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1. 发明申请

US20090292482A1 Methods and Systems for Generating Cell Lineage Tree of Multiple Cell Samples 有权
标题翻译：用于生成多细胞样品的细胞谱系树的方法和系统
公开(公告)号：US20090292482A1
公开(公告)日：2009-11-26
申请号：US11887551
申请日：2006-03-27
申请人： Dan Frumkin , Adam Wasserstrom , Shai Kaplan , Uriel Feige , Ehud Y. Shapiro
发明人： Dan Frumkin , Adam Wasserstrom , Shai Kaplan , Uriel Feige , Ehud Y. Shapiro
IPC分类号： G06F19/00 , C12Q1/02
CPC分类号： G06F19/18 , G06F19/14 , G06F19/24
摘要： A method of generating a cell lineage tree of a plurality of cells of an individual is provided. The method comprising: (a) determining at least one genotypic marker for each cell of the plurality of cells; and (b) computationally clustering data representing the at least one genotypic marker to thereby generate the cell lineage tree of the plurality of cells of the individual.
摘要翻译：提供了生成个体的多个细胞的细胞谱系树的方法。所述方法包括：（a）确定所述多个细胞中的每个细胞的至少一种基因型标记; 和（b）计算表示所述至少一个基因型标记的数据，从而生成所述个体的多个细胞的细胞谱系树。

2. 发明授权

US07917306B2 Methods and systems for generating cell lineage tree of multiple cell samples 有权
标题翻译：多细胞样本生成细胞谱系树的方法和系统
公开(公告)号：US07917306B2
公开(公告)日：2011-03-29
申请号：US11887551
申请日：2006-03-27
申请人： Dan Frumkin , Adam Wasserstrom , Shai Kaplan , Uriel Feige , Ehud Y. Shapiro
发明人： Dan Frumkin , Adam Wasserstrom , Shai Kaplan , Uriel Feige , Ehud Y. Shapiro
IPC分类号： C12P1/00
CPC分类号： G06F19/18 , G06F19/14 , G06F19/24
摘要： A method of generating a cell lineage tree of a plurality of cells of an individual is provided. The method comprising: (a) determining at least one genotypic marker for each cell of the plurality of cells; and (b) computationally clustering data representing the at least one genotypic marker to thereby generate the cell lineage tree of the plurality of cells of the individual.
摘要翻译：提供了生成个体的多个细胞的细胞谱系树的方法。所述方法包括：（a）确定所述多个细胞中的每个细胞的至少一种基因型标记; 和（b）计算表示所述至少一个基因型标记的数据，从而生成所述个体的多个细胞的细胞谱系树。

3. 发明申请

US20130084571A1 METHYLATION PROFILING OF DNA SAMPLES 审中-公开
标题翻译： DNA样品的甲基化分析
公开(公告)号：US20130084571A1
公开(公告)日：2013-04-04
申请号：US13641915
申请日：2011-04-19
申请人： Adam Wasserstrom , Dan Frumkin
发明人： Adam Wasserstrom , Dan Frumkin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6851 , C12Q1/6858 , C12Q1/6881 , C12Q2521/331 , C12Q2547/101 , C12Q2600/154 , C12Q2600/16 , C12Q2545/114
摘要： The present disclosure relates to methodology for fast and cost-effective identification of the source of DNA samples. DNA samples obtained from unknown or unrecognized tissues or cell types are analyzed according to the methodology described herein, yielding an identification of the tissue and/or cell type source. Identification is based on sequential biochemical procedures including methylation sensitive/dependent restriction and polymerase chain reaction, followed by analysis of the data. All biochemical steps are performed in a single test tube. The disclosure has immediate applications in forensic science for identification of the tissue source of DNA obtained from biological stains. The disclosure also has immediate applications in cancer diagnosis for identification.
摘要翻译：本公开涉及用于快速和成本有效地鉴定DNA样品来源的方法。根据本文所述的方法分析从未知或未识别的组织或细胞类型获得的DNA样品，产生组织和/或细胞类型来源的鉴定。鉴定是基于顺序生化程序，包括甲基化敏感/依赖性限制和聚合酶链反应，然后分析数据。所有生化步骤都在单个试管中进行。该披露在法医学中立即应用于鉴定从生物污渍获得的DNA的组织来源。该公开内容还可以在癌症诊断中立即应用于鉴定。

4. 发明申请

US20130078626A1 CATEGORIZATION OF DNA SAMPLES 有权
标题翻译： DNA样品的分类
公开(公告)号：US20130078626A1
公开(公告)日：2013-03-28
申请号：US13492187
申请日：2012-06-08
申请人： Adam Wasserstrom , Dan Frumkin
发明人： Adam Wasserstrom , Dan Frumkin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q1/6858 , C12Q1/6881 , C12Q2600/154 , C12Q2521/331 , C12Q2525/151 , C12Q2537/165
摘要： The present application describes methods for accurate and cost-effective categorization of DNA samples into different types of in vitro generated DNA or different types of natural DNA such as from different tissues and/or physiological/pathological states. The invention achieves categorization by comparing “signal ratios” that are correlated to ratios of methylation levels at specific genomic loci, but does not rely on calculation of actual methylation levels at any genomic locus. Therefore the disclosed inventive method eliminates the requirement for external DNA species and controls, thereby simplifying and increasing the accuracy of the assay. The described inventive technology also enables performing the categorization of DNA together with DNA profiling in the same reaction, thereby allowing for concomitant categorization and determination of identity of the samples.
摘要翻译：本申请描述了将DNA样品精确和成本有效地分类为不同类型的体外产生的DNA或不同类型的天然DNA例如来自不同组织和/或生理/病理状态的方法。本发明通过比较与特定基因座位点甲基化水平的比例相关的信号比例来实现分类，但不依赖于任何基因组位点处的实际甲基化水平的计算。因此，所公开的本发明方法消除了对外部DNA物种和对照的需求，从而简化并提高了测定的准确性。所描述的本发明技术还能够在相同的反应中进行DNA分类以及DNA分析，从而允许对样品的同一性进行同时分类和确定。

5. 发明申请

US20120190023A1 METHODS FOR DISTINGUISHING BETWEEN NATURAL AND ARTIFICIAL DNA SAMPLES 有权
标题翻译：用于自然和人造DNA样品鉴别的方法
公开(公告)号：US20120190023A1
公开(公告)日：2012-07-26
申请号：US13381565
申请日：2010-07-01
申请人： Adam Wasserstrom , Dan Frumkin
发明人： Adam Wasserstrom , Dan Frumkin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/154
摘要： The present invention provides methods for distinguishing between natural and artificial DNA in samples containing nucleic acid molecules. In addition, the present invention provides methods for verifying that DNA profiles obtained from samples represent natural DNA. In various embodiments, the methods employ an array of nucleic acid based procedures for verifying that a DNA sample originates from a natural source. The invention further provides kits for verifying that a DNA sample originates from a natural source employing the methods and reagents described in the disclosure.
摘要翻译：本发明提供了在含有核酸分子的样品中区分天然和人造DNA的方法。此外，本发明提供了用于验证从样品获得的DNA谱图表示天然DNA的方法。在各种实施方案中，所述方法采用基于核酸的程序阵列来验证DNA样品来源于天然来源。本发明还提供用于使用本公开中描述的方法和试剂来验证DNA样品来源于天然来源的试剂盒。

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