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1. 发明申请

US20050239893A1 Compositions of allosteric hemoglobin modifiers and methods of making the same 有权
标题翻译：变构血红蛋白修饰剂的组成及其制备方法
公开(公告)号：US20050239893A1
公开(公告)日：2005-10-27
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio Santos , Alexandre Carvalho , Douglas Johnson , Jeffrey Etter , Christopher Murray
发明人： Al Quick , Antonio Santos , Alexandre Carvalho , Douglas Johnson , Jeffrey Etter , Christopher Murray
IPC分类号： A61K31/195
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译：本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。本发明还包括用于纯化通过本发明方法形成的产品的改进方法。新的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）萃取粗组合物以降低杂质量，特别是聚合物杂质。还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

2. 发明授权

US07847120B2 Compositions of allosteric hemoglobin modifiers and methods of making the same 有权
标题翻译：变构血红蛋白修饰剂的组成及其制备方法
公开(公告)号：US07847120B2
公开(公告)日：2010-12-07
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
发明人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
IPC分类号： C07C229/00 , C07C65/03
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译：本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。本发明还包括用于纯化通过本发明方法形成的产品的改进方法。新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

3. 发明授权

US08122554B2 Scrubbing device 有权
标题翻译：擦洗装置
公开(公告)号：US08122554B2
公开(公告)日：2012-02-28
申请号：US11874390
申请日：2007-10-18
申请人： Ryan A. Schemmel , Christopher Murray , Mark Stratford , Benjamin J. Strutt , Patrick Marcil
发明人： Ryan A. Schemmel , Christopher Murray , Mark Stratford , Benjamin J. Strutt , Patrick Marcil
IPC分类号： A46B13/04 , A47L11/14 , A47L11/18
CPC分类号： A47L13/26 , A46B13/001 , Y10T29/53
摘要： An apparatus with a main unit, a dispenser, a clamp and a clamp structure. The main unit includes a housing, a battery in the housing, a motor in the housing and connected to the battery, and an output drive shaft driven by the motor. The dispenser includes a body that defines a body aperture and which has a reservoir for storing a fluid, and a nozzle in fluid communication with the reservoir. The dispenser is configured to permit the stored fluid to be dispensed from the reservoir through the nozzle. The clamp is coupled to either the main unit or the dispenser and includes a pivotable engagement member. The clamp structure is coupled to the other one of the main unit and the dispenser and includes a second engagement member that can be releasably engaged to the engagement member. The housing is received through the body aperture.
摘要翻译：具有主单元，分配器，夹具和夹具结构的设备。主单元包括壳体，壳体中的电池，壳体中的电动机并连接到电池，以及由电动机驱动的输出驱动轴。分配器包括限定主体孔的主体，其具有用于存储流体的储存器和与储存器流体连通的喷嘴。分配器被配置为允许储存的流体通过喷嘴从储存器分配。夹具联接到主单元或分配器，并且包括可枢转的接合构件。夹具结构联接到主单元和分配器中的另一个，并且包括能够可释放地接合到接合构件的第二接合构件。外壳通过身体孔径接收。

4. 发明授权

US07752630B2 System sending behavior modification hint to client to suggest alternative servers based on operating conditions of current server 有权
标题翻译：系统发送行为修改提示客户端根据当前服务器的运行条件建议替代服务器
公开(公告)号：US07752630B2
公开(公告)日：2010-07-06
申请号：US12194434
申请日：2008-08-19
申请人： Christopher Murray , John Zamick
发明人： Christopher Murray , John Zamick
IPC分类号： G06F15/173
CPC分类号： H04L67/1008 , H04L29/06 , H04L63/0892 , H04L67/1002 , H04L67/101 , H04L67/1025 , H04L67/1029 , H04L67/1034 , H04L67/1036 , H04L2029/06054
摘要： Techniques for adaptive load balancing using behavior modification hints are disclosed, including, in at least one embodiment, monitoring a server's operating conditions; determining, based on the server's operating conditions, when to send a behavior modification hint to one or more clients that are being served by the server; generating the behavior modification hint based on the server's operating conditions; and sending the behavior modification hint to the one or more clients. In at least one embodiment, a client receives the behavior modification hint and, based on the behavior modification hint, alters a timeout value related to the server or alters its preferred server.
摘要翻译：公开了使用行为修改提示的自适应负载平衡的技术，包括在至少一个实施例中监视服务器的操作条件; 基于服务器的操作条件确定何时向由服务器服务的一个或多个客户端发送行为修改提示; 根据服务器的运行状况生成行为修改提示; 并向一个或多个客户端发送行为修改提示。在至少一个实施例中，客户端接收行为修改提示，并且基于行为修改提示改变与服务器相关的超时值或改变其优选服务器。

5. 发明授权

US07592468B2 Production of Δ 9 tetrahydrocannabinol 有权
公开(公告)号：US07592468B2
公开(公告)日：2009-09-22
申请号：US10902698
申请日：2004-07-30
申请人： Neil J Goodwin , Nicolas J. Archer , Christopher Murray , Alan K. Greenwood , Derek Mchattie
发明人： Neil J Goodwin , Nicolas J. Archer , Christopher Murray , Alan K. Greenwood , Derek Mchattie
IPC分类号： C07D311/82 , G01N1/18 , B01D3/10 , B01D3/00
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is then converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.

6. 发明申请

US20090233930A9 Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia 审中-公开
标题翻译：新型2-氨基咪唑-4-酮化合物及其在制造用于治疗认知功能障碍，阿尔茨海默病，神经退行性和痴呆症药物中的应用
公开(公告)号：US20090233930A9
公开(公告)日：2009-09-17
申请号：US12094276
申请日：2006-11-20
申请人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
发明人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
IPC分类号： A61K31/5377 , C07D401/10 , A61K31/4725 , C07D339/08 , A61P25/28 , C07F7/08 , C12N9/99 , C07D413/12
CPC分类号： C07D233/88 , C07C25/22 , C07C25/24 , C07C39/373 , C07C43/1747 , C07C43/23 , C07C47/575 , C07C49/792 , C07C49/813 , C07C49/83 , C07C49/84 , C07D209/08 , C07D217/06 , C07D233/86 , C07D265/36 , C07D307/79 , C07D339/08 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/04 , C07F7/1804
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

7. 发明申请

US20070155790A1 Meta-benzamidine derivatives as serine protease inhibitors 失效
标题翻译：元 - 苯甲脒衍生物作为丝氨酸蛋白酶抑制剂
公开(公告)号：US20070155790A1
公开(公告)日：2007-07-05
申请号：US11712906
申请日：2007-03-02
申请人： John Liebeschuetz , William Wylie , Bohdan Waszkowycz , Christopher Murray , Andrew Rimmer , Pauline Welsh , Stuart Jones , Jonathan Roscoe , Stephen Young , Phillip Morgan
发明人： John Liebeschuetz , William Wylie , Bohdan Waszkowycz , Christopher Murray , Andrew Rimmer , Pauline Welsh , Stuart Jones , Jonathan Roscoe , Stephen Young , Phillip Morgan
IPC分类号： A61K31/445 , A61K31/195 , C07D211/26
CPC分类号： C07K5/0207 , A61K38/00 , C07C237/36 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D217/22 , C07D217/24 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D487/04
摘要： Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.
摘要翻译：其中R 1，R 2，R 3，各自为X，L，Y，Cy，Lp，D和n的式I化合物具有本说明书中所述的含义，其中未取代或取代的脒基被未取代或取代的氨基甲基取代的相应化合物可用作丝氨酸蛋白酶抑制剂。

8. 发明申请

US20070072869A1 CERTAIN GLYCINE DERIVATIVES AS FACTOR Xa INHIBITORS FOR USE IN THE TREATMENT OF THROMBOTIC DISORDERS 失效
标题翻译：某些谷氨酸衍生物作为用于治疗血栓性疾病的因子Xa抑制剂
公开(公告)号：US20070072869A1
公开(公告)日：2007-03-29
申请号：US11456589
申请日：2006-07-11
申请人： Michael Wiley , Daniel Sall , Christopher Murray , Stephen Young , Jolie Bastian
发明人： Michael Wiley , Daniel Sall , Christopher Murray , Stephen Young , Jolie Bastian
IPC分类号： A61K31/496 , A61K31/4545 , C07D403/14
CPC分类号： C07D401/14 , C07D211/26 , C07D211/58 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译：其中R，R 1，R 2，n和X 1具有本说明书中给出的含义的式（I）化合物是因子可用于治疗血栓形成障碍的Xa抑制剂。

9. 外观设计

USD537629S1 Fishing rod sleeve 有权
标题翻译：钓竿套
公开(公告)号：USD537629S1
公开(公告)日：2007-03-06
申请号：US29241498
申请日：2005-10-28
申请人： Christopher Murray
设计人： Christopher Murray

10. 发明申请

US20070017103A1 Table mount holder for battery powered scissors 审中-公开
标题翻译：用于电池供电的剪刀的桌面支架
公开(公告)号：US20070017103A1
公开(公告)日：2007-01-25
申请号：US11185903
申请日：2005-07-20
申请人： Michael Agronin , Christopher Murray , DeAnn Romjue
发明人： Michael Agronin , Christopher Murray , DeAnn Romjue
IPC分类号： B26B13/00
CPC分类号： B25H1/005
摘要： A tool holder, particularly for holding battery operated scissors, has a base with a mechanism coupled with the base to secure the base to a surface. A holder is coupled with the base. The holder includes a pair of members pivotal with respect to one another between an opened and closed position to receive and release the scissors. A locking mechanism locks the pair of members with respect to one another to lock the scissors between the members.
摘要翻译：特别是用于保持电池操作的剪刀的工具架具有底座，该基座具有与基座相结合的机构以将基座固定到表面。支架与底座相连。保持器包括一对在打开和关闭位置之间相对于彼此枢转的构件，以接收和释放剪刀。锁定机构相对于彼此锁定该对构件以将剪刀锁定在构件之间。

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