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1. 发明申请

US20070134708A1 Diagnostic targets against Johne's disease 审中-公开
标题翻译：诊断针对约翰氏病的目标
公开(公告)号：US20070134708A1
公开(公告)日：2007-06-14
申请号：US11635933
申请日：2006-12-08
申请人： Adel Talaat , Chia-Wei Wu
发明人： Adel Talaat , Chia-Wei Wu
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6883
摘要： A composition and method for detecting Mycobacterium infection are disclosed. The gcpE, pstA, kdpC, papA2, impA, umaA1, fabG2132, aceAB, mbtH2, lpqP, map0834c, cspB, lipN, and map 1634 genes of M. paratuberculosis are novel virulence determinants for Johne's disease. Eighteen M. paratuberculosis-specific genomic islands were identified. Twenty-four M. avium-specific genomic islands were identified. Inversion of three large genomic fragments (INV) in M. paratuberculosis was also identified. These genomic identifiers represent novel virulence determinants that can be used as diagnostics targets for mycobacterial infection, and could provide suitable targets for vaccine and drug developments against Johne's disease.
摘要翻译：公开了一种用于检测分枝杆菌感染的组合物和方法。副结核分枝杆菌的gcpE，pstA，kdpC，papA2，impA，umaA1，fabG2 13，aceAB，mbtH2，lpqP，map0834c，cspB，lipN和Map 1634基因是Johne's 疾病。鉴定了十八个副结核分枝杆菌特异性基因组岛。鉴定了二十四只鸟类特异性基因组岛。还鉴定了副结核分枝杆菌中三个大基因组片段（INV）的反转。这些基因组标识符代表可用作分枝杆菌感染诊断目标的新型毒力决定因子，可为针对Johne氏病的疫苗和药物开发提供合适的靶标。

2. 发明申请

US20070134274A1 Vaccine candidates against Johne's disease 有权
标题翻译：疫苗候选人抵抗约翰氏病
公开(公告)号：US20070134274A1
公开(公告)日：2007-06-14
申请号：US11636025
申请日：2006-12-08
申请人： Adel Talaat
发明人： Adel Talaat
IPC分类号： A61K48/00 , A61K39/04
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/552
摘要： A composition and method for immunizing a mammal infected with Mycobacterium are disclosed. The genes gcpE, psta, kdpC, papA2, impA, umaA1, fabG2_2, aceAB, mbtH2, lpqP, map0834c, cspB, lipN, and map1634 of M. paratuberculosis and the products that they encode are vaccine targets for Johne's and Crohn's disease. Eighteen M. paratuberculosis-specific genomic islands (MAPs) were identified. Three inverted large genomic fragments in M. paratuberculosis (INV) were also identified. These genomic identifiers represent novel virulence determinants that can be used as targets for vaccines and for developments of drugs against Johne's disease. The methods can be used to deliver an immunizing compound to a mammal, to provide an immune response against Johne's or Crohn's disease in the mammal.
摘要翻译：公开了用分枝杆菌感染的哺乳动物免疫组合物和方法。副结核分枝杆菌的基因gcpE，psta，kdpC，papA2，impA，umaA1，fabG2_2，aceAB，mbtH2，lpqP，map0834c，cspB，lipN和map1634及其编码的产物是约氏和克罗恩病的疫苗靶标。鉴定了十八个副结核分枝杆菌特异性基因组岛（MAPs）。还鉴定了副结核分枝杆菌（INV）中的三个倒置的大基因组片段。这些基因组识别符代表新的毒力决定因子，可以用作疫苗的靶标和针对约翰氏病的药物开发。所述方法可用于向哺乳动物递送免疫化合物，以在哺乳动物中提供针对约氏或克罗恩氏病的免疫应答。

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