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1. 发明申请

US20160375376A1 DEVICE AND METHOD OF A SUPERCRITICAL FLUID SYSTEM FOR DETECTING ANALYTES USING A LOW PRESSURE DETECTOR 审中-公开
标题翻译：用于使用低压检测器检测分析仪的超临界流体系统的装置和方法
公开(公告)号：US20160375376A1
公开(公告)日：2016-12-29
申请号：US14750437
申请日：2015-06-25
申请人： AGILENT TECHNOLOGIES, INC.
发明人： Edwin E. Wikfors
IPC分类号： B01D15/16 , B01D15/40
摘要： A device is provided in a supercritical fluid system, which uses a mobile phase output by a separation device, the mobile phase volumetrically expanding as it decompresses. The device includes a passive splitter and a shuttle valve. The passive splitter is configured to receive the mobile phase and to split the mobile phase into a primary flow stream and a split flow stream, where the primary flow stream is directed to a pressure maintenance device. The passive splitter is further configured to reduce pressure of the split flow stream, causing volumetric expansion of the split flow stream. The shuttle valve is configured to insert volumetric aliquots of the volumetrically expanded split flow stream into a dilution flow stream to provide a diluted split flow stream, and to direct the diluted split flow stream to a low pressure detector.
摘要翻译：在超临界流体系统中提供了一种装置，其使用由分离装置输出的流动相，流化相在其减压时容积扩大。该装置包括无源分流器和梭阀。无源分离器被配置为接收流动相并将流动相分成初级流和分流流，其中主流流被引导到压力维持装置。被动分流器还被配置成减小分流流的压力，引起分流流的体积膨胀。梭阀被配置成将体积扩大的分流流的体积等分试样插入稀释流流中以提供稀释的分流流，并将稀释的分流流引导到低压检测器。

2. 发明申请

US20170100682A1 APPARATUS AND METHOD FOR INTRODUCING A SAMPLE INTO A SEPARATION UNIT OF A CHROMATOGRAPHY SYSTEM 审中-公开
公开(公告)号：US20170100682A1
公开(公告)日：2017-04-13
申请号：US15314717
申请日：2014-05-29
申请人： Agilent Technologies, Inc.
发明人： Edwin E. Wikfors
IPC分类号： B01D15/14 , G01N30/20 , B01D15/32 , B01D15/18 , B01D15/40
CPC分类号： B01D15/40 , B01D15/1878 , G01N30/02 , G01N30/16 , G01N30/20 , G01N30/32 , G01N30/34 , G01N30/38 , G01N30/463 , G01N30/465 , G01N2030/324 , G01N2030/342
摘要： An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. The first pump system provides the first mobile phase component, first and second portions of the first mobile phase component flowing through first and second branches, respectively. The second pump system provides the second mobile phase component, a first portion of the second mobile phase component flowing through a third branch. The injection unit receives a combined stream of the first portions of the first and second mobile phase components provided via the first and third branches, respectively, and injects the sample into the combined stream to form a sample-containing stream, which is subsequently combined with the second portion of the first mobile phase component to form a diluted sample-containing stream.

3. 发明授权

US10376814B2 Impact centrifugal separator and associated methods for fraction collection in supercritical fluid systems 有权
$Impact centrifugal separator and associated methods for fraction collection in supercritical fluid systems$
公开(公告)号：US10376814B2
公开(公告)日：2019-08-13
申请号：US15542925
申请日：2015-01-30
申请人： Agilent Technologies, Inc.
发明人： Edwin E. Wikfors
IPC分类号： B01D1/14 , B04B7/00 , B01D11/02 , B01D15/24 , B01D15/40 , B01D19/00 , B01D46/00 , B04B11/06 , G01N30/82 , G01N30/84 , G01N30/88
摘要： A separator (e.g. an impact centrifugal separator) is for use in collection of liquid portions of a bi-phasic flowstream in a supercritical fluid system. A separator chamber defines an interior space, surrounded by a spiral channel and that has an exit at a lower portion of the separator chamber. A flowstream director (e.g. an entry lube) focuses the flowstream so that the flowstream impacts a wail of the spiral channel at an angle that promotes coalescence of the liquid component. The spiral channel may promote further coalescence of the liquid portions within the constraining spiral channel after impact. A central director may be included in the interior space of the separator chamber to promote flow of the gaseous component toward the exit. A dripper may be included in fluid communication with the spiral channel, for example, in the exit and to direct the coalesced liquid into a collection vessel.

4. 发明授权

US10695692B2 Device and method of a supercritical fluid system for detecting analytes using a low pressure detector 有权
公开(公告)号：US10695692B2
公开(公告)日：2020-06-30
申请号：US14750437
申请日：2015-06-25
申请人： AGILENT TECHNOLOGIES, INC.
发明人： Edwin E. Wikfors
IPC分类号： B01D15/16 , B01D15/40 , G01N30/32 , G01N30/84
摘要： A device is provided in a supercritical fluid system, which uses a mobile phase output by a separation device, the mobile phase volumetrically expanding as it decompresses. The device includes a passive splitter and a shuttle valve. The passive splitter is configured to receive the mobile phase and to split the mobile phase into a primary flow stream and a split flow stream, where the primary flow stream is directed to a pressure maintenance device. The passive splitter is further configured to reduce pressure of the split flow stream, causing volumetric expansion of the split flow stream. The shuttle valve is configured to insert volumetric aliquots of the volumetrically expanded split flow stream into a dilution flow stream to provide a diluted split flow stream, and to direct the diluted split flow stream to a low pressure detector.

5. 发明授权

US10478749B2 Apparatus and method for introducing a sample into a separation unit of a chromatography system 有权
公开(公告)号：US10478749B2
公开(公告)日：2019-11-19
申请号：US15314717
申请日：2014-05-29
申请人： Agilent Technologies, Inc.
发明人： Edwin E. Wikfors
IPC分类号： G01N30/20 , G01N30/34 , G01N30/16 , G01N30/32 , G01N30/38 , G01N30/46 , G01N30/02 , B01D15/14 , B01D15/40 , B01D15/32 , B01D15/18
摘要： An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. The first pump system provides the first mobile phase component, first and second portions of the first mobile phase component flowing through first and second branches, respectively. The second pump system provides the second mobile phase component, a first portion of the second mobile phase component flowing through a third branch. The injection unit receives a combined stream of the first portions of the first and second mobile phase components provided via the first and third branches, respectively, and injects the sample into the combined stream to form a sample-containing stream, which is subsequently combined with the second portion of the first mobile phase component to form a diluted sample-containing stream.

6. 发明申请

US20190184327A1 Gas-Liquid Separator for Collecting Chromatographic Fractions 审中-公开
公开(公告)号：US20190184327A1
公开(公告)日：2019-06-20
申请号：US16325855
申请日：2016-08-15
申请人： Agilent Technologies, Inc.
发明人： Edwin E. Wikfors , Samuel O. Colgate
IPC分类号： B01D53/04 , G01N30/80 , B01D15/08
CPC分类号： B01D53/0423 , B01D15/08 , B01D15/24 , B01D15/40 , B01D19/00 , B01D19/0042 , B01D19/0063 , B01D53/025 , G01N30/80 , G01N30/84
摘要： A gas-liquid separator includes a fluid inlet, a shell including an inside surface enclosing an interior space, an outlet structure with fingers converging toward a longitudinal axis, and a dripper including a dripper tip. The fingers terminate at fingertips located proximate to an outside surface of the dripper. Gas exit ports are defined between adjacent fingers, and by the dripper. The gas-liquid separator defines a liquid flow path from the fluid inlet, along the inside surface, along one or more of the fingers, converging along the dripper outside surface, and to the dripper tip. The gas-liquid separator also defines a gas flow path from the fluid inlet, through the interior space, and through the gas exit ports. The gas-liquid separator may be utilized in fluid separation systems such as liquid chromatography or supercritical fluid chromatography/extraction systems.

7. 发明授权

US11491419B2 Gas-liquid separator for collecting chromatographic fractions 有权
$Gas-liquid separator for collecting chromatographic fractions$
公开(公告)号：US11491419B2
公开(公告)日：2022-11-08
申请号：US16325855
申请日：2016-08-15
申请人： Agilent Technologies, Inc.
发明人： Edwin E. Wikfors , Samuel O. Colgate
IPC分类号： B01D19/00 , B01D15/08 , B01D15/24 , G01N30/80 , G01N30/84 , B01D15/40
摘要： A gas-liquid separator includes a fluid inlet, a shell including an inside surface enclosing an interior space, an outlet structure with fingers converging toward a longitudinal axis, and a dripper including a dripper tip. The fingers terminate at fingertips located proximate to an outside surface of the dripper. Gas exit ports are defined between adjacent fingers, and by the dripper. The gas-liquid separator defines a liquid flow path from the fluid inlet, along the inside surface, along one or more of the fingers, converging along the dripper outside surface, and to the dripper tip. The gas-liquid separator also defines a gas flow path from the fluid inlet, through the interior space, and through the gas exit ports. The gas-liquid separator may be utilized in fluid separation systems such as liquid chromatography or supercritical fluid chromatography/extraction systems.

8. 发明授权

US09945762B2 Apparatus and method for introducing sample into a separation unit of a chromatography system without disrupting a mobile phase 有权
公开(公告)号：US09945762B2
公开(公告)日：2018-04-17
申请号：US14586882
申请日：2014-12-30
申请人： AGILENT TECHNOLOGIES, INC.
发明人： Edwin E. Wikfors , Brian A. Bidlingmeyer , Klaus Witt
IPC分类号： G01N30/06 , G01N1/28 , G01N30/20 , G01N30/36 , G01N30/34
CPC分类号： G01N1/28 , G01N30/20 , G01N30/36 , G01N2030/202 , G01N2030/207 , G01N2030/342
摘要： A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.

9. 发明申请

US20180015390A1 IMPACT CENTRIFUGAL SEPARATOR AND ASSOCIATED METHODS FOR FRACTION COLLECTION IN SUPERCRITICAL FLUID SYSTEMS 审中-公开
公开(公告)号：US20180015390A1
公开(公告)日：2018-01-18
申请号：US15542925
申请日：2015-01-30
申请人： Agilent Technologies, Inc.
发明人： Edwin E. Wikfors
IPC分类号： B01D15/40 , B01D11/02 , B01D15/24 , B01D19/00 , B01D46/00 , B01D1/14 , G01N30/88 , B04B7/00 , B04B11/06 , G01N30/82 , G01N30/84
CPC分类号： B01D15/40 , B01D1/14 , B01D11/0203 , B01D11/0292 , B01D15/247 , B01D19/0057 , B01D46/0031 , B04B7/00 , B04B11/06 , G01N30/82 , G01N30/84 , G01N2030/8809
摘要： A separator (e.g. an impact centrifugal separator) is for use in collection of liquid portions of a bi-phasic flowstream in a supercritical fluid system. A separator chamber defines an interior space, surrounded by a spiral channel and that has an exit at a lower portion of the separator chamber. A flowstream director (e.g. an entry lube) focuses the flowstream so that the flowstream impacts a wail of the spiral channel at an angle that promotes coalescence of the liquid component. The spiral channel may promote further coalescence of the liquid portions within the constraining spiral channel after impact. A central director may be included in the interior space of the separator chamber to promote flow of the gaseous component toward the exit. A dripper may be included in fluid communication with the spiral channel, for example, in the exit and to direct the coalesced liquid into a collection vessel.

10. 发明申请

US20160187304A1 APPARATUS AND METHOD FOR INTRODUCING SAMPLE INTO A SEPARATION UNIT OF A CHROMATOGRAPHY SYSTEM WITHOUT DISRUPTING A MOBILE PHASE 有权
标题翻译：将样品引入色谱系统的分离单元而不破坏移动相的装置和方法
公开(公告)号：US20160187304A1
公开(公告)日：2016-06-30
申请号：US14586882
申请日：2014-12-30
申请人： AGILENT TECHNOLOGIES, INC.
发明人： Edwin E. Wikfors , Brian A. Bidlingmeyer , Klaus Witt
IPC分类号： G01N30/06 , G01N1/28
CPC分类号： G01N1/28 , G01N30/20 , G01N30/36 , G01N2030/202 , G01N2030/207 , G01N2030/342
摘要： A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.
摘要翻译：提供了一种用于将样品引入色谱系统的流动相的方法和系统。该方法包括首先将流动相直接引入色谱系统的分离单元，绕过样品环，流动相包括从加压的第一溶剂和第二溶剂计量的组合溶剂; 将样品加载到样品回路中，同时流动相继续直接导入分离单元; 在加压的第一溶剂中对样品环中的样品加压，同时流动相继续被直接引导到分离单元中; 并将样品环切换到流动相中，从而将加压的样品引入分离单元。

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