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1. 发明申请

US20060142311A1 Prodan-containing nucleotide and use thereof 审中-公开
标题翻译：含有Prodan的核苷酸及其用途
公开(公告)号：US20060142311A1
公开(公告)日：2006-06-29
申请号：US11135368
申请日：2005-05-24
申请人： Akimitsu Okamoto , Kazuki Tainaka , Isao Saito , Norihiko Takahashi
发明人： Akimitsu Okamoto , Kazuki Tainaka , Isao Saito , Norihiko Takahashi
IPC分类号： A61K31/522 , A61K31/513
CPC分类号： C07D239/54 , C07D473/34 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20
摘要： A compound represented by formula (1): wherein R1 is a substituent represented by formula (2): wherein R2 is ═O or —NH2, with the proviso that when R2 is ═O, H is attached to the 1-position N of the pyrimidine ring, and the bond between the 1-position N and the 6-position C is a single bond; or a substituent represented by formula (3): wherein R3 is —OH, ═O, or —NH2, with the proviso that when R3 is —OH or —NH2, R4 is H; when R3 is ═O, R4 is —NH2; and when R3 is ═O, H is attached to the 1-position N of the purine ring, and the bond between the 1-position N and the 6-position C is a single bond.
摘要翻译：由式（1）表示的化合物：其中R 1是由式（2）表示的取代基：其中R 2是-O或-NH 2， / SUB>，条件是当R 2为-O时，H与嘧啶环的1位氮连接，1位N和6位之间的键 C是单键; 或由式（3）表示的取代基：其中R 3是-OH，-O或-NH 2，条件是当R 3' / SUP>是-OH或-NH 2，R 4是H; 当R 3为-O时，R 4为-NH 2; 当R 3为-O时，H与嘌呤环的1位氮连接，1位N与6位C之间的键为单键。

2. 发明申请

US20080302674A1 Probe Unit, Apparatus for Identifying Nucleotide Region and Method of Identifying Nucleotide Region 审中-公开
标题翻译：探针单元，识别核苷酸区域的装置和识别核苷酸区域的方法
公开(公告)号：US20080302674A1
公开(公告)日：2008-12-11
申请号：US11667980
申请日：2005-12-21
申请人： Akimitsu Okamoto , Taku Kamei , Isao Saito
发明人： Akimitsu Okamoto , Taku Kamei , Isao Saito
IPC分类号： G01N33/487
CPC分类号： G01N33/5438 , C12Q1/6825 , C12Q2565/519 , C12Q2563/113
摘要： A probe unit for identifying a target nucleotide region in a target nucleic acid, the unit being provided with an electrode, a probe bound to the electrode and recognizes the target nucleic acid, and a hole-transfer-inducing agent bound to the probe, wherein a nucleotide region corresponding to the target nucleotide region is located between the hole-transfer-inducing-agent-binding site and the electrode-binding end of the probe. A state of the target nucleotide region in the target nucleic acid can be identified by comparing electrochemical signal levels by energy-induced hole transfers before and after the hybridization of such a probe unit with the target nucleic acid.
摘要翻译：用于鉴定目标核酸中的靶核苷酸区域的探针单元，所述单元设置有电极，与电极结合并识别靶核酸的探针和与探针结合的空穴传递诱导剂，其中与靶核苷酸区域对应的核苷酸区域位于探针的空穴传递诱导剂结合位点和电极结合末端之间。可以通过在这种探针单元与靶核酸的杂交之前和之后通过能量诱导的空穴转移比较电化学信号水平来鉴定靶核酸中靶核苷酸区的状态。

3. 发明申请

US20050059037A1 Nucleotide derivative and DNA microarray 有权
标题翻译：核苷酸衍生物和DNA微阵列
公开(公告)号：US20050059037A1
公开(公告)日：2005-03-17
申请号：US10795436
申请日：2004-03-09
申请人： Isao Saito , Akimitsu Okamoto , Yoshio Saito , Yasuko Yoshida , Kousuke Niwa
发明人： Isao Saito , Akimitsu Okamoto , Yoshio Saito , Yasuko Yoshida , Kousuke Niwa
IPC分类号： C07H19/04 , C07H19/067 , C07H21/00 , C07H21/04 , C12N15/09 , C12Q1/68 , G01N33/58
CPC分类号： C07H19/04 , C07H19/06 , C07H19/067 , C07H19/16 , C07H21/00 , C07H21/04 , C12Q1/6837 , Y10S436/809 , C12Q2565/549
摘要： A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intensity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is a thymine/uracil derivative (1) emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; a cytosine derivative (2) emitting light most intensely when the confronting base is guanine; an adenine derivative (3) emitting light most intensely when the confronting base is cytosine; a guanine derivative (4) emitting light most intensely when the confronting base is cytosine or thymine/uracil; and an adenine derivative (5) emitting light most intensely when the confronting base is thymine/uracil.
摘要翻译：在存在单链序列成员的情况下，新的核苷酸衍生物根据与单链序列杂交的伴侣链中的相应碱基类型经历荧光信号强度的变化，并且其是当与单链核苷酸序列杂交的伴侣链中的相对的碱基是腺嘌呤时，最强烈地发射光的胸腺嘧啶/尿嘧啶衍生物（1）当相对的碱是鸟嘌呤时，胞嘧啶衍生物（2）最强地发射光; 当面对的碱基是胞嘧啶时，腺苷衍生物（3）最强地发光; 当面对的碱基是胞嘧啶或胸腺嘧啶/尿嘧啶时，最强烈地发射光的鸟嘌呤衍生物（4）和当面对的碱是胸腺嘧啶/尿嘧啶时最强烈地发光的腺嘌呤衍生物（5）。

4. 发明授权

US07205396B2 Benzodeazaadenine derivative base and electronic material containing the same 失效
标题翻译：苯并恶唑衍生物基质和含有它们的电子材料
公开(公告)号：US07205396B2
公开(公告)日：2007-04-17
申请号：US10508138
申请日：2002-08-15
申请人： Isao Saito , Akimitsu Okamoto , Kazuo Tanaka
发明人： Isao Saito , Akimitsu Okamoto , Kazuo Tanaka
IPC分类号： C07H21/00 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/04 , B82Y10/00 , C07H19/04 , C07H19/22 , C07H19/23 , H01L51/0072 , H01L51/0093
摘要： A nucleic acid base for hole transportation in DNAs which does not cause oxidative decomposition; and an artificial DNA molecule which can realize effective hole transportation in DNAs while maintaining the double spiral structure of the DNAs. Provided are: a nucleic acid which contains a benzodeazaadenine derivative base represented by the general formula (I): (wherein R1, R2, R3, R4, R5, and R6 each independently represents hydrogen, amino, mono (lower alkyl) amino, di (lower alkyl) amino, hydroxy, lower alkoxy, halogeno, cyano, mercapto, lower alkylthio, or aryl; and R7 and R8 each independently represents hydrogen or a group bonded to phosphoric acid); and a polynucleotide comprising the nucleic acid.
摘要翻译： DNA不会引起氧化分解的空穴传输核酸碱基; 以及能够在保持DNA的双螺旋结构的同时实现DNA中有效空穴传输的人造DNA分子。提供：含有由通式（I）表示的苯并恶唑烷衍生物碱的核酸：

5. 发明授权

US07323555B2 Nucleotide derivative and DNA microarray 失效
标题翻译：核苷酸衍生物和DNA微阵列
公开(公告)号：US07323555B2
公开(公告)日：2008-01-29
申请号：US10746157
申请日：2003-12-24
申请人： Isao Saito , Akimitsu Okamoto , Yasuko Yoshida
发明人： Isao Saito , Akimitsu Okamoto , Yasuko Yoshida
IPC分类号： C07H21/02 , C07H21/04 , G01N33/53 , C12Q1/68
CPC分类号： C07H19/067 , C07H21/04 , Y10S436/809
摘要： A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intensity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is (1) a thymine/uracil derivative emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; (2) a cytosine derivative emitting light most intensely when the confronting base is guanine; (3) an adenine derivative emitting light most intensely when the confronting base is cytosine; and, (4) a guanine derivative emitting light most intensely when the confronting base is cytosine or thymine/uracil.
摘要翻译：在存在单链序列成员的情况下，新的核苷酸衍生物根据与单链序列杂交的伴侣链中的相应碱基类型经历荧光信号强度的变化，并且其是（1）当与单链核苷酸序列杂交的配对链中的相对碱基是腺嘌呤时，最强烈地发射光的胸腺嘧啶/尿嘧啶衍生物; （2）当对面的碱是鸟嘌呤时，最强烈地发射光的胞嘧啶衍生物; （3）当面对的碱基是胞嘧啶时，最强烈地发光的腺嘌呤衍生物; 和（4）当对面的碱基是胞嘧啶或胸腺嘧啶/尿嘧啶时，最强烈地发光的鸟嘌呤衍生物。

6. 发明申请

US20050142554A1 Benzodeazaadenine derivative base and electronic material containing the same 失效
标题翻译：苯并恶唑衍生物基质和含有它们的电子材料
公开(公告)号：US20050142554A1
公开(公告)日：2005-06-30
申请号：US10508138
申请日：2002-08-15
申请人： Isao Saito , Akimitsu Okamoto , Kazuo Tanaka
发明人： Isao Saito , Akimitsu Okamoto , Kazuo Tanaka
IPC分类号： C07H19/14 , C07H19/04 , C07H19/22 , C07H19/23 , C07H21/04 , H01L51/30 , C12Q1/68 , C12M1/34
CPC分类号： C07H21/04 , B82Y10/00 , C07H19/04 , C07H19/22 , C07H19/23 , H01L51/0072 , H01L51/0093
摘要： A nucleic acid base for hole transportation in DNAs which does not cause oxidative decomposition; and an artificial DNA molecule which can realize effective hole transportation in DNAs while maintaining the double spiral structure of the DNAs. Provided are: a nucleic acid which contains a benzodeazaadenine derivative base represented by the general formula (I): (wherein R1, R2, R3, R4, R5, and R6 each independently represents hydrogen, amino, mono (lower alkyl) amino, di (lower alkyl) amino, hydroxy, lower alkoxy, halogeno, cyano, mercapto, lower alkylthio, or aryl; and R7 and R8 each independently represents hydrogen or a group bonded to phosphoric acid); and a polynucleotide comprising the nucleic acid.
摘要翻译： DNA不会引起氧化分解的空穴传输核酸碱基; 以及能够在保持DNA的双螺旋结构的同时实现DNA中有效空穴传输的人造DNA分子。提供：含有由通式（I）表示的苯并恶唑腺苷衍生物碱的核酸：其中R 1，R 2，R 3， R 3，R 5，R 5和R 6各自独立地表示氢，氨基，单（低级烷基）氨基，二（低级烷基）氨基，羟基，低级烷氧基，卤代，氰基，巯基，低级烷硫基或芳基; R 7和R 8各自独立地表示氢或键合到磷酸）; 和包含该核酸的多核苷酸。

7. 发明授权

US07563886B2 Nucleoside releasing functional unit through oxidation and process for producing oligonucleotide containing thereof 失效
标题翻译：通过氧化产生核苷释放功能单元和用于生产含有其的寡核苷酸的方法
公开(公告)号：US07563886B2
公开(公告)日：2009-07-21
申请号：US10567364
申请日：2004-08-02
申请人： Isao Saito , Akimitsu Okamoto , Kazuo Tanaka
发明人： Isao Saito , Akimitsu Okamoto , Kazuo Tanaka
IPC分类号： C07H19/22
CPC分类号： C07H19/173 , C07H19/20 , C12Q1/6823 , C12Q2525/101
摘要： A method of easily releasing a useful substance bonded to oligonucleotide without impairing a target nucleic acid; and a novel base therefore. A nucleoside of nucleotide (oligonucleotide containing thereof) represented by the formula (I) (wherein each of X and Y independently represents —O—, —NH—, —N(alkyl)- or —S—; R represents a functional unit, a reporter unit or a biofunctional molecule; each of R1 and R2 independently represents a hydrogen atom, a phosphate bond group, a phosphoramidite group or a nucleotide; and n is a numeral of 1 to 10). There is further provided a method of releasing the R group moiety at base portion by the use of the oligonucleotide comprising the nucleotide.
摘要翻译：一种容易地释放与寡核苷酸结合而不损害目标核酸的有用物质的方法; 和一个新的基地。由式（I）表示的核苷酸（其含有寡核苷酸）的核苷（其中X和Y各自独立地表示-O - ， - NH - ， - N（烷基） - 或-S-; R表示官能单元，报告单元或生物功能分子; R 1和R 2各自独立地表示氢原子，磷酸键合基，亚磷酰胺基或核苷酸; n为1〜10的数）。还提供了通过使用包含该核苷酸的寡核苷酸在碱基部分释放R基团部分的方法。

8. 发明授权

US07414117B2 Nucleotide derivative and DNA microarray 有权
标题翻译：核苷酸衍生物和DNA微阵列
公开(公告)号：US07414117B2
公开(公告)日：2008-08-19
申请号：US10795436
申请日：2004-03-09
申请人： Isao Saito , Akimitsu Okamoto , Yoshio Saito , Yasuko Yoshida , Kousuke Niwa
发明人： Isao Saito , Akimitsu Okamoto , Yoshio Saito , Yasuko Yoshida , Kousuke Niwa
IPC分类号： C07H21/02 , C07H19/04 , C12Q1/68 , G01N33/53 , C07H21/00
CPC分类号： C07H19/04 , C07H19/06 , C07H19/067 , C07H19/16 , C07H21/00 , C07H21/04 , C12Q1/6837 , Y10S436/809 , C12Q2565/549
摘要： A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intendity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is a thymin/uracil derivative (1) emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; a cytosine derivative (2) emitting light most intensely when the confronting base is guanine; an adenine derivative (3) emitting light most intensely when the confronting base is cytosine; a guanine derivative (4) emitting light most intensely when the confronting base is cytosine or thymine/uracil; and an adrnine derivative (5) emitting light most intensely when the confronting base is thymine/uracil/.
摘要翻译：在存在单链序列成员的情况下，新的核苷酸衍生物依赖于与单链序列杂交的伴侣链中的相应碱基类型而经历荧光信号意图的变化，并且其是当与单链核苷酸序列杂交的伴侣链中的相对的碱基是腺嘌呤时，最强烈地发射光的甲氨喋呤/尿嘧啶衍生物（1）当相对的碱是鸟嘌呤时，胞嘧啶衍生物（2）最强地发射光; 当面对的碱基是胞嘧啶时，腺苷衍生物（3）最强地发光; 当面对的碱基是胞嘧啶或胸腺嘧啶/尿嘧啶时，最强烈地发射光的鸟嘌呤衍生物（4）和当相对底物是胸腺嘧啶/尿嘧啶时最强烈地发光的腺苷衍生物（5）。

9. 发明申请

US20070270582A1 Nucleoside Releasing Functional Unit Through Oxidation and Process for Producing Oligonucleotide Containing Thereof 失效
标题翻译：核苷释放功能单元通过氧化及其生产含有寡核苷酸的方法
公开(公告)号：US20070270582A1
公开(公告)日：2007-11-22
申请号：US10567364
申请日：2004-08-02
申请人： Isao Saito , Akimitsu Okamoto , Kazuo Tanaka
发明人： Isao Saito , Akimitsu Okamoto , Kazuo Tanaka
IPC分类号： C07H19/16
CPC分类号： C07H19/173 , C07H19/20 , C12Q1/6823 , C12Q2525/101
摘要： A method of easily releasing a useful substance bonded to oligonucleotide without impairing a target nucleic acid; and a novel base therefore. A nucleoside of nucleotide (oligonucleotide containing thereof) represented by the formula (I) (wherein each of X and Y independently represents —O—, —NH—, —N(alkyl)- or —S—; R represents a functional unit, a reporter unit or a biofunctional molecule; each of R1 and R2 independently represents a hydrogen atom, a phosphate bond group, a phosphoramidite group or a nucleotide; and n is a numeral of 1 to 10). There is further provided a method of releasing the R group moiety at base portion by the use of the oligonucleotide comprising the nucleotide.
摘要翻译：一种容易地释放与寡核苷酸结合而不损害目标核酸的有用物质的方法; 和一个新的基地。由式（I）表示的核苷酸（其含有寡核苷酸）的核苷（其中X和Y各自独立地表示-O - ， - NH - ， - N（烷基） - 或-S-; R表示官能单元，报告单元或生物功能分子; R 1和R 2各自独立地表示氢原子，磷酸键合基团，亚磷酰胺基团或核苷酸; n为数字1〜10）。还提供了通过使用包含该核苷酸的寡核苷酸在碱基部分释放R基团部分的方法。

10. 发明授权

US08383792B2 Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid 有权
标题翻译：具有衍生自单核苷或单核苷酸的结构的化合物，核酸，标记物质和用于检测核酸的方法和试剂盒
公开(公告)号：US08383792B2
公开(公告)日：2013-02-26
申请号：US12530574
申请日：2008-03-06
申请人： Akimitsu Okamoto , Shuji Ikeda , Takeshi Kubota
发明人： Akimitsu Okamoto , Shuji Ikeda , Takeshi Kubota
IPC分类号： C07H21/00 , C07H21/02 , C12Q1/68
CPC分类号： C07H19/073 , C07H21/04 , Y02P20/55
摘要： The present invention provides, for example, a labeling substance that allows the double helix structure of a nucleic acid to be detected effectively. The present invention provides a compound having a structure derived from mononucleoside or mononucleotide, with the structure being represented by the following formula (1), (1b), or (1c), a tautomer or stereoisomer thereof, or a salt thereof. In the above formulae, B is an atomic group having a nucleobase skeleton, E is an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or an atomic group having a peptide structure or a peptoid structure, and Z11 and Z12 each are a hydrogen atom, a protecting group, or an atomic group that exhibits fluorescence and may be identical to or different from each other.
摘要翻译：本发明提供例如能够有效检测核酸的双螺旋结构的标记物质。本发明提供具有衍生自单核苷或单核苷酸的结构的化合物，其结构由下式（1），（1b）或（1c）表示，其互变异构体或立体异构体或其盐。在上式中，B是具有核碱基骨架的原子团，E是具有脱氧核糖骨架的原子团，核糖骨架或其任一个衍生的结构，或具有肽结构或拟肽的原子团结构，Z 11和Z 12各自为氢原子，保护基或显示荧光且可以彼此相同或不同的原子团。

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