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    • 7. 发明授权
    • Methods and computer systems for analyzing high-throughput assays
    • 用于分析高通量测定的方法和计算机系统
    • US08447526B2
    • 2013-05-21
    • US11440195
    • 2006-05-23
    • Lee WengHongyue DaiSteven R. Bartz
    • Lee WengHongyue DaiSteven R. Bartz
    • G01N33/48G01N31/00G06G7/48G06G7/58
    • G01N33/5008G01N33/5091G06F19/18G06F19/20G06F19/24
    • The present invention provides methods and computer programs for detecting variations in measurements of a biological variable, e.g., variations in cell viability, under different conditions, e.g., with or without treatment of a drug, under the treatments of different drugs, or under different environmental conditions. The methods and programs of the invention determine a metric of difference between measurements under different condition, and make use of predetermined errors of the measurements, e.g., errors determined from an error model, to estimate the errors in the metric of difference. Such an approach provides a more accurate estimate of the errors of measurements, which, in turn, provides a more accurate estimate of the error of the difference metric.
    • 本发明提供了用于检测生物变量的测量变化的方法和计算机程序,例如在不同条件下,例如,在不同药物的治疗下或在不同环境下,在不同的条件下,例如,有或没有治疗药物时,细胞活力的变化 条件。 本发明的方法和程序确定在不同条件下的测量之间的差异的度量,并且利用预定的测量误差,例如从误差模型确定的误差来估计差异度量中的误差。 这种方法提供了对测量误差的更精确的估计,其反过来提供了差异度量的误差的更准确的估计。