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1. 发明授权

US4563303A Method for purification of filamentous hemagglutinin 失效
标题翻译：纯化丝状血凝素的方法
公开(公告)号：US4563303A
公开(公告)日：1986-01-07
申请号：US722381
申请日：1985-04-12
申请人： Akihiro Ginnaga , Shin Sakuma , Tsukasa Nishihara , Tomitaka Tashiro , Sadao Susumi , Tetsuo Kawahara , Hiroshi Mizokami
发明人： Akihiro Ginnaga , Shin Sakuma , Tsukasa Nishihara , Tomitaka Tashiro , Sadao Susumi , Tetsuo Kawahara , Hiroshi Mizokami
IPC分类号： C12P21/00 , A61K39/00 , C07K14/235 , A61K39/10
CPC分类号： C07K14/235 , A61K39/00 , Y10S435/822 , Y10S530/825
摘要： Improved method for the purification of filamentous hemagglutinin (F-HA) on industrial scale which comprises contacting a culture of a microorganism of the genus Bordetella with a cellulose sulfate gel, a polysaccharide gel chemically bound with dextran sulfate, or a crosslinked polysaccharide sulfate gel, thereby adsorbing F-HA on the gel, and then eluting F-HA from the gel. Said method can give a highly purified F-HA which does not contain any other proteins, lipid, saccharides, etc. and further undesirable endotoxin, and hence can be used for producing various reagents, medicines and pertussis vaccine.
摘要翻译：用于工业规模净化丝状血凝素（F-HA）的改进方法，其包括将博德特氏菌属的微生物的培养物与硫酸纤维素凝胶接触，与硫酸葡聚糖化学结合的多糖凝胶或交联的多糖硫酸凝胶，从而在凝胶上吸附F-HA，然后从凝胶中洗脱F-HA。所述方法可以得到不含任何其它蛋白质，脂质，糖类等的高度纯化的F-HA，以及不希望的内毒素，因此可用于生产各种试剂，药物和百日咳疫苗。

2. 发明授权

US4885359A Method for the purification of LPF-HA 失效
标题翻译： LPF-HA的纯化方法
公开(公告)号：US4885359A
公开(公告)日：1989-12-05
申请号：US122576
申请日：1987-11-16
申请人： Akihiro Ginnaga , Tsukasa Nishihara , Tetsuo Kawahara , Sadao Susumi , Hiroshi Mizokami , Mitsuo Sakoh
发明人： Akihiro Ginnaga , Tsukasa Nishihara , Tetsuo Kawahara , Sadao Susumi , Hiroshi Mizokami , Mitsuo Sakoh
IPC分类号： A61K39/10 , A61K39/00 , C07K14/235
CPC分类号： C07K14/235 , A61K39/00 , Y10S435/803 , Y10S530/825
摘要： Improved method for the purification of LPF-HA (Leucocytosis promoting far hemagglutinin) on industrial scale which comprises contacting a LPF-HA-containing solution from culture media of Bordetella pertussis with a cellulose sulfate gel, a crosslinked polysaccharide sulfate gel, or a polysaccharide gel chemically bound with dextran sulfate, thereby adsorbing LPF-HA on the gel, and then eluting LPF-HA from the gel. Said method can give a highly purified LPF-HA which does not contain any other proteins, lipid, saccharides, etc. and further undesirable endotoxin, and hence can be used for producing various reagents, medicines and pertussis vaccine.
摘要翻译：用于在工业规模上纯化LPF-HA（白细胞促进因子血凝素）的改进方法，其包括使来自百日咳博德特氏菌培养基的含LPF-HA的溶液与硫酸纤维素凝胶，交联多糖硫酸酯凝胶或多糖凝胶与硫酸葡聚糖化学结合，从而在凝胶上吸附LPF-HA，然后从凝胶洗脱LPF-HA。所述方法可以得到不含任何其它蛋白质，脂质，糖类等的高度纯化的LPF-HA，还可以产生不希望的内毒素，因此可用于生产各种试剂，药物和百日咳疫苗。

3. 发明授权

US4515714A Method for purification of hepatitis B virus surface antigen 失效
标题翻译：乙型肝炎病毒表面抗原纯化方法
公开(公告)号：US4515714A
公开(公告)日：1985-05-07
申请号：US586702
申请日：1984-03-06
申请人： Tetsuo Kawahara , Hiroshi Mizokami , Kyosuke Mizuno , Sadao Susumi
发明人： Tetsuo Kawahara , Hiroshi Mizokami , Kyosuke Mizuno , Sadao Susumi
IPC分类号： A61K39/29 , A61K39/00 , C07K14/02 , A61K39/12 , A61K39/42 , C07G7/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122 , Y10S530/806 , Y10S530/83
摘要： An improved method for the purification of hepatitis B virus surface anti by column chromatography, which is characteristic in using as a gel for the chromatography a sulfuric acid ester of a crosslinked polysaccharide or cellulose which is obtained by sulfating a crosslinked polysaccharide or cellulose. Said method can give a highly purified hepatitis B virus surface antigen which is useful for the preparation of hepatitis B virus vaccine.
摘要翻译：一种用于通过柱色谱纯化乙型肝炎病毒表面抗原的改进方法，其特征在于使用通过硫酸化交联的多糖或纤维素获得的交联多糖或纤维素的硫酸酯作为色谱的凝胶。所述方法可以给出用于制备乙型肝炎病毒疫苗的高度纯化的乙型肝炎病毒表面抗原。

4. 发明授权

US4954340A Method for activating hemocytes of bivalves for pearl production 失效
标题翻译：激活双壳类血细胞用于珍珠生产的方法
公开(公告)号：US4954340A
公开(公告)日：1990-09-04
申请号：US227400
申请日：1988-08-02
申请人： Haruhisa Maeda , Akira Tsujikawa , Sadao Susumi
发明人： Haruhisa Maeda , Akira Tsujikawa , Sadao Susumi
IPC分类号： A01K61/00 , A61K38/00 , A61K38/36 , A61P43/00
CPC分类号： A01K61/002
摘要： A preparation for activating hemocytes of bivalves for pearl production containing a mitogen as an effective component, and a method for producing pearl through nucleus insertion operation of a bivalve for pearl production which comprises treating a section of the mantle part of a donor to be inserted with a mitogen.By the treatment with the present preparation, hemocytes of the wound site due to the nucleus insertion operation are activated, tissue growth of the section of the mantle part of the donor is accelerated and a good pearl sac is formed around the nucleus. As a result, the number ejected nuclei is decreased and the pearl quality and production amount are enhanced.These effects are further enhanced by using a mitogen treated with an aluminum adjuvant or the like.
摘要翻译：用于激活含有丝裂原作为有效成分的珍珠生产的双壳类的血细胞的制备方法，以及通过用于珍珠生产的双壳类的核插入操作来生产珍珠的方法，其包括将待插入的供体的外套部分的一部分丝裂原。通过本制剂的处理，由于核插入操作引起的伤口部位的血细胞被激活，供体的外套部分的部分的组织生长被加速，并且在细胞核周围形成良好的珍珠囊。结果，排出的核数减少，珍珠质量和生产量增加。通过使用用铝佐剂等处理的有丝分裂原来进一步提高这些效果。

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