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1. 发明申请

US20070172912A1 Method for fluorescently staining tissue 审中-公开
标题翻译：组织荧光染色方法
公开(公告)号：US20070172912A1
公开(公告)日：2007-07-26
申请号：US11656373
申请日：2007-01-23
申请人： Akira Yamamoto , Yusuke Iimori , Mizue Saze , Mariko Ishiguro
发明人： Akira Yamamoto , Yusuke Iimori , Mizue Saze , Mariko Ishiguro
IPC分类号： G01N1/30 , G01N33/48
CPC分类号： G01N1/30 , A61K49/0043
摘要： It is intended to provide a method for fluorescently staining a tissue accurately and clearly by convenient procedures and a staining agent used in this method. The present invention provides a method for fluorescently staining a tissue, comprising treating a tissue with a solution comprising fluorescein or a salt thereof and then fluorescently observing the treated portion under an acidic condition of lower than pH 7.
摘要翻译：旨在提供通过方便的方法和用于该方法的染色剂来准确和清楚地对组织进行荧光染色的方法。本发明提供了一种对组织进行荧光染色的方法，包括用含有荧光素或其盐的溶液处理组织，然后在低于pH 7的酸性条件下荧光观察处理的部分。

2. 发明授权

US08298514B2 Agent for enhancing contrast of image of fluorescent staining of lumen of digestive tract 有权
标题翻译：用于增强消化道腔荧光染色图像对比度的药剂
公开(公告)号：US08298514B2
公开(公告)日：2012-10-30
申请号：US11762961
申请日：2007-06-14
申请人： Akira Yamamoto , Yusuke Iimori , Mizue Saze , Mariko Ishiguro , Pilryon Lee
发明人： Akira Yamamoto , Yusuke Iimori , Mizue Saze , Mariko Ishiguro , Pilryon Lee
IPC分类号： A61B5/00
CPC分类号： A61K49/0043 , A61K49/0071
摘要： The present invention provides an agent and a method for enhancing a contrast of an image of fluorescent staining of a lumen of the digestive tract with an intravenously administered fluorescent dye, wherein the agent for enhancing a contrast is an agent for a lumen of the digestive tract containing an aqueous solution having a buffer capacity and having a pH of 6 to 10.
摘要翻译：本发明提供了一种用于增强消化道腔的荧光染色与静脉内施用的荧光染料的对比度的药剂和方法，其中用于增强对比度的药剂是消化道腔的药剂含有缓冲能力并且pH为6〜10的水溶液。

3. 发明申请

US20070077202A1 Histostain composition for endoscope 审中-公开
标题翻译： Histostain内窥镜组成
公开(公告)号：US20070077202A1
公开(公告)日：2007-04-05
申请号：US11633567
申请日：2006-12-05
申请人： Akira Yamamoto , Yusuke Iimori , Mae Koyama , Mariko Ishiguro , Mizue Saze
发明人： Akira Yamamoto , Yusuke Iimori , Mae Koyama , Mariko Ishiguro , Mizue Saze
IPC分类号： A61K49/00
CPC分类号： A61K49/0021 , A61K49/006
摘要： The invention relates to a histostain composition for endoscope containing one or more members selected from colors derived from Monascus. The stain composition is a staining agent which sharpens the shapes of digestive tract lumen surfaces and the like with a light in the visible wavelength range, having a function of being excited by a light of specific wavelength to emit fluorescence, and being biologically safe and suitable for endoscopy.
摘要翻译：本发明涉及含有一种或多种选自红曲霉色素的成分的内窥镜组合物。染色组合物是用可见光波长范围内的光来消化管腔表面等的形状的染色剂，具有被特定波长的光激发以发射荧光的功能，并且具有生物安全性和适合性用于内窥镜检查。

4. 发明授权

US08052660B2 Liquid applicator for endoscope 有权
标题翻译：内窥镜用液体涂抹器
公开(公告)号：US08052660B2
公开(公告)日：2011-11-08
申请号：US11610081
申请日：2006-12-13
申请人： Akira Yamamoto , Tetsuya Nakamura , Yae Kurosawa , Yusuke Iimori , Pilryon Lee
发明人： Akira Yamamoto , Tetsuya Nakamura , Yae Kurosawa , Yusuke Iimori , Pilryon Lee
IPC分类号： A61M25/00 , B43M11/06 , A61B1/12
CPC分类号： A61M31/00
摘要： A liquid applicator for an endoscope configured to apply liquid to in vivo tissue includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a brush member provided at a distal end of the flexible tube, and a fluid channel formed in the flexible tube to supply the liquid to the brush member.
摘要翻译：构造成将液体施加到体内组织的内窥镜用液体涂布器包括：插入到内窥镜的治疗工具插入通道中的柔性管，以及设置在柔性管的远端的刷部件，以及流体通道形成在柔性管中以将液体供应到刷构件。

5. 发明授权

US07648728B2 Method for producing bone filter of calcium phosphate 失效
标题翻译：磷酸钙骨筛选方法
公开(公告)号：US07648728B2
公开(公告)日：2010-01-19
申请号：US11177409
申请日：2005-07-11
申请人： Akira Yamamoto , Yusuke Iimori , Yuko Miyazaki
发明人： Akira Yamamoto , Yusuke Iimori , Yuko Miyazaki
IPC分类号： A61K6/083
CPC分类号： A61L27/425 , A61F2/28 , A61F2/30767 , A61F2/4644 , A61F2002/30968 , A61F2310/00293 , A61F2310/00796 , A61L2430/02 , C04B28/346 , C04B2111/00836 , C04B14/366 , C04B40/0263
摘要： A method for producing a calcium phosphate bone filler by preparing a mixed liquid comprising a calcium solution and a phosphoric acid solution in such a manner that a substrate of calcium phosphate exists in the mixed liquid, thereby precipitating calcium phosphate on the substrate to form a coating layer, and heat-treating the resultant composite comprising the substrate and the coating layer.
摘要翻译：一种磷酸钙骨填料的制造方法，其特征在于，通过以混合液中存在磷酸钙的基质的方式制备包含钙溶液和磷酸溶液的混合液，从而使磷酸钙沉积在基材上形成涂层并对包含基材和涂层的所得复合物进行热处理。

6. 发明申请

US20060013894A1 Method for producing bone filler of calcium phosphate 失效
标题翻译：磷酸钙骨填料的制备方法
公开(公告)号：US20060013894A1
公开(公告)日：2006-01-19
申请号：US11177409
申请日：2005-07-11
申请人： Akira Yamamoto , Yusuke Iimori , Yuko Miyazaki
发明人： Akira Yamamoto , Yusuke Iimori , Yuko Miyazaki
IPC分类号： A61K33/42 , A61F2/28 , C09K3/00 , C04B12/02
CPC分类号： A61L27/425 , A61F2/28 , A61F2/30767 , A61F2/4644 , A61F2002/30968 , A61F2310/00293 , A61F2310/00796 , A61L2430/02 , C04B28/346 , C04B2111/00836 , C04B14/366 , C04B40/0263
摘要： A method for producing a calcium phosphate bone filler by preparing a mixed liquid comprising a calcium solution and a phosphoric acid solution in such a manner that a substrate of calcium phosphate exists in the mixed liquid, thereby precipitating calcium phosphate on the substrate to form a coating layer, and heat-treating the resultant composite comprising the substrate and the coating layer.
摘要翻译：一种磷酸钙骨填料的制造方法，其特征在于，通过以混合液中存在磷酸钙的基质的方式制备包含钙溶液和磷酸溶液的混合液，从而使磷酸钙沉积在基材上形成涂层并对包含基材和涂层的所得复合物进行热处理。

7. 发明授权

US07985177B2 Endoscope for magnified image observation 有权
标题翻译：内镜用于放大图像观察
公开(公告)号：US07985177B2
公开(公告)日：2011-07-26
申请号：US11567315
申请日：2006-12-06
申请人： Tetsuya Nakamura , Akira Yamamoto , Yae Kurosawa , Yusuke Iimori , Pilryon Lee
发明人： Tetsuya Nakamura , Akira Yamamoto , Yae Kurosawa , Yusuke Iimori , Pilryon Lee
IPC分类号： A61B1/06 , A61B1/00 , A61B5/05
CPC分类号： A61B1/012 , A61B1/0008 , A61B1/00165 , A61B1/00172 , A61B1/00181 , A61B1/00188 , A61B1/04 , G02B23/2423
摘要： An endoscope for magnified image observation configured to observe a magnified image of in vivo tissue comprises an insertion part configured to be inserted into a body, a magnified image observation port configured to take in the magnified image of the in vivo tissue in one of a state where the magnified image observation port is in contact with the in vivo tissue and a state where the magnified image observation port is in proximity to the in vivo tissue, the observation port being provided at a distal end of the insertion part, and a marking unit configured to mark the in vivo tissue in one of the state where the magnified image observation port is in contact with the in vivo tissue and the state where the magnified image observation port is in proximity to the in vivo tissue.
摘要翻译：用于观察体内组织的放大图像的放大图像观察用内窥镜包括被配置为插入到体内的插入部，被配置为以一种状态摄取体内组织的放大图像的放大图像观察端口其中放大图像观察端口与体内组织接触，放大图像观察端口接近体内组织的状态，观察端口设置在插入部分的远端，标记单元被配置为在放大图像观察端口与体内组织接触的状态和放大图像观察端口接近体内组织的状态之一标记体内组织。

8. 发明授权

US07588172B2 Liquid spray tool for endoscope 有权
标题翻译：内窥镜用液体喷雾工具
公开(公告)号：US07588172B2
公开(公告)日：2009-09-15
申请号：US11611245
申请日：2006-12-15
申请人： Akira Yamamoto , Tetsuya Nakamura , Yae Kurosawa , Yusuke Iimori , Pilryon Lee
发明人： Akira Yamamoto , Tetsuya Nakamura , Yae Kurosawa , Yusuke Iimori , Pilryon Lee
IPC分类号： B67D5/38
CPC分类号： A61B1/012 , A61B5/4839
摘要： A liquid spray tool for an endoscope includes a flexible tube to be inserted into and extracted from a treatment tool insertion channel of the endoscope, a liquid storage pouch configured to pool solution to be conveyed into the flexible tube therein, a liquid measuring pouch for measuring an amount of the solution which is arranged between a rear end of the flexible tube and a distal end of the liquid storage pouch, and a first one-way valve arranged between the liquid storage pouch and the liquid measuring pouch, the first one-way valve being configured to allow the solution to pass theretrough from an inside of the liquid storage pouch to an inside of the liquid measuring pouch, and to prevent the solution from passing theretrough from the inside of the liquid measuring pouch to the inside of the liquid storage pouch.
摘要翻译：一种用于内窥镜的液体喷射工具，包括：插入到内窥镜的治疗工具插入通道中并从其中取出的柔性管;液体储存袋，其构造成将要输送到其中的柔性管的溶液集中;用于测量的液体测量袋布置在柔性管的后端和液体储存袋的远端之间的溶液的量和布置在液体储存袋和液体测量袋之间的第一单向阀，第一单向阀构造成允许溶液从液体储存袋的内部通过液体测量袋的内部，并且防止溶液从液体测量袋的内部通过液体储存器的内部袋。

9. 发明授权

US07875255B2 Nanoparticles comprising calcium phosphate and ethylene imine compositions and methods of production thereof 有权
标题翻译：包含磷酸钙和乙烯亚胺组合物的纳米颗粒及其生产方法
公开(公告)号：US07875255B2
公开(公告)日：2011-01-25
申请号：US11531909
申请日：2006-09-14
申请人： Akira Yamamoto , Yusuke Iimori , Mae Koyama
发明人： Akira Yamamoto , Yusuke Iimori , Mae Koyama
IPC分类号： C01B15/16 , C01B25/26 , C12N15/00 , A61K48/00
CPC分类号： B82Y5/00 , C01B25/32 , Y10S977/773
摘要： Highly dispersible inorganic compound nanoparticles modified by functional molecules include the functional molecules; a high molecular nitrogen compound having at least two amino groups selected from primary amino groups, secondary amino groups and tertiary amino groups; and inorganic compound nanoparticles bonded to at least one amino group of the at least two amino groups. The high molecular nitrogen compound is modified by the functional molecules, and the inorganic compound nanoparticles are covered with the high molecular nitrogen compound modified by the functional molecules.
摘要翻译：通过功能分子改性的高分散性无机化合物纳米粒子包括功能分子; 具有至少两个选自伯氨基，仲氨基和叔氨基的氨基的高分子氮化合物; 和与至少两个氨基的至少一个氨基键合的无机化合物纳米颗粒。高分子氮化合物被功能分子改性，无机化合物纳米粒子被功能分子改性的高分子氮化合物覆盖。

10. 发明申请

US20070181479A1 Column and method of manufacturing the column 审中-公开
标题翻译：专栏和制造柱的方法
公开(公告)号：US20070181479A1
公开(公告)日：2007-08-09
申请号：US11602232
申请日：2006-11-21
申请人： Akira Yamamoto , Yusuke Iimori , Masaki Tanaka
发明人： Akira Yamamoto , Yusuke Iimori , Masaki Tanaka
IPC分类号： B01D15/08
CPC分类号： B01J20/282 , B01D15/206 , B01J20/048 , B01J20/2803 , B01J20/3028 , B01J2220/54 , B01J2220/84 , B01J2220/86
摘要： A column for adsorbing a component in a sample has a tubular member through which a sample flows. The column also has a stationary phase housed in the tubular member and formed by an aggregate of a plurality of particles. At least a portion of surfaces of the particles is made of the same material as at least a portion of an inner wall surface of the tubular member so that a component in the sample is adsorbed on both of the surfaces of the particles and the inner wall surface of the tubular member.
摘要翻译：用于吸附样品中的组分的柱具有样品流过的管状构件。该柱还具有容纳在管状构件中并由多个颗粒的聚集体形成的固定相。颗粒的表面的至少一部分由与管状构件的内壁表面的至少一部分相同的材料制成，使得样品中的组分被吸附在颗粒的两个表面上，并且内壁管状构件的表面。

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