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1. 发明申请

US20060235351A1 External preparation, method of applying external preparation, iontophoresis device, and percutaneous patch 审中-公开
标题翻译：外用剂，外用剂的应用方法，离子电渗疗法及经皮贴剂
公开(公告)号：US20060235351A1
公开(公告)日：2006-10-19
申请号：US11195351
申请日：2005-08-02
申请人： Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Kazuyuki Tsuji , Tsutomu Shibata , Akihiko Tanioka , Mie Minagawa
发明人： Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Kazuyuki Tsuji , Tsutomu Shibata , Akihiko Tanioka , Mie Minagawa
IPC分类号： A61N1/30 , A61K31/785 , A61K31/717
CPC分类号： A61N1/0444 , A61K9/0009 , A61K9/7023
摘要： The administration efficiency of a drug may be improved by establishing compatibility between the suppression of the release of a biological counter ion from a living body's biological interface and the maintenance of a good state of contact between each of a working electrode structure and a nonworking electrode structure and the biological interface. Coating films each composed of an external preparation containing: a hydrophilic polymer matrix agent; and an ion-exchange resin dispersed in the hydrophilic polymer matrix agent, or coating films each composed of an external preparation containing a hydrophilic polymer having an ion-exchange function are formed on the biological interface, and iontophoresis is performed through the coating films.
摘要翻译：药物的给药效率可以通过建立抑制生物体离子从活体生物界面的释放与维持工作电极结构和非工作电极结构之间的良好接触状态之间的相容性来改善和生物界面。涂膜各自由外用制剂组成，含有：亲水性聚合物基质剂; 在亲水性聚合物基质剂中分散有离子交换树脂，或者在生物界面上形成各自由含有具有离子交换功能的亲水性聚合物的外用制剂构成的涂膜，通过涂膜进行离子电渗疗法。

2. 发明授权

US07437189B2 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US07437189B2
公开(公告)日：2008-10-14
申请号：US11196783
申请日：2005-08-02
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
IPC分类号： A61N1/30 , A61M5/32
CPC分类号： A61N1/306
摘要： An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.
摘要翻译：离子电渗装置包括：第一电极; 生物界面接触构件，其包括具有前表面和后表面的基底，以及从所述基底的前表面突出并可以插入生物界面的多个针，所述生物界面接触构件允许离子的选择性渗透第一极性; 以及通过所述第一电极施加电位或电压并保持含有以所述第一极性充电的药物离子的药液的药物保持部，所述药物保持部插入在所述第一电极和所述生物界面接触部件之间。

3. 发明申请

US20070021711A1 Iontophoresis device controlling administration amount and administration period of plurality of drugs 审中-公开
标题翻译：离子渗透装置控制多种药物的给药量和给药期
公开(公告)号：US20070021711A1
公开(公告)日：2007-01-25
申请号：US11473515
申请日：2006-06-22
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044 , A61N1/0444 , A61N1/30
摘要： An iontophoresis device capable of administering a plurality of drugs to a living body while controlling the administration amounts and the administration periods thereof is described. The iontophoresis device may comprise: a power source device; a drug administration unit connected to the power source device and including at least two electrode structures that hold an ionic drug; and a current control unit that individually controls currents flowing to the electrode structures. A predetermined amount of the ionic drug may be released from each of the electrode structures to be administered transdermally to a living body in a predetermined period of time according to a current flowing from the current control unit.
摘要翻译：描述能够在控制给药量和给药期的同时向活体施用多种药物的离子电渗疗法装置。离子渗透装置可以包括：电源装置; 连接到电源装置并且包括至少两个保持离子药物的电极结构的药物管理单元; 以及电流控制单元，其分别控制流向电极结构的电流。预定量的离子药物可以从每个电极结构释放，以根据从电流控制单元流出的电流在预定时间段内经皮给予生物体。

4. 发明申请

US20060217654A1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US20060217654A1
公开(公告)日：2006-09-28
申请号：US11196783
申请日：2005-08-02
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
IPC分类号： A61N1/30
CPC分类号： A61N1/306
摘要： An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.
摘要翻译：离子电渗装置包括：第一电极; 生物界面接触构件，其包括具有前表面和后表面的基底，以及从所述基底的前表面突出并可以插入生物界面的多个针，所述生物界面接触构件允许离子的选择性渗透第一极性; 以及通过所述第一电极施加电位或电压并保持含有以所述第一极性充电的药物离子的药液的药物保持部，所述药物保持部插入在所述第一电极和所述生物界面接触部件之间。

5. 发明申请

US20090299265A1 Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same 审中-公开
标题翻译：具有形状记忆分离器和使用其的离子电渗装置的离子电渗电极组件
公开(公告)号：US20090299265A1
公开(公告)日：2009-12-03
申请号：US11992672
申请日：2006-10-02
申请人： Akihiko Tanioka , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Akihiko Tanioka , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/044 , A61N1/0448
摘要： An electrode assembly for iontophoresis including an electrode coupled to an electric power source device having a same polarity as that of the ionic drug in the electrode assembly, an electrolyte solution holding portion holding an electrolyte solution by being impregnated with the electrolyte solution, the electrolyte solution holding portion being placed adjacent to the electrode, a first ion exchange membrane operable to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the first ion exchange membrane being placed adjacent to the electrolyte solution holding portion, a drug solution holding portion holding the ionic drug by being impregnated with the ionic drug, the drug solution holding portion being placed adjacent to the first ion exchange membrane, a second ion exchange membrane operable to substantially pass ions having a polarity that is opposite the polarity of the ionic drug and substantially block ions having a polarity that is the same as the polarity of the ionic drug, the second ion exchange membrane being placed adjacent to the drug solution holding portion, and a shape-memory separator capable of being transformed between a first and a second configuration to respectively allow passage of a substance and blocking of the substance, the shape-memory separator placed adjacent to at least one surface of the first ion exchange membrane.
摘要翻译：一种用于离子电渗疗法的电极组件，其包括与电极组件中的离子药物极性相同的电源装置的电极，通过浸渍电解质溶液保持电解质溶液的电解液保持部分，保持部分被放置成与电极相邻，第一离子交换膜可操作以基本上通过具有与离子药物的极性相同的极性的离子，并且基本上阻挡具有与离子药物的极性相反的极性的离子，第一离子交换膜与电解质溶液保持部相邻配置，通过浸渍离子性药物而保持离子性药物的药液保持部，药液保持部与第一离子交换膜相邻配置，第二离子交换膜可操作以基本上通过具有相反极性的离子 e离子药物的极性，并且基本上阻挡具有与离子药物的极性相同的极性的离子，第二离子交换膜邻近药物溶液保持部分放置，以及形状记忆分离器，其能够在第一和第二构型之间转换以分别允许物质的通过和物质的阻塞，所述形状记忆隔离物与第一离子交换膜的至少一个表面相邻放置。

6. 发明申请

US20090221951A1 IONTOPHORESIS DEVICE AND ELECTRIC POWER SOURCE FOR AN IONTOPHORESIS DEVICE 审中-公开
标题翻译：静电装置和电源的静电装置
公开(公告)号：US20090221951A1
公开(公告)日：2009-09-03
申请号：US12066362
申请日：2006-09-13
申请人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A drug may be administered in accordance with a daily living pattern of a patient and/or a circadian rhythm of the drug.An iontophoresis device includes a working electrode assembly and a non-working electrode assembly for administering a drug by iontophoresis and an electric power source connected to the working electrode assembly and the non-working electrode assembly. Current control circuitry programmably controls a current that flows to each of the electrode assemblies according to a set pattern, and the drug is released based at least in part on the current.
摘要翻译：可以根据患者的日常生活方式和/或药物的昼夜节律来施用药物。离子电渗装置包括工作电极组件和用于通过离子电渗疗法给药的非工作电极组件和连接到工作电极组件和非工作电极组件的电源。电流控制电路可编程地控制根据设定模式流向每个电极组件的电流，并且至少部分地基于电流释放药物。

7. 发明申请

US20070071807A1 CAPSULE-TYPE DRUG-RELEASING DEVICE AND CAPSULE-TYPE DRUG-RELEASING DEVICE SYSTEM 审中-公开
标题翻译：胶囊型药物释放装置和胶囊型药物释放装置系统
公开(公告)号：US20070071807A1
公开(公告)日：2007-03-29
申请号：US11536194
申请日：2006-09-28
申请人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
发明人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
IPC分类号： A61N1/00 , A61K9/48
CPC分类号： A61K9/0009 , A61K9/0097 , A61K9/48
摘要： A capsule-type drug-releasing device is capable of freely controlling the release and stoppage of a drug and causing neither the back flow of contents of a stomach, an intestine, or the like nor clogging with the contents. A capsule-type drug-releasing device may include: a capsule-shaped casing; a cation exchange membrane arranged on the surface of the casing; a drug solution holding portion arranged inside the casing and on the inner side of the cation exchange membrane; an anion exchange membrane arranged on the inner side of the drug solution holding portion; an electrolyte solution holding portion arranged on the inner side of the anion exchange membrane; an electrode arranged on the inner side of the electrolyte solution holding portion; an electric power source connected to the electrode; a control portion capable of controlling energization from the electric power source to the electrode; and a transceiver portion causing the control portion to receive a signal from the outside of an organism.
摘要翻译：胶囊型药物释放装置能够自由地控制药物的释放和停止，并且不会引起胃，肠等的内容物的反流，也不会堵塞内容物。胶囊型药物释放装置可以包括：胶囊型壳体; 设置在所述壳体的表面上的阳离子交换膜; 药液保持部，其配置在所述壳体内部和所述阳离子交换膜的内侧; 阴离子交换膜，其设置在药液保持部的内侧; 设置在阴离子交换膜的内侧的电解液保持部，设置在所述电解液保持部的内侧的电极; 连接到电极的电源; 控制部，其能够控制从所述电源向所述电极的通电; 以及使得所述控制部分从生物体的外部接收信号的收发器部分。

8. 发明申请

US20070066930A1 Iontophoresis device and method of producing the same 审中-公开
标题翻译：离子电渗疗法装置及其制造方法
公开(公告)号：US20070066930A1
公开(公告)日：2007-03-22
申请号：US11471973
申请日：2006-06-20
申请人： Akihiko Tanioka , Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
发明人： Akihiko Tanioka , Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
IPC分类号： A61N1/30 , A61L33/00 , B32B18/00
CPC分类号： A61N1/0444 , A61N1/044 , A61N1/0448
摘要： An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.
摘要翻译：离子电渗装置及其制造方法可以在常规离子电渗装置的制造过程中减少材料损失，并且可以容易地实现生产方法的自动化和生产规模的增加。离子电渗装置可以用于施用通过将药物解离为活体而产生的第一极性的药物离子，并且可以包括：形成在第一基底的表面上的第一导电层; 由含有药物的药物涂层制成的药物层，所述药物层被层压在所述第一导电层上; 以及第一离子交换层，其由含有引入了交换基团的离子交换树脂的离子交换涂层构成，所述离子交换基团与所述第一极性离子具有抗衡离子，所述第一离子交换层层叠在所述药物层上。

9. 发明申请

US20070048362A1 General purpose electrolyte solution composition for iontophoresis 审中-公开
标题翻译：用于离子电渗疗法的通用电解质溶液组合物
公开(公告)号：US20070048362A1
公开(公告)日：2007-03-01
申请号：US11512756
申请日：2006-08-29
申请人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30 , A61F13/00
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/325
摘要： A single electrolyte solution composition may be used in an anode side and in a cathode side of an iontophoresis device. The electrolyte solution may include a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, both a component that is likely to be relatively reduced and a component that is likely to be relatively oxidized.
摘要翻译：单个电解质溶液组合物可用于离子电渗装置的阳极侧和阴极侧。电解质溶液可以包括具有低于水的氧化还原电位的化合物，所述化合物组合包括可能相对减少的组分和可能相对氧化的组分。

10. 发明授权

US07660626B2 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US07660626B2
公开(公告)日：2010-02-09
申请号：US11195364
申请日：2005-08-02
申请人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译：本发明提供了具有药物高效给药的离子电渗疗法装置。一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

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