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1. 发明授权

US5844801A Method of inspecting and manufacturing vehicle body 失效
标题翻译：车身检查和制造方法
公开(公告)号：US5844801A
公开(公告)日：1998-12-01
申请号：US530893
申请日：1995-09-20
申请人： Akira Kodama , Yasuhiko Kitano , Hiroya Miyaoka , Hisato Morita , Takashi Uehara , Hideaki Maruyama , Tadatoshi Tsuji , Nobuhiro Nagao , Yoshikazu Kaizu
发明人： Akira Kodama , Yasuhiko Kitano , Hiroya Miyaoka , Hisato Morita , Takashi Uehara , Hideaki Maruyama , Tadatoshi Tsuji , Nobuhiro Nagao , Yoshikazu Kaizu
IPC分类号： B62D65/00 , G01N21/88 , G06F17/60
CPC分类号： B62D65/005 , G01N21/88 , G01N21/8803
摘要： After outer panels have been assembled on a vehicle frame, they are coated with an aqueous lustering agent P, and then irradiated with a light beam L. Light reflected by the outer panels is processed to produce a degree and range of distortion thereof. Based on the produced degree and range of distortion, it is determined whether the outer panels suffer a surface distortion or not. The determined result is displayed on a display monitor. According to the displayed image, the outer panels are repaired and thereafter coated with a paint.
摘要翻译：在将外板组装在车架上之后，将它们涂覆在水性光泽剂P上，然后用光束L照射。由外板反射的光被加工以产生其变形程度和范围。基于产生的变形程度和范围，确定外部面板是否遭受表面变形。确定的结果显示在显示监视器上。根据显示的图像，外部面板被修复，然后用油漆涂覆。

2. 发明授权

US08212046B2 Process for producing crystal 有权
标题翻译：水晶生产工艺
公开(公告)号：US08212046B2
公开(公告)日：2012-07-03
申请号：US13168121
申请日：2011-06-24
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： C07D401/00
CPC分类号： C07D401/12 , A61K31/4439 , C30B7/00
摘要： The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.
摘要翻译：本发明涉及（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑的溶液的制备方法。（其中n'为约0至约0.1）或其盐，其特征在于包括从有机溶剂溶液或悬浮液中结晶，其中（R）-2 - [[[3-甲基-4-（2,2,2' - 三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑nH 2 O（其中n为约0.1至约1.0）或其盐已经溶解或悬浮等，并且提供了有效制备光学活性的方便的方法在工业上大规模地高收率地具有极高对映体过量的亚砜衍生物。

3. 发明授权

US07994332B2 Process for producing crystal 有权
标题翻译：水晶生产工艺
公开(公告)号：US07994332B2
公开(公告)日：2011-08-09
申请号：US12492735
申请日：2009-06-26
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： C07D401/00
CPC分类号： C07D401/12 , A61K31/4439 , C30B7/00
摘要： The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-benzimidazole.nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.
摘要翻译：本发明涉及（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑的溶液的制备方法。（其中n'为约0至约0.1）或其盐，其特征在于包括从有机溶剂溶液或悬浮液中结晶，其中（R）-2 - [[[3-甲基-4-（2,2,2' - 三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] - 苯并咪唑·nH 2 O（其中n为约0.1至约1.0）或其盐已经溶解或悬浮等，并且提供了有效地制造光学活性亚砜衍生物在工业规模上以高产率具有极高的对映体过量。

4. 发明授权

US5466472A Process for the production of a cultured milk beverage 失效
标题翻译：用于生产培养的牛奶饮料的方法
公开(公告)号：US5466472A
公开(公告)日：1995-11-14
申请号：US925662
申请日：1992-08-07
申请人： Yoshiharu Kuma , Tamotsu Setoyama , Hideaki Maruyama , Makiko Kawai
发明人： Yoshiharu Kuma , Tamotsu Setoyama , Hideaki Maruyama , Makiko Kawai
IPC分类号： A23C9/123 , A23C9/13 , A23C9/12
CPC分类号： A23C9/1307 , A23C9/1234 , A23Y2220/39
摘要： A cultured milk beverage contains at least 3.times.10.sup.8 cells/ml of at least one type of lactic acid bacterium selected from the group consisting of Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus helveticus and Lactobacillus jugurti and a mixture of a galactooligosaccharide, which is represented by the following formula:Gal-(Gal).sub.n -Glcwherein Gal means a galactose residual group, Glc denotes a glucose residual group, and n stands for an integer of 1-4, and a galactosyldisaccharide represented by the following formula:Gal-Rwherein R means a galactose residual group or a glucose residual group, and Gal has the same meaning as defined above, said galactosyldisaccharide being other than lactose. The cultured milk beverage can be produced providing the lactic acid bacterium and culturing the same to a population of at least 3.times.10.sup.8 cells/ml of the cultured milk beverage and then adding the mixture of the galactooligosaccharide and the galactosyldisaccharide to the resultant culture.
摘要翻译：培养的乳饮料含有至少3×10 8细胞/ ml的至少一种选自由干酪乳杆菌，嗜酸乳杆菌，瑞士乳杆菌和乳酸乳杆菌组成的组中的乳酸菌和由下列物质表示的低聚半乳糖的混合物式：Gal-（Gal）n-Glc其中Gal表示半乳糖残基，Glc表示葡萄糖残基，n表示1-4的整数，由下式表示的半乳糖二糖：Gal-R其中R 是指半乳糖残基或葡萄糖残基，Gal具有与上述相同的含义，所述半乳糖二糖不是乳糖。可以生产提供乳酸菌的培养的乳饮料，并将其培养至培养的奶饮料至少3×10 8细胞/ ml的群体，然后将所得的低聚半乳糖和半乳糖二糖的混合物加入到所得的培养物中。

5. 发明授权

US07569696B2 Process for producing crystal 有权
标题翻译：水晶生产工艺
公开(公告)号：US07569696B2
公开(公告)日：2009-08-04
申请号：US11515639
申请日：2006-09-05
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： C07D401/00
CPC分类号： C07D401/12 , A61K31/4439 , C30B7/00
摘要： The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-benzimidazole.nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.
摘要翻译：本发明涉及（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑的溶液的制备方法。（其中n'为约0至约0.1）或其盐，其特征在于包括从有机溶剂溶液或悬浮液中结晶，其中（R）-2 - [[[3-甲基-4-（2,2,2' - 三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] - 苯并咪唑·nH 2 O（其中n为约0.1至约1.0）或其盐已经溶解或悬浮等，并且提供了有效地制造光学活性亚砜衍生物在工业规模上以高产率具有极高的对映体过量。

6. 发明申请

US20080182994A1 Crystal of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid and process for producing the same 审中-公开
标题翻译： 2-乙氧基-1 - [[2' - （1H-四唑-5-基）联苯-4-基]甲基] -1H-苯并咪唑-7-羧酸的晶体及其制备方法
公开(公告)号：US20080182994A1
公开(公告)日：2008-07-31
申请号：US12073973
申请日：2008-03-12
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： C07D403/10
CPC分类号： C07D403/10
摘要： A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.
摘要翻译：制备2-乙氧基-1 - [[2' - （1H-四唑-5-基）联苯-4-基]甲基] -1H-苯并咪唑-7-羧酸（化合物（I））的晶体的方法，其特征在于将化合物（I）或其盐溶解或悬浮在包含非质子极性溶剂并使其结晶的溶剂中。通过该方法，可以容易地除去化合物（I）或其盐中难以除去的难以除去的污染物，例如锡化合物，化合物（I）的类似物和残余的有机溶剂。化合物（I）的晶体可以在工业规模上以高产率高效且容易地批量生产。

7. 发明授权

US07169799B2 Process for producing crystal 有权
公开(公告)号：US07169799B2
公开(公告)日：2007-01-30
申请号：US10275334
申请日：2001-05-15
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D401/12 , A61K31/4439 , C30B7/00
摘要： The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole·n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-benzimidazole·nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.

8. 发明申请

US20070004779A1 Process for producing crystal 有权
标题翻译：水晶生产工艺
公开(公告)号：US20070004779A1
公开(公告)日：2007-01-04
申请号：US11515639
申请日：2006-09-05
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/12 , A61K31/4439 , C30B7/00
摘要： The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-benzimidazole.nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.
摘要翻译：本发明涉及（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑的晶体的制备方法。其中n'为约0至约0.1）或其盐，其特征在于包括从有机溶剂溶液或悬浮液中结晶，其中（R）-2 - [[[3-甲基 -4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] - 苯并咪唑.NH 2 O（其中n为约0.1至约1.0）或其盐已经溶解或悬浮等，并且以工业上大规模提供以高产率有效地制备具有极高对映异构体过量的光学活性亚砜衍生物的方便方法。

9. 发明申请

US20060205801A1 Crystal and process for producing the same 审中-公开
标题翻译：水晶和生产过程相同
公开(公告)号：US20060205801A1
公开(公告)日：2006-09-14
申请号：US11432079
申请日：2006-05-11
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： A61K31/4184 , C07D403/02
CPC分类号： C07D403/10
摘要： A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.
摘要翻译：制备2-乙氧基-1 - [[2' - （1H-四唑-5-基）联苯-4-基]甲基] -1H-苯并咪唑-7-羧酸（化合物（I））的结晶的方法，其特征在于将化合物（I）或其盐溶解或悬浮在包含非质子极性溶剂并使其结晶的溶剂中。通过该方法，可以容易地除去化合物（I）或其盐中难以除去的难以除去的污染物，例如锡化合物，化合物（I）的类似物和残余的有机溶剂。化合物（I）的晶体可以在工业规模上以高产率高效且容易地批量生产。

10. 发明授权

US07067546B2 Crystal and process for producing the same 失效
标题翻译：水晶和生产过程相同
公开(公告)号：US07067546B2
公开(公告)日：2006-06-27
申请号：US10485593
申请日：2002-08-01
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： A61K31/41 , C07C255/00 , C07D257/00
CPC分类号： C07D403/10
摘要： A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.
摘要翻译：制备2-乙氧基-1 - [[2' - （1H-四唑-5-基）联苯-4-基]甲基] -1H-苯并咪唑-7-羧酸（化合物（I））的晶体的方法，其特征在于将化合物（I）或其盐溶解或悬浮在包含非质子极性溶剂并使其结晶的溶剂中。通过该方法，可以容易地除去化合物（I）或其盐中难以除去的难以除去的污染物，例如锡化合物，化合物（I）的类似物和残余的有机溶剂。化合物（I）的晶体可以在工业规模上以高产率高效且容易地批量生产。

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