing them and pharmaceutical compositions comprising them are disclosed.
摘要翻译：公开了式（I）的A组链霉素衍生物：其盐，其立体异构体的混合物，以及其制备方法和包含它们的药物组合物。

2. 发明授权

US08404678B2 Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use 有权
标题翻译：包含新的茅屋霉素衍生物的细胞毒剂及其治疗用途
公开(公告)号：US08404678B2
公开(公告)日：2013-03-26
申请号：US12689797
申请日：2010-01-19
申请人： Hervé Bouchard , Ravi V. J. Chari , Alain Commerçon , Yonghong Deng , Laurence Gauzy
发明人： Hervé Bouchard , Ravi V. J. Chari , Alain Commerçon , Yonghong Deng , Laurence Gauzy
IPC分类号： C07D487/00 , C07D519/00 , A61K31/5517
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.
摘要翻译：本发明涉及包含连接体的新颖的甲氧基衍生物。它还涉及包含一种或多种通过存在于茅屋霉素衍生物的接头上的连接基团与细胞结合剂共价连接的所述柚皮苷衍生物的缀合物分子。它还涉及制备汤姆米明衍生物和共轭分子。

3. 发明授权

US06232477B1 Methods of preparing new taxoids and pharmaceutical compositions containing them 失效
标题翻译：制备新紫杉烷和含有它们的药物组合物的方法
公开(公告)号：US06232477B1
公开(公告)日：2001-05-15
申请号：US09528448
申请日：2000-03-17
申请人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon
发明人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon
IPC分类号： C07D30514
CPC分类号： C07D305/14
摘要： Methods of preparing new taxoids of general formula (I) are presented: in which: R4 represents an alkanoyloxy radical in which the alkanoyl portion contains 2 to 6 carbon atoms in an unbranched or branched chain, this radical unsubstituted or substituted with one or more halogen atoms, an alkoxy radical containing 1 to 4 carbon atoms, or alternatively R4 represents a cycloalkanoyloxy radical in which the cycloalkanoyl portion contains 4 to 8 carbon atoms, or alternatively R4 represents a benzoyloxy radical; R5 represents an alkoxy radical containing 1 to 4 carbon atoms, substituted by an alkylthio radical containing 1 to 4 carbon atoms; and Z represents a hydrogen atom or a radical of general formula:
摘要翻译：提供了制备通式（I）的新紫杉烷的方法：其中：R4表示烷酰氧基，其中链烷酰基部分在无支链或支链上含有2-6个碳原子，该未取代的基团或被一个或多个卤素原子，含有1至4个碳原子的烷氧基，或者R4表示环烷酰氧基，其中环烷酰基部分含有4至8个碳原子，或者R4表示苯甲酰氧基; R5表示含有1至4个碳原子的烷氧基被含有1至4个碳原子的烷硫基取代; 和Z表示氢原子或通式如下的基团：

4. 发明授权

US06387946B1 Methods for treating pathological conditions of abnormal cell proliferation 有权
标题翻译：治疗异常细胞增殖病理状态的方法
公开(公告)号：US06387946B1
公开(公告)日：2002-05-14
申请号：US09985956
申请日：2001-09-25
申请人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon
发明人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon
IPC分类号： A61K31337
CPC分类号： C07D305/14 , Y02P20/55
摘要： New taxoids of general formula (I): their preparation and pharmaceutical compositions containing them. The new products of general formula (I) in which Z represents a radical of general formula (II): display noteworthy antitumour and antileukaemic properties.
摘要翻译：通式（I）的新紫杉烷类：它们的制备方法和含有它们的药物组合物。通式（I）的新产物，其中Z代表通式（Ⅱ）的基团：显示出显着的抗肿瘤和抗白血病性质。

5. 发明授权

US06593482B2 Methods for preparing new taxoids and pharmaceutical compositions containing them 失效
标题翻译：制备新紫杉烷和含有它们的药物组合物的方法
公开(公告)号：US06593482B2
公开(公告)日：2003-07-15
申请号：US10029954
申请日：2001-12-31
申请人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon , Iwao Ojima
发明人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon , Iwao Ojima
IPC分类号： C07D30500
CPC分类号： C07D205/08 , C07D305/14
摘要： Methods of preparing methylthiomethyloxy taxoids of formula (XXXIV) from baccatin and &bgr;-lactam are presented. These new taxoids display noteworthy anti-tumor and anti-leukemic properties.
摘要翻译：提出了从浆果赤霉素和β-内酰胺制备式（XXXIV）的甲硫基甲氧基紫杉烷的方法。这些新型紫杉醇具有显着的抗肿瘤和抗白血病特性。

6. 发明授权

US06372780B1 Methods of treating cell lines expressing multidrug resistance P-glycoprotein 有权
公开(公告)号：US06372780B1
公开(公告)日：2002-04-16
申请号：US09752779
申请日：2001-01-03
申请人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon
发明人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon
IPC分类号： A61K31337
摘要： Now taxoids of general formula (I) their preparation and pharmaceutical compositions containing them. The new products of general formula (I) in which Z represents a radical of general formula (II): display noteworthy antitumor and antileukaemic properties.

7. 发明授权

US06331635B1 Taxoids, their preparation and pharmaceutical compositions containing them 失效
标题翻译：紫杉烷类，它们的制备方法和含有它们的药物组合物
公开(公告)号：US06331635B1
公开(公告)日：2001-12-18
申请号：US09066929
申请日：1998-04-28
申请人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon
发明人： Hervé Bouchard , Jean-Dominique Bourzat , Alain Commerçon
IPC分类号： C07D26306
CPC分类号： C07D305/14 , Y02P20/55
摘要： New taxoids of general formula (I): their preparation and pharmaceutical compositions containing them. The new products of general formula (I) in which Z represents a radical of general formula (II): display noteworthy antitumour and antileukaemic properties.
摘要翻译：通式（I）的新紫杉烷类：它们的制备方法和含有它们的药物组合物。其中Z代表通式（II）的基团的通式（I）的新产品：显示出显着的抗肿瘤和抗白血病性质。

8. 发明授权

US07994161B2 Derivatives of 2-alkoxy-3,4,5-trihydroxy-alkyl amides, preparation and use thereof, and compositions containing the same 失效
标题翻译： 2-烷氧基-3,4,5-三羟基烷基酰胺的衍生物，其制备和用途，以及含有它们的组合物
公开(公告)号：US07994161B2
公开(公告)日：2011-08-09
申请号：US12267692
申请日：2008-11-10
申请人： Jidong Zhang , Yannick Benedetti , Alain Commerçon
发明人： Jidong Zhang , Yannick Benedetti , Alain Commerçon
IPC分类号： C07D243/24 , C07D243/12 , C07D267/02 , A61K31/55
CPC分类号： C07D243/12 , C07D243/26 , C07D267/14
摘要： The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide derivatives, to pharmaceutical compositions comprising such compounds, to methods of treatment comprising administering such compounds, to processes for the preparation of such compounds, and to intermediate precursors to such compounds.
摘要翻译：本发明涉及2-烷氧基-3,4,5-三羟基烷基酰胺衍生物，包含这些化合物的药物组合物，涉及治疗方法，包括给予这些化合物，制备这些化合物的方法，以及这些化合物的中间体前体。

9. 发明授权

US06444825B1 Process for the preparation of an oxazolidinecarboxylic acid which is useful for preparing therapeutically active taxoids 失效
标题翻译：可用于制备治疗活性紫杉烷的恶唑烷羧酸的制备方法
公开(公告)号：US06444825B1
公开(公告)日：2002-09-03
申请号：US08564345
申请日：1995-12-14
申请人： Jean-Dominique Bourzat , Alain Commerçon
发明人： Jean-Dominique Bourzat , Alain Commerçon
IPC分类号： C07D26302
CPC分类号： C07D263/04 , C07D305/14
摘要： A method for preparing an oxazolidinecarboxylic acid of general formula (I), which is useful for preparing therapeutically active taxoids of general formula (III), from an oxazolidinecarboxylic acid of general formula (II). In formulae (I), (II) and (III), R is a hydrogen atom or an acetyl radical; R1 is a benzyl radical or a radical of the general formula R2—O—CO—, wherein R2 is an optionally substituted alkyl radical, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl; each of R3 and R4, which are the same or different, is hydrogen, alkyl, alkoxy, optionally substituted aryl or optionally substituted aralkyl, or together they form a 4-7 membered ring; R5 is alkenyl, alkynyl, phenyl, formyl, alkanoyl, aroyl, hydroxymethyl, carboxy or alkyloxycarbonyl; and R′ is a hydrogen atom or an alkali or alkaline-earth metal atom or an alkyl radical with 1-4 carbon atoms optionally substituted by phenyl radical.
摘要翻译：一种制备通式（I）的恶唑烷羧酸的方法，其可用于由通式（II）的恶唑烷羧酸制备通式（III）的治疗活性紫杉烷类。在式（I），（II）和（III）中，R是氢原子或乙酰基; R 1是苄基或通式R 2 -O-CO-的基团，其中R 2是任选取代的烷基，烯基，炔基，环烷基，环烯基，双环烷基，苯基或杂环基; R 3和R 4各自相同或不同，为氢，烷基，烷氧基，任选取代的芳基或任选取代的芳烷基，或一起形成4-7元环; R5是烯基，炔基，苯基，甲酰基，烷酰基，芳酰基，羟甲基，羧基或烷氧基羰基; 并且R'是氢原子或碱金属或碱土金属原子或任选被苯基取代的具有1-4个碳原子的烷基。

10. 发明授权

US08314142B2 Dimers of artemisinin derivatives, preparation thereof and therapeutic use thereof 失效
标题翻译：青蒿素衍生物的二聚体，其制备及其治疗用途
公开(公告)号：US08314142B2
公开(公告)日：2012-11-20
申请号：US12244225
申请日：2008-10-02
申请人： Alain Commerçon , Jidong Zhang , Augustin Hittinger
发明人： Alain Commerçon , Jidong Zhang , Augustin Hittinger
IPC分类号： C07D309/00 , A61K31/335
CPC分类号： C07D313/04 , C07D321/04 , C07D323/04 , C07D493/22
摘要： The present invention relates to dimers of artemisinin derivatives, to processes for the preparation of such dimers, to methods of treatment comprising administration of such dimers, and to intermediates to such dimers.
摘要翻译：本发明涉及青蒿素衍生物的二聚体，制备这种二聚体的方法，包括给予这种二聚体的治疗方法以及这种二聚体的中间体。

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