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1. 发明申请

US20080213821A1 Microfluidic Cell Sorter System 审中-公开
标题翻译：微流控细胞分选系统
公开(公告)号：US20080213821A1
公开(公告)日：2008-09-04
申请号：US11579074
申请日：2005-05-06
申请人： Ai Qun Liu , Xiao Jun Liang , Xu Ming Zhang , Yi Sun , Peter Droge
发明人： Ai Qun Liu , Xiao Jun Liang , Xu Ming Zhang , Yi Sun , Peter Droge
IPC分类号： C12M1/34 , C12M1/36 , C12Q1/20 , H05H1/00
CPC分类号： G01N15/1484 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0645 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0622 , B81B2201/058 , B81C1/00444 , G01N15/1459 , G01N2015/149
摘要： A microfluidic system for separating, purifying and counting cell sub-populations, utilising steering of liquid flows in microfluidic channels in a cell focusing region (first dotted circle area); having the integration of the optical detection mechanism and a microchannel structure made from moulding. A master is photolithographically patterned on a soft PDMS silicon or polymer material. After being moulded and peeled off the master, the micro-channel structure is sealed on a hard substrate with openings punched through for wells (14, 12, 36, 38, 40). An optical detection region (20) discriminates different types of cells that have been formed into a single flow (30). Electromagnetic fields are used to steer (32) the flows of cells according to the signals from the optical detection region into branch channels leading to the punched wells for separate collection. The system can have parallel systems that increase throughput or cascade systems to provide several analysis steps. The optical system an micro-lens (24) for the system can be imbedded in the moulding material during formation of the mould.
摘要翻译：一种用于分离，纯化和计数细胞亚群的微流体系统，利用在细胞聚焦区域（第一虚线圆形区域）的微流体通道中的液体流的转向; 具有光学检测机构的一体化和由成型制成的微通道结构。在软PDMS硅或聚合物材料上光刻成型的母版。在模制和剥离主体之后，微通道结构被密封在具有穿孔的开口（14,12,36,38,40）的硬质基底上。光学检测区域（20）区分已形成单个流（30）的不同类型的单元。电磁场用于根据来自光学检测区域的信号将细胞流引导（32）到分支通道，通向冲孔以便分开收集。该系统可以具有增加吞吐量或级联系统的并行系统，以提供多个分析步骤。用于系统的微透镜（24）的光学系统可以在模具形成期间嵌入模制材料中。

2. 发明授权

US07767444B2 Cell analysis using laser with external cavity 有权
标题翻译：使用外腔激光进行细胞分析
公开(公告)号：US07767444B2
公开(公告)日：2010-08-03
申请号：US11139610
申请日：2005-05-31
申请人： Ai Qun Liu , Xiao Jun Liang , Xu Ming Zhang , Yi Sun
发明人： Ai Qun Liu , Xiao Jun Liang , Xu Ming Zhang , Yi Sun
IPC分类号： C12M1/34 , C12M3/00 , G01N21/00
CPC分类号： G01N21/0303 , G01N21/03 , G01N21/39 , G01N2021/0346 , G01N2021/391 , G01N2021/399 , Y10S435/808
摘要： An apparatus and method for analyzing biological cells and other particles using an external laser cavity. Microfluidic channels contain and transport biological cells to be analyzed. A laser diode provides light for cell analysis. An external cavity is provided between one surface of the laser diode and a mirror opposite thereto. A microlens set focuses the light on only one cell as it passes through the external cavity. The presence of the cell in the external cavity gives a weak feedback toward the laser diode. The emission frequency and the output power of the laser are both functions of the length of the external cavity. Therefore, the variation of cavity length can be deduced from these parameters, where the variation is caused by changing the refractive index or size of the cell in the cavity.
摘要翻译：使用外部激光腔分析生物细胞和其他颗粒的装置和方法。微流体通道含有并转运待分析的生物细胞。激光二极管为光源分析提供光源。在激光二极管的一个表面和与之相对的镜子之间设置一个外部空腔。微透镜组在通过外部空腔时将光聚焦在仅一个单元上。外部腔中存在电池给激光二极管带来弱反馈。激光器的发射频率和输出功率都是外腔长度的函数。因此，可以从这些参数推导出腔长度的变化，其中通过改变空腔中的电池的折射率或尺寸引起变化。

3. 发明申请

US20070267939A1 Systems and methods for improved control of micro-electrical-mechanical system (MEMS) electrostatic actuator 失效
标题翻译：用于改进微机电系统（MEMS）静电致动器的控制的系统和方法
公开(公告)号：US20070267939A1
公开(公告)日：2007-11-22
申请号：US11436411
申请日：2006-05-18
申请人： Bruno Borovic , Frank L. Lewis , Ai Qun Liu , Dan O. Popa
发明人： Bruno Borovic , Frank L. Lewis , Ai Qun Liu , Dan O. Popa
IPC分类号： H02N1/00
CPC分类号： H02N1/008 , H02K2201/18
摘要： Methods and apparatuses for sensing and adjusting lateral motion in a comb drive actuated MEMS device are provided. If lateral motion is sensed by a lateral motion sensor coupled to the comb drive actuated MEMS device, and the lateral motion is greater than a reference value, a feedback controller adjusts the lateral motion by providing a drive signal to a comb drive electrode of a comb drive actuator.
摘要翻译：提供了用于感测和调节梳状驱动MEMS装置中的横向运动的方法和装置。如果通过耦合到梳状驱动的MEMS装置的横向运动传感器感测到侧向运动，并且横向运动大于参考值，则反馈控制器通过向梳子的梳状驱动电极提供驱动信号来调节横向运动驱动执行器。

4. 发明授权

US09291547B2 Immersion refractometer 有权
$Immersion refractometer$
标题翻译：浸入折光仪
公开(公告)号：US09291547B2
公开(公告)日：2016-03-22
申请号：US13549169
申请日：2012-07-13
申请人： Ai Qun Liu , Lip Ket Chin
发明人： Ai Qun Liu , Lip Ket Chin
IPC分类号： G01N21/03 , G01N21/05 , B01L3/00 , G01N21/41
CPC分类号： G01N21/05 , B01L3/5027 , G01N21/41 , G01N2021/0325 , G01N2021/0346 , G01N2021/058
摘要： An immersion refractometer includes a microchamber having an inlet and an outlet for allowing a sample containing microorganism particles to flow therethrough, wherein the microchamber comprises at least one trapping site for trapping a microorganism particle in each respective trapping site, and a micromixer for mixing a plurality of liquids to form an external medium, wherein the micromixer and the microchamber are in fluid communication to introduce the external medium into the microchamber. Use of the present immersion refractometer in a method of identifying microorganism particles contained in a sample is also provided.
摘要翻译：浸入式折射计包括具有入口和出口的微室，该入口和出口用于允许含有微生物颗粒的样品流过其中，其中所述微室包括用于捕获每个各自捕获位点中的微生物颗粒的至少一个俘获位点和用于混合多个的微混合器的液体以形成外部介质，其中微型混合器和微型室流体连通以将外部介质引入微型室。还提供了本发明的浸没折射计在鉴定样品中所含的微生物颗粒的方法中的用途。

5. 发明申请

US20130016341A1 IMMERSION REFRACTOMETER 有权
标题翻译：沉降式压力计
公开(公告)号：US20130016341A1
公开(公告)日：2013-01-17
申请号：US13549169
申请日：2012-07-13
申请人： Ai Qun Liu , Lip Ket Chin
发明人： Ai Qun Liu , Lip Ket Chin
IPC分类号： G01N21/41
CPC分类号： G01N21/05 , B01L3/5027 , G01N21/41 , G01N2021/0325 , G01N2021/0346 , G01N2021/058
摘要： An immersion refractometer includes a microchamber having an inlet and an outlet for allowing a sample containing microorganism particles to flow therethrough, wherein the microchamber comprises at least one trapping site for trapping a microorganism particle in each respective trapping site, and a micromixer for mixing a plurality of liquids to form an external medium, wherein the micromixer and the microchamber are in fluid communication to introduce the external medium into the microchamber. Use of the present immersion refractometer in a method of identifying microorganism particles contained in a sample is also provided.
摘要翻译：浸入式折射计包括具有入口和出口的微室，该入口和出口用于允许含有微生物颗粒的样品流过其中，其中所述微室包括用于捕获每个各自捕获位点中的微生物颗粒的至少一个俘获位点和用于混合多个的微混合器的液体以形成外部介质，其中微型混合器和微型室流体连通以将外部介质引入微型室。还提供了本发明的浸没折射计在鉴定样品中所含的微生物颗粒的方法中的用途。

6. 发明授权

US07548011B2 Systems and methods for improved control of micro-electrical-mechanical system (MEMS) electrostatic actuator 失效
标题翻译：用于改进微机电系统（MEMS）静电致动器的控制的系统和方法
公开(公告)号：US07548011B2
公开(公告)日：2009-06-16
申请号：US11436411
申请日：2006-05-18
申请人： Bruno Borovic , Frank L. Lewis , Ai Qun Liu , Dan O. Popa
发明人： Bruno Borovic , Frank L. Lewis , Ai Qun Liu , Dan O. Popa
IPC分类号： H02N1/00
CPC分类号： H02N1/008 , H02K2201/18
摘要： Methods and apparatuses for sensing and adjusting lateral motion in a comb drive actuated MEMS device are provided. If lateral motion is sensed by a lateral motion sensor coupled to the comb drive actuated MEMS device, and the lateral motion is greater than a reference value, a feedback controller adjusts the lateral motion by providing a drive signal to a comb drive electrode of a comb drive actuator.
摘要翻译：提供了用于感测和调节梳状驱动MEMS装置中的横向运动的方法和装置。如果通过耦合到梳状驱动的MEMS装置的横向运动传感器感测到侧向运动，并且横向运动大于参考值，则反馈控制器通过向梳子的梳状驱动电极提供驱动信号来调节横向运动驱动执行器。

7. 发明授权

US06788843B2 Optical crossconnect and mirror systems 失效
标题翻译：光学交叉连接和镜像系统
公开(公告)号：US06788843B2
公开(公告)日：2004-09-07
申请号：US10223596
申请日：2002-08-19
申请人： Ai Qun Liu , Vadakke Matham Murukeshan , Xuming Zhang , Chao Lu
发明人： Ai Qun Liu , Vadakke Matham Murukeshan , Xuming Zhang , Chao Lu
IPC分类号： G02B635
CPC分类号： G02B6/358 , G02B6/266 , G02B6/3512 , G02B6/3546 , G02B6/3552 , G02B6/357 , G02B6/3572 , G02B6/3584 , G02B6/3594 , G02B26/0841
摘要： The invention features the drawbridge assembly and its applications in optical switches, optical crossconnects, optical add/drop multiplexers and variable optical attenuators. In optical switches and optical crossconnects, an array of the drawbridge assemblies can be used to redirect the multiple input lights to multiple outputs. In add/drop multiplexers, the drawbridge assemblies can select the light channels to be added and dropped. In the attenuator embodiment, a vertical mirror is inserted into two fibers, the first one as the input and the second one as output. The drawbridge assembly controls the position of the vertical mirror for blocking a certain portion of the light and enabling the attenuation. The continuous change of the mirror position results in variable attenuation. A series of VOA form a multi-channel VOA system on a single substrate.
摘要翻译：本发明的特征在于吊桥组件及其在光开关，光交叉连接器，光分插复用器和可变光衰减器中的应用。在光学开关和光学交叉连接中，可以使用吊桥组件的阵列将多个输入灯重定向到多个输出。在分插复用器中，吊桥组件可以选择要添加和删除的光通道。在衰减器实施例中，垂直反射镜被插入到两根光纤中，第一根光纤作为输入，第二根光纤作为输出。吊桥组件控制垂直反射镜的位置，以阻挡光的某一部分并实现衰减。反射镜位置的连续变化导致可变衰减。一系列VOA在单个基板上形成多通道VOA系统。

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