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1. 发明申请

US20100010014A1 AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE 有权
标题翻译：氨基嘧啶化合物和使用方法
公开(公告)号：US20100010014A1
公开(公告)日：2010-01-14
申请号：US12562853
申请日：2009-09-18
申请人： Adrian Leonard Smith , Paul Edward Brennan , Frenel Fils DeMorin , Gang Lin , Nick A. Paras , Daniel Martin Retz , Elizabeth Rainbeau
发明人： Adrian Leonard Smith , Paul Edward Brennan , Frenel Fils DeMorin , Gang Lin , Nick A. Paras , Daniel Martin Retz , Elizabeth Rainbeau
IPC分类号： A61K31/506 , C07D417/04 , C07D417/14 , A61P19/02 , A61P35/00
CPC分类号： C07D417/14 , C07D409/14
摘要： The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.
摘要翻译：本发明涉及用于治疗由polo样激酶1（Plk1）介导的疾病的氨基嘧啶化合物。本发明还涉及这种氨基嘧啶化合物及其组合物在治疗与异常细胞生长和不想要的细胞增殖相关的疾病状态中的治疗用途。

2. 发明授权

US07977366B2 Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation 失效
标题翻译：用嗜中性粒细胞活化化学抑制剂治疗粘连嗜中性粒细胞炎症性疾病或抑制呼吸爆发
公开(公告)号：US07977366B2
公开(公告)日：2011-07-12
申请号：US10575683
申请日：2004-10-14
申请人： Hyunsil Han , Gang Lin , Carl Nathan
发明人： Hyunsil Han , Gang Lin , Carl Nathan
IPC分类号： A61K31/4709 , A61K31/41 , A61P37/00
CPC分类号： A61K31/425 , A61K31/415 , C07D231/22 , C07D277/74 , C07D495/04 , Y02A50/414 , Y02A50/423 , Y02A50/475
摘要： The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.
摘要翻译：本发明涉及在有效治疗炎症性疾病的条件下，用有效量的本申请所述通式（I）的化合物治疗受试者的炎症性疾病的方法。本发明还涉及一种抑制嗜中性粒细胞呼吸爆发的方法，而不会通过将嗜中性粒细胞与上述化合物接触而抑制嗜中性粒细胞的脱粒或细菌杀伤。

3. 发明授权

US5591896A Solid-state gas sensors 失效
标题翻译：固态气体传感器
公开(公告)号：US5591896A
公开(公告)日：1997-01-07
申请号：US552219
申请日：1995-11-02
申请人： Gang Lin
发明人： Gang Lin
IPC分类号： G01N27/62 , G01N27/68 , G01N27/70 , G01T1/185 , H01L49/00 , G01T1/18 , G01N27/52
CPC分类号： G01T1/185 , G01N27/70
摘要： Solid state gas sensors are provided, the use of which permits quantitative measurement of gaseous contaminants or change of composition of a gas or atmosphere being monitored. The gas sensor comprises at least a base, a first electrode, a second electrode. The first electrode has a finely tapered end to strengthen the electric field intensity in the gap between the first and the second electrodes. The sensing is based on ionization potential difference between the molecules of the contaminating gas and of the atmosphere. When a high voltage is applied to the electrodes, it creates a strong electric field between the electrodes, especially a very strong electric field around the tapered end of the first electrode. When the potential is sufficiently high, the gas in the vicinity of the tapered end of the first electrode will be ionized. The ions and electrons generated by the ionization create an electric current flows between the two electrodes and across the gap. The changes of this electric current with gas contamination or changes in the gas composition are used as sensing signals. Unlike other gas sensors, there is no chemical reaction, absorption or adsorption involved in this sensing process. The gas sensors of this invention may be manufactured by lithographic micromachining techniques at very low cost, and they can be easily integrated with controller and signal processing circuits to upgrade to smart microsensors. Further, in an alternative embodiment, a micro-actuator to control the gap between the two electrodes is integrated with the sensors. In another alternative embodiment, a third electrode may be mounted so as to control the intensity of the electric field.
摘要翻译：提供了固态气体传感器，其使用允许定量测量气体污染物或正在监视的气体或大气的组成变化。气体传感器至少包括基座，第一电极，第二电极。第一电极具有微细的端部，以增强第一和第二电极之间的间隙中的电场强度。感测是基于污染气体和大气的分子之间的电离电位差。当向电极施加高电压时，其在电极之间产生强电场，特别是在第一电极的锥形端周围的非常强的电场。当电位足够高时，第一电极的锥形端附近的气体将被离子化。通过电离产生的离子和电子产生电流在两个电极之间并跨过间隙流动。这种电流随气体污染或气体组成变化的变化被用作感测信号。与其他气体传感器不同，在该感测过程中不存在化学反应，吸收或吸附。本发明的气体传感器可以通过非常低成本的光刻微加工技术制造，并且可以容易地与控制器和信号处理电路集成以升级到智能微传感器。此外，在替代实施例中，用于控制两个电极之间的间隙的微致动器与传感器集成。在另一替代实施例中，可以安装第三电极以便控制电场的强度。

4. 发明申请

US20120212314A1 POWER MODULE AND CIRCUIT BOARD ASSEMBLY THEREOF 有权
标题翻译：电源模块和电路板组件
公开(公告)号：US20120212314A1
公开(公告)日：2012-08-23
申请号：US13408631
申请日：2012-02-29
申请人： Han Li , Gang Lin , Jing Chen , Jinfa Zhang
发明人： Han Li , Gang Lin , Jing Chen , Jinfa Zhang
IPC分类号： H01F27/29
CPC分类号： H05K7/1432 , H01F27/292 , H01F2027/408 , H02M3/33592 , Y02B70/1475
摘要： A power module mounted on a system board comprises a printed circuit board having an extension part, at least one primary winding coil disposed on a first side of the extension part. The at least one primary winding coil is disposed at a primary side of the power module. The power module further comprises a PCB winding formed on the extension part at a secondary side of the power module, a first magnetic core assembly, and a connector. The first magnetic core assembly comprises a first magnetic part and a second magnetic part. The at least one primary winding coil and the extension part are enclosed between the first magnetic part and the second magnetic part.
摘要翻译：安装在系统板上的功率模块包括具有延伸部分的印刷电路板，设置在延伸部分的第一侧上的至少一个初级绕组线圈。所述至少一个初级绕组线圈设置在所述功率模块的初级侧。功率模块还包括形成在功率模块的次级侧的延伸部分上的PCB绕组，第一磁芯组件和连接器。第一磁芯组件包括第一磁性部分和第二磁性部分。所述至少一个初级绕组线圈和所述延伸部分被封装在所述第一磁性部分和所述第二磁性部分之间。

5. 发明申请

US20080242620A1 Biologically active peptide comprising tyrosyl-seryl-valine (YSV) 失效
标题翻译：包含酪氨酰 - 丝氨酰 - 缬氨酸（YSV）的生物活性肽
公开(公告)号：US20080242620A1
公开(公告)日：2008-10-02
申请号：US11930171
申请日：2007-10-31
申请人： Wai Ming WONG , Gang Lin
发明人： Wai Ming WONG , Gang Lin
IPC分类号： A61K38/06 , A61P35/00
CPC分类号： C07K5/0812 , A61K38/00
摘要： The tripeptide Tyrosyl-seryl-valine is disclosed with its use as a pharmaceutical composition. A method is also disclosed making a pharmaceutical composition comprising providing the tripeptide Tyrosyl-seryl-valine and mixing said tripeptide with a pharmaceutical acceptable carrier.
摘要翻译：公开了三肽酪氨酰 - 丝氨酰缬氨酸作为药物组合物的用途。还公开了一种制备药物组合物的方法，其包括提供三肽酪氨酰 - 丝氨酰缬氨酸并将所述三肽与药学上可接受的载体混合。

6. 发明申请

US20060072230A1 Apparatus and method for testing magnetic disk drive components using drive-based parts 有权
标题翻译：使用基于驱动器的部件测试磁盘驱动器部件的装置和方法
公开(公告)号：US20060072230A1
公开(公告)日：2006-04-06
申请号：US11245250
申请日：2005-10-05
申请人： Robert Eaton , Gang Lin , Tao Lin , Amir Companieh , Rob Milby , Ron Carroll , Robert Kimball
发明人： Robert Eaton , Gang Lin , Tao Lin , Amir Companieh , Rob Milby , Ron Carroll , Robert Kimball
IPC分类号： G11B20/10
CPC分类号： G11B5/4555 , G11B5/455 , G11B20/1816 , G11B27/36
摘要： An apparatus and method for testing a component of a magnetic disk drive in which one or more drive-based components is used in the testing process. Each of the drive-based components is based on a corresponding one of the components of the magnetic disk drive. During testing, the component to be tested and at least one of the drive-based components are selectively engaged.
摘要翻译：一种用于测试在测试过程中使用一个或多个基于驱动器的部件的磁盘驱动器的部件的装置和方法。每个基于驱动器的组件基于磁盘驱动器的相应组件之一。在测试期间，待测试的部件和至少一个基于驱动器的部件被选择性地接合。

7. 发明授权

US08432630B1 Disk drive component test system 有权
标题翻译：磁盘驱动器组件测试系统
公开(公告)号：US08432630B1
公开(公告)日：2013-04-30
申请号：US12828086
申请日：2010-06-30
申请人： Tao Lin , Gang Lin
发明人： Tao Lin , Gang Lin
IPC分类号： G11B27/36 , G01R33/12
CPC分类号： G11B5/455 , G11B5/09
摘要： A hard drive component test system is provided. The hard drive component test system includes a rack having multiple test bays with first test sub-assemblies mounted in respective ones of the of test bays. A test control system is electrically coupled to each of the first test sub-assemblies. Each of the test bays is configured to receive a second test sub-assembly and to engage the second test sub-assembly with the first test sub-assembly mounted in the respective bay to form a drive assembly. The test control system is configured to selectively execute a test process on the drive assemblies mounted in the rack.
摘要翻译：提供了硬盘驱动器组件测试系统。硬盘驱动器部件测试系统包括具有多个测试托架的机架，其中第一测试子组件安装在相应的测试托架中。测试控制系统电耦合到每个第一测试子组件。每个测试托架被配置成接收第二测试子组件并使第二测试子组件与安装在相应的间隔中的第一测试子组件接合以形成驱动组件。测试控制系统被配置为在安装在机架中的驱动器组件上选择性地执行测试过程。

8. 发明申请

US20110118274A1 PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER 审中-公开
标题翻译：缓释抑制剂及其在治疗病原体感染和癌症中的应用
公开(公告)号：US20110118274A1
公开(公告)日：2011-05-19
申请号：US12674820
申请日：2008-08-25
申请人： Carl Nathan , Gang Lin
发明人： Carl Nathan , Gang Lin
IPC分类号： A61K31/41 , A61K31/422 , A61K31/427 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/497 , C07D419/04 , A61P35/00 , A61P31/06 , A61P31/00 , A61P31/04 , A61P31/08
CPC分类号： C07D419/04 , A61K31/42 , A61K31/425
摘要： The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
摘要翻译：本发明涉及蛋白酶体抑制剂及其在治疗受试者病原体感染或癌症的方法中的用途。所述方法涉及向受试者施用式（I）的化合物。（I）其中：Q是式或式，其中交叉虚线示出了形成连接Q与式（I）化合物的其余部分的键。式（I）化合物的其余取代基在本申请中定义。

9. 发明授权

US07284104B1 Volume-based incremental backup and recovery of files 有权
标题翻译：基于卷的增量备份和文件恢复
公开(公告)号：US07284104B1
公开(公告)日：2007-10-16
申请号：US10610134
申请日：2003-06-30
申请人： Weibao Wu , Anand A. Kekre , Gang Lin
发明人： Weibao Wu , Anand A. Kekre , Gang Lin
IPC分类号： G06F12/16
CPC分类号： G06F11/1451 , G06F11/1458 , G06F11/1469 , G06F2201/84 , Y10S707/99953 , Y10S707/99955
摘要： Various embodiments of systems and methods for performing volume-based incremental backups are disclosed. A method may involve generating a snappoint of a volume. The snappoint indicates which portions (e.g., blocks or extents) of the volume have been modified between a time at which the snappoint was generated and a time at which a subsequent snappoint was generated. The method may also involve accessing information mapping the file to the volume and, if the snappoint identifies as having been modified any blocks of the volume to which the file maps, copying those blocks from the subsequent snappoint to the backup device. Portions not identified as having been modified by the snappoint are not copied. Program instructions implementing such a method may be stored on a computer accessible medium.
摘要翻译：公开了用于执行基于卷的增量备份的系统和方法的各种实施例。一种方法可以涉及产生卷的snappoint。 snappoint指示在生成snappoint的时间和生成后续snappoint的时间之间已经修改了卷的哪些部分（例如，块或扩展盘）。该方法还可以涉及访问将文件映射到卷的信息，并且如果snappoint识别为文件映射到的卷的任何块的任何块，则将这些块从后续snappoint复制到备份设备。未被识别为被snappoint修改的部分不被复制。实现这种方法的程序指令可以存储在计算机可访问介质上。

10. 发明申请

US20070021448A1 Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation 失效
标题翻译：用嗜中性粒细胞活化化学抑制剂治疗粘连嗜中性粒细胞炎症性疾病或抑制呼吸爆发
公开(公告)号：US20070021448A1
公开(公告)日：2007-01-25
申请号：US10575683
申请日：2004-10-14
申请人： Hyunsil Han , Gang Lin , Carl Nathan
发明人： Hyunsil Han , Gang Lin , Carl Nathan
IPC分类号： A61K31/519 , A61K31/4709 , A61K31/428 , A61K31/4152
CPC分类号： A61K31/425 , A61K31/415 , C07D231/22 , C07D277/74 , C07D495/04 , Y02A50/414 , Y02A50/423 , Y02A50/475
摘要： The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without or inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.
摘要翻译：本发明涉及在有效治疗炎症性疾病的条件下，用有效量的本申请所述通式（I）的化合物治疗受试者的炎症性疾病的方法。本发明还涉及一种通过使嗜中性粒细胞与上述化合物接触而抑制嗜中性粒细胞呼吸爆发而不抑制或抑制嗜中性粒细胞脱颗粒或细菌性杀伤的方法。

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