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    • 1. 发明申请
    • MASS SPECTROMETER SYSTEM
    • 质谱仪系统
    • US20090189063A1
    • 2009-07-30
    • US12330374
    • 2008-12-08
    • Akihiro SanoAtsumu HirabayashiYasushi TeruiKinya KobayashiKiyomi YoshinariKenko UchidaToshiyuki Yokosuka
    • Akihiro SanoAtsumu HirabayashiYasushi TeruiKinya KobayashiKiyomi YoshinariKenko UchidaToshiyuki Yokosuka
    • H01J49/00
    • G01N33/6851G01N33/6848H01J49/0031H01J49/0036H01J49/004
    • During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSn spectrum is effectively utilized in each step of the MSn involving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1 analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.
    • 在通过串联质谱法对蛋白质或肽进行结构分析期间,作为串联质谱目标,可以避免衍生自已经测量并且大量表达的蛋白质的肽离子。 迄今为止难以分析的,从微量蛋白质衍生的肽可以在实时测定中作为串联质谱图目标自动确定。 关于已经测量的蛋白质和源自蛋白质的肽的数据被自动存储在内部数据库中。 存储的数据与测量数据高精度对照以确定同位素峰。 以这种方式,可以在测量的实际时间内进行未被测定为下一个串联分析的靶标的肽峰的过程,并且可以避免衍生自相同蛋白质的肽的冗余测量。 包含在MSn谱中的信息在涉及多级解离和质谱(MSn)的MSn的每个步骤中被有效地利用,使得用于确定下一个分析内容的流程和为母体离子的选择 例如,MSn + 1分析可以在实时测量和高效率和精确度下进行优化。 因此,用户关注的目标可以进行串联质谱,无需浪费测量。
    • 7. 发明授权
    • Diagnostic ultrasound Doppler imaging system and Doppler imaging method
for ultrasonic diagnosis
    • 诊断超声多普勒成像系统和多普勒超声诊断成像方法
    • US5860927A
    • 1999-01-19
    • US867815
    • 1997-06-03
    • Fumiyasu SakaguchiMasao TakimotoAkihiro Sano
    • Fumiyasu SakaguchiMasao TakimotoAkihiro Sano
    • A61B8/00A61B8/08G01S15/58G01S15/89
    • G01S15/8979A61B8/488G01S15/582G01S15/899
    • In order to enable quantitative and ready assessment of the kinetics of a tissue on the basis of motion information of the tissue resulting from analysis performed according to the Doppler method, and to enable ready observation of a temporal change in motion of the tissue, there is provided, as one aspect, a diagnostic ultrasound Doppler imaging system. The system comprises a unit for scanning an object with ultrasonic waves over a cross section of the object to produce an echo signal representing electrical quantities proportional to ultrasonic waves reflected from the object; a unit for extracting from the echo signal a Doppler signal emanating from a tissue in motion inside the object; and a unit for analyzing the frequency of the Doppler signal to obtain two-dimensional image data concerning the motion of the tissue on the cross section frame by frame. The system further comprises a unit for superposing a plurality of old and new frames of the two-dimensional image data computed time-sequentially; and a unit for displaying the superposed two-dimensional image data. The displaying unit includes a circuit for coloring the superposed two-dimensional image data according to the motion of the tissue.
    • 为了能够根据根据多普勒方法进行的分析得到的组织的运动信息,对组织的动力学进行定量和准备评估,并且能够准确观察组织运动的时间变化, 作为一个方面,提供诊断超声多普勒成像系统。 该系统包括用于在物体的横截面上用超声波扫描物体以产生表示与从物体反射的超声波成比例的电量的回波信号的单元; 用于从所述回波信号中提取从所述物体内的运动中的组织发出的多普勒信号的单元; 以及用于分析多普勒信号的频率以获得关于横截面上的组织的运动的二维图像数据的单元。 该系统还包括用于叠加计算的二维图像数据的多个旧的和新的帧的时间顺序的单元; 以及用于显示叠加的二维图像数据的单元。 显示单元包括根据组织的运动使叠加的二维图像数据着色的电路。