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    • 1. 发明申请
    • Systems, methods and computer readable media for performing a domain-specific metasearch, and visualizing search results therefrom
    • 用于执行域特定元搜索的系统,方法和计算机可读介质,以及从其中可视化搜索结果
    • US20050278321A1
    • 2005-12-15
    • US11166696
    • 2005-06-24
    • Aditya VailayaAllan KuchinskyRobert Kincaid
    • Aditya VailayaAllan KuchinskyRobert Kincaid
    • G06F7/00G06F19/28
    • G06F17/30864G06F17/30991G06F19/28Y10S707/99935Y10S707/99943
    • Systems, methods and computer readable media for performing a domain-specific metasearch, and obtaining search results therefrom. A metasearch engine capable of accessing generic, web-based search engines and domain-relevant search engines is provided to receive one or more queries inputted by a user, and to search for documents on at least one the generic, web-based search engines and domain-relevant search engines which are relevant to the queries. Raw data search results are fetched in the form of text documents. Relevant data including semantic information are extracted from the raw data search results, and converted to a local format. The relevant data having been converted to the local format may be visualized as a network visualization. Additionally or alternatively, the raw data search results may be ranked and/or filtered based on the linking of the relevant data. Visualization of the raw data having been ranked and/or filtered may be performed in addition to, or alternative to visualization of the network.
    • 用于执行域特定元搜索的系统,方法和计算机可读介质,以及从其获得搜索结果。 提供了能够访问通用的,基于网络的搜索引擎和域相关搜索引擎的元搜索引擎,用于接收用户输入的一个或多个查询,并且在至少一个通用的基于web的搜索引擎上搜索文档,以及 与查询相关的域相关搜索引擎。 原始数据搜索结果以文本文档的形式提取。 从原始数据搜索结果中提取包括语义信息的相关数据,并将其转换为本地格式。 已经转换为本地格式的相关数据可以被可视化为网络可视化。 另外或替代地,可以基于相关数据的链接对原始数据搜索结果进行排名和/或过滤。 已经排序和/或过滤的原始数据的可视化可以除了网络的可视化之外或替代以进行。
    • 4. 发明授权
    • Domain specific knowledge-based metasearch system and methods of using
    • 基于域知识的元搜索系统和使用方法
    • US06920448B2
    • 2005-07-19
    • US10033823
    • 2001-12-19
    • Robert KincaidSimon HandleyAditya VailayaParvathi Chundi
    • Robert KincaidSimon HandleyAditya VailayaParvathi Chundi
    • G06F17/30
    • G06F17/30713G06F17/30864Y10S707/99933
    • A system and method for performing domain-specific knowledge based metasearches. A metasearch engine is provided for accessing a searching text-based documents using generic search engines while simultaneously being able to access publication based databases and sequence databases as well as in-house proprietary databases and any database capable of being interfaced with a web interface so as to produce search results in text format. A data mining module is also provided for organizing raw data obtained by unsupervised clustering, simple relevance ranking, and categorization, all of which are done independently of one another. The system is capable of storing previous search data for use in query refinement or subsequent searches based upon the stored data. A search results collection browser may be provided for analyzing current browsing patterns of the user for developing weighting factors to be used in ordering the results of future searches.
    • 一种用于执行基于领域的知识基于metasearches的系统和方法。 提供了一种元搜索引擎,用于使用通用搜索引擎访问基于文本的文档,同时能够访问基于发布的数据库和序列数据库,以及内部专有数据库和能够与Web界面进行连接的任何数据库,以便 以文本格式生成搜索结果。 还提供了一种数据挖掘模块,用于组织通过无监督聚类获得的原始数据,简单的相关性排序和分类,所有这些都是独立于彼此完成的。 该系统能够基于所存储的数据存储先前的搜索数据以用于查询细化或后续搜索。 可以提供搜索结果收集浏览器,用于分析用户的当前浏览模式,以开发用于排序未来搜索结果的加权因子。
    • 5. 发明申请
    • Methods and systems, for ontological integration of disparate biological data
    • 用于本体论整合不同生物数据的方法和系统
    • US20050216459A1
    • 2005-09-29
    • US11128896
    • 2005-05-12
    • Aditya VailayaRobert Kincaid
    • Aditya VailayaRobert Kincaid
    • G06F7/00G06F19/12
    • G16B50/00G16B5/00
    • Methods, systems and computer readable media for correlating data from data sets to higher level categories of characterization of the data. Data from a first set of data is analyzed to determine where members of the first set map to an ontology. Data from a second set of data is analyzed to determine where members of the second set map to the ontology. From such analysis a subset of the first set of data is identified and a subset of the second set of data is identified. The subset of the first set of data is statistically analyzed with regard to its mapping to the ontology, and a first set of ontology terms are identified that are statistically differentiated by members of the subset of the first set of data. The subset of the second set of data is statistically analyzed with regard to its mapping to the ontology, and a second set of ontology terms is identified that are statistically differentiated by members of the subset of the second set of data. Correlation of the first set of ontology terms with the second set of ontology terms may further be performed.
    • 用于将来自数据集的数据与数据的更高级别表征相关联的方法,系统和计算机可读介质。 分析来自第一组数据的数据,以确定第一组的成员映射到本体的位置。 分析来自第二组数据的数据以确定第二集合的成员映射到本体的位置。 从这样的分析中,识别第一组数据的子集,并且识别第二组数据的子集。 第一组数据的子集关于其对本体的映射进行统计分析,并且识别由第一组数据的子集的成员统计地区分的第一组本体术语。 第二组数据的子集关于其与本体的映射进行统计分析,并且识别由第二组数据的子集的成员统计地区分的第二组本体术语。 可以进一步执行第一组本体项与第二组本体术语的相关性。
    • 7. 发明申请
    • System and methods for visualizing and manipulating multiple data values with graphical views of biological relationships
    • 用生物学关系的图形视图来可视化和操纵多个数据值的系统和方法
    • US20050027729A1
    • 2005-02-03
    • US10928494
    • 2004-08-27
    • Allan KuchinskyRobert Kincaid
    • Allan KuchinskyRobert Kincaid
    • G06F7/00G06F19/12G06F19/20G06F19/26
    • G16B45/00G16B5/00G16B25/00
    • Methods, systems and computer readable media for visualizing multiple data values adjacent graphical representations of entities in a diagram representing biological relationships between the entities. A diagram of interconnected entities representing biological relationships between the entities is displayed. A data set having rows of data values, each row containing values representing a single entity is provided, wherein at least some of the entities are represented on the diagram. At least one row of data values from the dataset is overlaid on the displayed diagram such that the row of data values appears adjacent the entity on the diagram that matches the entity in the data set that the row of data characterizes. The display of the row of data values is scaled so that components of the display are dimensionally proportional to numerical values of the data values taken from the data set.
    • 方法,系统和计算机可读介质,用于在表示实体之间的生物关系的图中的实体的图形表示之间可视化多个数据值。 显示表示实体之间的生物关系的互连实体的图。 提供了具有数据值行的数据集,每行包含表示单个实体的值,其中在图中表示至少一些实体。 来自数据集的至少一行数据值被覆盖在显示的图上,使得数据行的行出现在与图中数据集中表示的数据集中的实体相匹配的实体上。 数据值行的显示被缩放,使得显示器的组件在尺寸上与从数据集获取的数据值的数值成比例。
    • 10. 发明申请
    • Method and system for analysis of array-based, comparative-hybridization data
    • 基于阵列的比较杂交数据的分析方法和系统
    • US20060084067A1
    • 2006-04-20
    • US10953958
    • 2004-09-29
    • Zohar YakhiniAmir Ben-DorRobert Kincaid
    • Zohar YakhiniAmir Ben-DorRobert Kincaid
    • C12Q1/68G06F19/00
    • G16B25/00C12Q1/6841
    • Embodiments of the present invention include methods and systems for analysis of comparative genomic hybridization (“CGH”) data, including CGH data obtained from microarray experiments. Various embodiments of the present invention include parametric and non-parametric normalization methods for CGH data, methods for identifying sets of one or more contiguous chromosomal DNA subsequences that are amplified or deleted in cells from particular tissue samples, and methods for determining amplifications and deletions common to a set of analyzed samples. When combined with well-designed microarray-based experimental systems, method embodiments of the present invention provide markedly increased quantitative precision in the identification of chromosomal abnormalities, including amplified and deleted DNA subsequences based on CGH data.
    • 本发明的实施方案包括用于分析比较基因组杂交(“CGH”)数据的方法和系统,包括从微阵列实验获得的CGH数据。 本发明的各种实施方案包括用于CGH数据的参数和非参数归一化方法,用于鉴定在特定组织样品的细胞中扩增或缺失的一个或多个连续染色体DNA亚序列的集合的方法,以及用于确定扩增和缺失的方法 到一组分析的样品。 当与精心设计的基于微阵列的实验系统结合使用时,本发明的方法实施例提供了显着增加的染色体异常鉴定的定量精确度,包括基于CGH数据的扩增和缺失的DNA子序列。