专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5591648A Antibodies for mevalonic acid and methods for immunological determination of mevalonic acid by using them 失效
标题翻译：甲羟戊酸的抗体及使用它们免疫测定甲羟戊酸的方法
公开(公告)号：US5591648A
公开(公告)日：1997-01-07
申请号：US518173
申请日：1995-08-23
申请人： Akio Hayashi , Makoto Hiramatsu , Nobuyuki Hamanaka
发明人： Akio Hayashi , Makoto Hiramatsu , Nobuyuki Hamanaka
IPC分类号： C07K16/18 , C12N15/06 , C12P21/08 , G01N33/53
CPC分类号： C07K16/18
摘要： Polyclonal and monoclonal antibodies are obtained specific to mevalonic acid, having low cross-reactivity with mevalonic acid analogues, such as glutaric acid, 3-methylglutaric acid and 3-hydroxy-3-methylglutaric acid. The antibodies may be used for determination of mevalonic acid providing an immunoassay excellent in sensitivity, specificity and reproducibility.
摘要翻译：获得特异于甲羟戊酸的多克隆和单克隆抗体，与甲羟戊酸类似物如戊二酸，3-甲基戊二酸和3-羟基-3-甲基戊二酸具有低交叉反应性。抗体可用于测定甲羟戊酸，提供灵敏度，特异性和重现性优异的免疫测定。

2. 发明授权

US5470956A Antibodies for mevalonic acid and methods for immunological determination of mevalonic acid by using them 失效
标题翻译：甲羟戊酸的抗体及使用它们免疫测定甲羟戊酸的方法
公开(公告)号：US5470956A
公开(公告)日：1995-11-28
申请号：US184178
申请日：1994-01-21
申请人： Akio Hayashi , Makoto Hiramatsu , Nobuyuki Hamanaka
发明人： Akio Hayashi , Makoto Hiramatsu , Nobuyuki Hamanaka
IPC分类号： C07K16/18 , C12N15/06 , C12P21/08 , C07K16/06
CPC分类号： C07K16/18
摘要： Polyclonal and monoclonal antibodies are obtained specific to mevalonic acid, having low cross-reactivity with mevalonic acid analogues, such as glutaric acid, 3-methylglutaric acid and 3-hydroxy-3-methylglutaric acid. The antibodies may be used for determination of mevalonic acid providing an immunoassay excellent in sensitivity, specificity and reproducibility.
摘要翻译：获得特异于甲羟戊酸的多克隆和单克隆抗体，与甲羟戊酸类似物如戊二酸，3-甲基戊二酸和3-羟基-3-甲基戊二酸具有低交叉反应性。抗体可用于测定甲羟戊酸，提供灵敏度，特异性和重现性优异的免疫测定。

3. 发明授权

US06197993B1 Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient 失效
标题翻译：萘氧基乙酸衍生物和包含它们的药物组合物作为活性成分
公开(公告)号：US06197993B1
公开(公告)日：2001-03-06
申请号：US09440674
申请日：1999-11-16
申请人： Yuuki Nagao , Kazuhiko Torisu , Nobuyuki Hamanaka
发明人： Yuuki Nagao , Kazuhiko Torisu , Nobuyuki Hamanaka
IPC分类号： C07C25500
CPC分类号： C07D257/04 , C07C43/23 , C07C59/68 , C07C59/70 , C07C69/712 , C07C217/28 , C07C217/60 , C07C233/18 , C07C255/16 , C07C317/18 , C07C317/22 , C07C323/16 , C07C323/21 , C07C2602/10
摘要： The naphthyloxyacetic acid derivatives of the formula (I) wherein A is H, -(alkylene)COOR1, -(alkylene)CONR2R3, -(alkylene)OH, -(alkylene)tetrazole, -(alkylene)CN; E is single bond or alkylene; G is —S—, —SO—, —SO2—, —O— or —NR4—; L is alkylene, —(CH2)m—CH═CH—(CH2)n— or —(CH2)x—CH(OH)— (CH2)y—; M is phenyl, phenyl(thio, oxy, amino), diphenylmethyl, diphenylmethyl(thio, oxy, amino), and pharmaceutical composition comprising them as an active ingradient. The compounds of the formula (I) can combine PGE2 receptor and exhibit the activity to antagonize or agonize for PGE2 receptor. Therefore, they are useful as anti-hyperlipemia, for the prevention of abortion, for analgesics, as antidiarrheals, sleep inducer, diuretic, anti-diabetes, abortient, cathartics, antiulcer, anti-gastritis or antihypertensive etc.
摘要翻译：式（I）的萘氧基乙酸衍生物，其中A是H， - （亚烷基）COOR1， - （亚烷基）CONR2R3， - （亚烷基）OH， - （亚烷基）四唑， - （亚烷基） E是单键或亚烷基; G是-S - ， - SO - ， - SO 2 - ， - O-或-NR 4 - ; L是亚烷基， - （CH 2）m -CH = CH-（CH 2）n - 或 - （CH 2）x -CH（OH） - （CH 2）y - M是苯基，苯基（硫代，氧基，氨基），二苯基甲基，二苯基甲基（硫代，氧基，氨基），以及包含它们作为活性成分的药物组合物。式（I）化合物可以组合PGE 2受体并表现出拮抗或激动PGE2受体的活性。因此，它们可用作抗高血脂，防止流产，镇痛药，止泻药，睡眠诱导剂，利尿剂，抗糖尿病，止痛药，通气药，抗溃疡药，抗胃炎或抗高血压药等。

4. 发明授权

US6001877A Phenylalkan(en)oic acid 失效
标题翻译：苯基（en）酸
公开(公告)号：US6001877A
公开(公告)日：1999-12-14
申请号：US81549
申请日：1998-05-20
申请人： Mitoshi Konno , Takahiko Nakae , Nobuyuki Hamanaka
发明人： Mitoshi Konno , Takahiko Nakae , Nobuyuki Hamanaka
IPC分类号： C07C59/52 , C07C59/64 , C07C59/68 , C07C59/90 , C07C69/734 , C07C205/34 , C07C205/56 , C07C233/47 , C07C233/54 , C07C233/81 , C07C235/16 , C07C235/20 , C07C235/34 , C07C235/42 , C07C235/78 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/51 , C07C323/19 , C07C405/00 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/48 , C07D275/02 , C07D275/03 , C07D277/42 , C07D277/46 , C07D279/02 , C07D295/185 , A61K31/195
CPC分类号： C07D207/27 , C07C205/34 , C07C205/56 , C07C233/47 , C07C233/54 , C07C233/81 , C07C235/16 , C07C235/20 , C07C235/34 , C07C235/42 , C07C235/78 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/51 , C07C323/19 , C07C405/0066 , C07C59/52 , C07C59/64 , C07C59/68 , C07C59/90 , C07C69/734 , C07D209/08 , C07D209/48 , C07D275/03 , C07D277/42 , C07D277/46 , C07D279/02 , C07D295/185 , C07C2101/14
摘要： The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B.sub.4.
摘要翻译：下式所示的苯烷（en）酸：对白三烯B4具有拮抗作用。

5. 发明授权

US5723493A Naphthyloxyacetic acid 失效
标题翻译：萘氧基乙酸
公开(公告)号：US5723493A
公开(公告)日：1998-03-03
申请号：US768291
申请日：1996-12-17
申请人： Yuuki Nagao , Takayuki Maruyama , Nobuyuki Hamanaka
发明人： Yuuki Nagao , Takayuki Maruyama , Nobuyuki Hamanaka
IPC分类号： C07C311/08 , C07C311/13 , C07C311/20 , C07C311/27 , C07C311/28 , C07C311/29 , A61K31/195
CPC分类号： C07C311/13 , C07C311/08 , C07C311/20 , C07C311/27 , C07C311/28 , C07C311/29
摘要： (1) Naphthyloxyaetic acid represented by the compound of the formula (I): ##STR1## and non-toxic salts thereof, (2) process for the preparation of the compounds represented by the compound of the formula (I) described hereinbefore, (3) PGE.sub.2 antagonist or agonist containing the compound represented by the compound of the formula (I) as the active ingredient. The compounds represented by the compounds of the formula (I) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgesic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE.sub.2 antagonists, and an uterine contractile activity, a promoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, hypotensive activity as PGE.sub.2 agonists. The compounds bind to PGE.sub.2 receptor and have an activity of antagonist or agonist against the action thereof.
摘要翻译：（1）由式（I）的化合物代表的萘乙酸：其中，（I）化合物及其无毒盐，（2）由上述式（I）的化合物表示的化合物的制备方法，（3）PGE2拮抗剂或含有式（I）化合物所代表的化合物作为活性成分的激动剂。由式（I）化合物表示的化合物可以适用于具有子宫收缩抑制作用，止痛作用，消化性蠕动抑制作用，睡眠诱导作用PGE2拮抗剂和子宫收缩的药物活动，消化性蠕动的促进作用，胃酸分泌的抑制作用，作为PGE2激动剂的降血压活性。该化合物与PGE2受体结合，并具有拮抗剂或激动剂抵抗其作用的活性。

6. 发明授权

US4208428A Prostaglandin analogues 失效
标题翻译：前列腺素类似物
公开(公告)号：US4208428A
公开(公告)日：1980-06-17
申请号：US924343
申请日：1978-07-13
申请人： Masayasu Kurono , Nobuyuki Hamanaka , Shigeru Sakuyama , Takeshi Chiba , Hisao Nakai
发明人： Masayasu Kurono , Nobuyuki Hamanaka , Shigeru Sakuyama , Takeshi Chiba , Hisao Nakai
IPC分类号： A61K31/557 , A61K31/19 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/40 , C07C177/00 , A61K31/215
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12 , C07F9/4018
摘要： The invention relates to prostaglandin analogues of the general formula: ##STR1## (wherein A represents a grouping of the formula: ##STR2## B represents an alkylene group containing from 1 to 7 carbon atoms or a group ##STR3## (wherein the group --(CH.sub.2).sub.n --may be attached to the ortho, meta or para position of the phenyl ring and m and n, which may be the same or different, each represent an integer from 1 to 5 inclusive, the sum of the integers represented by m and n being from 2 to 6 inclusive), X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, W represents ethylene or trans-vinylene, Z represents a halogen atom, and R.sup.1 represents a hydrogen atom or an alkyl group containing from 1 to 12 carbon atoms) and cyclodextrin clathrates of such acids and esters and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof, which possess characteristic prostaglandin-like properties.
摘要翻译：本发明涉及以下通式的前列腺素类似物：其中A代表下式的基团：B代表含有1至7个碳原子的亚烷基或基团（IMAGE）（其中基团 - （CH 2）n - 可以连接到苯环的邻位，间位或对位，m和n可以相同或不同，各自表示1至5的整数，包括端值的整数，由 m和n为2至6的整数），X表示亚乙基或顺式亚乙烯基，Y表示亚乙基或反式亚乙烯基，W表示亚乙基或反式亚乙烯基，Z表示卤素原子，R1表示氢原子或烷基含有1至12个碳原子的基团）和这些酸和酯的环糊精包合物，并且当R 1表示氢原子时，其无毒盐具有特征性前列腺素样特性。

7. 发明授权

US6018068A Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients 失效
标题翻译：萘氧基乙酸衍生物和包含与活性成分相同的药物
公开(公告)号：US6018068A
公开(公告)日：2000-01-25
申请号：US102
申请日：1998-01-26
申请人： Yuuki Nagao , Kazuhiko Torisu , Nobuyuki Hamanaka
发明人： Yuuki Nagao , Kazuhiko Torisu , Nobuyuki Hamanaka
IPC分类号： C07C59/68 , C07C69/712 , C07C217/60 , C07C233/18 , C07C255/16 , C07C317/18 , C07C323/16 , C07D257/04 , C07C321/12 , C07C317/00
CPC分类号： C07D257/04 , C07C217/60 , C07C233/18 , C07C255/16 , C07C317/18 , C07C323/16 , C07C59/68 , C07C69/712
摘要： The naphthyloxyacetic acid derivatives of the formula (I) ##STR1## wherein A is H, --(alkylene)COOR.sup.1, --(alkylene)CONR.sup.2 R.sup., --(alkylene)OH, --(alkylene)tetrazole, --(alkylene)CN; E is single bond or alkylene; G is --S--, --SO--, --SO.sub.2 --, --O-- or --NR.sup.4 --; L is alkylene, --(CH.sub.2).sub.m --CH=CH--(CH.sub.2).sub.n -- or --(CH.sub.2).sub.x --CH(OH)--(CH.sub.2).sub.y --; M is phenyl, phenyl(thio, oxy, amino), diphenylmethyl, diphenylmethyl(thio, oxy, amino), and pharmaceutical composition comprising them as an active ingradient. The compounds of the formula (I) can combine PGE.sub.2 receptor and exhibit the activity to antagonize or agonize for PGE.sub.2 receptor. Therefore, they are useful as anti-hyperlipemia, for the prevention of abortion, for analgesics, as antidiarrheals, sleep inducer, diuretic, anti-diabetes, abortient, cathartics, antiulcer, anti-gastritis or antihypertensive etc.
摘要翻译： PCT No.PCT / JP96 / 01833 Sec。 371日期1998年1月26日 102（e）日期1998年1月26日PCT提交1996年7月2日PCT公布。公开号WO97 / 05091 日本时间1997年2月13日其中A为H， - （亚烷基）COOR1 - （亚烷基）CONR2R， - （亚烷基）OH， - （亚烷基）四唑， - （亚烷基）CN的式（I）的萘氧基乙酸衍生物 E是单键或亚烷基; G是-S - ， - SO - ， - SO 2 - ， - O-或-NR 4 - ; L是亚烷基， - （CH 2）m -CH = CH-（CH 2）n - 或 - （CH 2）x -CH（OH） - （CH 2）y - M是苯基，苯基（硫代，氧基，氨基），二苯基甲基，二苯基甲基（硫代，氧基，氨基），以及包含它们作为活性成分的药物组合物。式（I）化合物可以组合PGE 2受体并表现出拮抗或激动PGE2受体的活性。因此，它们可用作抗高血脂，防止流产，镇痛药，止泻药，睡眠诱导剂，利尿剂，抗糖尿病，止痛药，通气药，抗溃疡药，抗胃炎或抗高血压药等。

8. 发明授权

US5663417A Carbocyclic sulfonamides 失效
标题翻译：碳环磺酰胺
公开(公告)号：US5663417A
公开(公告)日：1997-09-02
申请号：US187008
申请日：1994-01-27
申请人： Nobuyuki Hamanaka , Tsumoru Miyamoto
发明人： Nobuyuki Hamanaka , Tsumoru Miyamoto
IPC分类号： A61K31/557 , A61P43/00 , C07C303/38 , C07C303/40 , C07C311/07 , C07C311/10 , C07C311/11 , C07C311/12 , C07C311/13 , C07C311/14 , C07C311/19 , C07C311/20 , C07C311/27 , C07C311/29 , C07D493/08 , A61K31/215 , A61K31/18 , C07C69/608
CPC分类号： C07C311/19 , C07C311/07 , C07C311/10 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/20 , C07C311/27 , C07C311/29
摘要： (1) Prostaglandin (PG) E.sub.2 antagonist or agonist containing carbocyclic sulfonamides represented by the compound of the formula (I): ##STR1## cyclodextrin clathrates thereof, non-toxic salts thereof as active ingredient, (2) carbocyclic sulfonamides represented by the compound of the formula (II): ##STR2## cyclodextrin clathrates thereof, non-toxic salts thereof, (3) process for the preparation of the compound represented by the compound of the formula (II) described hereinbefore, (4) PGE.sub.2 antagonist or agonist containing the compound represented by the compound of the formula (II) as active ingredient.The compounds represented by the compounds of the formula (I) and (II) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgetic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE.sub.2 antagonists, and an uterine contractile activity, a promoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, a hypotensive activity as PGE.sub.2 agonists, because they bind onto PGE.sub.2 receptor and have an activity of antagonist or agonist against the action thereof.
摘要翻译：（1）由式（I）化合物表示的前列腺素（PG）E2拮抗剂或含有碳环磺酰胺的激动剂：其作为活性成分的无毒盐，（2）代表的碳环磺酰胺通式（II）的化合物：其中，式（II）的环糊精包合物，其无毒盐，（3）由上述式（II）的化合物表示的化合物的制备方法，（ 4）含有由式（II）化合物表示的化合物作为活性成分的PGE 2拮抗剂或激动剂。由式（I）和（II）化合物表示的化合物可适用于具有子宫收缩抑制作用，止痛作用，消化性蠕动抑制作用，睡眠诱导作用PGE2拮抗剂的药物，因为它们结合PGE2受体并且具有针对其作用的拮抗剂或激动剂的活性，因此其作为PGE2激动剂具有低血压活性，作为消化道蠕动的促进作用，胃酸分泌的抑制作用。

9. 发明授权

US5480998A Oxime derivative 失效
标题翻译：肟衍生物
公开(公告)号：US5480998A
公开(公告)日：1996-01-02
申请号：US215019
申请日：1994-03-17
申请人： Nobuyuki Hamanaka , Kanji Takahashi , Hidekado Tokumoto
发明人： Nobuyuki Hamanaka , Kanji Takahashi , Hidekado Tokumoto
IPC分类号： A61K31/19 , A61K31/215 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , C07C239/20 , C07C251/54 , C07D207/335 , C07D213/53 , C07D213/30 , C07D213/42 , C07D213/54
CPC分类号： C07D213/53 , C07C239/20 , C07C251/54 , C07C2102/10
摘要： An oxime derivative (I): ##STR1## that D ring and B bonding to D ring are (i)-(iv), wherein R.sup.1 is hydrogen, lower alkyl; R.sup.2 is hydrogen, alkyl, phenyl, cycloalkyl, monocyclic ring containing nitrogen, lower alkyl substituted by benzene ring or cycloalkyl, lower alkyl substituted by monocyclic ring containing nitrogen; R.sup.3 is alkyl, phenyl, cycloalkyl, monocyclic ring containing nitrogen, lower alkyl substituted by benzene ring or cycloalkyl, lower alkyl substituted by monocyclic ring containing nitrogen; e is 3-5, f is 1-3, p is 1-4, q is 1-2, r is 1-3; the position of the bond to D ring in (iii) and (iv) is a or b, and the ring in R.sup.2 and R.sup.3 may be substituted by lower alkyl, alkoxy, halogen, nitro, trihalomethyl; and salts thereof, possess an agonistic activity on PGl2 receptor, and therefore are useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension.
摘要翻译：肟衍生物（I）：D环和B键合到D环的肟衍生物（I）是（i） - （iv），其中R 1是氢，低级烷基; R2是氢，烷基，苯基，环烷基，含氮的单环，被苯环或环烷基取代的低级烷基，被含氮的单环取代的低级烷基; R3是烷基，苯基，环烷基，含氮的单环，被苯环或环烷基取代的低级烷基，被含氮的单环取代的低级烷基; e为3-5，f为1-3，p为1-4，q为1-2，r为1-3; （iii）和（iv）中键与D环的位置是a或b，R2和R3中的环可以被低级烷基，烷氧基，卤素，硝基，三卤代甲基取代; 其盐具有对PG1受体的激动作用，因此可用于预防和/或治疗血栓形成，动脉硬化，缺血性心脏病，胃溃疡和高血压。

10. 发明授权

US4389413A 9,11-Methano-13-aza-11a-carbathrombanoic acid analogues 失效
公开(公告)号：US4389413A
公开(公告)日：1983-06-21
申请号：US285723
申请日：1981-07-22
申请人： Nobuyuki Hamanaka , Shinsuke Hashimoto , Masaki Hayashi
发明人： Nobuyuki Hamanaka , Shinsuke Hashimoto , Masaki Hayashi
IPC分类号： C07C33/14 , C07C405/00 , C07D309/12 , A61K31/557 , C07C101/14
CPC分类号： C07C33/14 , C07C405/0091 , C07D309/12 , Y10S514/826
摘要： The 9,11-methano-13-aza-11a-carbathrombanoic acid analogues of the general formula: ##STR1## [wherein A represents ##STR2## (in which m is an integer of 1 to 6, the double bond between the carbon atoms in positions 5 and 6 in (iv) is in cis or trans-configuration or a mixture thereof and the phenylene group in (iv) represents o-, m- or p-phenylene), R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group of 1 to 12 carbon atoms, two R.sup.2 both represent hydrogen atoms or methyl groups, R.sup.3 represents a hydrogen atom or a hydroxy group, R.sup.4 represents a single bond or a straight- or branched-chain alkylene group of 1 to 5 carbon atoms, R.sup.5 represents(i) a straight- or branched-chain alkyl, alkoxy or alkylthio group of 1 to 8 carbon atoms,(ii) a cycloalkyl or cycloalkyloxy group of 4 to 7 carbon atoms being unsubstituted or substituted by at least one straight- or branched-chain alkyl group of 1 to 8 carbon atoms or ##STR3## in which Z represents a single bond, an oxygen atom or a sulfur atom and R.sup.6 may occupy any of the free positions on the phenyl ring and represents a hydrogen atom, a halogen atom, a hydroxy group, a straight- or branched-chain alkyl or alkoxy group of 1 to 5 carbon atoms, a trihalomethyl group, an amino group or a mono- or dialkyl-amino group of 1 to 5 carbon atoms)and the wavy line attached to the carbon atom in position 15 represents .alpha.- or .beta.-configuration or a mixture thereof, provided that, when R.sup.3 represents a hydroxy group and R.sup.4 represents a single bond, R.sup.5 does not represent an alkoxy group, an alkylthio group, a cycloalkyloxy group, a phenoxy group and a phenylthio group],and cyclodextrin clathrates thereof, and when R.sup.1 represents a hydrogen atom, non-toxic salts thereof, possess strong inhibitory activities on platelet aggregation and on aorta contraction, and are useful for prevention and treatment of diseases which are induced by thromboxane A.sub.2.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式