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1. 发明授权

US4615977A Method for the cultivation of normal diploid cells and cultivation medium used therefor 失效
标题翻译：用于培养正常二倍体细胞的方法和用于其的培养基
公开(公告)号：US4615977A
公开(公告)日：1986-10-07
申请号：US446144
申请日：1982-12-02
申请人： Akio Hasegawa , Sadakazu Horiguchi
发明人： Akio Hasegawa , Sadakazu Horiguchi
IPC分类号： C12N5/00
CPC分类号： C12N5/0037 , C12N2500/25 , C12N2500/46 , C12N2501/11
摘要： A method and medium for the multiplication of normal diploid cells from mammals is described, comprising cultivating the cells in a culture medium containing an amine derivative or derivatives represented by the general formula: NR.sup.1 R.sup.2 R.sup.3 (wherein R.sup.1, R.sup.2 and R.sup.3 represents a straight, branched or cyclic alkyl group or a hydrogen atom, provided that R.sup.1, R.sup.2 and R.sup.3 are not hydrogen atoms at the same time. Addition of these specific amine derivatives permits multiplication of normal diploid cells in a culture medium containing a limited concentration of serum. These amine derivatives are inexpensive and can be stored for a long period of time, and their storage and handling are easy. The use of these amine derivatives overcomes various problems encountered in using serum in the multiplication of normal diploid cells according to conventional methods.
摘要翻译：描述了用于从哺乳动物繁殖正常二倍体细胞的方法和培养基，包括在含有胺衍生物的培养基中培养细胞或通式为NR1R2R3（其中R1，R2和R3表示直链，支链或环状烷基或氢原子，条件是R1，R2和R3不同时为氢原子，这些特异性胺衍生物的添加允许正常二倍体细胞在含有有限浓度血清的培养基中增殖，这些胺衍生物这些胺衍生物的使用克服了常规方法在正常二倍体细胞增殖中使用血清时遇到的各种问题。

2. 发明授权

US08121629B2 Radio device 有权
标题翻译：无线电设备
公开(公告)号：US08121629B2
公开(公告)日：2012-02-21
申请号：US11887188
申请日：2006-03-29
申请人： Peter Davis , Satoko Itaya , Jun Hasegawa , Akio Hasegawa , Naoto Kadowaki , Sadao Obana
发明人： Peter Davis , Satoko Itaya , Jun Hasegawa , Akio Hasegawa , Naoto Kadowaki , Sadao Obana
IPC分类号： H04B7/00
CPC分类号： H04W40/30 , H04B7/155 , H04L45/26 , H04W40/12 , H04W40/24
摘要： Radio devices (31 to 43) receive a prescribed number of Hello packets from each of n radio devices existing within one hop from each radio device, detects six pairs of maximum and minimum values MAX[1] and MIN[1] to MAX[6] and MIN[6] based on the plurality of reception signal strengths of the plurality of received Hello packets, detects two adjacent maximum values having the largest difference among six pairs of maximum and minimum values D_MAX[1] and D_MIN[1] to D_MAX[6] and D_MIN[6] when the six maximum values MAX[1] to MAX[6] are in descending order, and determines the average of two minimum values corresponding to the detected two maximum values as a threshold. The radio devices (31 to 43) each produce a routing table including routes having reception signal strengths equal to or more than the threshold.
摘要翻译：无线电设备（31至43）从每个无线电设备接收来自存在于一跳内的n个无线电设备中的每个无线电设备的规定数量的Hello分组，检测到六对最大值和最小值MAX [1]和MIN [1]至MAX [6 ]和MIN [6]基于多个接收的Hello分组的多个接收信号强度，检测在六对最大值和最小值D_MAX [1]和D_MIN [1]到D_MAX中具有最大差异的两个相邻最大值 [6]和D_MIN [6]当六个最大值MAX [1]至MAX [6]处于降序时，并将与检测到的两个最大值相对应的两个最小值的平均值确定为阈值。无线装置（31〜43）各自产生包含具有等于或大于阈值的接收信号强度的路由的路由表。

3. 发明授权

US07890112B2 Radio device having fewer route disconnections and switchings by using control packets to maintain radio links 有权
标题翻译：无线电设备通过使用控制分组来维持无线电链路，具有较少的路由断开和切换
公开(公告)号：US07890112B2
公开(公告)日：2011-02-15
申请号：US11896531
申请日：2007-09-04
申请人： Tetsuya Ito , Jun Hasegawa , Satoko Itaya , Akira Matsumoto , Hiroyuki Iizuka , Yuichiro Ezure , Akio Hasegawa , Peter Davis , Naoto Kadowaki , Sadao Obana
发明人： Tetsuya Ito , Jun Hasegawa , Satoko Itaya , Akira Matsumoto , Hiroyuki Iizuka , Yuichiro Ezure , Akio Hasegawa , Peter Davis , Naoto Kadowaki , Sadao Obana
IPC分类号： H04W40/00
CPC分类号： H04W40/24 , H04W84/18
摘要： The route maintenance unit outputs a period setting request to the period setting unit when the communication unit normally receives a Hello packet for the first time. The period setting unit sets a link connection confirmation period in response to the period setting request and outputs the set period to the route maintenance unit. The route maintenance unit maintains a radio link between the radio device in which the route maintenance unit is provided and an adjacent device upon receiving a data packet other than a Hello packet from the adjacent radio device even if a Hello packet is not received in the link connection confirmation period. Consequently, route disconnection or switching occurs less often.
摘要翻译：当通信单元首次正常接收到Hello分组时，路由维护单元向周期设置单元输出周期设置请求。周期设定单元响应于周期设置请求设置链路连接确认周期，并将设置的周期输出到路线维护单元。路由维护单元在从邻接无线设备接收到除了Hello报文以外的数据分组的情况下，即使没有在链路中接收到Hello分组，也保持在提供路由维护单元的无线设备与相邻设备之间的无线链路连接确认期。因此，路由断开或切换较少发生。

4. 发明授权

US07697590B2 Communicating apparatus and communicating method 失效
标题翻译：通讯装置及通讯方式
公开(公告)号：US07697590B2
公开(公告)日：2010-04-13
申请号：US10560574
申请日：2004-06-11
申请人： Ken Umeno , Akio Hasegawa , Minghui Kao
发明人： Ken Umeno , Akio Hasegawa , Minghui Kao
IPC分类号： H04B1/00
CPC分类号： H04B1/707
摘要： A chaos spreading code c(n) is inputted to a spreading unit 32. Data D1 and c(n) are multiplied in the spreading unit 32. A chaos spreading code d(n) is inputted to a spreading unit 42. Data D2 and d(n) are multiplied in the spreading unit 42. The chaos spreading codes c(n) and d(n) orthogonally cross each other. Outputs of the spreading units 32 and 42 are added by an adder 35 and transmitted through a transmitting unit 36 to a transmission path 38. By making an initial value which is set in a chaos sequence generator having a construction of a digital circuit different, the chaos spreading codes which orthogonally cross can be formed. Since the chaos spreading codes c(n) and d(n) orthogonally cross, an orthogonal modulating unit having a construction of an analog circuit for amplitude-modulating carriers which orthogonally cross can be made unnecessary and the construction can be simplified.
摘要翻译：混乱扩展码c（n）被输入到扩展单元32.数据D1和c（n）在扩展单元32中相乘。混沌扩展码d（n）被输入到扩展单元42.数据D2和 d（n）在扩展单元42中相乘。混沌扩展码c（n）和d（n）正交交叉。扩展单元32和42的输出由加法器35相加，并通过发送单元36发送到传输路径38.通过使具有数字电路结构不同的混沌序列发生器中设置的初始值，可以形成正交交叉的混沌扩展码。由于混沌扩展码c（n）和d（n）正交交叉，所以可以使得具有用于正交交叉的幅度调制载波的模拟电路的结构的正交调制单元不需要，并且可以简化结构。

5. 发明授权

US08041377B2 Radio device for preventing isolated radio devices in network 有权
标题翻译：用于防止网络中的隔离无线电设备的无线电设备
公开(公告)号：US08041377B2
公开(公告)日：2011-10-18
申请号：US11905006
申请日：2007-09-27
申请人： Satoko Itaya , Jun Hasegawa , Akio Hasegawa , Peter Davis , Tetsuya Ito , Akira Matsumoto , Naoto Kadowaki , Sadao Obana
发明人： Satoko Itaya , Jun Hasegawa , Akio Hasegawa , Peter Davis , Tetsuya Ito , Akira Matsumoto , Naoto Kadowaki , Sadao Obana
IPC分类号： H04B7/00
CPC分类号： H04W40/24 , H04B17/318 , H04W40/12
摘要： A radio device is located far from other radio devices in a radio network system. The radio device determines a threshold WIth for detecting a strength equal to or more than the minimum strength of radio waves transmitted/received in a stable radio wave environment based on a plurality of reception signal strengths of Hello packets received from radio devices adjacent to the radio device. Then, if the number of radio devices adjacent to the radio device when the threshold WIth is introduced is less than a standard value (such as five), the radio device stores the adjacent radio devices in the neighbor list without introducing the threshold WIth, and then, maintains in the routing table the routing information of routes passing through the adjacent radio devices based on the neighbor list.
摘要翻译：无线电设备位于远离无线电网络系统中的其他无线电设备的位置。无线电设备基于从与无线电设备相邻的无线电设备接收的多个接收信号强度来确定用于检测等于或大于在稳定无线电波环境中发送/接收的无线电波的最小强度的强度的阈值设备。然后，如果在引入阈值WIth时与无线电设备相邻的无线设备的数量小于标准值（例如5），则无线设备将相邻的无线电设备存储在邻居列表中而不引入阈值WIth，并且然后根据邻居列表在路由表中维护通过相邻无线设备的路由的路由信息。

6. 发明授权

US4505893A Purified plasminogen activator, process for its production and thrombolytic composition containing it 失效
标题翻译：纯化的纤溶酶原激活剂，其生产过程及含有溶血栓组合物
公开(公告)号：US4505893A
公开(公告)日：1985-03-19
申请号：US519347
申请日：1983-08-01
申请人： Toshihito Mori , Hideo Yoshizaki , Akio Hasegawa
发明人： Toshihito Mori , Hideo Yoshizaki , Akio Hasegawa
IPC分类号： C12N9/64 , A61K38/00 , A61K38/46 , A61K38/48 , A61P7/02 , C12N5/02 , C12N9/72 , C12R1/91 , A61K37/48 , C12P21/00
CPC分类号： C12N9/6456 , A61K38/00
摘要： A plasminogen activator obtained from a tissue cultured liquor of human normal tissue derived cells, e.g., human embryonic derived cells, human placenta derived cells etc., and having the following properties:(a) molecular weight measured by gel filtration: 63,000.+-.10,000,(b) isoelectric point: 7.0-8.5,(c) affinity to fibrin: present,(d) affinity to concanavalin A: present,(e) optimum pH: 7-9.5, and(f) stability: does not lose activity at 60.degree. C. for 10 hours but loses about 5% of activity at pH 2-3 at 98.degree. C. for a minute; a process for the production of the aforesaid plasminogen activator; and a thrombolytic composition containing the aforesaid plasminogen activator as an active ingredient are disclosed.
摘要翻译：从人正常组织衍生细胞（例如人胚胎衍生细胞，人胎盘衍生细胞等）的组织培养液中获得并具有以下性质的纤溶酶原激活剂：（a）通过凝胶过滤测量的分子量：63,000 +/- 10,000，（b）等电点：7.0-8.5，（c）对纤维蛋白的亲和力：存在，（d）对伴刀豆球蛋白的亲和力A：存在，（e）最适pH：7-9.5和（f）稳定性：不失去在60℃下活化10小时，但在98℃在pH 2-3下失去约5％的活性一分钟; 一种生产上述纤溶酶原激活物的方法; 并且公开了含有上述纤溶酶原激活剂作为活性成分的血栓溶解组合物。

7. 发明申请

US20080076461A1 Radio device for preventing isolated radio devices in network 有权
标题翻译：用于防止网络中的隔离无线电设备的无线电设备
公开(公告)号：US20080076461A1
公开(公告)日：2008-03-27
申请号：US11905006
申请日：2007-09-27
申请人： Satoko Itaya , Jun Hasegawa , Akio Hasegawa , Peter Davis , Tetsuya Ito , Akira Matsumoto , Naoto Kadowaki , Sadao Obana
发明人： Satoko Itaya , Jun Hasegawa , Akio Hasegawa , Peter Davis , Tetsuya Ito , Akira Matsumoto , Naoto Kadowaki , Sadao Obana
IPC分类号： H04B7/00
CPC分类号： H04W40/24 , H04B17/318 , H04W40/12
摘要： A radio device is located far from other radio devices in a radio network system. The radio device determines a threshold WIth for detecting a strength equal to or more than the minimum strength of radio waves transmitted/received in a stable radio wave environment based on a plurality of reception signal strengths of Hello packets received from radio devices adjacent to the radio device. Then, if the number of radio devices adjacent to the radio device when the threshold WIth is introduced is less than a standard value (such as five), the radio device stores the adjacent radio devices in the neighbor list without introducing the threshold WIth, and then, maintains in the routing table the routing information of routes passing through the adjacent radio devices based on the neighbor list.
摘要翻译：无线电设备位于远离无线电网络系统中的其他无线电设备的位置。无线电设备基于从与无线电设备相邻的无线电设备接收的多个接收信号强度来确定用于检测等于或大于在稳定无线电波环境中发送/接收的无线电波的最小强度的强度的阈值设备。然后，如果在引入阈值WIth时与无线电设备相邻的无线设备的数量小于标准值（例如5），则无线设备将相邻的无线电设备存储在邻居列表中而不引入阈值WIth，并且然后根据邻居列表在路由表中维护通过相邻无线设备的路由的路由信息。

8. 发明申请

US20080062901A1 Radio apparatus 有权
标题翻译：无线电设备
公开(公告)号：US20080062901A1
公开(公告)日：2008-03-13
申请号：US11896170
申请日：2007-08-30
申请人： Naoto Kadowaki , Peter Davis , Jun Hasegawa , Akio Hasegawa , Sadao Obana
发明人： Naoto Kadowaki , Peter Davis , Jun Hasegawa , Akio Hasegawa , Sadao Obana
IPC分类号： H04B7/00
CPC分类号： H04B1/707 , H04W72/02 , H04W84/18 , H04W88/02
摘要： Radio apparatuses each has a plurality of channels and, when data is to be transmitted, selects a specific channel having relatively low signal interference from the plurality of channels. Each radio apparatus spreads transmission data with a prescribed spread code arbitrarily selected from a plurality of spread codes, and modulates the spread spectrum signal with the frequency of the specific channel to transmit. As a result, delay in an autonomously established wireless network can be reduced.
摘要翻译：无线电装置各自具有多个信道，并且当要发送数据时，从多个信道中选择具有相对低的信号干扰的特定信道。每个无线电设备利用从多个扩展码任意选择的规定的扩展码扩展发送数据，并且以特定信道的频率对扩频信号进行调制以进行发送。结果，可以减少自主建立的无线网络中的延迟。

9. 发明申请

US20060209926A1 Communication device and communication method 失效
标题翻译：通信设备和通信方式
公开(公告)号：US20060209926A1
公开(公告)日：2006-09-21
申请号：US10560574
申请日：2004-06-11
申请人： Ken Umeno , Akio Hasegawa , Minghui Keo
发明人： Ken Umeno , Akio Hasegawa , Minghui Keo
IPC分类号： H04B1/00
CPC分类号： H04B1/707
摘要： A chaos spreading code c(n) is inputted to a spreading unit 32. Data D1 and c(n) are multiplied in the spreading unit 32. A chaos spreading code d(n) is inputted to a spreading unit 42. Data D2 and d(n) are multiplied in the spreading unit 42. The chaos spreading codes c(n) and d(n) orthogonally cross each other. Outputs of the spreading units 32 and 42 are added by an adder 35 and transmitted through a transmitting unit 36 to a transmission path 38. By making an initial value which is set in a chaos sequence generator having a construction of a digital circuit different, the chaos spreading codes which orthogonally cross can be formed. Since the chaos spreading codes c(n) and d(n) orthogonally cross, an orthogonal modulating unit having a construction of an analog circuit for amplitude-modulating carriers which orthogonally cross can be made unnecessary and the construction can be simplified.
摘要翻译：乱序扩展码c（n）被输入到扩展单元32。数据D 1和c（n）在扩展单元32中相乘。乱序扩展码d（n）被输入到扩展单元42。数据D 2和d（n）在扩展单元42中相乘。混沌扩展码c（n）和d（n）正交交叉。扩展单元32和42的输出由加法器35相加，并通过发送单元36发送到传输路径38。通过使具有数字电路结构的混沌序列发生器中设定的初始值不同，可以形成正交交叉的混沌扩频码。由于混沌扩展码c（n）和d（n）正交交叉，所以可以使得具有用于正交交叉的幅度调制载波的模拟电路的结构的正交调制单元不需要，并且可以简化结构。

10. 发明授权

US4568544A Aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method 失效
标题翻译：以增加的浓度溶解于其中的组织纤溶酶原激活剂的水溶液和方法
公开(公告)号：US4568544A
公开(公告)日：1986-02-04
申请号：US705896
申请日：1985-02-26
申请人： Akio Hasegawa , Shuhei Kondo
发明人： Akio Hasegawa , Shuhei Kondo
IPC分类号： A61K38/00 , A61K47/18 , C07K16/40 , C12N9/72 , C12N9/96 , C12N9/48 , A61K35/48 , A61K37/04 , A61K37/54
CPC分类号： C12N9/6459 , A61K47/183 , A61K9/0019 , C07K16/40 , C12N9/96 , C12Y304/21069 , A61K38/00
摘要： An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration which comprises an aqueous medium and, dissolved therein, a high purity tissue plasminogen activator and at least one dissolution aid selected from the group consisting of lysine, ornithine and salts thereof, and a method for increasing a solubility of a high purity tissue plasminogen activator in an aqueous medium comprising adding said at least one dissolution aid to an aqueous solution of a high purity tissue plasminogen activator. The present aqueous solution contains a high purity tissue plasminogen activator dissolved therein at an increased concentration and the activity of the tissue plasminogen activator can be maintained during handling and storage of the aqueous solution. Therefore, not only can be easily and efficiently performed the treatment of a tissue plasminogen activator in each purification step but also can be stored safely, stably an aqueous tissue plasminogen activator solution as a final product.
摘要翻译：组织纤溶酶原激活剂的水溶液以增加的浓度溶解在其中，其包含水性介质，并溶解于其中，高纯度组织纤溶酶原激活剂和至少一种选自赖氨酸，鸟氨酸及其盐的溶解助剂和一种用于增加高纯度组织纤溶酶原激活剂在水性介质中的溶解度的方法，包括将所述至少一种溶解助剂加入到高纯度组织纤溶酶原激活剂的水溶液中。本发明的水溶液含有以增加的浓度溶解于其中的高纯度组织纤溶酶原激活物，并且可以在处理和储存水溶液期间维持组织纤溶酶原激活剂的活性。因此，不仅可以容易且有效地进行各纯化步骤中的组织纤溶酶原激活剂的治疗，而且可以安全，稳定地存储水性组织纤溶酶原激活剂溶液作为最终产品。

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