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1. 发明授权

US11219643B2 Compositions for cellular restoration and methods of making and using same 有权
公开(公告)号：US11219643B2
公开(公告)日：2022-01-11
申请号：US16111832
申请日：2018-08-24
申请人： Advanced ReGen Medical Technologies, LLC
发明人： Vincent C. Giampapa
IPC分类号： A61K35/15 , A61K38/18 , A61K35/12
摘要： A method comprising obtaining a first cell sample from a first subject; obtaining a second cell sample from a second subject; culturing the first cell sample in the presence of at least a portion of a culture media of the second cell sample for a time period ranging from about 24 hours to about 6 weeks to produce a restoring composition; and contacting the restoring composition with the second cell sample for a period of time ranging from about 24 hours to about 6 weeks to produce a restored composition.

2. 发明申请

US20180360878A1 Compositions for Cellular Restoration and Methods of Making and Using Same 审中-公开
公开(公告)号：US20180360878A1
公开(公告)日：2018-12-20
申请号：US16111832
申请日：2018-08-24
申请人： Advanced ReGen Medical Technologies, LLC
发明人： Vincent C. Giampapa
IPC分类号： A61K35/15 , A61K38/18 , A61K35/12
摘要： A method comprising obtaining a first cell sample from a first subject; obtaining a second cell sample from a second subject; culturing the first cell sample in the presence of at least a portion of a culture media of the second cell sample for a time period ranging from about 24 hours to about 6 weeks to produce a restoring composition; and contacting the restoring composition with the second cell sample for a period of time ranging from about 24 hours to about 6 weeks to produce a restored composition.

3. 发明申请

US20160108370A1 REPROGRAMMING OF AGED ADULT STEM CELLS 审中-公开
标题翻译：老年成纤维细胞的分化
公开(公告)号：US20160108370A1
公开(公告)日：2016-04-21
申请号：US14922353
申请日：2015-10-26
申请人： ADVANCED REGEN MEDICAL TECHNOLOGIES, LLC
发明人： Steven J. Greco , Vincent C. Giampapa
IPC分类号： C12N5/074 , A61K35/12
CPC分类号： C12N5/0696 , A61K35/12 , C12N2500/84
摘要： A method comprising (a) obtaining young adult stem cells (YASC) from a first subject; (b) lysing the YASC to generate a lysate comprising an intracellular matrix (ICM) and other cellular components; (c) filtering the lysate through a filter having a membrane size of equal to or less than 0.4 micron to obtain a filtrate; and (d) applying the filtrate to a culture of aged adult stem cells (AASC) for a time period ranging from about 24 hours to about 30 days to generate a reprogrammed AASC (R-AASC) wherein the AASC were obtained from a second subject and wherein the R-AASC when infused into a breast cancer stem model results in a reduced number of breast cancer cells in bone marrow in comparison to a breast cancer stem model having AASC that have not been reprogrammed.
摘要翻译：一种方法，包括（a）从第一受试者获得幼年成体干细胞（YASC）; （b）裂解YASC以产生包含细胞内基质（ICM）和其它细胞组分的裂解物; （c）通过膜尺寸等于或小于0.4微米的过滤器过滤裂解物以获得滤液; 和（d）将滤液施用于老化成体干细胞培养物（AASC）约24小时至约30天的时间，以产生重编程的AASC（R-AASC），其中AASC获自第二受试者并且当与具有未被重新编程的AASC的乳腺癌干模型相比时，当输注到乳腺癌干模型中时，R-AASC导致骨髓中乳腺癌细胞数量减少。

4. 发明授权

US10772911B2 Cell free compositions for cellular restoration and methods of making and using same 有权
公开(公告)号：US10772911B2
公开(公告)日：2020-09-15
申请号：US15128660
申请日：2015-03-24
申请人： Advanced ReGen Medical Technologies, LLC
发明人： Steven John Greco , Vincent C. Giampapa
IPC分类号： A61K35/12 , A61K45/06 , A61K38/18 , A61K38/19 , A61K38/22 , A61K31/7105 , A61K35/15
摘要： A pharmaceutical formulation comprising exosomes derived from mobilized stem cells, and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles. A pharmaceutical formulation comprising a microvesicles derived from mobilized stem cells, and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles. A pharmaceutical formulation comprising an exosome-derived and/or microvesicle derived molecule and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles.

5. 发明授权

US11286463B2 Reprogramming of aged adult stem cells 有权
公开(公告)号：US11286463B2
公开(公告)日：2022-03-29
申请号：US14922353
申请日：2015-10-26
申请人： Advanced Regen Medical Technologies, LLC
发明人： Steven J. Greco , Vincent C. Giampapa
IPC分类号： C12N5/074 , A61K35/12
摘要： A method comprising (a) obtaining young adult stem cells (YASC) from a first subject; (b) lysing the YASC to generate a lysate comprising an intracellular matrix (ICM) and other cellular components; (c) filtering the lysate through a filter having a membrane size of equal to or less than 0.4 micron to obtain a filtrate; and (d) applying the filtrate to a culture of aged adult stem cells (AASC) for a time period ranging from about 24 hours to about 30 days to generate a reprogrammed AASC (R-AASC) wherein the AASC were obtained from a second subject and wherein the R-AASC when infused into a breast cancer stem model results in a reduced number of breast cancer cells in bone marrow in comparison to a breast cancer stem model having AASC that have not been reprogrammed.

6. 发明授权

US09994814B2 Method for cellular restoration 有权
公开(公告)号：US09994814B2
公开(公告)日：2018-06-12
申请号：US14889942
申请日：2014-04-09
申请人： Advanced Regen Medical Technologies, LLC
发明人： Vincent C. Giampapa
IPC分类号： C12N5/00 , C12N5/074 , A61K45/06 , A61K35/545 , A61K35/28
CPC分类号： C12N5/0607 , A61K35/28 , A61K35/545 , A61K45/06 , C12N2502/03 , A61K2300/00
摘要： A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition.

7. 发明申请

US20150174166A1 Compositions for Cellular Restoration and Methods of Making and Using Same 审中-公开
标题翻译：细胞恢复的组成和制作和使用方法
公开(公告)号：US20150174166A1
公开(公告)日：2015-06-25
申请号：US14577978
申请日：2014-12-19
申请人： Advanced ReGen Medical Technologies, LLC
发明人： Vincent C. Giampapa
IPC分类号： A61K35/12
CPC分类号： A61K35/15 , A61K35/12 , A61K38/18
摘要： A method comprising obtaining a first cell sample from a first subject; obtaining a second cell sample from a second subject; culturing the first cell sample in the presence of at least a portion of a culture media of the second cell sample for a time period ranging from about 24 hours to about 6 weeks to produce a restoring composition; and contacting the restoring composition with the second cell sample for a period of time ranging from about 24 hours to about 6 weeks to produce a restored composition.
摘要翻译：一种方法，包括从第一受试者获得第一细胞样品; 从第二受试者获得第二细胞样品; 在第二细胞样品的培养基的至少一部分的存在下培养第一细胞样品约24小时至约6周的时间段以产生恢复组合物; 并使恢复组合物与第二细胞样品接触约24小时至约6周的时间段以产生恢复的组合物。

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